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Typically, a TA locus consists of a pair of genes: one encodes a stable toxin that inhibits essential cellular functions, and another encodes a labile antitoxin that neutralizes the activity of its cognate toxin. The known TA loci can be classified into 8 types based on the nature and mode of action of the antitoxins, namely types I to VIII described in the review by Dukas JurÄ—nas et al. (2022). The majority of described toxins are proteins (types I to VII), while the toxins are RNAs for type VIII TA pairs. Antitoxins are proteins for types II and IV to VII TA pairs but are RNAs in types I, III and VIII TA pairs.




TA family Toxin Antitoxin Toxin target Number of Exp. TA loci
relBE relE relB mRNA cleavage (translation) 58 experimental
parDE parE parD DNA gyrase (replication) 11 experimental
higBA higB higA mRNA cleavage (translation) 22 experimental
vapBC vapC vapB translation 69 experimental
mazEF mazF mazE mRNA cleavage (Translation) 35 experimental
phd-doc doc phd phosphorylate EF-Tu (Translation) 5 experimental
ccdAB ccdB ccdA DNA gyrase (replication) 6 experimental
hipBA hipA hipB phosphorylate EF-Tu (Translation) 10 experimental
hicAB hicA hicB mRNA cleavage 11 experimental
mqsRA mqsR mqsA mRNA cleavage (translation) 4 experimental

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experimentalThe number of experimentally validated TA loci