NZ_CP1165471..158971

MGE detailed information

MGE type: Non-Mobilizable plasmid        MGE length: 158971 bp
Accession: NZ_CP116547        Location: 1..158971         Organism: Enterococcus faecium strain K189-3       Replicon: plasmid pK189-3-A


Gene structure


The 5 kb flanking regions of this MGE are displayed.

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML74_RS12835 (PML74_12835) 1..1041 + 1041 WP_002297425.1 replication initiator protein A -
PML74_RS12840 (PML74_12840) 1880..2212 + 333 WP_002322486.1 type IV conjugative transfer system protein TraE -
PML74_RS12845 (PML74_12845) 2831..3172 + 342 Protein_2 DUF5406 family protein -
PML74_RS12850 (PML74_12850) 3286..3525 + 240 WP_002331333.1 hypothetical protein -
PML74_RS12855 (PML74_12855) 3592..3792 + 201 WP_002331334.1 hypothetical protein -
PML74_RS12860 (PML74_12860) 3845..4525 + 681 WP_002331335.1 IS6 family transposase IS1216E Transposase
PML74_RS12865 (PML74_12865) 5131..5532 + 402 WP_002299892.1 IS200-IS605 family transposase ISBce3 Transposase
PML74_RS12870 (PML74_12870) 5556..6674 + 1119 WP_002320593.1 IS200-IS605 family transposase ISEfa4 Transposase
PML74_RS12875 (PML74_12875) 6870..7541 + 672 WP_002331336.1 class A sortase -
PML74_RS12880 (PML74_12880) 7593..9569 + 1977 WP_002331337.1 SpaA isopeptide-forming pilin-related protein -
PML74_RS12885 (PML74_12885) 9584..10336 + 753 WP_002331338.1 Sortase A VF
PML74_RS12890 (PML74_12890) 10352..11107 + 756 WP_002331339.1 pilin N-terminal domain-containing protein -
PML74_RS12895 (PML74_12895) 11120..11380 + 261 WP_002331340.1 hypothetical protein -
PML74_RS12900 (PML74_12900) 11377..13467 + 2091 WP_002331341.1 isopeptide-forming domain-containing fimbrial protein -
PML74_RS12905 (PML74_12905) 13494..13958 + 465 WP_025477660.1 hypothetical protein -
PML74_RS12910 (PML74_12910) 13955..14197 + 243 WP_002305229.1 DUF5415 family protein -
PML74_RS12915 (PML74_12915) 14215..14517 + 303 WP_002295662.1 hypothetical protein -
PML74_RS12920 (PML74_12920) 14587..16662 + 2076 WP_002331343.1 hypothetical protein -
PML74_RS12925 (PML74_12925) 16662..19271 + 2610 WP_002331344.1 type IV secretory system conjugative DNA transfer family protein -
PML74_RS12930 (PML74_12930) 19268..21634 + 2367 WP_002331345.1 hypothetical protein -
PML74_RS12935 (PML74_12935) 21686..22018 + 333 WP_002295656.1 hypothetical protein -
PML74_RS12940 (PML74_12940) 22019..22612 + 594 WP_002331346.1 hypothetical protein -
PML74_RS12945 (PML74_12945) 22775..24799 + 2025 WP_272019710.1 ATPase -
PML74_RS12950 (PML74_12950) 24799..26004 + 1206 WP_002331349.1 glucosaminidase domain-containing protein -
PML74_RS12955 (PML74_12955) 26020..26670 + 651 WP_002297495.1 hypothetical protein -
PML74_RS12960 (PML74_12960) 26681..27487 + 807 WP_002331350.1 hypothetical protein -
PML74_RS12965 (PML74_12965) 27510..27740 + 231 WP_002297493.1 hypothetical protein -
PML74_RS12970 (PML74_12970) 27898..28833 + 936 WP_002297492.1 hypothetical protein -
PML74_RS12975 (PML74_12975) 28877..29146 + 270 WP_002331351.1 hypothetical protein -
PML74_RS12980 (PML74_12980) 29356..29643 + 288 WP_002331352.1 hypothetical protein -
PML74_RS12985 (PML74_12985) 29661..30083 + 423 WP_002331353.1 hypothetical protein -
PML74_RS12990 (PML74_12990) 30103..31695 + 1593 WP_033624447.1 hypothetical protein Relaxase
PML74_RS12995 (PML74_12995) 31707..32042 + 336 WP_002331355.1 hypothetical protein -
PML74_RS13000 (PML74_13000) 32189..32383 + 195 WP_002302840.1 hypothetical protein -
PML74_RS13005 (PML74_13005) 32519..33769 - 1251 WP_002287107.1 IS110 family transposase ISSpn10 Transposase
PML74_RS13010 (PML74_13010) 34179..36551 + 2373 WP_002331356.1 ArdC-like ssDNA-binding domain-containing protein -
PML74_RS13015 (PML74_13015) 36612..38081 + 1470 Protein_36 toprim domain-containing protein -
PML74_RS13020 (PML74_13020) 38092..40296 + 2205 WP_002331358.1 type IA DNA topoisomerase -
PML74_RS13025 (PML74_13025) 40312..40461 + 150 WP_002295632.1 hypothetical protein -
PML74_RS13030 (PML74_13030) 40542..41138 + 597 WP_002299811.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
PML74_RS13035 (PML74_13035) 41151..42050 + 900 WP_002299810.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
PML74_RS13040 (PML74_13040) 42053..42538 + 486 WP_002295626.1 single-stranded DNA-binding protein -
PML74_RS13045 (PML74_13045) 42560..42817 + 258 WP_002299808.1 hypothetical protein -
PML74_RS13050 (PML74_13050) 42976..43120 - 145 Protein_43 putative holin-like toxin -
PML74_RS13055 (PML74_13055) 43253..43513 + 261 WP_002299806.1 hypothetical protein -
PML74_RS13060 (PML74_13060) 43962..44168 + 207 WP_002330430.1 hypothetical protein -
PML74_RS13065 (PML74_13065) 44168..44419 + 252 WP_002300797.1 hypothetical protein -
PML74_RS13070 (PML74_13070) 44435..44590 + 156 WP_002300799.1 hypothetical protein -
PML74_RS13075 (PML74_13075) 44600..44872 + 273 WP_002300801.1 hypothetical protein -
PML74_RS13080 (PML74_13080) 45317..45496 + 180 WP_002300804.1 hypothetical protein -
PML74_RS13085 (PML74_13085) 45555..45911 + 357 WP_002311569.1 hypothetical protein -
PML74_RS13090 (PML74_13090) 46880..47833 - 954 WP_000222572.1 IS30 family transposase IS1252 Transposase
PML74_RS13095 (PML74_13095) 47954..48217 + 264 WP_002300807.1 uberolysin/carnocyclin family circular bacteriocin -
PML74_RS13100 (PML74_13100) 48589..49767 + 1179 WP_000997695.1 IS256 family transposase ISEf1 Transposase
PML74_RS13105 (PML74_13105) 50155..52101 + 1947 WP_002300833.1 PTS sugar transporter subunit IIA -
PML74_RS13110 (PML74_13110) 52104..52559 + 456 WP_002300835.1 PTS sugar transporter subunit IIA -
PML74_RS13115 (PML74_13115) 52573..53901 + 1329 WP_002300836.1 PTS transporter subunit IIC -
PML74_RS13120 (PML74_13120) 53935..54219 + 285 WP_002300838.1 PTS sugar transporter subunit IIB -
PML74_RS13125 (PML74_13125) 54221..54736 + 516 WP_002300840.1 YjbQ family protein -
PML74_RS13130 (PML74_13130) 54752..55414 + 663 WP_002300841.1 Ribulose-phosphate 3-epimerase VF
PML74_RS13135 (PML74_13135) 55421..55993 + 573 WP_002300842.1 3-hexulose-6-phosphate isomerase VF
PML74_RS13140 (PML74_13140) 56180..57700 - 1521 WP_002300843.1 IS66 family transposase ISDeal1 Transposase
PML74_RS13145 (PML74_13145) 57943..58128 - 186 WP_002305884.1 IS66 family transposase ISEbi1 Transposase
PML74_RS13150 (PML74_13150) 58112..58294 - 183 WP_002300846.1 hypothetical protein -
PML74_RS13155 (PML74_13155) 58535..58753 + 219 Protein_64 IS256 family transposase ISLgar5 Transposase
PML74_RS13160 (PML74_13160) 59248..59847 + 600 WP_002301839.1 Tyrosine recombinase XerC VF
PML74_RS13165 (PML74_13165) 59911..60510 + 600 WP_002322465.1 AbiH family protein -
PML74_RS13170 (PML74_13170) 60540..61191 - 652 Protein_67 IS6 family transposase IS1216V Transposase
PML74_RS13175 (PML74_13175) 61526..62398 - 873 WP_002305879.1 ROK family protein -
PML74_RS13180 (PML74_13180) 62662..64608 - 1947 WP_002352509.1 sucrose-specific PTS transporter subunit IIBC -
PML74_RS13185 (PML74_13185) 64793..66232 + 1440 WP_002302078.1 sucrose-6-phosphate hydrolase -
PML74_RS13190 (PML74_13190) 66234..67196 + 963 WP_002302077.1 LacI family DNA-binding transcriptional regulator -
PML74_RS13195 (PML74_13195) 67366..68792 - 1427 Protein_72 IS3 family transposase ISEfa10 Transposase
PML74_RS13200 (PML74_13200) 69035..69490 + 456 WP_002301718.1 IS200-IS605 family transposase ISAac3 Transposase
PML74_RS13205 (PML74_13205) 69755..69853 + 99 Protein_74 IS30 family transposase -
PML74_RS13210 (PML74_13210) 70076..70306 - 231 WP_002289255.1 resolvase -
PML74_RS13215 (PML74_13215) 70536..71354 - 819 WP_002289254.1 MurR/RpiR family transcriptional regulator -
PML74_RS13220 (PML74_13220) 71515..72204 + 690 WP_002289253.1 N-acetylmannosamine-6-phosphate 2-epimerase -
PML74_RS13225 (PML74_13225) 72218..73720 + 1503 WP_002289252.1 PTS transporter subunit EIIC -
PML74_RS13230 (PML74_13230) 73733..74209 + 477 WP_002300328.1 PTS glucose transporter subunit IIA -
PML74_RS13240 (PML74_13240) 76987..77505 + 519 WP_002287870.1 ClbS/DfsB family four-helix bundle protein -
PML74_RS13245 (PML74_13245) 79581..80666 + 1086 WP_002301591.1 tyrosine recombinase XerS -
PML74_RS13250 (PML74_13250) 80774..81727 - 954 WP_000222572.1 IS30 family transposase IS1252 Transposase
PML74_RS13255 (PML74_13255) 81858..83108 - 1251 WP_002301126.1 PTS sugar transporter subunit IIC -
PML74_RS13260 (PML74_13260) 83127..84053 - 927 WP_002298736.1 PEP phosphonomutase -
PML74_RS13265 (PML74_13265) 84132..85127 - 996 WP_002301128.1 tagatose-bisphosphate aldolase -
PML74_RS13270 (PML74_13270) 85143..86312 - 1170 WP_002301130.1 SIS domain-containing protein -
PML74_RS13275 (PML74_13275) 86328..87062 - 735 WP_002301131.1 GntR family transcriptional regulator -
PML74_RS13285 (PML74_13285) 89254..90593 + 1340 WP_086953915.1 IS3 family transposase ISEnfa3 Transposase
PML74_RS13290 (PML74_13290) 90984..92276 - 1293 WP_002301811.1 IS256 family transposase ISBsu2 Transposase
PML74_RS13295 (PML74_13295) 92550..92810 - 261 WP_002313174.1 hypothetical protein -
PML74_RS13300 (PML74_13300) 93061..94239 + 1179 WP_000997695.1 IS256 family transposase ISEf1 Transposase
PML74_RS13305 (PML74_13305) 94537..94827 + 291 Protein_94 DDE-type integrase/transposase/recombinase -
PML74_RS13310 (PML74_13310) 94810..95690 - 881 Protein_95 IS3 family transposase ISEfa8 Transposase
PML74_RS13315 (PML74_13315) 95892..96287 - 396 WP_002287876.1 aspartate 1-decarboxylase -
PML74_RS13320 (PML74_13320) 96297..97145 - 849 WP_002287875.1 pantoate--beta-alanine ligase -
PML74_RS13325 (PML74_13325) 97160..97543 - 384 Protein_98 3-methyl-2-oxobutanoate hydroxymethyltransferase -
PML74_RS13335 (PML74_13335) 98910..99356 - 447 Protein_100 3-methyl-2-oxobutanoate hydroxymethyltransferase -
PML74_RS13340 (PML74_13340) 99368..100228 - 861 WP_002349114.1 Rossmann-like and DUF2520 domain-containing protein -
PML74_RS13345 (PML74_13345) 100466..101635 + 1170 WP_002300493.1 IS256 family transposase ISEfa13 Transposase
PML74_RS13350 (PML74_13350) 101960..103279 - 1320 WP_002300494.1 HAMP domain-containing sensor histidine kinase -
PML74_RS13355 (PML74_13355) 103276..103929 - 654 WP_002285815.1 Transcriptional regulatory protein QseB VF
PML74_RS13360 (PML74_13360) 104217..105150 + 934 Protein_105 ISL3 family transposase IS1476 Transposase
PML74_RS13365 (PML74_13365) 105058..105873 - 816 WP_002302255.1 aminotransferase class V-fold PLP-dependent enzyme -
PML74_RS13370 (PML74_13370) 105824..106033 - 210 WP_002302256.1 hypothetical protein -
PML74_RS13375 (PML74_13375) 106310..107542 + 1233 Protein_108 ISL3 family transposase ISEfa11 Transposase
PML74_RS13380 (PML74_13380) 107690..108721 - 1032 WP_002302261.1 Vitamin B12 import ATP-binding protein BtuD VF
PML74_RS13385 (PML74_13385) 108728..109558 - 831 WP_002313180.1 ABC transporter permease -
PML74_RS13390 (PML74_13390) 109555..110370 - 816 WP_002330693.1 ABC transporter permease subunit -
PML74_RS13395 (PML74_13395) 110367..111191 - 825 WP_002302267.1 alkaline phosphatase family protein -
PML74_RS13400 (PML74_13400) 111181..112281 - 1101 WP_002302268.1 extracellular solute-binding protein -
PML74_RS13405 (PML74_13405) 112459..113244 + 786 WP_002302270.1 PHP domain-containing protein -
PML74_RS13410 (PML74_13410) 113277..113660 + 384 WP_002330694.1 hypothetical protein -
PML74_RS13415 (PML74_13415) 113836..114072 + 237 WP_002322470.1 Putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase VF
PML74_RS13420 (PML74_13420) 114084..114251 + 168 WP_077828693.1 peptidylprolyl isomerase -
PML74_RS13425 (PML74_13425) 114373..115668 - 1296 WP_002296623.1 ISL3 family transposase IS1251 Transposase
PML74_RS13430 (PML74_13430) 115739..116632 - 894 WP_080114582.1 radical SAM protein -
PML74_RS13435 (PML74_13435) 117266..118726 + 1461 Protein_120 IS1182 family transposase ISEfa7 Transposase
PML74_RS13440 (PML74_13440) 118649..118978 - 330 WP_228780303.1 IS1182 family transposase ISEfa7 Transposase
PML74_RS13445 (PML74_13445) 119192..120568 - 1377 WP_002301195.1 ABC transporter permease -
PML74_RS13450 (PML74_13450) 120568..121224 - 657 WP_002298083.1 putative ABC transporter ATP-binding protein VF
PML74_RS13455 (PML74_13455) 121234..122511 - 1278 WP_002301194.1 ABC transporter permease -
PML74_RS13460 (PML74_13460) 122530..122685 - 156 Protein_125 4Fe-4S binding protein -
PML74_RS13465 (PML74_13465) 122761..123923 + 1163 WP_102829665.1 IS3 family transposase ISEfa8 Transposase
PML74_RS13470 (PML74_13470) 124029..124244 + 216 Protein_127 IS256 family transposase ISEf1 Transposase
PML74_RS13475 (PML74_13475) 124535..125059 - 525 WP_002352518.1 hypothetical protein -
PML74_RS13480 (PML74_13480) 125084..125992 - 909 WP_002295743.1 IS982 family transposase ISEfm1 Transposase
PML74_RS13485 (PML74_13485) 126061..126612 - 552 WP_002330700.1 hypothetical protein -
PML74_RS13490 (PML74_13490) 126668..127222 - 555 WP_002301108.1 tyrosine-type recombinase/integrase -
PML74_RS13495 (PML74_13495) 127628..128536 - 909 WP_016925867.1 IS982 family transposase ISEfm1 Transposase
PML74_RS13500 (PML74_13500) 128744..129922 - 1179 WP_002340536.1 IS256 family transposase ISEfm2 Transposase
PML74_RS13505 (PML74_13505) 130943..131428 - 486 WP_080114350.1 hypothetical protein -
PML74_RS13510 (PML74_13510) 131504..132184 - 681 WP_002328842.1 IS6 family transposase IS1297 Transposase
PML74_RS13515 (PML74_13515) 132518..133411 + 894 WP_002316719.1 neutral zinc metallopeptidase -
PML74_RS13525 (PML74_13525) 133951..135236 + 1286 Protein_137 cytochrome P450 -
PML74_RS13530 (PML74_13530) 135308..136933 - 1626 WP_002331388.1 peptide ABC transporter substrate-binding protein -
PML74_RS13535 (PML74_13535) 137424..137873 + 450 WP_002331389.1 DIP1984 family protein -
PML74_RS13540 (PML74_13540) 138190..138771 - 582 WP_002331293.1 IS630 family transposase ISBs2 Transposase
PML74_RS13545 (PML74_13545) 138790..140133 - 1344 WP_002332322.1 PFL family protein -
PML74_RS13550 (PML74_13550) 140148..140414 - 267 WP_002290085.1 ACT domain-containing protein -
PML74_RS13555 (PML74_13555) 140517..141185 - 669 WP_002331291.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
PML74_RS13560 (PML74_13560) 141467..142327 + 861 Protein_144 MATE family efflux transporter -
PML74_RS13565 (PML74_13565) 142327..142941 - 615 Protein_145 PTS beta-glucoside transporter subunit IIBC -
PML74_RS13570 (PML74_13570) 142961..143203 - 243 WP_002331325.1 PTS sugar transporter subunit IIB -
PML74_RS13575 (PML74_13575) 143308..143523 - 216 Protein_147 DDE-type integrase/transposase/recombinase -
PML74_RS13580 (PML74_13580) 143688..144470 - 783 WP_002331326.1 hypothetical protein -
PML74_RS13585 (PML74_13585) 144703..146505 - 1803 WP_002331327.1 exonuclease domain-containing protein -
PML74_RS13590 (PML74_13590) 146568..147053 - 486 WP_227326759.1 hypothetical protein -
PML74_RS13595 (PML74_13595) 147426..147647 - 222 WP_002331328.1 helix-turn-helix transcriptional regulator -
PML74_RS13600 (PML74_13600) 147790..148119 - 330 Protein_152 recombinase family protein -
PML74_RS13605 (PML74_13605) 148195..148731 + 537 Protein_153 IS6 family transposase IS1216E Transposase
PML74_RS13610 (PML74_13610) 148814..150109 - 1296 WP_002297185.1 ISL3 family transposase ISEfa5 Transposase
PML74_RS13615 (PML74_13615) 150245..150397 + 153 Protein_155 IS6 family transposase -
PML74_RS13620 (PML74_13620) 150431..150604 - 174 WP_229214455.1 hypothetical protein -
PML74_RS13625 (PML74_13625) 150616..151353 - 738 WP_002331331.1 S8 family serine peptidase -
PML74_RS13630 (PML74_13630) 151613..152161 - 549 WP_002292681.1 hypothetical protein -
PML74_RS13635 (PML74_13635) 152162..153019 - 858 WP_002292680.1 ParA family protein -
PML74_RS13640 (PML74_13640) 153304..153591 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
PML74_RS13645 (PML74_13645) 153581..153910 - 330 WP_002292678.1 AbrB family transcriptional regulator -
PML74_RS13650 (PML74_13650) 153987..154259 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin Detail
PML74_RS13655 (PML74_13655) 154259..154522 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin Detail
PML74_RS13660 (PML74_13660) 154628..155551 - 924 WP_002331332.1 hypothetical protein -
PML74_RS13665 (PML74_13665) 156110..156427 - 318 WP_002290394.1 type II toxin-antitoxin system RelE/ParE family toxin -
PML74_RS13670 (PML74_13670) 156428..156682 - 255 WP_002297424.1 hypothetical protein -
PML74_RS13675 (PML74_13675) 156942..157082 - 141 WP_002290398.1 hypothetical protein -
PML74_RS13680 (PML74_13680) 157720..157806 - 87 Protein_168 single-stranded DNA-binding protein -

Similar MGE(s)


Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.

Detail Organism MGE type Related TA Genome accession Coordinates Mash
distance