MGE detailed information
MGE type: Conjugative plasmid MGE length: 120930 bp
Accession: NZ_CP101223 Location: 1..120930 Organism: Escherichia coli strain EC21Z-144 Replicon: plasmid pEC21Z144-121K-NDM5
Accession: NZ_CP101223 Location: 1..120930 Organism: Escherichia coli strain EC21Z-144 Replicon: plasmid pEC21Z144-121K-NDM5
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NML25_RS24815 (46) | 46..1077 | + | 1032 | WP_000907866.1 | plasmid replication initiator RepA | - |
| NML25_RS24820 (1775) | 1775..1990 | + | 216 | WP_000841013.1 | hypothetical protein | - |
| NML25_RS24825 (1987) | 1987..2979 | + | 993 | WP_001579760.1 | hypothetical protein | - |
| NML25_RS24830 (3038) | 3038..3655 | - | 618 | WP_000521604.1 | ProQ/FINO family protein | - |
| NML25_RS24835 (3850) | 3850..5406 | - | 1557 | WP_001579759.1 | AAA family ATPase | - |
| NML25_RS24840 (5671) | 5671..6261 | - | 591 | WP_000194568.1 | hypothetical protein | - |
| NML25_RS24845 (6261) | 6261..6518 | - | 258 | WP_000371888.1 | hypothetical protein | - |
| NML25_RS24850 (6847) | 6847..7950 | + | 1104 | WP_001127573.1 | nucleotide-binding protein | - |
| NML25_RS24855 (7980) | 7980..9140 | + | 1161 | WP_064148452.1 | DUF4238 domain-containing protein | - |
| NML25_RS24860 (9152) | 9152..9856 | + | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| NML25_RS24865 (9910) | 9910..10014 | - | 105 | Protein_10 | recombinase family protein | - |
| NML25_RS24870 (10253) | 10253..11467 | + | 1215 | WP_001532073.1 | type II site-specific deoxyribonuclease | - |
| NML25_RS24875 (11501) | 11501..12934 | - | 1434 | WP_001288435.1 | DNA cytosine methyltransferase | - |
| NML25_RS24880 (13028) | 13028..13300 | + | 273 | Protein_13 | IS1 family transposase | - |
| NML25_RS24885 (13557) | 13557..14254 | + | 698 | WP_103215986.1 | IS1 family transposase IS1R | Transposase |
| NML25_RS24890 (14375) | 14375..15213 | - | 839 | Protein_15 | Streptomycin 3''-adenylyltransferase | ARG |
| NML25_RS24895 (15362) | 15362..16375 | + | 1014 | WP_000845048.1 | IS91 family transposase ISAzo26 | Transposase |
| NML25_RS24900 (16578) | 16578..16928 | + | 351 | WP_000454193.1 | DUF3330 domain-containing protein | - |
| NML25_RS24905 (17162) | 17162..17716 | + | 555 | Protein_18 | IS6-like element IS26 family transposase | - |
| NML25_RS24910 (17768) | 17768..18472 | - | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| NML25_RS24915 (18542) | 18542..18694 | + | 153 | Protein_20 | IS6 family transposase IS15DI | Transposase |
| NML25_RS24920 (18743) | 18743..19648 | - | 906 | Protein_21 | IS4 family transposase IS10R | Transposase |
| NML25_RS24925 (19791) | 19791..20651 | + | 861 | WP_000557454.1 | SPbeta prophage-derived aminoglycoside N(3')-acetyltransferase-like protein YokD | ARG |
| NML25_RS24930 (20664) | 20664..21206 | + | 543 | WP_000587837.1 | AAA family ATPase | - |
| NML25_RS24935 (21688) | 21688..21879 | - | 192 | WP_000951934.1 | hypothetical protein | - |
| NML25_RS24940 (21903) | 21903..22130 | + | 228 | WP_000248278.1 | hypothetical protein | - |
| NML25_RS24945 (22181) | 22181..23308 | + | 1128 | WP_014837927.1 | DUF3883 domain-containing protein | - |
| NML25_RS24950 (23345) | 23345..24049 | + | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| NML25_RS24955 (24104) | 24104..24970 | - | 867 | Protein_28 | IS91 family transposase ISAzo26 | Transposase |
| NML25_RS24960 (25115) | 25115..25612 | + | 498 | WP_001083725.1 | IS1595 family transposase ISSsu9 | ARG |
| NML25_RS24965 (25724) | 25724..26014 | + | 291 | WP_001336345.1 | DUF1010 domain-containing protein | - |
| NML25_RS24970 (26020) | 26020..26858 | + | 839 | Protein_31 | Streptomycin 3''-adenylyltransferase | ARG |
| NML25_RS24975 (26975) | 26975..27322 | + | 348 | WP_000679427.1 | Multidrug transporter EmrE | ARG |
| NML25_RS24980 (27316) | 27316..28155 | + | 840 | WP_000259031.1 | Dihydropteroate synthase | ARG |
| NML25_RS24985 (28560) | 28560..30101 | + | 1542 | WP_000050481.1 | IS91 family transposase ISVsa3 | Transposase |
| NML25_RS24990 (30414) | 30414..30788 | + | 375 | Protein_35 | twin-arginine translocation (TAT) pathway signal sequence domain protein | - |
| NML25_RS24995 (30888) | 30888..31445 | + | 558 | Protein_36 | twin-arginine translocation (TAT) pathway signal sequence domain protein | - |
| NML25_RS25000 (31456) | 31456..32094 | - | 639 | WP_004201168.1 | phosphoribosylanthranilate isomerase | - |
| NML25_RS25005 (32099) | 32099..32464 | - | 366 | WP_004201167.1 | bleomycin binding protein Ble-MBL | - |
| NML25_RS25010 (32468) | 32468..33280 | - | 813 | WP_023408309.1 | Metallo-beta-lactamase type 2 | ARG |
| NML25_RS25015 (33381) | 33381..33674 | - | 294 | Protein_40 | IS30 family transposase ISAba125 | Transposase |
| NML25_RS25020 (33839) | 33839..34543 | + | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| NML25_RS25025 (34737) | 34737..35087 | - | 351 | Protein_42 | 60 kDa chaperonin | VF |
| NML25_RS25030 (35150) | 35150..35698 | + | 549 | WP_014342204.1 | cation:proton antiporter | - |
| NML25_RS25035 (35779) | 35779..36534 | - | 756 | WP_012372818.1 | 16S rRNA (guanine(1405)-N(7))-methyltransferase | ARG |
| NML25_RS25040 (36704) | 36704..37564 | - | 861 | WP_000027057.1 | Beta-lactamase TEM | ARG |
| NML25_RS25045 (37747) | 37747..37938 | - | 192 | Protein_46 | helix-turn-helix domain-containing protein | - |
| NML25_RS25050 (38092) | 38092..38796 | + | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| NML25_RS25055 (38852) | 38852..38962 | + | 111 | Protein_48 | korC | - |
| NML25_RS25060 (39481) | 39481..40614 | + | 1134 | WP_000545983.1 | DUF3800 domain-containing protein | - |
| NML25_RS25065 (40634) | 40634..40918 | + | 285 | WP_000642771.1 | hypothetical protein | - |
| NML25_RS25070 (41089) | 41089..41736 | - | 648 | WP_000074712.1 | hypothetical protein | - |
| NML25_RS25075 (41724) | 41724..42059 | - | 336 | WP_000628093.1 | hypothetical protein | - |
| NML25_RS25080 (42239) | 42239..42820 | - | 582 | WP_000139427.1 | hypothetical protein | - |
| NML25_RS25085 (43390) | 43390..43740 | + | 351 | WP_000493380.1 | hypothetical protein | - |
| NML25_RS25090 (43810) | 43810..44418 | + | 609 | WP_063074920.1 | hypothetical protein | - |
| NML25_RS25095 (44486) | 44486..45268 | + | 783 | WP_001372173.1 | site-specific integrase | - |
| NML25_RS25100 (45406) | 45406..45681 | - | 276 | WP_000239529.1 | hypothetical protein | - |
| NML25_RS25105 (45675) | 45675..46319 | - | 645 | WP_000633913.1 | division plane positioning ATPase MipZ | - |
| NML25_RS25110 (46548) | 46548..47519 | + | 972 | WP_001103690.1 | plasmid segregation protein ParM | - |
| NML25_RS25115 (47524) | 47524..47916 | + | 393 | WP_000340829.1 | plasmid partitioning/stability family protein | - |
| NML25_RS25120 (47921) | 47921..49192 | - | 1272 | WP_000457523.1 | Y-family DNA polymerase | - |
| NML25_RS25125 (49192) | 49192..49629 | - | 438 | WP_000109071.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| NML25_RS25130 (49626) | 49626..49874 | - | 249 | WP_000618110.1 | DinI-like family protein | - |
| NML25_RS25135 (50292) | 50292..51194 | + | 903 | WP_072748701.1 | DUF1281 domain-containing protein | - |
| NML25_RS25140 (51191) | 51191..51502 | + | 312 | WP_032072582.1 | hypothetical protein | - |
| NML25_RS25145 (51579) | 51579..52262 | + | 684 | WP_000086147.1 | DNA methylase | - |
| NML25_RS25150 (52263) | 52263..52484 | + | 222 | WP_001104881.1 | hypothetical protein | - |
| NML25_RS25155 (52498) | 52498..52932 | + | 435 | WP_000274500.1 | DUF1380 family protein | - |
| NML25_RS25160 (52978) | 52978..53754 | + | 777 | WP_001005023.1 | hypothetical protein | - |
| NML25_RS25165 (54166) | 54166..54591 | + | 426 | WP_001579750.1 | antirestriction protein | - |
| NML25_RS25170 (54638) | 54638..55060 | + | 423 | WP_000271744.1 | DUF1380 family protein | - |
| NML25_RS25175 (55057) | 55057..55248 | + | 192 | WP_001027495.1 | hypothetical protein | - |
| NML25_RS25180 (55319) | 55319..55633 | + | 315 | WP_001434357.1 | hypothetical protein | - |
| NML25_RS25185 (56017) | 56017..56544 | + | 528 | WP_001276107.1 | single-stranded DNA-binding protein | - |
| NML25_RS25190 (56602) | 56602..56835 | + | 234 | WP_000006020.1 | DUF905 domain-containing protein | - |
| NML25_RS25195 (56894) | 56894..58852 | + | 1959 | WP_001145485.1 | ParB/RepB/Spo0J family partition protein | - |
| NML25_RS25200 (58907) | 58907..59341 | + | 435 | WP_001387500.1 | conjugation system SOS inhibitor PsiB | - |
| NML25_RS25205 (59338) | 59338..60057 | + | 720 | WP_001276270.1 | plasmid SOS inhibition protein A | - |
| NML25_RS25210 (60054) | 60054..60650 | + | 597 | Protein_79 | hypothetical protein | - |
| NML25_RS25215 (61112) | 61112..61612 | + | 501 | WP_000117611.1 | antirestriction protein ArdA | - |
| NML25_RS25220 (62341) | 62341..62775 | + | 435 | WP_000218863.1 | hypothetical protein | - |
| NML25_RS25225 (62869) | 62869..63135 | + | 267 | WP_001247862.1 | hypothetical protein | - |
| NML25_RS25230 (63200) | 63200..64126 | + | 927 | WP_000038402.1 | ISNCY family transposase ISRor2 | VF |
| NML25_RS25235 (64149) | 64149..64346 | + | 198 | WP_001348086.1 | hypothetical protein | - |
| NML25_RS25240 (64377) | 64377..64628 | - | 252 | WP_000148285.1 | helix-turn-helix transcriptional regulator | - |
| NML25_RS25245 (65208) | 65208..66056 | + | 849 | WP_001077023.1 | DUF4942 domain-containing protein | - |
| NML25_RS25250 (66142) | 66142..66477 | - | 336 | WP_000157098.1 | hypothetical protein | - |
| NML25_RS25255 (66711) | 66711..67043 | + | 333 | WP_001283947.1 | IncI1-type relaxosome accessory protein NikA | - |
| NML25_RS25260 (67054) | 67054..69753 | + | 2700 | WP_001405892.1 | hypothetical protein | Relaxase |
| NML25_RS25265 (69790) | 69790..72081 | - | 2292 | WP_001289276.1 | F-type conjugative transfer protein TrbC | - |
| NML25_RS25270 (72074) | 72074..73144 | - | 1071 | WP_000151582.1 | IncI1-type conjugal transfer protein TrbB | - |
| NML25_RS25275 (73163) | 73163..74371 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (74551) | 74551..74613 | - | 63 | NuclAT_0 | - | Antitoxin Detail |
| - (74551) | 74551..74613 | - | 63 | NuclAT_0 | - | Antitoxin Detail |
| - (74551) | 74551..74613 | - | 63 | NuclAT_0 | - | Antitoxin Detail |
| - (74551) | 74551..74613 | - | 63 | NuclAT_0 | - | Antitoxin Detail |
| NML25_RS25280 (74663) | 74663..74815 | + | 153 | WP_001303307.1 | Hok/Gef family protein | Toxin Detail |
| NML25_RS25285 (74887) | 74887..75138 | - | 252 | WP_001291968.1 | hypothetical protein | - |
| - (75525) | 75525..75576 | - | 52 | NuclAT_1 | - | - |
| - (75525) | 75525..75576 | - | 52 | NuclAT_1 | - | - |
| - (75525) | 75525..75576 | - | 52 | NuclAT_1 | - | - |
| - (75525) | 75525..75576 | - | 52 | NuclAT_1 | - | - |
| NML25_RS25290 (76062) | 76062..76238 | - | 177 | WP_001054900.1 | hypothetical protein | - |
| NML25_RS25295 (76447) | 76447..76656 | - | 210 | WP_001140545.1 | hemolysin expression modulator Hha | - |
| NML25_RS25300 (76754) | 76754..77368 | - | 615 | WP_000578649.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| NML25_RS25305 (77444) | 77444..79612 | - | 2169 | WP_000698360.1 | IncI1-type conjugal transfer membrane protein TraY | - |
| NML25_RS25310 (79709) | 79709..80293 | - | 585 | WP_001579774.1 | IncI1-type conjugal transfer protein TraX | - |
| NML25_RS25315 (80322) | 80322..81524 | - | 1203 | WP_001189159.1 | IncI1-type conjugal transfer protein TraW | - |
| NML25_RS25320 (81491) | 81491..82105 | - | 615 | WP_000337394.1 | IncI1-type conjugal transfer protein TraV | - |
| NML25_RS25325 (82105) | 82105..85149 | - | 3045 | WP_001024752.1 | IncI1-type conjugal transfer protein TraU | - |
| NML25_RS25330 (85239) | 85239..86039 | - | 801 | WP_001164788.1 | IncI1-type conjugal transfer protein TraT | - |
| NML25_RS25335 (86023) | 86023..86211 | - | 189 | WP_001277255.1 | putative conjugal transfer protein TraS | - |
| NML25_RS25340 (86275) | 86275..86679 | - | 405 | WP_000086960.1 | IncI1-type conjugal transfer protein TraR | - |
| NML25_RS25345 (86730) | 86730..87257 | - | 528 | WP_001055569.1 | conjugal transfer protein TraQ | - |
| NML25_RS25350 (87257) | 87257..87961 | - | 705 | WP_000801920.1 | IncI1-type conjugal transfer protein TraP | - |
| NML25_RS25355 (87961) | 87961..89250 | - | 1290 | WP_063074922.1 | conjugal transfer protein TraO | - |
| NML25_RS25360 (89253) | 89253..90236 | - | 984 | WP_001191878.1 | hypothetical protein | VF |
| NML25_RS25365 (90247) | 90247..90939 | - | 693 | WP_000138552.1 | DotI/IcmL family type IV secretion protein | - |
| NML25_RS25370 (90936) | 90936..91283 | - | 348 | WP_001055900.1 | conjugal transfer protein | - |
| NML25_RS25375 (91301) | 91301..95068 | - | 3768 | WP_001579768.1 | DUF5710 domain-containing protein | - |
| NML25_RS25380 (95158) | 95158..95709 | - | 552 | WP_000014584.1 | Phospholipase D | VF |
| NML25_RS25385 (95724) | 95724..96014 | - | 291 | WP_001372180.1 | hypothetical protein | - |
| NML25_RS25390 (96011) | 96011..97159 | - | 1149 | WP_001024972.1 | putative protein YggR | VF |
| NML25_RS25395 (97156) | 97156..97974 | - | 819 | WP_000646097.1 | hypothetical protein | VF |
| NML25_RS25400 (97971) | 97971..98429 | - | 459 | WP_001079808.1 | hypothetical protein | VF |
| NML25_RS25405 (98824) | 98824..99408 | - | 585 | WP_000977522.1 | histidine phosphatase family protein | - |
| NML25_RS25410 (99468) | 99468..100670 | - | 1203 | WP_000976353.1 | conjugal transfer protein TraF | - |
| NML25_RS25415 (100756) | 100756..101580 | - | 825 | WP_001238929.1 | conjugal transfer protein TraE | - |
| NML25_RS25420 (101731) | 101731..102885 | - | 1155 | WP_001139958.1 | site-specific integrase | - |
| NML25_RS25425 (103689) | 103689..103937 | - | 249 | WP_001349157.1 | hypothetical protein | - |
| NML25_RS25430 (104573) | 104573..105943 | - | 1371 | WP_001393542.1 | hypothetical protein | VF |
| NML25_RS25435 (105943) | 105943..106599 | - | 657 | WP_001193553.1 | hypothetical protein | VF |
| NML25_RS25440 (106584) | 106584..107144 | - | 561 | WP_000014116.1 | hypothetical protein | VF |
| NML25_RS25445 (107154) | 107154..107768 | - | 615 | WP_254825277.1 | hypothetical protein | VF |
| NML25_RS25450 (107786) | 107786..108883 | - | 1098 | WP_001208805.1 | hypothetical protein | VF |
| NML25_RS25455 (108896) | 108896..110449 | - | 1554 | WP_000362202.1 | hypothetical protein | VF |
| NML25_RS25460 (110460) | 110460..110912 | - | 453 | WP_001247334.1 | hypothetical protein | VF |
| NML25_RS25465 (110899) | 110899..112194 | - | 1296 | WP_000752772.1 | hypothetical protein | VF |
| NML25_RS25470 (112187) | 112187..113869 | - | 1683 | WP_000748143.1 | hypothetical protein | VF |
| NML25_RS25475 (113883) | 113883..114320 | - | 438 | WP_000539807.1 | hypothetical protein | VF |
| NML25_RS25480 (114320) | 114320..115387 | - | 1068 | WP_001302629.1 | hypothetical protein | VF |
| NML25_RS25485 (116011) | 116011..116307 | - | 297 | WP_000494779.1 | hypothetical protein | - |
| NML25_RS25490 (116483) | 116483..116737 | - | 255 | WP_001136187.1 | PilI type IV pilus biogenesis protein | - |
| NML25_RS25495 (116899) | 116899..117450 | - | 552 | WP_000744644.1 | hypothetical protein | - |
| NML25_RS25500 (117623) | 117623..118306 | - | 684 | WP_000213859.1 | conjugal transfer protein TraC | - |
| NML25_RS25505 (118560) | 118560..119093 | - | 534 | WP_001372168.1 | transcription termination/antitermination NusG family protein | - |
| NML25_RS25510 (119535) | 119535..119822 | - | 288 | WP_000074855.1 | conjugal transfer protein TraA | - |
| NML25_RS25515 (119860) | 119860..120018 | - | 159 | Protein_140 | ash family protein | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|