MGE detailed information
MGE type: Conjugative plasmid MGE length: 155161 bp
Accession: NZ_CP093319 Location: 1..155161 Organism: Escherichia coli strain HUM3355 Replicon: plasmid pHUM3355_B
Accession: NZ_CP093319 Location: 1..155161 Organism: Escherichia coli strain HUM3355 Replicon: plasmid pHUM3355_B
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MLA23_RS23675 (1) | 1..978 | + | 978 | WP_000361611.1 | RepB family plasmid replication initiator protein | - |
| MLA23_RS23680 (1263) | 1263..2003 | - | 741 | WP_001514245.1 | tyrosine-type recombinase/integrase | - |
| MLA23_RS23685 (2124) | 2124..2312 | - | 189 | WP_001332052.1 | hypothetical protein | - |
| MLA23_RS23690 (2686) | 2686..3588 | - | 903 | WP_001312822.1 | hypothetical protein | VF |
| MLA23_RS23695 (3657) | 3657..4766 | - | 1110 | WP_000771475.1 | SDR family oxidoreductase | - |
| MLA23_RS23700 (5199) | 5199..6152 | - | 954 | WP_000280980.1 | Protease 7 | VF |
| MLA23_RS23705 (6256) | 6256..6645 | + | 390 | WP_001332050.1 | IS110 family transposase ISEc20 | Transposase |
| MLA23_RS23710 (7449) | 7449..7628 | - | 180 | Protein_7 | transposase | - |
| MLA23_RS23715 (7767) | 7767..8980 | + | 1214 | WP_162842477.1 | IS3 family transposase IS629 | Transposase |
| MLA23_RS23720 (9128) | 9128..9453 | - | 326 | Protein_9 | IS3 family transposase ISLad1 | Transposase |
| MLA23_RS23725 (9499) | 9499..9839 | + | 341 | Protein_10 | IS3 family transposase | - |
| MLA23_RS23730 (10434) | 10434..11621 | + | 1188 | WP_000928804.1 | efflux RND transporter periplasmic adaptor subunit | - |
| MLA23_RS23735 (11618) | 11618..13558 | + | 1941 | WP_000733252.1 | Macrolide export ATP-binding/permease protein MacB | VF |
| MLA23_RS23740 (13562) | 13562..14932 | + | 1371 | WP_001312828.1 | efflux transporter outer membrane subunit | - |
| MLA23_RS23745 (15406) | 15406..15600 | + | 195 | Protein_14 | IS200-IS605 family transposase IS200C | Transposase |
| MLA23_RS23750 (15729) | 15729..16670 | - | 942 | WP_000974762.1 | hypothetical protein | - |
| MLA23_RS23755 (16905) | 16905..18294 | - | 1390 | Protein_16 | ISNCY family transposase ISKpn21 | Transposase |
| MLA23_RS23760 (18604) | 18604..18753 | - | 150 | Protein_17 | IS3 family transposase IS2 | Transposase |
| MLA23_RS23765 (18931) | 18931..20124 | - | 1194 | WP_000450494.1 | GTP-binding protein | - |
| MLA23_RS23775 (23203) | 23203..23496 | + | 294 | WP_000738422.1 | increased serum survival lipoprotein Iss | - |
| MLA23_RS23780 (23554) | 23554..23753 | - | 200 | Protein_21 | lysis protein | - |
| MLA23_RS23785 (24307) | 24307..25331 | + | 1025 | Protein_22 | integrase core domain-containing protein | - |
| MLA23_RS23790 (26642) | 26642..27757 | + | 1116 | WP_263852551.1 | Elloramycin glycosyltransferase ElmGT | VF |
| MLA23_RS23795 (27897) | 27897..31556 | + | 3660 | WP_001442133.1 | Multidrug efflux ATP-binding/permease protein | VF |
| MLA23_RS23800 (31660) | 31660..32889 | + | 1230 | WP_000933672.1 | Enterochelin esterase | VF |
| MLA23_RS23805 (32974) | 32974..33930 | + | 957 | WP_000271277.1 | Ferri-bacillibactin esterase BesA | VF |
| MLA23_RS23810 (33975) | 33975..36152 | - | 2178 | WP_001222186.1 | Ferric enterobactin receptor | VF |
| MLA23_RS23815 (37006) | 37006..38040 | - | 1035 | WP_001190234.1 | 3-deoxy-7-phosphoheptulonate synthase | - |
| MLA23_RS23820 (38221) | 38221..38522 | + | 302 | Protein_29 | hypothetical protein | - |
| MLA23_RS23825 (38600) | 38600..38908 | - | 309 | WP_000377483.1 | DUF6404 family protein | - |
| MLA23_RS23830 (39061) | 39061..39186 | - | 126 | Protein_31 | type II toxin-antitoxin system toxin YacB | - |
| MLA23_RS23835 (39186) | 39186..39454 | - | 269 | Protein_32 | type II toxin-antitoxin system antitoxin YacA | - |
| MLA23_RS23840 (40065) | 40065..41339 | + | 1275 | WP_000489608.1 | HlyD family secretion protein | - |
| MLA23_RS23845 (41332) | 41332..43428 | + | 2097 | WP_000184924.1 | microcin H47 export transporter peptidase/ATP-binding subunit MchF | - |
| MLA23_RS23850 (43598) | 43598..43909 | - | 312 | WP_001259758.1 | colicin V | - |
| MLA23_RS23855 (43887) | 43887..44123 | - | 237 | WP_001323890.1 | colicin V immunity protein | - |
| MLA23_RS23860 (44242) | 44242..44685 | + | 444 | WP_001323891.1 | dehydrogenase | - |
| MLA23_RS23865 (44657) | 44657..45061 | + | 405 | WP_001389361.1 | hypothetical protein | - |
| MLA23_RS23870 (45063) | 45063..45332 | + | 270 | WP_000379710.1 | SemiSWEET transporter | - |
| MLA23_RS23875 (45329) | 45329..45595 | + | 267 | WP_001017350.1 | FAD-dependent oxidoreductase | - |
| MLA23_RS23880 (45651) | 45651..46103 | - | 453 | WP_000670963.1 | acyltransferase | - |
| MLA23_RS23885 (46396) | 46396..46656 | + | 261 | WP_000343091.1 | hypothetical protein | - |
| MLA23_RS23890 (46653) | 46653..47243 | + | 591 | WP_001518980.1 | hypothetical protein | - |
| MLA23_RS23895 (47305) | 47305..47520 | - | 216 | Protein_44 | DUF6404 family protein | - |
| MLA23_RS23900 (47649) | 47649..47984 | + | 336 | WP_001080729.1 | colicin 1A immunity protein | - |
| MLA23_RS23905 (48006) | 48006..49886 | - | 1881 | WP_001283335.1 | colicin Ia central receptor-binding domain-containing protein | - |
| MLA23_RS23910 (50072) | 50072..50920 | - | 849 | WP_001057989.1 | 3'-5' exonuclease | - |
| MLA23_RS23915 (50966) | 50966..51244 | - | 279 | WP_001384452.1 | type II toxin-antitoxin system toxin YacB | Toxin Detail |
| MLA23_RS23920 (51244) | 51244..51513 | - | 270 | WP_000079941.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin Detail |
| MLA23_RS23925 (52157) | 52157..53908 | - | 1752 | Protein_50 | Tn3 family transposase TnpA_TnAs1 | Transposase |
| MLA23_RS23930 (53912) | 53912..54304 | + | 393 | WP_001351729.1 | isochorismatase family cysteine hydrolase | - |
| MLA23_RS23935 (54442) | 54442..55326 | + | 885 | WP_000058717.1 | EamA family transporter | - |
| MLA23_RS23940 (55358) | 55358..56557 | - | 1200 | WP_000804064.1 | Tetracycline resistance protein, class C | ARG |
| MLA23_RS23945 (56663) | 56663..57313 | + | 651 | WP_000164043.1 | tetracycline resistance transcriptional repressor TetR(A) | - |
| MLA23_RS23950 (57345) | 57345..57587 | - | 243 | WP_000844627.1 | transposase | - |
| MLA23_RS23955 (57645) | 57645..60611 | - | 2967 | WP_001138014.1 | Tn3 family transposase TnpA_TnAs1 | Transposase |
| MLA23_RS23960 (60615) | 60615..61175 | - | 561 | WP_001161490.1 | Tn3 family transposase TnpR_TnAs1 | Transposase |
| MLA23_RS23965 (61351) | 61351..61701 | - | 351 | WP_000454193.1 | DUF3330 domain-containing protein | - |
| MLA23_RS23970 (61904) | 61904..62917 | - | 1014 | WP_000845048.1 | IS91 family transposase ISAzo26 | Transposase |
| MLA23_RS23975 (63073) | 63073..63546 | + | 474 | WP_001317507.1 | Dihydrofolate reductase type 1 | ARG |
| MLA23_RS23980 (63698) | 63698..64402 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| MLA23_RS23985 (64466) | 64466..64804 | + | 339 | Protein_62 | Tn3 family transposase TnpR_Tn3 | Transposase |
| MLA23_RS23990 (64987) | 64987..65847 | + | 861 | WP_000027057.1 | Beta-lactamase TEM | ARG |
| MLA23_RS23995 (65994) | 65994..66275 | + | 282 | Protein_64 | transposase zinc-binding domain-containing protein | - |
| MLA23_RS24000 (66434) | 66434..67138 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| MLA23_RS24005 (67188) | 67188..67907 | + | 720 | Protein_66 | helicase RepA family protein | - |
| MLA23_RS24010 (67894) | 67894..68796 | + | 903 | WP_001518958.1 | replication protein C, IncQ-type | - |
| MLA23_RS24015 (69053) | 69053..69868 | + | 816 | WP_001043265.1 | Dihydropteroate synthase | ARG |
| MLA23_RS24020 (69929) | 69929..70732 | + | 804 | WP_001082319.1 | Aminoglycoside 3'-phosphotransferase | ARG |
| MLA23_RS24025 (70732) | 70732..71568 | + | 837 | WP_000480968.1 | hypothetical protein | ARG |
| MLA23_RS24030 (71629) | 71629..72333 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| MLA23_RS24035 (72398) | 72398..73648 | - | 1251 | Protein_72 | transposase | - |
| MLA23_RS24040 (73723) | 73723..74391 | - | 669 | WP_001300294.1 | putative signaling protein | VF |
| MLA23_RS24045 (74427) | 74427..74663 | - | 237 | WP_000993386.1 | broad-spectrum mercury transporter MerE | - |
| MLA23_RS24050 (74660) | 74660..75022 | - | 363 | WP_001277456.1 | mercury resistance co-regulator MerD | - |
| MLA23_RS24055 (75040) | 75040..76734 | - | 1695 | WP_000105636.1 | mercury(II) reductase | - |
| MLA23_RS24060 (76786) | 76786..77208 | - | 423 | WP_001340589.1 | organomercurial transporter MerC | - |
| MLA23_RS24065 (77244) | 77244..77519 | - | 276 | WP_000732292.1 | mercury resistance system periplasmic binding protein MerP | - |
| MLA23_RS24070 (77533) | 77533..77883 | - | 351 | WP_001294663.1 | mercuric transport protein MerT | - |
| MLA23_RS24075 (77955) | 77955..78389 | + | 435 | WP_000429836.1 | IS607 family transposase ISChh1 | Transposase |
| MLA23_RS24080 (78733) | 78733..79590 | - | 858 | WP_001514234.1 | incFII family plasmid replication initiator RepA | - |
| MLA23_RS24085 (79583) | 79583..79657 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| MLA23_RS24090 (79882) | 79882..80142 | - | 261 | WP_000083819.1 | replication regulatory protein RepA | - |
| MLA23_RS24095 (80382) | 80382..80972 | - | 591 | WP_000766816.1 | DUF2726 domain-containing protein | - |
| MLA23_RS24100 (81011) | 81011..81220 | - | 210 | WP_001514235.1 | hemolysin expression modulator Hha | - |
| MLA23_RS24105 (81266) | 81266..81727 | - | 462 | WP_001514236.1 | thermonuclease family protein | - |
| MLA23_RS24110 (81972) | 81972..82184 | - | 213 | WP_001371875.1 | ANR family transcriptional regulator | - |
| MLA23_RS24115 (82317) | 82317..82877 | - | 561 | WP_000840464.1 | fertility inhibition protein FinO | - |
| MLA23_RS24120 (82980) | 82980..83840 | - | 861 | WP_000704522.1 | putative protein YcjY | VF |
| MLA23_RS24125 (83899) | 83899..84645 | - | 747 | WP_000205766.1 | conjugal transfer pilus acetylase TraX | - |
| MLA23_RS24130 (84665) | 84665..89935 | - | 5271 | WP_001514237.1 | Multifunctional conjugation protein TraI | Relaxase |
| MLA23_RS24135 (89935) | 89935..92088 | - | 2154 | WP_001369365.1 | type IV conjugative transfer system coupling protein TraD | - |
| MLA23_RS24140 (92341) | 92341..93072 | - | 732 | WP_000850424.1 | conjugal transfer complement resistance protein TraT | - |
| MLA23_RS24145 (93086) | 93086..93595 | - | 510 | WP_000628099.1 | conjugal transfer entry exclusion protein TraS | - |
| MLA23_RS24150 (93592) | 93592..96417 | - | 2826 | WP_001007045.1 | conjugal transfer mating-pair stabilization protein TraG | - |
| MLA23_RS24155 (96414) | 96414..97787 | - | 1374 | WP_001137358.1 | conjugal transfer pilus assembly protein TraH | - |
| MLA23_RS24160 (97787) | 97787..98149 | - | 363 | WP_010379880.1 | P-type conjugative transfer protein TrbJ | - |
| MLA23_RS24165 (98079) | 98079..98624 | - | 546 | WP_000052618.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| MLA23_RS24170 (98611) | 98611..98895 | - | 285 | WP_000624110.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| MLA23_RS24175 (99014) | 99014..99361 | - | 348 | WP_001287677.1 | conjugal transfer protein TrbA | - |
| MLA23_RS24180 (99377) | 99377..100120 | - | 744 | WP_001514239.1 | type-F conjugative transfer system pilin assembly protein TraF | - |
| MLA23_RS24185 (100113) | 100113..100370 | - | 258 | WP_000864325.1 | conjugal transfer protein TrbE | - |
| MLA23_RS24190 (100397) | 100397..102205 | - | 1809 | WP_000821846.1 | type-F conjugative transfer system mating-pair stabilization protein TraN | - |
| MLA23_RS24195 (102202) | 102202..102840 | - | 639 | WP_000777693.1 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| MLA23_RS24200 (102849) | 102849..103841 | - | 993 | WP_000830839.1 | conjugal transfer pilus assembly protein TraU | - |
| MLA23_RS24205 (103838) | 103838..104470 | - | 633 | WP_001203720.1 | type-F conjugative transfer system protein TraW | - |
| MLA23_RS24210 (104467) | 104467..104853 | - | 387 | WP_000214082.1 | type-F conjugative transfer system protein TrbI | - |
| MLA23_RS24215 (104850) | 104850..107477 | - | 2628 | WP_001064252.1 | type IV secretion system protein TraC | - |
| MLA23_RS24220 (107637) | 107637..107858 | - | 222 | WP_001278689.1 | conjugal transfer protein TraR | - |
| MLA23_RS24225 (107993) | 107993..108508 | - | 516 | WP_000809841.1 | type IV conjugative transfer system lipoprotein TraV | - |
| MLA23_RS24230 (108505) | 108505..108756 | - | 252 | WP_001038342.1 | conjugal transfer protein TrbG | - |
| MLA23_RS24235 (108768) | 108768..108965 | - | 198 | WP_001324648.1 | conjugal transfer protein TrbD | - |
| MLA23_RS24240 (108952) | 108952..109542 | - | 591 | WP_000002796.1 | conjugal transfer pilus-stabilizing protein TraP | - |
| MLA23_RS24245 (109532) | 109532..110959 | - | 1428 | WP_000146685.1 | F-type conjugal transfer pilus assembly protein TraB | - |
| MLA23_RS24250 (110959) | 110959..111687 | - | 729 | WP_001230787.1 | type-F conjugative transfer system secretin TraK | - |
| MLA23_RS24255 (111674) | 111674..112240 | - | 567 | WP_000399785.1 | type IV conjugative transfer system protein TraE | - |
| MLA23_RS24260 (112262) | 112262..112573 | - | 312 | WP_000012106.1 | type IV conjugative transfer system protein TraL | - |
| MLA23_RS24265 (112588) | 112588..112953 | - | 366 | WP_000994779.1 | type IV conjugative transfer system pilin TraA | - |
| MLA23_RS24270 (112986) | 112986..113387 | - | 402 | WP_001369361.1 | conjugal transfer relaxosome DNA-bindin protein TraY | - |
| MLA23_RS24275 (113480) | 113480..114169 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| MLA23_RS24280 (114356) | 114356..114739 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| MLA23_RS24285 (115154) | 115154..115663 | + | 510 | WP_000759163.1 | hypothetical protein | VF |
| MLA23_RS24290 (115959) | 115959..116780 | - | 822 | WP_001234468.1 | DUF932 domain-containing protein | - |
| MLA23_RS24295 (116899) | 116899..117186 | - | 288 | WP_000107520.1 | hypothetical protein | - |
| MLA23_RS24300 (117487) | 117487..117784 | + | 298 | Protein_125 | hypothetical protein | - |
| MLA23_RS24305 (118085) | 118085..118204 | - | 120 | WP_227898123.1 | Hok/Gef family protein | - |
| MLA23_RS24310 (118152) | 118152..118265 | - | 114 | Protein_127 | DUF5431 family protein | - |
| - (118299) | 118299..118510 | + | 212 | NuclAT_0 | - | - |
| - (118299) | 118299..118510 | - | 212 | NuclAT_0 | - | - |
| - (118299) | 118299..118510 | - | 212 | NuclAT_0 | - | - |
| - (118299) | 118299..118510 | - | 212 | NuclAT_0 | - | - |
| - (118299) | 118299..118510 | - | 212 | NuclAT_0 | - | - |
| MLA23_RS24315 (118455) | 118455..119241 | - | 787 | Protein_128 | plasmid SOS inhibition protein A | - |
| MLA23_RS24320 (119238) | 119238..119672 | - | 435 | WP_000845922.1 | conjugation system SOS inhibitor PsiB | - |
| MLA23_RS24325 (119727) | 119727..119978 | - | 252 | Protein_130 | hypothetical protein | - |
| MLA23_RS24330 (120165) | 120165..121706 | + | 1542 | WP_001298859.1 | IS21 family transposase ISEc12 | Transposase |
| MLA23_RS24335 (121721) | 121721..122467 | + | 747 | WP_001016257.1 | IS21 family transposase ISEc12 | Transposase |
| MLA23_RS24340 (122555) | 122555..124273 | - | 1719 | Protein_133 | ParB/RepB/Spo0J family partition protein | - |
| MLA23_RS24345 (124337) | 124337..124570 | - | 234 | WP_000005988.1 | DUF905 family protein | - |
| MLA23_RS24350 (124677) | 124677..125165 | - | 489 | Protein_135 | single-stranded DNA-binding protein | - |
| MLA23_RS24355 (125466) | 125466..125885 | + | 420 | WP_015056142.1 | hypothetical protein | - |
| MLA23_RS24360 (125971) | 125971..126534 | - | 564 | WP_001332335.1 | class I SAM-dependent methyltransferase | - |
| MLA23_RS24365 (126582) | 126582..127943 | - | 1362 | WP_000170680.1 | DUF3560 domain-containing protein | - |
| MLA23_RS24370 (127995) | 127995..128225 | - | 231 | WP_000218642.1 | hypothetical protein | - |
| MLA23_RS24375 (128742) | 128742..128995 | + | 254 | Protein_140 | hypothetical protein | - |
| MLA23_RS24380 (129219) | 129219..129401 | - | 183 | WP_001027505.1 | hypothetical protein | - |
| MLA23_RS24385 (129401) | 129401..129862 | - | 462 | WP_042007484.1 | DUF1380 family protein | - |
| MLA23_RS24390 (129862) | 129862..130287 | - | 426 | WP_001198922.1 | antirestriction protein | - |
| MLA23_RS24395 (130689) | 130689..131660 | + | 972 | WP_000082154.1 | IS110 family transposase ISEc32 | Transposase |
| MLA23_RS24400 (131921) | 131921..132133 | - | 213 | WP_000092896.1 | hypothetical protein | - |
| MLA23_RS24405 (132146) | 132146..132721 | - | 576 | WP_000343071.1 | hypothetical protein | - |
| MLA23_RS24410 (132790) | 132790..133137 | - | 348 | WP_001350917.1 | hypothetical protein | - |
| MLA23_RS24415 (133134) | 133134..133303 | - | 170 | Protein_148 | hypothetical protein | - |
| MLA23_RS24420 (133768) | 133768..134739 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| MLA23_RS24425 (134739) | 134739..135905 | - | 1167 | WP_001238646.1 | Sporulation initiation inhibitor protein Soj | VF |
| MLA23_RS24430 (136205) | 136205..136903 | - | 699 | Protein_151 | IS1 family transposase IS1A | Transposase |
| MLA23_RS24435 (137428) | 137428..139629 | - | 2202 | WP_000973517.1 | Ferric aerobactin receptor | VF |
| MLA23_RS24440 (139655) | 139655..140988 | - | 1334 | Protein_153 | L-lysine N6-monooxygenase | VF |
| MLA23_RS24445 (140985) | 140985..142727 | - | 1743 | WP_001015721.1 | Aerobactin synthase | VF |
| MLA23_RS24450 (142727) | 142727..143674 | - | 948 | WP_000011907.1 | N(6)-hydroxylysine O-acetyltransferase | VF |
| MLA23_RS24455 (143675) | 143675..145399 | - | 1725 | WP_000602863.1 | N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase | VF |
| MLA23_RS24460 (145535) | 145535..146728 | + | 1194 | WP_000095526.1 | MFS transporter | - |
| MLA23_RS24465 (147108) | 147108..147488 | - | 381 | WP_001318207.1 | fluoride efflux transporter CrcB | - |
| MLA23_RS24470 (147829) | 147829..148242 | - | 414 | Protein_159 | phosphopyruvate hydratase | - |
| MLA23_RS24475 (148240) | 148240..148497 | + | 258 | Protein_160 | transposase | - |
| MLA23_RS24480 (148731) | 148731..149588 | - | 858 | WP_000968139.1 | Manganese transport system membrane protein MntB | ARG |
| MLA23_RS24485 (149585) | 149585..150442 | - | 858 | WP_000992806.1 | Manganese transport system membrane protein MntB | ARG |
| MLA23_RS24490 (150439) | 150439..151266 | - | 828 | WP_000983710.1 | Iron(3+)-hydroxamate import ATP-binding protein FhuC | VF |
| MLA23_RS24495 (151266) | 151266..152180 | - | 915 | WP_001514243.1 | Putative metal ABC transporter substrate-binding protein Hpf | VF |
| MLA23_RS24500 (152536) | 152536..153233 | + | 698 | WP_223155668.1 | IS1 family transposase IS1S | Transposase |
| MLA23_RS24505 (153413) | 153413..153926 | - | 514 | Protein_166 | DUF4113 domain-containing protein | - |
| MLA23_RS24510 (153987) | 153987..154091 | - | 105 | Protein_167 | AAA family ATPase | - |
| MLA23_RS24515 (154093) | 154093..154416 | - | 324 | Protein_168 | IS21 family transposase IS21 | Transposase |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|