Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 50966..51513 Replicon plasmid pHUM3355_B
Accession NZ_CP093319
Organism Escherichia coli strain HUM3355

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag MLA23_RS23915 Protein ID WP_001384452.1
Coordinates 50966..51244 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag MLA23_RS23920 Protein ID WP_000079941.1
Coordinates 51244..51513 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLA23_RS23885 (46396) 46396..46656 + 261 WP_000343091.1 hypothetical protein -
MLA23_RS23890 (46653) 46653..47243 + 591 WP_001518980.1 hypothetical protein -
MLA23_RS23895 (47305) 47305..47520 - 216 Protein_44 DUF6404 family protein -
MLA23_RS23900 (47649) 47649..47984 + 336 WP_001080729.1 colicin 1A immunity protein -
MLA23_RS23905 (48006) 48006..49886 - 1881 WP_001283335.1 colicin Ia central receptor-binding domain-containing protein -
MLA23_RS23910 (50072) 50072..50920 - 849 WP_001057989.1 3'-5' exonuclease -
MLA23_RS23915 (50966) 50966..51244 - 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
MLA23_RS23920 (51244) 51244..51513 - 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
MLA23_RS23925 (52157) 52157..53908 - 1752 Protein_50 Tn3-like element TnAs1 family transposase -
MLA23_RS23930 (53912) 53912..54304 + 393 WP_001351729.1 isochorismatase family cysteine hydrolase -
MLA23_RS23935 (54442) 54442..55326 + 885 WP_000058717.1 EamA family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / dfrA5 / blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..155161 155161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T238090 WP_001384452.1 NZ_CP093319:c51244-50966 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T238090 NZ_LR890204:1886242-1886344 [Klebsiella pneumoniae]
GCAAGGCGGCTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT238090 WP_000079941.1 NZ_CP093319:c51513-51244 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT238090 NZ_LR890204:c1886351-1886206 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGCCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References