MGE detailed information
MGE type: Mobilizable plasmid MGE length: 128928 bp
Accession: NZ_CP080305 Location: 1..128928 Organism: Klebsiella pneumoniae strain KP-CT77 Replicon: plasmid pCT77-KPC
Accession: NZ_CP080305 Location: 1..128928 Organism: Klebsiella pneumoniae strain KP-CT77 Replicon: plasmid pCT77-KPC
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K0E63_RS28075 (1) | 1..858 | + | 858 | WP_032495102.1 | incFII family plasmid replication initiator RepA | - |
| K0E63_RS28080 (1797) | 1797..2450 | + | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| K0E63_RS28085 (2543) | 2543..2800 | + | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| K0E63_RS28090 (2733) | 2733..3134 | + | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| K0E63_RS28095 (3383) | 3383..3798 | + | 416 | Protein_4 | IS1-like element IS1B family transposase | - |
| K0E63_RS28100 (3834) | 3834..4379 | - | 546 | Protein_5 | Tn3 family transposase TnpA_Tn3 | Transposase |
| K0E63_RS28105 (4445) | 4445..5149 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K0E63_RS28110 (5214) | 5214..5804 | + | 591 | Protein_7 | IS91 family transposase ISSbo1 | Transposase |
| K0E63_RS28115 (6260) | 6260..6964 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K0E63_RS28120 (7015) | 7015..7632 | - | 618 | Protein_9 | IS91 family transposase ISSbo1 | Transposase |
| K0E63_RS28125 (7642) | 7642..7830 | - | 189 | WP_000957857.1 | hypothetical protein | - |
| K0E63_RS28130 (7922) | 7922..8458 | + | 537 | WP_064441864.1 | Tn3 family transposase TnpR_Tn3 | Transposase |
| K0E63_RS28135 (8641) | 8641..9501 | + | 861 | WP_000027057.1 | Beta-lactamase TEM | ARG |
| K0E63_RS28140 (9671) | 9671..10426 | + | 756 | WP_012372818.1 | 16S rRNA (guanine(1405)-N(7))-methyltransferase | ARG |
| K0E63_RS28145 (10507) | 10507..10821 | - | 315 | Protein_14 | hypothetical protein | - |
| K0E63_RS28150 (10876) | 10876..11580 | - | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| K0E63_RS28155 (11646) | 11646..11711 | + | 66 | Protein_16 | IS1 family transposase | - |
| K0E63_RS28160 (13160) | 13160..13394 | + | 235 | Protein_17 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K0E63_RS28165 (13522) | 13522..13803 | + | 282 | WP_001333089.1 | hypothetical protein | - |
| K0E63_RS28170 (13926) | 13926..14276 | - | 351 | WP_000361389.1 | plasmid partitioning/stability family protein | - |
| K0E63_RS28175 (14279) | 14279..15241 | - | 963 | WP_000959884.1 | plasmid segregation protein ParM | - |
| K0E63_RS28180 (15388) | 15388..15681 | + | 294 | WP_032146011.1 | hypothetical protein | - |
| K0E63_RS28185 (15758) | 15758..16441 | + | 684 | WP_000085883.1 | DNA methylase | - |
| K0E63_RS28190 (16442) | 16442..16663 | + | 222 | WP_001104881.1 | hypothetical protein | - |
| K0E63_RS28195 (16677) | 16677..17111 | + | 435 | WP_000274503.1 | DUF1380 family protein | - |
| K0E63_RS28200 (17162) | 17162..17938 | + | 777 | WP_001383963.1 | hypothetical protein | - |
| K0E63_RS28205 (18356) | 18356..18781 | + | 426 | WP_001198928.1 | antirestriction protein | - |
| K0E63_RS28210 (18828) | 18828..19250 | + | 423 | WP_000271762.1 | DUF1380 family protein | - |
| K0E63_RS28215 (19247) | 19247..19438 | + | 192 | WP_001027493.1 | hypothetical protein | - |
| K0E63_RS28220 (19752) | 19752..21419 | - | 1668 | WP_012372796.1 | group II intron reverse transcriptase/maturase | - |
| K0E63_RS29900 (22148) | 22148..22302 | - | 155 | Protein_30 | hypothetical protein | - |
| K0E63_RS28225 (22819) | 22819..23049 | + | 231 | WP_000218642.1 | hypothetical protein | - |
| K0E63_RS28230 (23101) | 23101..24462 | + | 1362 | WP_000170695.1 | DUF3560 domain-containing protein | - |
| K0E63_RS28235 (24509) | 24509..25072 | + | 564 | WP_015059007.1 | class I SAM-dependent methyltransferase | - |
| K0E63_RS29905 (25158) | 25158..25613 | - | 456 | Protein_34 | hypothetical protein | - |
| K0E63_RS28240 (25915) | 25915..26442 | + | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
| K0E63_RS28245 (26500) | 26500..26733 | + | 234 | WP_000006003.1 | DUF905 family protein | - |
| K0E63_RS28250 (26794) | 26794..28817 | + | 2024 | Protein_37 | ParB/RepB/Spo0J family partition protein | - |
| K0E63_RS28255 (28886) | 28886..29320 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
| K0E63_RS28260 (29317) | 29317..30036 | + | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
| - (30048) | 30048..30272 | + | 225 | NuclAT_0 | - | - |
| - (30048) | 30048..30272 | + | 225 | NuclAT_0 | - | - |
| - (30048) | 30048..30272 | + | 225 | NuclAT_0 | - | - |
| - (30048) | 30048..30272 | + | 225 | NuclAT_0 | - | - |
| K0E63_RS29910 (30258) | 30258..30407 | + | 150 | Protein_40 | plasmid maintenance protein Mok | - |
| K0E63_RS28265 (30349) | 30349..30474 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| K0E63_RS28270 (30793) | 30793..31089 | - | 297 | Protein_42 | hypothetical protein | - |
| K0E63_RS28275 (31389) | 31389..31685 | + | 297 | WP_001272251.1 | hypothetical protein | - |
| K0E63_RS28280 (31796) | 31796..32617 | + | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
| K0E63_RS28285 (32914) | 32914..33561 | - | 648 | WP_015059008.1 | hypothetical protein | VF |
| K0E63_RS28290 (33838) | 33838..34221 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| K0E63_RS28295 (34502) | 34502..35206 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K0E63_RS28300 (35260) | 35260..35583 | - | 324 | Protein_48 | class II aldolase/adducin family protein | - |
| K0E63_RS28305 (35576) | 35576..36828 | - | 1253 | Protein_49 | four-carbon acid sugar kinase family protein | - |
| K0E63_RS28310 (36840) | 36840..37742 | - | 903 | WP_002903955.1 | NAD(P)-dependent oxidoreductase | - |
| K0E63_RS28315 (38004) | 38004..38765 | + | 762 | WP_002210513.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| K0E63_RS28320 (38786) | 38786..39646 | - | 861 | WP_002904004.1 | Beta-lactamase SHV-2 | ARG |
| K0E63_RS28325 (39783) | 39783..39851 | + | 69 | Protein_53 | IS6 family transposase | - |
| K0E63_RS28330 (39887) | 39887..42853 | - | 2967 | WP_001138014.1 | Tn3 family transposase TnpA_TnAs1 | Transposase |
| K0E63_RS28335 (42857) | 42857..43417 | - | 561 | WP_001161490.1 | Tn3 family transposase TnpR_TnAs1 | Transposase |
| K0E63_RS28340 (43809) | 43809..44426 | + | 618 | Protein_56 | replication protein | - |
| K0E63_RS28345 (44960) | 44960..45238 | + | 279 | WP_013213990.1 | hypothetical protein | - |
| K0E63_RS28350 (45349) | 45349..45774 | + | 426 | WP_013213989.1 | antirestriction protein | - |
| K0E63_RS28355 (45902) | 45902..46057 | + | 156 | WP_013213988.1 | hypothetical protein | - |
| K0E63_RS28360 (46103) | 46103..46399 | + | 297 | WP_013213987.1 | transcriptional regulator | - |
| K0E63_RS28365 (46503) | 46503..47384 | + | 882 | Protein_61 | IS1182 family transposase ISKpn6 | Transposase |
| K0E63_RS28370 (47634) | 47634..48515 | - | 882 | WP_004199234.1 | Carbapenem-hydrolyzing beta-lactamase KPC | ARG |
| K0E63_RS28375 (48791) | 48791..49771 | - | 981 | WP_013213985.1 | IS481 family transposase ISKpn27 | Transposase |
| K0E63_RS28380 (49894) | 49894..50355 | - | 462 | Protein_64 | Tn3 family transposase TnpR_Tn3 | Transposase |
| K0E63_RS28385 (50407) | 50407..51111 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K0E63_RS28390 (51176) | 51176..52348 | - | 1173 | Protein_66 | transposase | - |
| K0E63_RS28395 (52423) | 52423..53091 | - | 669 | WP_001300294.1 | putative signaling protein | VF |
| K0E63_RS28400 (53127) | 53127..53363 | - | 237 | WP_000993386.1 | broad-spectrum mercury transporter MerE | - |
| K0E63_RS28405 (53360) | 53360..53722 | - | 363 | WP_001277456.1 | mercury resistance co-regulator MerD | - |
| K0E63_RS28410 (53740) | 53740..55434 | - | 1695 | WP_000105636.1 | mercury(II) reductase | - |
| K0E63_RS28415 (55486) | 55486..55908 | - | 423 | WP_001340589.1 | organomercurial transporter MerC | - |
| K0E63_RS28420 (55944) | 55944..56219 | - | 276 | WP_000732292.1 | mercury resistance system periplasmic binding protein MerP | - |
| K0E63_RS28425 (56233) | 56233..56583 | - | 351 | WP_001294663.1 | mercuric transport protein MerT | - |
| K0E63_RS28430 (56655) | 56655..57089 | + | 435 | WP_000429836.1 | IS607 family transposase ISChh1 | Transposase |
| K0E63_RS28435 (57168) | 57168..58172 | + | 1005 | WP_000427619.1 | IS110 family transposase IS5075 | Transposase |
| K0E63_RS28440 (58700) | 58700..60100 | - | 1401 | WP_004152084.1 | copper resistance membrane spanning protein PcoS | - |
| K0E63_RS28445 (60097) | 60097..60777 | - | 681 | WP_001188930.1 | Transcriptional activator protein CopR | VF |
| K0E63_RS28450 (60832) | 60832..61761 | - | 930 | WP_004213583.1 | copper resistance inner membrane protein PcoD | - |
| K0E63_RS28455 (61766) | 61766..62146 | - | 381 | WP_000025662.1 | copper resistance system metallochaperone PcoC | - |
| K0E63_RS28460 (62186) | 62186..63076 | - | 891 | WP_029884201.1 | copper resistance outer membrane transporter PcoB | - |
| K0E63_RS28465 (63082) | 63082..64899 | - | 1818 | WP_004213580.1 | multicopper oxidase PcoA | - |
| K0E63_RS28470 (65133) | 65133..65600 | + | 468 | WP_048336866.1 | hypothetical protein | - |
| K0E63_RS28475 (65867) | 65867..66604 | + | 738 | WP_004118669.1 | Murein DD-endopeptidase MepM | VF |
| K0E63_RS28480 (66638) | 66638..66835 | - | 198 | WP_000843497.1 | DUF2933 domain-containing protein | - |
| K0E63_RS28485 (66876) | 66876..69323 | - | 2448 | WP_004098955.1 | Ag(+)-translocating P-type ATPase SilP | - |
| K0E63_RS28490 (69450) | 69450..69890 | - | 441 | WP_000758228.1 | DUF411 domain-containing protein | - |
| K0E63_RS28495 (69977) | 69977..73123 | - | 3147 | WP_004098958.1 | Cu(+)/Ag(+) efflux RND transporter permease subunit SilA | - |
| K0E63_RS28500 (73134) | 73134..74426 | - | 1293 | WP_004213579.1 | Cu(+)/Ag(+) efflux RND transporter periplasmic adaptor subunit SilB | - |
| K0E63_RS28505 (74540) | 74540..74902 | - | 363 | WP_004213578.1 | cation efflux system protein CusF | - |
| K0E63_RS28510 (74931) | 74931..76316 | - | 1386 | WP_004213577.1 | Cation efflux system protein CusC | VF |
| K0E63_RS28515 (76506) | 76506..77186 | + | 681 | WP_004213574.1 | Transcriptional regulatory protein CusR | VF |
| K0E63_RS28520 (77179) | 77179..78654 | + | 1476 | WP_211589127.1 | Cu(+)/Ag(+) sensor histidine kinase | - |
| K0E63_RS28525 (78905) | 78905..79336 | + | 432 | WP_023302802.1 | silver-binding protein SilE | - |
| K0E63_RS28530 (79480) | 79480..79830 | + | 351 | WP_004213569.1 | DUF305 domain-containing protein | - |
| K0E63_RS28535 (80217) | 80217..81125 | - | 909 | WP_023302803.1 | HNH endonuclease | - |
| K0E63_RS28540 (81762) | 81762..82736 | + | 975 | WP_004213565.1 | sensor domain-containing diguanylate cyclase | - |
| K0E63_RS28545 (82915) | 82915..83160 | + | 246 | Protein_97 | hypothetical protein | - |
| K0E63_RS28550 (83321) | 83321..84265 | + | 945 | WP_011977810.1 | hypothetical protein | - |
| K0E63_RS28555 (84302) | 84302..84694 | + | 393 | WP_011977811.1 | hypothetical protein | - |
| K0E63_RS28560 (84752) | 84752..85273 | + | 522 | WP_013214008.1 | hypothetical protein | - |
| K0E63_RS28565 (85319) | 85319..85522 | + | 204 | WP_011977813.1 | hypothetical protein | - |
| K0E63_RS28570 (85552) | 85552..86556 | + | 1005 | WP_011977814.1 | hypothetical protein | - |
| K0E63_RS28575 (86740) | 86740..87519 | + | 780 | WP_013214009.1 | site-specific integrase | - |
| K0E63_RS28580 (87565) | 87565..87822 | - | 258 | WP_013214010.1 | hypothetical protein | - |
| K0E63_RS28585 (87951) | 87951..88064 | - | 114 | WP_014343462.1 | hypothetical protein | - |
| K0E63_RS28590 (88600) | 88600..89466 | + | 867 | WP_004118283.1 | replication initiation protein | - |
| K0E63_RS28595 (90576) | 90576..91781 | + | 1206 | WP_011977818.1 | AAA family ATPase | - |
| K0E63_RS28600 (91781) | 91781..92755 | + | 975 | WP_011977819.1 | ParB family protein | - |
| K0E63_RS28605 (92837) | 92837..94108 | - | 1272 | WP_013214011.1 | Y-family DNA polymerase | - |
| K0E63_RS28610 (94108) | 94108..94539 | - | 432 | WP_001568036.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| K0E63_RS28615 (94946) | 94946..96433 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| K0E63_RS28620 (96682) | 96682..97653 | + | 972 | WP_004152353.1 | plasmid segregation protein ParM | - |
| K0E63_RS28625 (97656) | 97656..98327 | + | 672 | WP_013214012.1 | plasmid partitioning/stability family protein | - |
| K0E63_RS28630 (98390) | 98390..98620 | + | 231 | WP_001568040.1 | hypothetical protein | - |
| K0E63_RS29915 (98816) | 98816..98985 | + | 170 | Protein_115 | hypothetical protein | - |
| K0E63_RS28635 (99057) | 99057..99758 | + | 702 | WP_001568041.1 | DNA methylase | - |
| K0E63_RS28640 (99758) | 99758..99979 | + | 222 | WP_001568042.1 | hypothetical protein | - |
| K0E63_RS28645 (99989) | 99989..100408 | + | 420 | WP_001568043.1 | DUF1380 domain-containing protein | - |
| K0E63_RS28650 (100462) | 100462..101229 | + | 768 | WP_013214013.1 | hypothetical protein | - |
| K0E63_RS28655 (101910) | 101910..102338 | + | 429 | WP_001568045.1 | antirestriction protein | - |
| K0E63_RS28660 (102381) | 102381..102887 | + | 507 | WP_013214014.1 | antirestriction protein ArdA | - |
| K0E63_RS28665 (102930) | 102930..103121 | + | 192 | WP_001568047.1 | hypothetical protein | - |
| K0E63_RS28670 (103309) | 103309..103563 | + | 255 | WP_011977779.1 | DNA polymerase III subunit theta | - |
| K0E63_RS28675 (103598) | 103598..103918 | + | 321 | WP_001568049.1 | hypothetical protein | - |
| K0E63_RS28680 (104598) | 104598..104825 | + | 228 | WP_001568050.1 | hypothetical protein | - |
| K0E63_RS28685 (104917) | 104917..105147 | + | 231 | WP_001568051.1 | hypothetical protein | - |
| K0E63_RS28690 (105199) | 105199..106554 | + | 1356 | WP_014343515.1 | DUF3560 domain-containing protein | - |
| K0E63_RS28695 (106602) | 106602..107165 | + | 564 | WP_014343514.1 | methyltransferase | - |
| K0E63_RS28700 (107998) | 107998..108540 | + | 543 | WP_014343512.1 | single-stranded DNA-binding protein | - |
| K0E63_RS28705 (108589) | 108589..108837 | + | 249 | WP_001568055.1 | DUF905 domain-containing protein | - |
| K0E63_RS28710 (108907) | 108907..110964 | + | 2058 | WP_015493064.1 | ParB/RepB/Spo0J family partition protein | - |
| K0E63_RS28715 (111009) | 111009..111440 | + | 432 | WP_001568057.1 | conjugation system SOS inhibitor PsiB | - |
| K0E63_RS28720 (111437) | 111437..112165 | + | 729 | WP_001568058.1 | plasmid SOS inhibition protein A | - |
| K0E63_RS28725 (112162) | 112162..112488 | + | 327 | WP_013023807.1 | hypothetical protein | - |
| K0E63_RS28730 (112544) | 112544..112918 | + | 375 | WP_014343510.1 | hypothetical protein | - |
| K0E63_RS29920 (113088) | 113088..113237 | + | 150 | Protein_136 | DUF5431 family protein | - |
| K0E63_RS28735 (113188) | 113188..113304 | + | 117 | WP_055313929.1 | type I toxin-antitoxin system Hok family toxin | - |
| K0E63_RS28740 (113997) | 113997..114269 | + | 273 | WP_040245921.1 | hypothetical protein | - |
| K0E63_RS28745 (114266) | 114266..114616 | + | 351 | WP_040245917.1 | hypothetical protein | - |
| K0E63_RS28750 (114631) | 114631..114948 | + | 318 | WP_014343505.1 | hypothetical protein | - |
| K0E63_RS28755 (115789) | 115789..116145 | + | 357 | WP_014343501.1 | hypothetical protein | - |
| K0E63_RS28760 (116206) | 116206..116418 | + | 213 | WP_014343500.1 | hypothetical protein | - |
| K0E63_RS28765 (116429) | 116429..116653 | + | 225 | WP_014343499.1 | hypothetical protein | - |
| K0E63_RS28770 (116734) | 116734..117054 | + | 321 | WP_014343498.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K0E63_RS28775 (117044) | 117044..117322 | + | 279 | WP_004152721.1 | helix-turn-helix transcriptional regulator | - |
| K0E63_RS29925 (117326) | 117326..117430 | + | 105 | Protein_146 | transcriptional regulator | - |
| K0E63_RS28780 (118259) | 118259..119080 | + | 822 | WP_004152492.1 | DUF932 domain-containing protein | - |
| K0E63_RS28785 (119113) | 119113..119442 | + | 330 | WP_013214015.1 | DUF5983 family protein | - |
| K0E63_RS28790 (119475) | 119475..119960 | - | 486 | WP_014343495.1 | hypothetical protein | VF |
| K0E63_RS28795 (120351) | 120351..120767 | + | 417 | WP_014343494.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| K0E63_RS28800 (120967) | 120967..121704 | + | 738 | WP_154244330.1 | conjugal transfer protein TrbJ | - |
| K0E63_RS28805 (121819) | 121819..122025 | + | 207 | WP_171773970.1 | TraY domain-containing protein | - |
| K0E63_RS28810 (122087) | 122087..122455 | + | 369 | WP_004194426.1 | type IV conjugative transfer system pilin TraA | - |
| K0E63_RS28815 (122469) | 122469..122774 | + | 306 | WP_004144424.1 | type IV conjugative transfer system protein TraL | - |
| K0E63_RS28820 (122794) | 122794..123159 | + | 366 | Protein_155 | type IV conjugative transfer system protein TraE | - |
| K0E63_RS28825 (123214) | 123214..123558 | - | 345 | Protein_156 | IS6 family transposase IS26 | Transposase |
| K0E63_RS28830 (123610) | 123610..124314 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K0E63_RS28835 (124339) | 124339..124539 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| K0E63_RS28840 (124559) | 124559..125305 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| K0E63_RS28845 (125360) | 125360..125920 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| K0E63_RS28850 (126052) | 126052..126252 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| K0E63_RS28855 (126638) | 126638..127237 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| K0E63_RS28860 (127299) | 127299..127631 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (127832) | 127832..127891 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (127832) | 127832..127891 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (127832) | 127832..127891 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (127832) | 127832..127891 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| K0E63_RS28865 (127936) | 127936..128085 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin Detail |
| K0E63_RS28870 (128369) | 128369..128617 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
| K0E63_RS29930 (128732) | 128732..128916 | + | 185 | Protein_166 | protein CopA/IncA | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|