MGE detailed information
MGE type: Integrative_Conjugative_Elements MGE length: 167674 bp
Accession: NZ_CP038164 Location: 1024744..1192417 Organism: Enterococcus faecium strain HB2-2 Replicon: chromosome
Accession: NZ_CP038164 Location: 1024744..1192417 Organism: Enterococcus faecium strain HB2-2 Replicon: chromosome
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3O52_RS04950 (E3O52_05135) | 1020389..1021417 | - | 1029 | WP_100970546.1 | DUF916 and DUF3324 domain-containing protein | - |
| E3O52_RS04955 (E3O52_05140) | 1021437..1024607 | - | 3171 | Protein_979 | Ig-like domain-containing protein | - |
| E3O52_RS04960 (E3O52_05145) | 1024829..1025713 | - | 885 | WP_002291161.1 | diacylglycerol kinase family lipid kinase | - |
| E3O52_RS04965 (E3O52_05150) | 1025808..1026245 | - | 438 | WP_002336024.1 | hypothetical protein | - |
| E3O52_RS04970 (E3O52_05155) | 1026411..1027362 | - | 952 | Protein_982 | IS30 family transposase | - |
| E3O52_RS04975 (E3O52_05160) | 1027527..1028438 | - | 912 | WP_002288548.1 | Foldase protein PrsA | VF |
| E3O52_RS04980 (E3O52_05165) | 1028815..1029453 | - | 639 | WP_002291166.1 | putative ABC transporter ATP-binding protein YknY | VF |
| E3O52_RS04985 (E3O52_05170) | 1029457..1031440 | - | 1984 | Protein_985 | DUF1430 domain-containing protein | - |
| E3O52_RS04990 (E3O52_05175) | 1031619..1032284 | + | 666 | WP_002291169.1 | helix-turn-helix domain-containing protein | - |
| E3O52_RS04995 (E3O52_05190) | 1034313..1035489 | + | 1177 | Protein_987 | IS256-like element ISEf1 family transposase | - |
| E3O52_RS05000 (E3O52_05200) | 1036309..1037139 | - | 831 | WP_005874445.1 | hypothetical protein | VF |
| E3O52_RS05005 (E3O52_05205) | 1037231..1039108 | - | 1878 | WP_081140346.1 | hypothetical protein | VF |
| E3O52_RS05010 (E3O52_05210) | 1039105..1040526 | - | 1422 | WP_104758426.1 | hypothetical protein | VF |
| E3O52_RS05015 (E3O52_05215) | 1040529..1043981 | - | 3453 | WP_105459788.1 | hypothetical protein | VF |
| E3O52_RS05020 (E3O52_05220) | 1044336..1045832 | + | 1497 | WP_010718305.1 | helix-turn-helix domain-containing protein | - |
| E3O52_RS05025 (E3O52_05225) | 1046409..1046747 | - | 339 | WP_231592960.1 | DNA methyltransferase | - |
| E3O52_RS05030 (E3O52_05230) | 1047508..1047786 | - | 279 | WP_002314576.1 | hypothetical protein | - |
| E3O52_RS05035 (E3O52_05235) | 1047862..1048107 | - | 246 | WP_002313380.1 | helix-turn-helix transcriptional regulator | - |
| E3O52_RS05040 | 1048434..1048652 | + | 219 | WP_223315553.1 | hypothetical protein | - |
| E3O52_RS05045 (E3O52_05250) | 1049160..1049441 | + | 282 | Protein_997 | tyrosine-type recombinase/integrase | - |
| E3O52_RS05050 (E3O52_05260) | 1050932..1052109 | + | 1178 | Protein_998 | IS256 family transposase ISEf1 | Transposase |
| E3O52_RS05055 (E3O52_05265) | 1052219..1054930 | - | 2712 | WP_214308105.1 | DEAD/DEAH box helicase family protein | - |
| E3O52_RS05060 (E3O52_05270) | 1054923..1056644 | - | 1722 | WP_272025073.1 | site-specific DNA-methyltransferase | - |
| E3O52_RS05065 | 1056658..1056813 | - | 156 | WP_272025074.1 | hypothetical protein | - |
| E3O52_RS05070 (E3O52_05275) | 1057155..1057337 | - | 183 | WP_214308103.1 | hypothetical protein | - |
| E3O52_RS05075 (E3O52_05280) | 1057371..1057592 | + | 222 | Protein_1003 | site-specific integrase | - |
| E3O52_RS05080 | 1058005..1058277 | - | 273 | WP_272025075.1 | hypothetical protein | - |
| E3O52_RS05085 | 1058411..1058623 | - | 213 | WP_272025076.1 | hypothetical protein | - |
| E3O52_RS05090 | 1059142..1059459 | - | 318 | WP_272025077.1 | hypothetical protein | - |
| E3O52_RS05095 | 1060163..1060642 | - | 480 | WP_272025078.1 | SIR2 family protein | - |
| E3O52_RS05100 | 1060722..1061096 | - | 375 | WP_272025079.1 | hypothetical protein | - |
| E3O52_RS05105 (E3O52_05290) | 1061734..1063122 | - | 1389 | WP_231414985.1 | relaxase/mobilization nuclease domain-containing protein | - |
| E3O52_RS05110 (E3O52_05295) | 1063107..1063712 | - | 606 | WP_105459774.1 | hypothetical protein | - |
| E3O52_RS05115 (E3O52_05300) | 1063705..1063965 | - | 261 | WP_272025080.1 | hypothetical protein | - |
| E3O52_RS05120 (E3O52_05305) | 1064039..1064626 | - | 588 | WP_272025081.1 | phage replisome organizer N-terminal domain-containing protein | - |
| E3O52_RS05125 (E3O52_05310) | 1064764..1065048 | - | 285 | WP_105459776.1 | helix-turn-helix domain-containing protein | - |
| E3O52_RS05130 (E3O52_05315) | 1065202..1065813 | + | 612 | WP_272025082.1 | helix-turn-helix transcriptional regulator | - |
| E3O52_RS05135 (E3O52_05320) | 1066044..1067186 | + | 1143 | WP_105459778.1 | Tyrosine recombinase XerC ; Integrase | Integrase |
| E3O52_RS05140 (E3O52_05325) | 1067283..1068674 | - | 1392 | WP_002287686.1 | Fe-S cluster assembly protein SufB | - |
| E3O52_RS05145 (E3O52_05330) | 1068679..1069149 | - | 471 | WP_002287684.1 | SUF system NifU family Fe-S cluster assembly protein | - |
| E3O52_RS05150 (E3O52_05335) | 1069136..1070371 | - | 1236 | WP_002325111.1 | cysteine desulfurase | - |
| E3O52_RS05155 (E3O52_05340) | 1070368..1071654 | - | 1287 | WP_002338538.1 | Fe-S cluster assembly protein SufD | - |
| E3O52_RS05160 (E3O52_05345) | 1071667..1072440 | - | 774 | WP_002287679.1 | Fe-S cluster assembly ATPase SufC | - |
| E3O52_RS05165 (E3O52_05350) | 1072637..1073485 | - | 849 | WP_002287678.1 | Methionine-binding lipoprotein MetQ | VF |
| E3O52_RS05170 (E3O52_05355) | 1073509..1074195 | - | 687 | WP_002287674.1 | methionine ABC transporter permease | - |
| E3O52_RS05175 (E3O52_05360) | 1074188..1075222 | - | 1035 | WP_002304234.1 | Methionine import ATP-binding protein MetN 2 | VF |
| E3O52_RS05180 (E3O52_05365) | 1075617..1075955 | - | 339 | WP_002291179.1 | glycine cleavage system protein H | - |
| E3O52_RS05185 (E3O52_05370) | 1075957..1076313 | - | 357 | WP_002295166.1 | arsenate reductase family protein | - |
| E3O52_RS05190 (E3O52_05375) | 1076319..1077506 | - | 1188 | WP_002291183.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
| E3O52_RS05195 (E3O52_05385) | 1077697..1078542 | - | 846 | WP_002327411.1 | HTH-type transcriptional regulator CysL | VF |
| E3O52_RS05200 (E3O52_05390) | 1078776..1079741 | + | 966 | WP_002291188.1 | TDT family transporter | - |
| E3O52_RS05205 (E3O52_05405) | 1080241..1081284 | + | 1044 | WP_002298276.1 | putative sulfate exporter family transporter | - |
| E3O52_RS05210 (E3O52_05410) | 1081346..1081810 | - | 465 | WP_002298278.1 | methylated-DNA--[protein]-cysteine S-methyltransferase | - |
| E3O52_RS05215 (E3O52_05415) | 1082056..1083003 | + | 948 | WP_002289773.1 | Prophage bactoprenol glucosyl transferase | VF |
| E3O52_RS05220 (E3O52_05420) | 1083214..1085286 | - | 2073 | WP_033585993.1 | DNA topoisomerase III | - |
| E3O52_RS05225 (E3O52_05425) | 1085219..1085596 | - | 378 | WP_002291196.1 | DUF1033 family protein | - |
| E3O52_RS05230 (E3O52_05430) | 1085725..1086285 | - | 561 | WP_002323745.1 | TetR/AcrR family transcriptional regulator | - |
| E3O52_RS05235 (E3O52_05435) | 1086435..1087727 | + | 1293 | WP_002291199.1 | multidrug efflux MFS transporter | - |
| E3O52_RS05240 (E3O52_05440) | 1087787..1088905 | - | 1119 | WP_272025083.1 | aminotransferase | - |
| E3O52_RS05245 (E3O52_05445) | 1088919..1090340 | - | 1422 | WP_002286721.1 | arginine-ornithine antiporter | - |
| E3O52_RS05250 (E3O52_05450) | 1090586..1091707 | - | 1122 | WP_002286726.1 | tRNA 2-thiouridine(34) synthase MnmA | - |
| E3O52_RS05255 (E3O52_05455) | 1092111..1092710 | + | 600 | WP_105459779.1 | metallophosphoesterase family protein | - |
| E3O52_RS05260 (E3O52_05460) | 1092848..1094134 | - | 1287 | WP_002327674.1 | multidrug efflux MFS transporter EfmA | - |
| E3O52_RS05265 (E3O52_05465) | 1094405..1094749 | - | 345 | WP_002286736.1 | DUF1831 domain-containing protein | - |
| E3O52_RS05270 (E3O52_05470) | 1094886..1096031 | - | 1146 | WP_002295158.1 | cysteine desulfurase family protein | - |
| E3O52_RS05275 (E3O52_05475) | 1096210..1097184 | - | 975 | WP_002286741.1 | ribose-phosphate diphosphokinase | - |
| E3O52_RS05280 (E3O52_05480) | 1097264..1098139 | - | 876 | WP_002286745.1 | dihydrolipoamide dehydrogenase | - |
| E3O52_RS05285 (E3O52_05485) | 1098269..1100176 | + | 1908 | WP_002301660.1 | M13-type metalloendopeptidase | - |
| E3O52_RS05290 (E3O52_05495) | 1100594..1103872 | - | 3279 | WP_010728132.1 | right-handed parallel beta-helix repeat-containing protein | - |
| E3O52_RS05295 (E3O52_05500) | 1104144..1104689 | - | 546 | WP_002298881.1 | isochorismatase family cysteine hydrolase | - |
| E3O52_RS05300 (E3O52_05505) | 1104701..1105393 | - | 693 | WP_002291218.1 | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase | - |
| E3O52_RS05305 (E3O52_05510) | 1105412..1105696 | - | 285 | WP_002286760.1 | cell wall synthase accessory phosphoprotein MacP | - |
| E3O52_RS05310 (E3O52_05515) | 1105709..1106272 | - | 564 | WP_002323741.1 | NUDIX hydrolase | - |
| E3O52_RS05315 (E3O52_05520) | 1106500..1107162 | + | 663 | WP_002286764.1 | 5-bromo-4-chloroindolyl phosphate hydrolysis family protein | - |
| E3O52_RS05320 (E3O52_05525) | 1107286..1108482 | + | 1197 | WP_002286766.1 | toxic anion resistance protein | - |
| E3O52_RS05325 (E3O52_05530) | 1108583..1109959 | - | 1377 | WP_002286768.1 | amino acid permease | - |
| E3O52_RS05330 (E3O52_05535) | 1109996..1110862 | - | 867 | WP_002286769.1 | GRP family sugar transporter | - |
| E3O52_RS05335 (E3O52_05540) | 1110951..1111976 | - | 1026 | WP_002286770.1 | sensor histidine kinase | - |
| E3O52_RS05340 (E3O52_05545) | 1111994..1112668 | - | 675 | WP_002291233.1 | Response regulator protein GraR | VF |
| E3O52_RS05345 (E3O52_05550) | 1112849..1113745 | - | 897 | WP_002327672.1 | hypothetical protein | VF |
| E3O52_RS05350 (E3O52_05555) | 1113849..1115516 | - | 1668 | WP_105459780.1 | SpaH/EbpB family LPXTG-anchored major pilin | - |
| E3O52_RS05355 (E3O52_05560) | 1115509..1116821 | - | 1313 | Protein_1059 | hypothetical protein | VF |
| E3O52_RS05360 (E3O52_05570) | 1116821..1121328 | - | 4508 | Protein_1060 | SpaA isopeptide-forming pilin-related protein | - |
| E3O52_RS05365 (E3O52_05575) | 1121626..1122144 | - | 519 | WP_002286782.1 | phosphatase PAP2 family protein | - |
| E3O52_RS05370 (E3O52_05580) | 1122146..1122763 | - | 618 | WP_105459781.1 | YesL family protein | - |
| E3O52_RS05375 (E3O52_05585) | 1122760..1123614 | - | 855 | WP_002286786.1 | carbohydrate ABC transporter permease | - |
| E3O52_RS05380 (E3O52_05590) | 1123611..1124522 | - | 912 | WP_002286787.1 | sugar ABC transporter permease | - |
| E3O52_RS05385 (E3O52_05595) | 1124563..1125897 | - | 1335 | WP_002286788.1 | ABC transporter substrate-binding protein | - |
| E3O52_RS05390 (E3O52_05600) | 1126105..1126935 | + | 831 | WP_002286789.1 | manganese catalase family protein | - |
| E3O52_RS05395 (E3O52_05610) | 1127179..1127428 | - | 250 | Protein_1067 | transposase | - |
| E3O52_RS05400 (E3O52_05615) | 1127619..1127813 | - | 195 | WP_002295146.1 | hypothetical protein | - |
| E3O52_RS05410 (E3O52_05625) | 1129549..1130721 | - | 1173 | WP_146708620.1 | IS256 family transposase IS256 | Transposase |
| E3O52_RS05415 | 1130782..1130967 | + | 186 | WP_272025088.1 | hypothetical protein | - |
| E3O52_RS05420 (E3O52_05635) | 1131444..1132554 | + | 1111 | Protein_1072 | IS3-like element IS1485 family transposase | - |
| E3O52_RS05425 (E3O52_05640) | 1133419..1133760 | - | 342 | WP_002327666.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin Detail |
| E3O52_RS05430 (E3O52_05645) | 1133760..1133990 | - | 231 | WP_002323011.1 | hypothetical protein | Antitoxin Detail |
| E3O52_RS05435 (E3O52_05655) | 1134286..1134624 | + | 339 | WP_002327665.1 | hypothetical protein | - |
| E3O52_RS05440 (E3O52_05660) | 1134825..1135400 | - | 576 | WP_002327664.1 | SOS response-associated peptidase family protein | - |
| E3O52_RS05445 (E3O52_05680) | 1136075..1136656 | - | 582 | WP_002286813.1 | TetR/AcrR family transcriptional regulator | - |
| E3O52_RS05450 (E3O52_05685) | 1136839..1137465 | - | 627 | WP_002286816.1 | cysteine hydrolase | - |
| E3O52_RS05455 (E3O52_05690) | 1137487..1138815 | - | 1329 | WP_002327663.1 | FAD-containing oxidoreductase | - |
| E3O52_RS05460 (E3O52_05695) | 1138973..1139374 | - | 402 | WP_002318340.1 | organic hydroperoxide resistance protein | - |
| E3O52_RS05465 (E3O52_05700) | 1139460..1139666 | - | 207 | WP_002293677.1 | hypothetical protein | - |
| E3O52_RS05470 (E3O52_05705) | 1139761..1141263 | - | 1503 | WP_002286827.1 | Phosphomannomutase/phosphoglucomutase | VF |
| E3O52_RS05475 (E3O52_05710) | 1141281..1141736 | - | 456 | WP_002286829.1 | arginine repressor | - |
| E3O52_RS05480 (E3O52_05715) | 1141834..1142451 | - | 618 | WP_002325134.1 | GyrI-like domain-containing protein | - |
| E3O52_RS05485 (E3O52_05720) | 1142672..1144045 | + | 1374 | WP_002293681.1 | MFS transporter | - |
| E3O52_RS05490 (E3O52_05725) | 1144120..1145232 | + | 1113 | WP_002286834.1 | FAD-dependent oxidoreductase | - |
| E3O52_RS05495 (E3O52_05730) | 1145304..1146941 | - | 1638 | WP_002327662.1 | phosphoenolpyruvate carboxykinase (ATP) | - |
| E3O52_RS05500 (E3O52_05735) | 1147109..1147717 | - | 609 | WP_002286836.1 | LysM domain-containing protein | - |
| E3O52_RS05505 (E3O52_05740) | 1148099..1149250 | - | 1152 | WP_272025084.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
| E3O52_RS05510 (E3O52_05745) | 1149269..1150021 | - | 753 | WP_002327661.1 | hypothetical protein | - |
| E3O52_RS05515 (E3O52_05750) | 1150161..1151111 | - | 951 | WP_002327660.1 | Manganese ABC transporter substrate-binding lipoprotein | VF |
| E3O52_RS05520 (E3O52_05755) | 1151112..1151951 | - | 840 | WP_002286845.1 | Manganese transport system membrane protein MntB | VF |
| E3O52_RS05525 (E3O52_05760) | 1151948..1152694 | - | 747 | WP_002327659.1 | High-affinity zinc uptake system ATP-binding protein ZnuC | VF |
| E3O52_RS05530 (E3O52_05765) | 1152932..1154302 | + | 1371 | WP_002327658.1 | amino acid permease | - |
| E3O52_RS05535 (E3O52_05770) | 1154357..1155253 | - | 897 | WP_002327657.1 | LysM peptidoglycan-binding domain-containing protein | - |
| E3O52_RS05540 | 1155367..1155537 | - | 171 | WP_002286849.1 | hypothetical protein | - |
| E3O52_RS05545 (E3O52_05775) | 1155534..1156211 | - | 678 | WP_002286851.1 | NAD(P)H-dependent oxidoreductase | - |
| E3O52_RS05550 (E3O52_05780) | 1156302..1157207 | - | 906 | WP_002286852.1 | AraC family transcriptional regulator | - |
| E3O52_RS05555 (E3O52_05785) | 1157382..1158836 | + | 1455 | WP_002293689.1 | glycoside-pentoside-hexuronide (GPH):cation symporter | - |
| E3O52_RS05560 (E3O52_05790) | 1158852..1159883 | + | 1032 | WP_002331671.1 | aldose epimerase family protein | - |
| E3O52_RS05565 (E3O52_05795) | 1159890..1161077 | + | 1188 | WP_002286858.1 | galactokinase | - |
| E3O52_RS05570 (E3O52_05800) | 1161233..1162615 | + | 1383 | WP_002323727.1 | Y-family DNA polymerase | - |
| E3O52_RS05575 (E3O52_05805) | 1162587..1162973 | + | 387 | WP_002293692.1 | hypothetical protein | - |
| E3O52_RS05580 (E3O52_05810) | 1163169..1163837 | - | 669 | WP_002297894.1 | DUF421 domain-containing protein | - |
| E3O52_RS05585 (E3O52_05815) | 1164026..1164823 | - | 798 | Protein_1105 | IS3 family transposase ISEfa10 | Transposase |
| E3O52_RS05590 (E3O52_05820) | 1165104..1166483 | - | 1380 | WP_002301224.1 | FAD-dependent oxidoreductase | - |
| E3O52_RS05595 (E3O52_05825) | 1166659..1167828 | - | 1170 | WP_002321347.1 | pyridoxal phosphate-dependent aminotransferase | - |
| E3O52_RS05600 (E3O52_05830) | 1167803..1168954 | - | 1152 | WP_002297890.1 | M20 family metallopeptidase | - |
| E3O52_RS05605 (E3O52_05835) | 1168914..1170275 | - | 1362 | WP_002286872.1 | aspartate kinase | - |
| E3O52_RS05610 (E3O52_05840) | 1170272..1171273 | - | 1002 | WP_002286873.1 | aspartate-semialdehyde dehydrogenase | - |
| E3O52_RS05615 (E3O52_05845) | 1171289..1171984 | - | 696 | WP_002327652.1 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase | VF |
| E3O52_RS05620 (E3O52_05850) | 1171990..1172706 | - | 717 | WP_002286877.1 | 4-hydroxy-tetrahydrodipicolinate reductase | - |
| E3O52_RS05625 (E3O52_05855) | 1172703..1173584 | - | 882 | WP_002286879.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| E3O52_RS05630 (E3O52_05860) | 1173587..1174387 | - | 801 | WP_002294349.1 | diaminopimelate epimerase | - |
| E3O52_RS05635 (E3O52_05865) | 1174374..1175633 | - | 1260 | WP_002327651.1 | diaminopimelate decarboxylase | - |
| E3O52_RS05640 | 1175848..1176096 | - | 249 | WP_002305974.1 | hypothetical protein | - |
| E3O52_RS05645 (E3O52_05870) | 1176120..1176683 | - | 564 | WP_002289434.1 | elongation factor P | - |
| E3O52_RS05650 (E3O52_05885) | 1177110..1178027 | + | 918 | WP_002297881.1 | cysteine synthase family protein | - |
| E3O52_RS05655 (E3O52_05890) | 1178040..1179185 | + | 1146 | WP_002289438.1 | cystathionine gamma-synthase | - |
| E3O52_RS05660 (E3O52_05895) | 1179356..1179814 | + | 459 | WP_002289439.1 | S-ribosylhomocysteine lyase | VF |
| E3O52_RS05665 (E3O52_05900) | 1179973..1180443 | + | 471 | WP_002289440.1 | glutathione peroxidase | - |
| E3O52_RS05685 (E3O52_05930) | 1186185..1186541 | - | 357 | WP_002297829.1 | Spx/MgsR family RNA polymerase-binding regulatory protein | - |
| E3O52_RS05690 (E3O52_05935) | 1186555..1186965 | - | 411 | WP_002286258.1 | Spx/MgsR family RNA polymerase-binding regulatory protein | - |
| E3O52_RS05695 (E3O52_05940) | 1187116..1188069 | + | 954 | WP_272025085.1 | IS30 family transposase IS1252 | Transposase |
| E3O52_RS05700 (E3O52_05945) | 1188379..1190565 | - | 2187 | WP_002286261.1 | ATP-dependent helicase | - |
| E3O52_RS05705 (E3O52_05950) | 1190783..1191466 | + | 684 | WP_002286265.1 | YoaK family protein | - |
| E3O52_RS05710 (E3O52_05960) | 1191547..1192266 | - | 720 | WP_002321450.1 | deoxynucleoside kinase | - |
| E3O52_RS05715 (E3O52_05970) | 1192580..1192786 | - | 207 | WP_002286271.1 | hypothetical protein | - |
| E3O52_RS05720 (E3O52_05975) | 1193032..1193634 | + | 603 | WP_002296063.1 | accessory gene regulator B family protein | - |
| E3O52_RS05725 (E3O52_05980) | 1193775..1195076 | + | 1302 | WP_272025086.1 | sensor histidine kinase | - |
| E3O52_RS05730 (E3O52_05985) | 1195142..1196101 | + | 960 | WP_272025087.1 | IS30-like element IS6770 family transposase | - |
| E3O52_RS05735 (E3O52_05990) | 1196136..1196864 | + | 729 | WP_002328270.1 | LytTR family DNA-binding domain-containing protein | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|