MGE detailed information
MGE type: Conjugative plasmid MGE length: 130897 bp
Accession: NZ_AP023435 Location: 1..130897 Organism: Escherichia coli strain M719 Replicon: plasmid pM71902
Accession: NZ_AP023435 Location: 1..130897 Organism: Escherichia coli strain M719 Replicon: plasmid pM71902
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2043_RS24040 (1) | 1..258 | + | 258 | WP_000083833.1 | replication regulatory protein RepA | - |
| M2043_RS24045 (494) | 494..568 | + | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| M2043_RS24050 (561) | 561..1389 | + | 829 | Protein_2 | incFII family plasmid replication initiator RepA | - |
| M2043_RS24055 (2328) | 2328..3011 | + | 684 | WP_248537782.1 | CPBP family intramembrane metalloprotease | - |
| M2043_RS24060 (3072) | 3072..3329 | + | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| M2043_RS24065 (3262) | 3262..3663 | + | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| M2043_RS24070 (3911) | 3911..4326 | + | 416 | Protein_6 | IS1-like element IS1B family transposase | - |
| M2043_RS24075 (4362) | 4362..4906 | - | 545 | Protein_7 | Tn3 family transposase TnpA_Tn3 | Transposase |
| M2043_RS24080 (4972) | 4972..5675 | - | 704 | Protein_8 | IS6 family transposase IS15DI | Transposase |
| M2043_RS24085 (5898) | 5898..6707 | + | 810 | WP_000161640.1 | hypothetical protein | - |
| M2043_RS24090 (6848) | 6848..8125 | - | 1278 | WP_000625667.1 | DUF2254 domain-containing protein | - |
| M2043_RS24095 (8189) | 8189..10186 | - | 1998 | WP_005032116.1 | choline BCCT transporter BetT | - |
| M2043_RS24100 (10438) | 10438..10542 | - | 105 | Protein_12 | protein YdfV | - |
| M2043_RS24105 (10567) | 10567..10806 | + | 240 | WP_000534857.1 | type II toxin-antitoxin system antitoxin RelB | - |
| M2043_RS24110 (10806) | 10806..10967 | + | 162 | Protein_14 | type II toxin-antitoxin system mRNA interferase RelE | - |
| M2043_RS24115 (11102) | 11102..11647 | + | 546 | WP_001493763.1 | plasmid pRiA4b ORF-3 family protein | - |
| M2043_RS24120 (11784) | 11784..12356 | + | 573 | WP_001493762.1 | Tn3 family transposase TnpR_ISPa40 | Transposase |
| M2043_RS24125 (12393) | 12393..13784 | + | 1392 | WP_001493761.1 | ISKra4 family transposase ISKpn19 | Transposase |
| M2043_RS24130 (13817) | 13817..14245 | + | 429 | Protein_18 | Tn3 family transposase TnpR_ISMex22 | Transposase |
| M2043_RS24135 (14564) | 14564..15220 | - | 657 | WP_001516695.1 | Pentapeptide repeat protein | ARG |
| M2043_RS24140 (15615) | 15615..16630 | + | 1016 | Protein_20 | IS3 family transposase ISEc36 | Transposase |
| M2043_RS24145 (16673) | 16673..19456 | - | 2784 | Protein_21 | Tn3 family transposase TnpA_Tn3 | Transposase |
| M2043_RS24150 (19521) | 19521..19814 | + | 294 | WP_116961751.1 | WbuC family cupin fold metalloprotein | - |
| M2043_RS24155 (19861) | 19861..20736 | - | 876 | WP_000239590.1 | Beta-lactamase CTX-M-1 | ARG |
| M2043_RS24160 (20992) | 20992..22254 | - | 1263 | WP_000608644.1 | IS1380 family transposase ISEcp1 | Transposase |
| M2043_RS24165 (22436) | 22436..22654 | - | 219 | WP_001143771.1 | Tn3 family transposase TnpA_Tn3 | Transposase |
| M2043_RS24170 (22818) | 22818..23375 | + | 558 | WP_001235713.1 | Tn3 family transposase TnpR_Tn3 | Transposase |
| M2043_RS24175 (23556) | 23556..24416 | + | 861 | WP_000027057.1 | Beta-lactamase TEM | ARG |
| M2043_RS24180 (25033) | 25033..26364 | + | 1332 | Protein_28 | group II intron reverse transcriptase/maturase | - |
| M2043_RS24185 (26468) | 26468..26623 | + | 156 | Protein_29 | type II toxin-antitoxin system antitoxin YacA | - |
| M2043_RS24190 (26623) | 26623..26901 | + | 279 | Protein_30 | type II toxin-antitoxin system toxin YacB | - |
| M2043_RS24195 (26993) | 26993..27516 | - | 524 | Protein_31 | IS1 family transposase | - |
| M2043_RS24200 (28043) | 28043..28492 | + | 450 | WP_029702172.1 | hypothetical protein | - |
| M2043_RS24205 (28708) | 28708..29405 | + | 698 | WP_224053117.1 | IS1 family transposase IS1X2 | Transposase |
| M2043_RS24210 (29445) | 29445..30185 | + | 741 | WP_029702141.1 | IS91 family transposase ISMno23 | Transposase |
| M2043_RS24215 (30481) | 30481..30749 | + | 269 | Protein_35 | type II toxin-antitoxin system ParD family antitoxin | - |
| M2043_RS24220 (30736) | 30736..31026 | + | 291 | Protein_36 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| M2043_RS24225 (31093) | 31093..31275 | + | 183 | WP_042004909.1 | hypothetical protein | - |
| M2043_RS24230 (31396) | 31396..32136 | + | 741 | WP_001586233.1 | tyrosine-type recombinase/integrase | - |
| M2043_RS24235 (32459) | 32459..33448 | - | 990 | WP_123002471.1 | RepB family plasmid replication initiator protein | - |
| M2043_RS24240 (34336) | 34336..34605 | + | 270 | WP_001275013.1 | DUF1778 domain-containing protein | Antitoxin Detail |
| M2043_RS24245 (34609) | 34609..35139 | + | 531 | WP_000348883.1 | GNAT family N-acetyltransferase | Toxin Detail |
| M2043_RS24250 (35140) | 35140..35357 | + | 218 | Protein_42 | transposase | - |
| M2043_RS24255 (35413) | 35413..35729 | - | 317 | Protein_43 | type II toxin-antitoxin system VapC family toxin | - |
| M2043_RS24260 (35726) | 35726..35956 | - | 231 | WP_001261274.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| M2043_RS24265 (35913) | 35913..36011 | + | 99 | Protein_45 | hypothetical protein | - |
| M2043_RS24270 (36155) | 36155..38776 | - | 2622 | WP_001586230.1 | hypothetical protein | - |
| M2043_RS24275 (39167) | 39167..39668 | + | 502 | Protein_47 | HEPN family nuclease | - |
| M2043_RS24280 (39681) | 39681..40118 | + | 438 | WP_001403959.1 | hypothetical protein | - |
| M2043_RS24285 (40064) | 40064..40453 | + | 390 | WP_001403960.1 | hypothetical protein | - |
| M2043_RS24290 (40620) | 40620..41753 | + | 1134 | WP_000545985.1 | DUF3800 domain-containing protein | - |
| M2043_RS24295 (41787) | 41787..42299 | - | 513 | WP_001586228.1 | hypothetical protein | - |
| M2043_RS24300 (42586) | 42586..44151 | + | 1566 | WP_001586226.1 | AAA family ATPase | - |
| M2043_RS24305 (44208) | 44208..45077 | - | 870 | WP_001586225.1 | hypothetical protein | - |
| M2043_RS24310 (45079) | 45079..46167 | - | 1089 | Protein_54 | transcriptional regulator | - |
| M2043_RS24315 (46460) | 46460..47392 | - | 933 | WP_000991831.1 | S-4TM family putative pore-forming effector | - |
| M2043_RS24320 (47396) | 47396..48391 | - | 996 | WP_000246635.1 | hypothetical protein | - |
| M2043_RS24325 (49069) | 49069..49419 | + | 351 | WP_039052452.1 | hypothetical protein | - |
| M2043_RS24330 (49489) | 49489..50097 | + | 609 | WP_039052451.1 | hypothetical protein | - |
| M2043_RS24335 (50165) | 50165..50925 | + | 761 | Protein_59 | tyrosine-type recombinase/integrase | - |
| M2043_RS24340 (51063) | 51063..51338 | - | 276 | WP_000239529.1 | hypothetical protein | - |
| M2043_RS24345 (51332) | 51332..51976 | - | 645 | WP_000633913.1 | division plane positioning ATPase MipZ | - |
| M2043_RS24350 (52205) | 52205..53176 | + | 972 | WP_039052450.1 | plasmid segregation protein ParM | - |
| M2043_RS24355 (53181) | 53181..53573 | + | 393 | WP_039052449.1 | plasmid partitioning/stability family protein | - |
| M2043_RS24360 (53578) | 53578..54668 | - | 1091 | Protein_64 | translesion error-prone DNA polymerase V subunit UmuC | - |
| M2043_RS24365 (55082) | 55082..56062 | - | 981 | WP_039052448.1 | IS5 family transposase ISKpn26 | Transposase |
| M2043_RS24370 (56405) | 56405..58669 | - | 2265 | WP_039052447.1 | UvrD-helicase domain-containing protein | - |
| M2043_RS24375 (58671) | 58671..59447 | - | 777 | WP_039052454.1 | hypothetical protein | - |
| M2043_RS24380 (60430) | 60430..61548 | - | 1119 | Protein_68 | IS3-like element ISSen4 family transposase | - |
| M2043_RS24385 (61570) | 61570..62787 | + | 1218 | WP_061856962.1 | IS4 family transposase IS10R | Transposase |
| M2043_RS24390 (62797) | 62797..63213 | - | 417 | WP_000275180.1 | Transposon Tn10 TetD protein | VF |
| M2043_RS24395 (63301) | 63301..63894 | + | 594 | WP_000428546.1 | tetracyline resistance-associated transcriptional repressor TetC | - |
| M2043_RS24400 (64007) | 64007..65212 | - | 1206 | WP_001089068.1 | Tetracycline resistance protein, class B | ARG |
| M2043_RS24405 (65294) | 65294..65917 | + | 624 | WP_000088605.1 | Tetracycline repressor protein class B from transposon Tn10 | VF |
| M2043_RS24410 (65895) | 65895..66581 | - | 687 | WP_001284954.1 | winged helix-turn-helix domain-containing protein | - |
| M2043_RS24415 (66589) | 66589..66975 | - | 387 | WP_000460651.1 | hypothetical protein | - |
| M2043_RS24420 (66968) | 66968..67288 | - | 321 | WP_000562370.1 | antibiotic biosynthesis monooxygenase | - |
| M2043_RS24430 (68393) | 68393..69046 | - | 654 | WP_039052615.1 | DUF5710 domain-containing protein | - |
| M2043_RS24435 (69084) | 69084..69431 | - | 348 | WP_077877391.1 | hypothetical protein | - |
| M2043_RS24440 (69617) | 69617..70066 | + | 450 | Protein_80 | hypothetical protein | - |
| M2043_RS24445 (70482) | 70482..70907 | + | 426 | WP_061856959.1 | antirestriction protein | - |
| M2043_RS24450 (70956) | 70956..71147 | + | 192 | WP_001027495.1 | hypothetical protein | - |
| M2043_RS24455 (71289) | 71289..71585 | - | 297 | Protein_83 | hypothetical protein | - |
| M2043_RS24460 (72100) | 72100..72329 | + | 230 | Protein_84 | hypothetical protein | - |
| M2043_RS24465 (72381) | 72381..73742 | + | 1362 | WP_039052595.1 | DUF3560 domain-containing protein | - |
| M2043_RS24470 (73790) | 73790..74353 | + | 564 | WP_001377760.1 | class I SAM-dependent methyltransferase | - |
| M2043_RS24475 (74441) | 74441..74864 | - | 424 | Protein_87 | hypothetical protein | - |
| M2043_RS24480 (75047) | 75047..75967 | + | 921 | WP_039052596.1 | aminoimidazole riboside kinase | - |
| M2043_RS24485 (76135) | 76135..77652 | + | 1518 | WP_039052597.1 | carbohydrate porin | - |
| M2043_RS24490 (77713) | 77713..79083 | + | 1371 | WP_000344915.1 | sucrose-specific PTS transporter subunit IIBC | - |
| M2043_RS24495 (79083) | 79083..80492 | + | 1410 | WP_039052598.1 | sucrose-6-phosphate hydrolase | - |
| M2043_RS24500 (80518) | 80518..81525 | + | 1008 | WP_001232702.1 | LacI family DNA-binding transcriptional regulator | - |
| M2043_RS24505 (81989) | 81989..82606 | - | 618 | Protein_93 | ISL3 family transposase ISEc38 | Transposase |
| M2043_RS24510 (82779) | 82779..83476 | + | 698 | WP_103215986.1 | IS1 family transposase IS1G | Transposase |
| M2043_RS24515 (83556) | 83556..83687 | - | 132 | Protein_95 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| M2043_RS24520 (83678) | 83678..84006 | - | 329 | Protein_96 | hypothetical protein | - |
| M2043_RS24525 (84307) | 84307..84594 | + | 288 | WP_061856957.1 | hypothetical protein | - |
| M2043_RS24530 (84713) | 84713..85534 | + | 822 | WP_061856956.1 | DUF932 domain-containing protein | - |
| M2043_RS24535 (85830) | 85830..86432 | - | 603 | WP_077878371.1 | hypothetical protein | VF |
| M2043_RS24540 (86752) | 86752..87135 | + | 384 | WP_061856954.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| M2043_RS24545 (87322) | 87322..88011 | + | 690 | WP_061856953.1 | conjugal transfer transcriptional regulator TraJ | - |
| M2043_RS24550 (88104) | 88104..88505 | + | 402 | WP_001369361.1 | conjugal transfer relaxosome DNA-bindin protein TraY | - |
| M2043_RS24555 (88538) | 88538..88900 | + | 363 | WP_039052460.1 | type IV conjugative transfer system pilin TraA | - |
| M2043_RS24560 (88905) | 88905..89216 | + | 312 | WP_000012106.1 | type IV conjugative transfer system protein TraL | - |
| M2043_RS24565 (89238) | 89238..89805 | + | 568 | Protein_105 | type IV conjugative transfer system protein TraE | - |
| M2043_RS24570 (89792) | 89792..90519 | + | 728 | Protein_106 | type-F conjugative transfer system secretin TraK | - |
| M2043_RS24575 (90519) | 90519..91970 | + | 1452 | WP_176486943.1 | F-type conjugal transfer pilus assembly protein TraB | - |
| M2043_RS24580 (91960) | 91960..92520 | + | 561 | WP_039052464.1 | conjugal transfer pilus-stabilizing protein TraP | - |
| M2043_RS24585 (92507) | 92507..92827 | + | 321 | WP_001057302.1 | conjugal transfer protein TrbD | - |
| M2043_RS24590 (92820) | 92820..93071 | + | 252 | WP_039052465.1 | conjugal transfer protein TrbG | - |
| M2043_RS24595 (93068) | 93068..93583 | + | 516 | WP_039052466.1 | type IV conjugative transfer system lipoprotein TraV | - |
| M2043_RS24600 (93718) | 93718..93939 | + | 222 | WP_001278685.1 | conjugal transfer protein TraR | - |
| M2043_RS24605 (94099) | 94099..96726 | + | 2628 | WP_001064265.1 | type IV secretion system protein TraC | - |
| M2043_RS24610 (96723) | 96723..97109 | + | 387 | WP_000099693.1 | type-F conjugative transfer system protein TrbI | - |
| M2043_RS24615 (97106) | 97106..97738 | + | 633 | WP_039052467.1 | type-F conjugative transfer system protein TraW | - |
| M2043_RS24620 (97735) | 97735..98727 | + | 993 | WP_000830835.1 | conjugal transfer pilus assembly protein TraU | - |
| M2043_RS24625 (98736) | 98736..99374 | + | 639 | WP_039052468.1 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| M2043_RS24630 (99371) | 99371..99751 | + | 381 | WP_039052469.1 | hypothetical protein | - |
| M2043_RS24635 (99987) | 99987..101849 | + | 1863 | WP_224053115.1 | type-F conjugative transfer system mating-pair stabilization protein TraN | - |
| M2043_RS24640 (101876) | 101876..102133 | + | 258 | WP_039023152.1 | conjugal transfer protein TrbE | - |
| M2043_RS24645 (102126) | 102126..102869 | + | 744 | WP_001030376.1 | type-F conjugative transfer system pilin assembly protein TraF | - |
| M2043_RS24650 (102885) | 102885..103232 | + | 348 | WP_001287894.1 | conjugal transfer protein TrbA | - |
| M2043_RS24655 (103351) | 103351..103635 | + | 285 | WP_000624110.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| M2043_RS24660 (103622) | 103622..104167 | + | 546 | WP_039052470.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| M2043_RS24665 (104097) | 104097..104459 | + | 363 | WP_071550055.1 | P-type conjugative transfer protein TrbJ | - |
| M2043_RS24670 (104459) | 104459..105832 | + | 1374 | WP_039023150.1 | conjugal transfer pilus assembly protein TraH | - |
| M2043_RS24675 (105829) | 105829..107286 | + | 1458 | Protein_127 | conjugal transfer mating-pair stabilization protein TraG | - |
| M2043_RS24680 (107327) | 107327..108865 | - | 1539 | Protein_128 | IS66 family transposase ISEc22 | Transposase |
| M2043_RS24685 (108885) | 108885..109257 | - | 373 | Protein_129 | IS66 family insertion sequence element accessory protein TnpB | - |
| M2043_RS24690 (109379) | 109379..109657 | - | 279 | WP_001341328.1 | IS66 family transposase ISEc22 | Transposase |
| M2043_RS24695 (109738) | 109738..111104 | + | 1367 | Protein_131 | conjugal transfer protein TraG | - |
| M2043_RS24700 (111123) | 111123..111620 | + | 498 | WP_000605862.1 | entry exclusion protein | - |
| M2043_RS24705 (111681) | 111681..112347 | + | 667 | Protein_133 | IS66-like element accessory protein TnpA | - |
| M2043_RS24710 (112405) | 112405..112695 | + | 291 | Protein_134 | IS66 family insertion sequence element accessory protein TnpB | - |
| M2043_RS24720 (112975) | 112975..114152 | + | 1178 | Protein_135 | IS66 family transposase ISCro1 | Transposase |
| M2043_RS24725 (114174) | 114174..114281 | + | 108 | WP_032282290.1 | IS66 family transposase ISCro1 | Transposase |
| M2043_RS24730 (114344) | 114344..115075 | + | 732 | WP_000850422.1 | conjugal transfer complement resistance protein TraT | - |
| M2043_RS24735 (115328) | 115328..117535 | + | 2208 | WP_039052471.1 | type IV conjugative transfer system coupling protein TraD | - |
| M2043_RS24740 (117544) | 117544..117942 | - | 399 | WP_039023147.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| M2043_RS24745 (117942) | 117942..118169 | - | 228 | WP_039023146.1 | toxin-antitoxin system antitoxin VapB | Antitoxin Detail |
| M2043_RS24750 (118251) | 118251..123521 | + | 5271 | WP_039023145.1 | Multifunctional conjugation protein TraI | Relaxase |
| M2043_RS24755 (123797) | 123797..125333 | + | 1537 | Protein_142 | IS21-like element ISEc12 family transposase | - |
| M2043_RS24760 (125347) | 125347..126092 | + | 746 | Protein_143 | IS21-like element ISEc12 family helper ATPase IstB | - |
| M2043_RS24765 (126120) | 126120..126866 | + | 747 | WP_052273601.1 | conjugal transfer pilus acetylase TraX | - |
| M2043_RS24770 (126921) | 126921..127481 | + | 561 | WP_001567328.1 | fertility inhibition protein FinO | - |
| M2043_RS24775 (127612) | 127612..127821 | + | 210 | WP_039023209.1 | hypothetical protein | - |
| M2043_RS24780 (128233) | 128233..128859 | + | 627 | WP_029702149.1 | NYN domain-containing protein | - |
| M2043_RS24785 (129011) | 129011..129580 | + | 570 | WP_029702150.1 | DUF2726 domain-containing protein | - |
| M2043_RS24790 (129793) | 129793..130221 | + | 429 | WP_029702151.1 | hypothetical protein | - |
| - (130360) | 130360..130421 | - | 62 | NuclAT_0 | - | - |
| - (130360) | 130360..130421 | - | 62 | NuclAT_0 | - | - |
| - (130360) | 130360..130421 | - | 62 | NuclAT_0 | - | - |
| - (130360) | 130360..130421 | - | 62 | NuclAT_0 | - | - |
| M2043_RS24795 (130465) | 130465..130614 | + | 150 | WP_001367749.1 | Hok/Gef family protein | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|