Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | kacAT/ElaA-DUF1778 |
| Location | 34336..35139 | Replicon | plasmid pM71902 |
| Accession | NZ_AP023435 | ||
| Organism | Escherichia coli strain M719 | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | G3CAI8 |
| Locus tag | M2043_RS24245 | Protein ID | WP_000348883.1 |
| Coordinates | 34609..35139 (+) | Length | 177 a.a. |
Antitoxin (Protein)
| Gene name | KacA | Uniprot ID | G3CAI7 |
| Locus tag | M2043_RS24240 | Protein ID | WP_001275013.1 |
| Coordinates | 34336..34605 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2043_RS24210 (29445) | 29445..30185 | + | 741 | WP_029702141.1 | tyrosine-type recombinase/integrase | - |
| M2043_RS24215 (30481) | 30481..30749 | + | 269 | Protein_35 | type II toxin-antitoxin system ParD family antitoxin | - |
| M2043_RS24220 (30736) | 30736..31026 | + | 291 | Protein_36 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| M2043_RS24225 (31093) | 31093..31275 | + | 183 | WP_042004909.1 | hypothetical protein | - |
| M2043_RS24230 (31396) | 31396..32136 | + | 741 | WP_001586233.1 | tyrosine-type recombinase/integrase | - |
| M2043_RS24235 (32459) | 32459..33448 | - | 990 | WP_123002471.1 | RepB family plasmid replication initiator protein | - |
| M2043_RS24240 (34336) | 34336..34605 | + | 270 | WP_001275013.1 | DUF1778 domain-containing protein | Antitoxin |
| M2043_RS24245 (34609) | 34609..35139 | + | 531 | WP_000348883.1 | GNAT family N-acetyltransferase | Toxin |
| M2043_RS24250 (35140) | 35140..35357 | + | 218 | Protein_42 | transposase | - |
| M2043_RS24255 (35413) | 35413..35729 | - | 317 | Protein_43 | type II toxin-antitoxin system VapC family toxin | - |
| M2043_RS24260 (35726) | 35726..35956 | - | 231 | WP_001261274.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| M2043_RS24265 (35913) | 35913..36011 | + | 99 | Protein_45 | hypothetical protein | - |
| M2043_RS24270 (36155) | 36155..38776 | - | 2622 | WP_001586230.1 | hypothetical protein | - |
| M2043_RS24275 (39167) | 39167..39668 | + | 502 | Protein_47 | HEPN family nuclease | - |
| M2043_RS24280 (39681) | 39681..40118 | + | 438 | WP_001403959.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | qnrS1 / blaCTX-M-15 / blaTEM-1B / tet(B) | - | 1..130897 | 130897 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 177 a.a. Molecular weight: 20321.20 Da Isoelectric Point: 6.4889
>T37747 WP_000348883.1 NZ_AP023435:34609-35139 [Escherichia coli]
MDGLRIEIFSEEVEYQLSNFDCGEEYLNTFLTDHLQRQHSSKILRGYLLVTREDRPRVMGYYTLSGSCFEKILLPSKTQQ
KRVPYKNVPSVTLGRLAIDKSIHHQGYGETLVTHAMKVVYQASQAVGIHGMFVEALNDNAKKFYLRLGFIQLKEENCDSL
FYPTKSIEVLFEVNDE
MDGLRIEIFSEEVEYQLSNFDCGEEYLNTFLTDHLQRQHSSKILRGYLLVTREDRPRVMGYYTLSGSCFEKILLPSKTQQ
KRVPYKNVPSVTLGRLAIDKSIHHQGYGETLVTHAMKVVYQASQAVGIHGMFVEALNDNAKKFYLRLGFIQLKEENCDSL
FYPTKSIEVLFEVNDE
Download Length: 531 bp
>T37747 NZ_AP023435:34609-35139 [Escherichia coli]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATCAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGCAACGTCAGCACAGTAGTAAGATTTTACGGGGTTATCTGCTCGTGACGAGAGAGG
ATAGACCACGTGTCATGGGGTACTACACCCTGTCAGGCAGTTGCTTTGAGAAAATACTTCTCCCCAGCAAAACACAACAA
AAGCGTGTGCCCTACAAAAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AGGCGCTGAACGATAACGCCAAAAAATTCTACCTTCGACTGGGTTTTATACAGTTAAAGGAAGAAAACTGTGATTCGCTC
TTCTACCCGACAAAATCTATTGAAGTATTGTTCGAAGTAAATGACGAATAA
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATCAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGCAACGTCAGCACAGTAGTAAGATTTTACGGGGTTATCTGCTCGTGACGAGAGAGG
ATAGACCACGTGTCATGGGGTACTACACCCTGTCAGGCAGTTGCTTTGAGAAAATACTTCTCCCCAGCAAAACACAACAA
AAGCGTGTGCCCTACAAAAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AGGCGCTGAACGATAACGCCAAAAAATTCTACCTTCGACTGGGTTTTATACAGTTAAAGGAAGAAAACTGTGATTCGCTC
TTCTACCCGACAAAATCTATTGAAGTATTGTTCGAAGTAAATGACGAATAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10229.63 Da Isoelectric Point: 6.4702
>AT37747 WP_001275013.1 NZ_AP023435:34336-34605 [Escherichia coli]
MSALKKQRIDLRLNEDDKHMIEEAAAMTNQSISQFMVSTASARAAEVIDQHRRLLLNEESWNLVMDAITNPPAPNDRLKR
ATNRLRELE
MSALKKQRIDLRLNEDDKHMIEEAAAMTNQSISQFMVSTASARAAEVIDQHRRLLLNEESWNLVMDAITNPPAPNDRLKR
ATNRLRELE
Download Length: 270 bp
>AT37747 NZ_AP023435:34336-34605 [Escherichia coli]
ATGTCAGCACTGAAGAAGCAGCGCATCGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCCATTTCGCAGTTCATGGTCAGTACCGCCTCAGCACGTGCTGCTGAAGTTATTGATCAGCACCGTCGCC
TGCTCCTCAATGAGGAGTCCTGGAATCTGGTTATGGATGCAATCACTAATCCGCCAGCACCAAATGACCGGCTGAAACGC
GCCACTAACCGTCTCCGGGAACTGGAGTAA
ATGTCAGCACTGAAGAAGCAGCGCATCGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCCATTTCGCAGTTCATGGTCAGTACCGCCTCAGCACGTGCTGCTGAAGTTATTGATCAGCACCGTCGCC
TGCTCCTCAATGAGGAGTCCTGGAATCTGGTTATGGATGCAATCACTAATCCGCCAGCACCAAATGACCGGCTGAAACGC
GCCACTAACCGTCTCCGGGAACTGGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|