| Effector Protein ID: 88658269 |
 T4SS name [ID] | VirB [493] |
| Gene symbol | - |
| Locus tag | ECH_0261 |
| Strain | Ehrlichia chaffeensis str. Arkansas |
| Replicon | chromosome [GenBank: NC_007799] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 244693..245487 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | Etf-2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Etf-2 can inhibit bead phagocytosis. Etf-2 promotes infection of eukaryotic cells by E. chaffeensis and that PNA-mediated inhibition of Etf-2 counters infection. |
| UniProt ID | Q2GHK1 |
| KEGG ID | ech:ECH_0261 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 264 a.a. [Download] |
| >gi|88658269|ref|YP_507082.1| hypothetical protein ECH_0261 [Ehrlichia chaffeensis str. Arkansas] MPTTLGTVASSILNTTSNTTNGTITATAESTSSILESTTNTASNIYNTTTSAVTSAIETTASNAFNNVTN ITNSIITTSTESISSFIESATSTANNIHNTIFSGITSPTGNITNTTSITNTTSNDNKQETTLALIGIFFF SLLLLAFIICIHSKHTRANQRHQDEEIPLTEENSDKKKGYKKHGDVIRFDDGSVLPVSVRCDENTDVRHG RSPRVIETNDSVTPVYNFSNGPSSRLTDLLDDFVQSVDYGIAHARQACGRFFRR |
| - |
| Nucleotide Sequence: 795 bp [Download] |
| >gi|88657561|ref|NC_007799.1|:c245487-244693 Ehrlichia chaffeensis str. Arkansas, complete genome ATGCCAACAACACTAGGGACTGTAGCTAGTAGTATTTTAAATACTACTAGTAACACAACAAACGGTACAA TAACAGCTACTGCAGAAAGTACCAGTTCTATTCTAGAATCAACAACAAATACCGCATCAAATATTTATAA TACAACAACCTCTGCAGTAACCTCAGCAATAGAAACTACAGCCAGCAATGCTTTTAATAACGTTACTAAC ATAACAAATAGTATAATAACAACTTCCACAGAAAGTATCAGTTCTTTTATAGAATCAGCAACAAGTACCG CAAACAATATTCATAATACAATATTCTCTGGAATAACCTCACCAACAGGGAATATCACAAATACTACTAG TATTACTAATACAACATCCAATGATAACAAACAGGAGACCACCTTAGCGCTCATAGGCATATTCTTTTTT TCCTTATTATTATTAGCATTTATTATCTGTATTCACTCAAAACATACAAGAGCCAATCAACGTCATCAAG ACGAAGAGATACCATTAACAGAAGAAAATTCCGACAAAAAAAAGGGATACAAAAAACATGGTGATGTTAT TAGGTTTGACGATGGTAGTGTGCTACCAGTATCTGTAAGATGCGATGAGAATACAGATGTTAGGCACGGT CGCTCACCACGTGTTATAGAAACAAACGACTCGGTTACACCTGTGTACAATTTTTCAAACGGACCTAGCT CTCGATTAACAGACCTACTAGATGACTTTGTTCAGAGTGTAGATTATGGTATAGCTCACGCTCGTCAAGC ATGTGGTAGATTTTTTCGCAGATAA |
| Reference |
(1) Yan Q et al. (2018). Ehrlichia type IV secretion system effector Etf-2 binds to active RAB5 and delays endosome maturation. Proc Natl Acad Sci U S A. 115(38):E8977-E8986. [PudMed:30181274] 
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| experimental literature |