Effector Protein ID: 88658118 |
![]() | VirB [493] |
![]() | - |
![]() | ECH_0825 |
![]() | Ehrlichia chaffeensis str. Arkansas |
![]() | chromosome [GenBank: NC_007799] [Browse all T4SS(s) in this replicon] |
![]() | 841411..842553 [+] |
![]() | hypothetical protein |
![]() | Protein |
![]() | Etf-1 |
![]() | T4CP Depedent |
![]() | ECH0825 prevents ROS-induced cellular damage and apoptosis to allow intracellular infection by upregulating MnSOD (Liu, et al. 2012) Etf-1 interacts with the RAB5-BECN1-PIK3C3 autophagy master regulator complex via GTP-bound RAB5, to induce autophagy. |
![]() | Q2GG12 |
![]() | ech:ECH_0825 |
![]() | NA |
![]() | NA |
Protein Sequence: 380 a.a. [Download] |
>gi|88658118|ref|YP_507621.1| hypothetical protein ECH_0825 [Ehrlichia chaffeensis str. Arkansas] MLTFLKKGANVVIKAAITPTTSKLPHQESVGKYLGGMLKSIIPGQKDPAEKHFDLRMHNRTHKLGVELPA RTRIDGHEQEVALKVPSYKLPYQTLQKFAAWQEQDKEGEVEETKKDTLTSLINPVSATQEFIRSNTADKY FEKLKALDQQLKEIGGKVTVNSTPGRYKQGLTIELDVSNKSRIAIEKDVRLVLEGLGINDEELVKTFTKR LYKSSTDKKMSSADIHTEKTSSNTDSKDNSNNQDHDIVSPAKRHGSDTVSAVQRQGDDILSSSQEQSSKT GSPTNSTGISNSDFSLTNPQNMPYSRTPMQSSQMLQQLQNQILMQQKPERIFSQAMPTVMQQEIDEIAED LCQGLNEGPTQGNSNNIGKHFSNPGKVHAR |
- |
Nucleotide Sequence: 1143 bp [Download] |
>gi|88657561|ref|NC_007799.1|:841411-842553 Ehrlichia chaffeensis str. Arkansas, complete genome ATGCTTACTTTCTTAAAGAAAGGTGCAAATGTTGTTATAAAAGCAGCTATAACACCCACCACTAGTAAAT TACCCCATCAAGAAAGCGTAGGTAAATACCTTGGAGGCATGCTGAAAAGTATTATTCCAGGTCAAAAAGA TCCTGCTGAGAAACACTTTGACTTAAGAATGCACAACCGTACCCACAAACTGGGGGTAGAATTACCAGCA AGAACAAGAATAGATGGTCATGAGCAAGAAGTAGCTCTGAAAGTACCATCTTATAAATTACCATATCAAA CTTTACAAAAATTCGCAGCATGGCAAGAACAAGATAAAGAAGGAGAGGTAGAAGAAACTAAAAAAGATAC CTTAACATCACTTATTAATCCTGTATCAGCAACTCAAGAGTTCATTAGAAGTAATACTGCTGATAAATAT TTTGAAAAATTAAAAGCACTTGATCAGCAATTGAAAGAAATAGGAGGAAAAGTTACAGTAAATTCTACTC CAGGTAGATATAAACAAGGATTAACTATAGAATTAGATGTTTCCAACAAATCAAGAATAGCAATAGAGAA AGATGTACGACTTGTTCTAGAAGGTTTAGGTATAAATGATGAAGAATTAGTCAAAACTTTTACTAAAAGA CTATATAAATCATCTACTGATAAAAAAATGAGTTCAGCAGATATTCACACTGAGAAAACTAGTTCTAATA CTGATAGCAAAGACAATTCTAATAATCAAGATCATGATATAGTATCACCAGCTAAAAGACATGGAAGTGA TACAGTATCAGCAGTACAAAGGCAAGGAGATGATATACTATCATCATCTCAAGAACAGAGTAGTAAAACT GGATCACCAACTAACAGTACTGGTATATCAAACAGTGATTTTTCACTTACAAATCCTCAAAATATGCCTT ATTCTAGGACCCCTATGCAGAGTTCACAAATGCTACAGCAGTTGCAAAATCAAATATTGATGCAACAAAA ACCTGAAAGGATATTTTCACAGGCTATGCCTACTGTTATGCAACAAGAAATCGATGAAATAGCAGAAGAT TTATGTCAAGGTCTTAATGAAGGGCCAACACAAGGTAATTCAAACAATATAGGAAAGCATTTTAGTAATC CAGGAAAAGTACATGCAAGATAA |
Reference |
(1) Sharma P et al. (2017). Peptide Nucleic Acid Knockdown and Intra-host Cell Complementation of Ehrlichia Type IV Secretion System Effector. Front Cell Infect Microbiol. 7:228. [PudMed:28638803] ![]() |
(2) Lin M et al. (2016). Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase. Autophagy. 12(11):2145-2166. [PudMed:27541856] ![]() |
(3) Liu H; Bao W; Lin M; Niu H; Rikihisa Y (2012). Ehrlichia type IV secretion effector ECH0825 is translocated to mitochondria and curbs ROS and apoptosis by upregulating host MnSOD. Cell Microbiol. 14(7):1037-50. [PudMed:22348527] ![]() |
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