| Effector Protein ID: 88607707 |
 T4SS name [ID] | VirB [503] |
| Gene symbol | ank |
| Locus tag | APH_0740 |
| Strain | Anaplasma phagocytophilum HZ |
| Replicon | chromosome [GenBank: NC_007797] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 784800..788498 [-] |
| Product | ankyrin |
| Effector type | Protein |
| Descripton | AnkA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | AnkA binds eukaryotic DNA, and regulates CYBB expression |
| UniProt ID | Q2GJY2 |
| KEGG ID | aph:APH_0740 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 2.2e-57, Aligned region: 16..81 Ank_2 [PF12796], Evalue: 2.2e-57, Aligned region: 127..188 Ank_2 [PF12796], Evalue: 2.2e-57, Aligned region: 193..290 Ank_2 [PF12796], Evalue: 2.2e-57, Aligned region: 458..524 Ank_2 [PF12796], Evalue: 2.2e-57, Aligned region: 610..743 Ank_2 [PF12796], Evalue: 2.2e-57, Aligned region: 694..770 Ank_2 [PF12796], Evalue: 2.2e-57, Aligned region: 746..793 Ank_2 [PF12796], Evalue: 2.2e-57, Aligned region: 818..868 Ank_4 [PF13637], Evalue: 3.1e-41, Aligned region: 145..187 Ank_4 [PF13637], Evalue: 3.1e-41, Aligned region: 714..761 Ank [PF00023], Evalue: 1.5e-40, Aligned region: 827..858 Ank_5 [PF13857], Evalue: 1.3e-31, Aligned region: 131..186 Ank_5 [PF13857], Evalue: 1.3e-31, Aligned region: 827..868 |
| Protein Sequence: 1232 a.a. [Download] |
| >gi|88607707|ref|YP_505319.1| ankyrin [Anaplasma phagocytophilum HZ] MLTEEEKKKSAGALQAIITGDYESFQASVQGISSEGLNTPVDYEGRTLLHYAASSRNGNFYGILVERGCV TNIRDAYGFTPEQAREKAGYARTQWYGADVNDPGVSRQLMTQAVQQSAKGNMYAALAILDLVRNDDANIQ VNEKGHSVLHLACIEGSNPSFTSSLMLKGCSLNIKDVDGNTPLHTAAFSVGKNALGNLDVLCDKALIADV NAKGPGGNTPLHIATERMDHQKVEHLLSRLSDISVANDAGETVCHIVAKQWPRRDVLPYIDKMQEAVSSN IEGNRECAEALIFPDKKGMSAVQYAIRRHIPEAEKIFEKAINIADKVYGLASSEVESLFTCPNPEDASTL VHFVSSNGTPNFDSLAKRVLEEAYHRYGEKPFTNLDVAGNAPIHAAAQKSTVGVFEQVVRYTPESVVNQL APNGKAPIHMIVEDEPSHKSVSIKLQMLIGNVRNIPSINVPSPVTGETPAVAAYKGGNTEDVKTMLRCNS MDVDARSHDGRTIIHYAAKDGNLEILQQALGRKSSYSKFPVKDGVPTPGVYAIREASGGKVSLQALDMLM RYEPHPQHVAVEAVRTGAVGVLEHLITTEVISVNEEITTPEGKKTTLTAEALTSGKYGVVKALIKNSADV NASPEPAITLGIQGRCFQGSKAIKHLKRVVEAGAHINTPTGSMSPLAAAVQAANEASNLKEANKIVNFLL HRGADLSSTEHTGTPALHLATAAGNHRTAMLLLDKGAPATQRDARGRTALHIAAANGDGKLYRMIAKKCP DSCQPLCSDMGDTALHEALYSDNVTEKCFLKMLKESRKHLSNSSFFGDLLNTPQEANGDTLLHLAASRGF GKACKILLKAGASVSVVNVEGKTPVDVADPSLKTRPWFFGKSVVTMMAERVQVPEGGFPPYLPPESPTPS LGSISSFESVSALSSLGSGLDTAGAEESIYEEIKDTAKGTTEVESTYTTVGAEESIYEEIKDTAKGTTEV ESTYTTVGAEGPRTPEGEDLYATVGAAITSEAQASDAASSKGERPESIYADPFDIVKPRQERPESIYADP FAAERTSSGVTTFGPKEEPIYATVKKGPKKSDTSQKEGTASEKVCSTITVIKKKVKPQVPARTSSLPTKE GIGSDKDLSSGTSSSFAAELQAQRGKLRPVKGGAPDSTKDKTATSIFSSKEFKKELTKAAEGLQGAVEEA QKGDGGAAKAKQDLGMESGAPGSQPEAPQSEGPKSVKGGRGR |
| - |
| Nucleotide Sequence: 3699 bp [Download] |
| >gi|88606690|ref|NC_007797.1|:c788498-784800 Anaplasma phagocytophilum HZ, complete genome ATGTTGACAGAAGAAGAAAAGAAAAAGAGCGCCGGTGCTCTGCAAGCCATTATCACAGGAGATTACGAGA GTTTTCAGGCGTCCGTTCAGGGAATTTCTTCCGAAGGACTTAATACTCCCGTTGATTATGAGGGGAGAAC ACTACTGCACTATGCAGCTTCATCCCGTAATGGTAATTTCTATGGCATTCTGGTTGAAAGAGGATGTGTT ACTAATATCAGAGATGCTTATGGATTTACTCCAGAACAAGCACGTGAGAAGGCAGGGTATGCACGCACAC AGTGGTATGGAGCAGATGTAAATGACCCTGGTGTATCTAGGCAGTTAATGACGCAAGCTGTTCAGCAGTC TGCGAAAGGTAACATGTATGCTGCTCTCGCTATATTAGACCTTGTGCGTAATGACGATGCAAACATTCAG GTCAATGAGAAAGGGCATAGTGTTTTGCATCTAGCATGTATTGAAGGCAGTAATCCATCTTTCACTTCAT CCCTCATGCTAAAGGGTTGTTCTTTAAACATTAAGGATGTAGATGGTAATACGCCATTACATACAGCTGC GTTTTCAGTAGGCAAAAATGCTTTAGGCAATCTTGATGTACTATGCGACAAAGCTCTTATAGCAGATGTT AATGCTAAGGGACCGGGTGGAAACACTCCGCTTCATATTGCTACGGAGCGTATGGATCACCAGAAAGTAG AGCATCTTCTCTCAAGGTTAAGTGATATTAGCGTTGCAAATGATGCTGGTGAAACCGTTTGCCACATTGT TGCAAAGCAATGGCCAAGGCGGGATGTTTTACCATACATTGACAAGATGCAAGAAGCGGTGTCGTCAAAT ATTGAGGGCAATCGCGAGTGTGCAGAGGCACTAATATTCCCGGATAAAAAAGGGATGAGTGCAGTACAGT ATGCTATTAGAAGGCATATACCGGAGGCTGAGAAGATCTTCGAGAAGGCCATTAACATTGCAGATAAAGT GTATGGCTTAGCTTCTTCAGAAGTAGAATCTCTCTTTACATGTCCTAATCCAGAGGACGCATCAACGCTG GTGCATTTTGTATCTTCTAATGGGACCCCAAATTTTGATTCTCTTGCGAAAAGGGTATTGGAGGAAGCAT ATCATAGGTATGGAGAGAAACCTTTTACTAATTTAGATGTTGCAGGTAATGCACCTATACATGCTGCAGC ACAAAAATCAACAGTGGGGGTTTTTGAGCAGGTGGTAAGATACACTCCTGAGTCTGTTGTAAATCAATTA GCACCGAATGGCAAAGCGCCTATTCACATGATAGTTGAGGATGAGCCAAGCCATAAAAGCGTAAGCATTA AATTGCAGATGTTGATTGGGAATGTGCGTAATATTCCATCAATCAATGTACCATCCCCAGTGACAGGTGA AACGCCTGCGGTAGCTGCGTATAAAGGGGGCAACACTGAGGATGTTAAGACTATGTTACGCTGTAATAGC ATGGACGTAGATGCTCGGTCACATGATGGTAGAACTATAATACATTACGCAGCAAAGGATGGAAATTTAG AGATATTGCAGCAGGCTCTTGGAAGGAAGAGTAGTTATTCTAAGTTTCCTGTAAAGGATGGTGTTCCTAC TCCAGGTGTATATGCGATTCGTGAAGCAAGTGGTGGAAAAGTATCGCTACAAGCACTTGACATGTTAATG AGATATGAGCCTCACCCGCAGCATGTTGCTGTCGAGGCAGTAAGAACAGGTGCAGTAGGTGTATTGGAGC ACCTTATTACCACTGAAGTGATTAGTGTAAATGAAGAAATTACAACTCCTGAAGGAAAAAAGACAACTTT GACCGCTGAAGCACTAACTAGTGGTAAATATGGTGTAGTGAAGGCGTTAATTAAAAACAGTGCTGATGTA AATGCGTCTCCAGAACCAGCTATTACTTTGGGTATACAAGGAAGGTGCTTTCAGGGGAGTAAAGCTATAA AGCATTTAAAGCGTGTTGTAGAAGCTGGGGCACATATAAATACTCCTACCGGATCTATGAGCCCTTTAGC TGCTGCAGTTCAAGCGGCAAATGAGGCAAGTAACCTTAAAGAGGCTAATAAGATTGTAAATTTCCTTTTA CATAGGGGTGCAGATCTTTCGTCTACGGAACACACTGGAACTCCAGCCTTGCATTTAGCAACAGCTGCTG GCAACCATAGGACTGCTATGTTGCTCTTGGATAAAGGGGCTCCAGCAACGCAGAGAGATGCTAGGGGTAG GACGGCTTTACATATAGCAGCTGCTAATGGTGACGGTAAGCTATATAGGATGATTGCGAAAAAATGCCCA GATAGCTGTCAACCACTCTGTTCTGATATGGGAGATACAGCGTTACATGAGGCTTTATATTCTGATAATG TTACAGAAAAATGCTTTTTAAAGATGCTTAAAGAGTCTCGAAAGCATTTGTCAAACTCATCTTTTTTCGG AGACTTGCTTAATACTCCTCAAGAAGCAAATGGTGACACGTTACTGCATCTGGCTGCATCGCGTGGTTTC GGTAAAGCATGTAAAATACTACTAAAGGCTGGGGCGTCAGTATCAGTCGTGAATGTAGAGGGAAAAACAC CGGTAGATGTTGCGGATCCATCATTGAAAACTCGTCCGTGGTTTTTTGGAAAGTCCGTTGTCACAATGAT GGCTGAACGTGTTCAAGTTCCTGAAGGGGGATTCCCACCATATCTGCCGCCTGAAAGTCCAACTCCTTCT TTAGGATCTATTTCAAGTTTTGAGAGTGTCTCTGCGCTATCATCCTTGGGTAGTGGCCTAGATACTGCAG GAGCTGAGGAGTCTATCTACGAAGAAATTAAGGATACAGCAAAAGGTACAACGGAAGTTGAAAGCACATA TACAACTGTAGGAGCTGAGGAGTCTATCTACGAAGAAATTAAGGATACAGCAAAAGGTACAACGGAAGTT GAAAGCACATATACAACTGTAGGAGCTGAAGGTCCGAGAACACCAGAAGGTGAAGATCTGTATGCTACTG TGGGAGCTGCAATTACTTCCGAGGCGCAAGCATCAGATGCGGCGTCATCTAAGGGAGAAAGGCCGGAATC CATTTATGCTGATCCATTTGATATAGTGAAACCTAGGCAGGAAAGGCCTGAATCTATCTATGCTGACCCA TTTGCTGCGGAACGAACATCTTCTGGAGTAACGACATTTGGCCCTAAGGAAGAGCCGATTTATGCAACAG TGAAAAAGGGTCCTAAGAAGAGTGATACTTCTCAAAAAGAAGGAACAGCTTCTGAAAAAGTCTGCTCAAC AATAACTGTGATTAAGAAGAAAGTGAAACCTCAGGTTCCAGCTAGGACAAGTAGTTTGCCTACTAAAGAA GGTATAGGTTCTGATAAAGACCTGAGTTCAGGAACTAGTAGCTCTTTTGCAGCTGAGCTGCAAGCACAAA GGGGTAAATTGCGTCCTGTGAAGGGAGGTGCTCCGGATTCTACCAAAGACAAAACAGCTACTTCTATATT CTCCAGTAAAGAGTTCAAAAAGGAACTAACAAAAGCTGCCGAAGGATTACAGGGAGCAGTTGAAGAAGCT CAGAAGGGTGATGGAGGAGCTGCAAAGGCAAAGCAAGATCTTGGCATGGAATCTGGTGCCCCAGGATCTC AACCAGAAGCTCCTCAAAGTGAAGGCCCTAAGTCTGTAAAAGGAGGTCGCGGTAGGTAG |
| Reference |
(1) Rikihisa Y; Lin M; Niu H (2010). Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum. Cell Microbiol. 12(9):1213-21. [PudMed:20670295] 
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(2) Lin M; den Dulk-Ras A; Hooykaas PJ; Rikihisa Y (2007). Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infection. Cell Microbiol. 9(11):2644-57. [PudMed:17587335]
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| experimental literature |