| Effector Protein ID: 88606850 |
 T4SS name [ID] | VirB [503] |
| Gene symbol | - |
| Locus tag | APH_0859 |
| Strain | Anaplasma phagocytophilum HZ |
| Replicon | chromosome [GenBank: NC_007797] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 912788..913549 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | Ats-1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Ats-1 translocates across the inclusion membrane, localizes in the host cell mitochondria, and prevents apoptosis at the mitochondria. (Niu et al. 2010) |
| UniProt ID | Q2GJL5 |
| KEGG ID | aph:APH_0859 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 253 a.a. [Download] |
| >gi|88606850|ref|YP_505436.1| hypothetical protein APH_0859 [Anaplasma phagocytophilum HZ] MDIGARMDHNRAKNECGALLDLRKKLEETGGKISVERTGDGFTRMLVIKIDTKNKSEEEVEKEVQLVLGT LGVGSKILAKSIAKELMHQAKTKDMNALAPVSHTPPAQSKPDSDIQENSEKSASADAKNRSQAPDQEENS PRDTTRRNSTTNGEERIFSLSGDASPSRPSSGAGTDQAVQQAHFLRDSEDRVHGSSGITNQGAAAMQQAV LSAARGLSDVSHDDSAQTQGNPTVTPLVSAQNRGPETHGKGTR |
| - |
| Nucleotide Sequence: 762 bp [Download] |
| >gi|88606690|ref|NC_007797.1|:912788-913549 Anaplasma phagocytophilum HZ, complete genome ATGGATATTGGCGCCAGAATGGATCATAACCGAGCTAAAAACGAGTGTGGTGCGCTTTTAGATCTTAGAA AAAAGCTGGAAGAAACAGGTGGTAAGATTTCCGTAGAGCGCACAGGCGACGGCTTCACTAGAATGCTAGT GATAAAAATAGACACAAAAAATAAATCAGAGGAAGAGGTAGAAAAAGAAGTACAACTGGTACTGGGCACT CTAGGTGTTGGAAGTAAAATACTGGCCAAGTCCATTGCTAAAGAGCTAATGCACCAAGCAAAAACAAAAG ATATGAATGCTCTTGCTCCAGTAAGCCATACTCCTCCTGCACAATCAAAACCTGACAGTGATATTCAAGA AAATAGTGAAAAATCTGCATCAGCAGACGCTAAAAATAGATCTCAGGCACCTGATCAAGAAGAAAATTCA CCCCGTGATACAACCCGCAGAAACTCTACTACAAATGGAGAAGAACGCATTTTCTCATTGAGCGGAGATG CGTCACCTAGCAGACCTTCTTCAGGTGCAGGCACCGATCAGGCCGTTCAGCAAGCACACTTCCTAAGAGA CTCAGAGGATCGTGTGCATGGCAGCAGCGGTATCACCAACCAAGGAGCAGCGGCTATGCAACAAGCGGTG CTTTCTGCTGCTAGAGGACTAAGCGATGTTTCTCATGATGATTCAGCACAAACACAAGGGAATCCTACTG TCACTCCTTTAGTAAGCGCACAGAATAGAGGCCCAGAAACACATGGTAAAGGTACGAGGTAA |
| Reference |
(1) Rikihisa Y; Lin M; Niu H (2010). Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum. Cell Microbiol. 12(9):1213-21. [PudMed:20670295] 
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(2) Niu H; Kozjak-Pavlovic V; Rudel T; Rikihisa Y (2010). Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction. PLoS Pathog. 6(2):e1000774. [PudMed:20174550]
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| experimental literature |