| Effector Protein ID: 82700091 |
 T4SS name [ID] | VirB [376] |
| Gene symbol | - |
| Locus tag | BAB1_1279 |
| Strain | Brucella melitensis biovar Abortus 2308 |
| Replicon | chromosome II [GenBank: NC_007618] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1240034..1240561 [-] |
| Product | hexapeptide repeat-containing transferase |
| Effector type | Protein |
| Descripton | RicA |
| T4CP requirement | T4CP Indepedent |
| Target/Effection | RicA was demonstrated to interact with human small GTPase Rab2 involved in trafficking |
| UniProt ID | Q2YQG1 |
| KEGG ID | bmf:BAB1_1279 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Hexapep [PF00132], Evalue: 2.6e-19, Aligned region: 17..47 Hexapep [PF00132], Evalue: 2.6e-19, Aligned region: 75..105 Hexapep [PF00132], Evalue: 2.6e-19, Aligned region: 90..124 |
| Protein Sequence: 175 a.a. [Download] |
| >gi|82700091|ref|YP_414665.1| hexapeptide repeat-containing transferase [Brucella melitensis biovar Abortus 2308] MPIYAYNGHKPQFADRESNWIAPDATLIGKVVVGENAGFWFGAVLRGDNEPITIGADTNVQEQTIMHTDI GFPLTIGAGCTIGHRAILHGCTIGENTLIGMGAIVLNGAKVGKNCLIGAGTLVKEGMEIPDNSLVVGSPA RVLRQLDDAAVEKLRASAKHYVERGHSFMRGMEPA |
| - |
| Nucleotide Sequence: 528 bp [Download] |
| >gi|82698932|ref|NC_007618.1|:c1240561-1240034 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence ATGCCGATCTATGCATATAACGGGCACAAGCCGCAGTTTGCGGACCGCGAGAGCAACTGGATTGCACCGG ATGCGACGCTGATCGGCAAGGTGGTCGTGGGCGAGAATGCGGGTTTCTGGTTCGGCGCGGTGTTGCGCGG CGATAATGAGCCAATCACTATCGGTGCCGATACCAATGTGCAGGAACAGACGATCATGCACACCGATATC GGCTTTCCGCTGACCATCGGTGCGGGCTGCACTATCGGGCACCGTGCGATTCTCCATGGCTGCACGATTG GCGAGAATACTCTTATCGGCATGGGCGCGATTGTGCTCAATGGCGCGAAGGTCGGCAAGAATTGCCTTAT CGGGGCGGGAACATTGGTGAAAGAAGGGATGGAAATCCCTGATAATTCGCTTGTTGTCGGCTCTCCCGCG CGTGTCCTGCGCCAGCTTGACGATGCTGCCGTTGAAAAGCTGCGGGCCTCTGCAAAGCATTATGTGGAGA GGGGACATTCCTTCATGCGCGGCATGGAGCCTGCCTGA |
| Reference |
| (1) von Bargen K; Gorvel JP; Salcedo SP (2012). Internal affairs: investigating the Brucella intracellular lifestyle. FEMS Microbiol Rev. 36(3):533-62. [PudMed:22373010] |
| (2) de Jong MF; Tsolis RM (2012). Brucellosis and type IV secretion. Future Microbiol. 7(1):47-58. [PudMed:22191446] |
(3) de Barsy M; Jamet A; Filopon D; Nicolas C; Laloux G; Rual JF; Muller A; Twizere JC; Nkengfac B; Vandenhaute J; Hill DE; Salcedo SP; Gorvel JP; Letesson JJ; De Bolle X (2011). Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2. Cell Microbiol. 13(7):1044-58. [PudMed:21501366] 
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| experimental literature |