| Effector Protein ID: 82699619 |
 T4SS name [ID] | VirB [376] |
| Gene symbol | - |
| Locus tag | BAB1_0756 |
| Strain | Brucella melitensis biovar Abortus 2308 |
| Replicon | chromosome II [GenBank: NC_007618] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 739186..740019 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | BtpB |
| T4CP requirement | T4CP Indepedent |
| Target/Effection | BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells.BtpB plays a major role in the modulation of host innate immune response during infection. |
| UniProt ID | Q2YN91 |
| KEGG ID | bmf:BAB1_0756 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | TIR_2 [PF13676], Evalue: 7.50E-08, Aligned region: 144-270 |
| Protein Sequence: 277 a.a. [Download] |
| >gi|82699619|ref|YP_414193.1| hypothetical protein BAB1_0756 [Brucella melitensis biovar Abortus 2308] MPCTFDLSRCVNQHEYTDQKIAEKFGKLDGAELAELTRLPTIFAYEAACKLDPKFGLIRDVTVRRGQVRI EYEFIPVQPFLTVADFDTLAFELDIGNWEMNRTHWAVKDVNLPKELHTAKGITLPSWTRQASRAVDITQH DFDVGLSFPGEARGLVEQVARELEARVGPNAYFYDNNYVSQLARPSLDTLLQDIYRNRCKLIVVFVGDDY QRKDWCGVEFRAIREIIMARAEQRIMFVRVDDGAVDGVFRTDGYVDARRFNPSEIAQFIAERVALIT |
| - |
| Nucleotide Sequence: 834 bp [Download] |
| >gi|82698932|ref|NC_007618.1|:739186-740019 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence GTGCCATGTACATTCGACCTGTCGCGTTGCGTTAACCAGCACGAATACACGGATCAGAAGATTGCCGAGA AGTTCGGAAAGCTAGACGGGGCCGAACTGGCGGAATTGACGCGCCTTCCCACGATTTTCGCCTATGAGGC TGCCTGCAAGCTTGATCCCAAGTTCGGGCTCATCCGCGATGTTACGGTAAGGCGCGGGCAAGTGCGAATC GAGTACGAGTTCATCCCGGTCCAGCCCTTCCTGACGGTAGCAGACTTCGACACCCTCGCATTCGAGCTTG ATATTGGCAATTGGGAGATGAATCGTACGCACTGGGCGGTCAAAGACGTAAACCTGCCCAAGGAGCTGCA CACGGCCAAAGGAATAACTCTGCCGTCGTGGACGCGACAGGCGAGCCGTGCCGTCGATATCACTCAGCAC GATTTTGACGTCGGTCTCTCTTTTCCCGGTGAGGCACGCGGGCTGGTCGAGCAAGTGGCCCGCGAACTCG AGGCACGCGTCGGTCCAAACGCCTATTTTTACGACAACAATTATGTTTCCCAGCTTGCCCGACCGTCGCT CGACACCCTACTTCAGGACATCTACCGCAACCGCTGCAAACTGATCGTAGTCTTCGTCGGCGACGACTAT CAGCGAAAAGACTGGTGCGGCGTCGAGTTCCGCGCGATTCGCGAAATTATCATGGCACGGGCCGAACAAC GGATCATGTTCGTGCGTGTGGACGATGGCGCTGTCGATGGCGTGTTTCGCACGGACGGCTACGTGGATGC GAGACGGTTCAATCCTTCTGAGATCGCCCAGTTCATCGCCGAGCGCGTCGCCCTCATCACCTAG |
| Reference |
(1) Salcedo SP et al. (2013). BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
. Front. Cell. Infect. Microbiol.
. 2013.00028
. [PudMed:23847770] 
|
| experimental literature |