| Effector Protein ID: 82699179 |
 T4SS name [ID] | VirB [376] |
| Gene symbol | - |
| Locus tag | BAB1_0279 |
| Strain | Brucella melitensis biovar Abortus 2308 |
| Replicon | chromosome II [GenBank: NC_007618] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 275959..276711 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | btp1 |
| T4CP requirement | T4CP Indepedent |
| Target/Effection | Btp1 down-modulates maturation of infected dendritic cells by interfering with the TLR2 signaling pathway. |
| UniProt ID | Q2YPC4 |
| KEGG ID | bmf:BAB1_0279 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | TIR_2 [PF13676], Evalue: 3.0e-18, Aligned region: 121-249 TIR [PF01582], Evalue: 9.0e-13, Aligned region: 118-245 |
| Protein Sequence: 250 a.a. [Download] |
| >gi|82699179|ref|YP_413753.1| hypothetical protein BAB1_0279 [Brucella melitensis biovar Abortus 2308] MSKEKQAQSKAHKAQQAISSAKSLSTQKSKMSELERATRDGAAIGKKRADIAKKIADKAKQLSSYQAKQF KADEQAVKKVAQEQKRLSDERTKHEAFIKQSLSSMRTTASATMEAEEEYDFFISHASEDKEAFVQDLAAA LRDLGAKIFYDAYTLKVGDSLRRKIDQGLANSKFGIVVLSEHFFSKQWPARELDGLTAMEIGGQTRILPI WHKVSYDEVRRFSPSLADKVALNTSLKSVEEIAKELHSLI |
| - |
| Nucleotide Sequence: 753 bp [Download] |
| >gi|82698932|ref|NC_007618.1|:c276711-275959 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence ATGTCTAAAGAGAAACAAGCCCAATCAAAAGCCCACAAAGCCCAACAAGCTATCAGTTCAGCAAAATCAC TCTCCACACAGAAAAGCAAAATGTCAGAGCTTGAGCGCGCCACGAGGGATGGTGCCGCGATTGGCAAGAA GCGAGCGGATATCGCCAAAAAAATTGCCGATAAGGCAAAACAGTTAAGCTCCTATCAGGCTAAGCAATTC AAAGCTGATGAGCAGGCTGTTAAAAAGGTCGCGCAGGAGCAAAAGCGTTTATCAGATGAGCGAACCAAGC ATGAAGCTTTCATCAAACAATCATTGAGCTCCATGCGAACAACTGCGAGCGCGACTATGGAAGCAGAAGA AGAATACGATTTCTTCATATCACATGCGAGCGAAGACAAAGAAGCATTCGTTCAGGATCTAGCCGCCGCG CTTCGCGACCTAGGAGCTAAGATTTTCTATGACGCATATACGTTGAAGGTCGGTGACAGCCTTCGGCGCA AAATCGATCAGGGGCTCGCGAACTCCAAATTTGGCATAGTTGTTCTATCGGAACACTTTTTTAGCAAGCA ATGGCCCGCAAGAGAATTAGATGGACTGACGGCAATGGAAATTGGCGGACAGACGCGAATATTGCCGATC TGGCATAAAGTTTCCTACGATGAAGTTCGGCGTTTCAGTCCCTCATTGGCCGACAAAGTGGCACTGAACA CATCGCTAAAGAGCGTGGAAGAAATCGCGAAAGAACTGCATTCCCTTATCTGA |
| Reference |
(1) Salcedo SP et al. (2008). Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1. PLoS Pathog. 4(2):e21. [PudMed:18266466] 
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| experimental literature |