| Effector Protein ID: 54295395 |
 T4SS name [ID] | Dot/Icm [41] |
| Gene symbol | - |
| Locus tag | lpl2481 |
| Strain | Legionella pneumophila str. Lens |
| Replicon | chromosome [GenBank: NC_006369] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2821747..2823135 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LegK3 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5WTP3 |
| KEGG ID | lpf:lpl2481 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pkinase [PF00069], Evalue: 2e-25, Aligned region: 50..311 Pkinase_Tyr [PF07714], Evalue: 7.1e-12, Aligned region: 50..309 |
| Protein Sequence: 462 a.a. [Download] |
| >gi|54295395|ref|YP_127810.1| hypothetical protein lpl2481 [Legionella pneumophila str. Lens] MFDRNIKEIINELQEKDLLPGTGKIIGGPRNQFDKKGEIKQGYLFSVINKEPIGKGGFASVYPVTLYRQG ETGFAKKSTDHKKFVTKKFNLNKLKIKYTNLNIENLIEKEFEFCQKAGHLSIKPPVYNNNKCYLTMKRMP GIDLNRIFNKLMANPHYLTEGQRIKITYALLLALKNQVIDKGIIHRDIKPENIHVKVVNPVEVNIFDYGL AKNAGEDDNLFPGSESWAAPEMFTGLKHDSKADIFSMGRVIAFLWGESATNYLSNNPLNKSRNAAKNLNL PAQVKWVEPFLKQMLAERQEDRIEIDSAINQFKQLASINAPKLKLPQSSIKNHSNINNLCFFQNPTKSTN NSALTQLNIQRDIKKDLQELLENLPSEFSHYRSNIIFKNTIGRFTTIQKMMNELNQIMDENESQDIPMEL YDFIHQYQNKFLHASEANIIRKINGFLEDIEYQNLTNSGFEL |
| - |
| Nucleotide Sequence: 1389 bp [Download] |
| >gi|54292964|ref|NC_006369.1|:2821747-2823135 Legionella pneumophila str. Lens, complete genome ATGTTTGATAGAAATATAAAAGAAATAATCAATGAATTACAAGAAAAGGATTTACTTCCGGGCACTGGAA AAATTATCGGCGGACCCCGAAATCAATTTGATAAGAAAGGAGAGATAAAACAAGGGTATCTTTTTTCAGT TATTAACAAAGAACCAATAGGAAAAGGTGGGTTCGCTTCTGTTTATCCTGTTACGTTGTATCGGCAAGGT GAAACTGGATTTGCTAAAAAATCTACTGATCATAAGAAGTTTGTAACAAAGAAATTTAATTTAAATAAAC TTAAAATAAAATACACCAACTTAAATATAGAAAATTTAATTGAAAAAGAGTTTGAGTTTTGTCAAAAAGC AGGGCACTTAAGTATAAAACCACCTGTTTACAATAATAATAAATGTTATCTGACGATGAAACGAATGCCA GGGATAGATTTAAATCGTATCTTCAATAAATTAATGGCTAATCCTCATTATCTTACAGAGGGTCAGCGAA TTAAGATAACCTATGCTTTATTATTGGCTTTGAAAAATCAGGTGATTGATAAAGGAATTATTCATCGAGA TATAAAGCCTGAGAATATTCATGTTAAAGTGGTTAACCCTGTTGAAGTGAATATTTTCGATTACGGACTT GCCAAAAATGCAGGCGAAGACGATAACCTATTTCCTGGAAGTGAAAGTTGGGCAGCGCCTGAAATGTTTA CTGGCTTAAAGCACGATAGTAAAGCTGATATTTTTTCAATGGGAAGAGTGATTGCCTTCTTATGGGGCGA AAGTGCTACAAACTATTTGAGCAATAACCCCCTTAATAAAAGCCGAAATGCAGCAAAAAACCTTAATTTG CCCGCACAAGTTAAATGGGTAGAGCCATTTTTGAAACAAATGTTAGCGGAAAGACAAGAGGATAGAATAG AGATTGATTCCGCAATAAACCAATTTAAGCAACTTGCGTCCATTAACGCGCCGAAGCTTAAATTACCTCA ATCCTCAATAAAGAATCACTCAAATATTAATAATCTCTGCTTTTTTCAAAATCCAACTAAAAGCACAAAC AATTCTGCTCTTACACAATTAAATATTCAGCGGGATATCAAAAAGGATTTGCAGGAATTATTAGAGAATC TTCCTAGTGAATTTTCTCATTATCGCAGTAATATAATTTTTAAAAACACAATAGGCCGTTTTACAACAAT ACAAAAAATGATGAATGAACTAAATCAGATCATGGATGAAAACGAATCTCAAGATATACCCATGGAATTA TATGATTTTATTCATCAATATCAGAATAAATTTTTGCATGCAAGCGAAGCTAATATTATAAGAAAAATAA ATGGCTTCTTAGAAGATATAGAGTATCAAAATTTAACCAATTCAGGCTTTGAATTATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Hervet E; Charpentier X; Vianney A; Lazzaroni JC; Gilbert C; Atlan D; Doublet P (2011). Protein kinase LegK2 is a type IV secretion system effector involved in endoplasmic reticulum recruitment and intracellular replication of Legionella pneumophila. Infect Immun. 79(5):1936-50. [PudMed:21321072] 
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| experimental literature |
| in silico analysis literature |