| Effector Protein ID: 54295326 |
 T4SS name [ID] | Dot/Icm [41] |
| Gene symbol | lepB |
| Locus tag | lpl2411 |
| Strain | Legionella pneumophila str. Lens |
| Replicon | chromosome [GenBank: NC_006369] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2740414..2744298 [+] |
| Product | effector protein B, substrate of the Dot/Icm secretion system |
| Effector type | Protein |
| Descripton | LepB |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LepB is a Rab1-specific GTPase-activating protein, which facilitates the removal of Rab1 by stimulating GTP hydrolysis. |
| UniProt ID | Q5WTW2 |
| KEGG ID | lpf:lpl2411 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1294 a.a. [Download] |
| >gi|54295326|ref|YP_127741.1| effector protein B, substrate of the Dot/Icm secretion system [Legionella pneumophila str. Lens] MLTYQGKEIVRFKEKTGGKNKSDVDGFYKDSDGRKFFIKKPGDPRELFTELFAGLLLKEFMKRGLIDESY FPSLICADVIQFEDKSYGLIQPLVSFDELHKIIGTSYGDGSDRNTIKETFFGPGYYAGITKQNKYFGLSM ALMFSLLLGAHSVHSGNIVVLKGEGEEKSKQFGRIDWGDAFRYFAHRNNNDNLLYAYENRGWFNYKSLTK DYFLNYKKINGLFPAMAEKARQLQSKLNPELLIEIVTSALKNIPADLIEEKTKIQLAAYMCMDSFKEVTF GPKGNCKDFAIAMATLLENRLGKIAVLKDMSPLSNPEELYQSILELKPLTLLMTSSTSFSETINQWADIL KTTDMEKFSFDSNPINLPELVKQFNLYVDELAITCEANNVWAKERIDSTPNLFALYDNSGGEAIHGHAFV PYYKESIVLRRLFTVDPNTFNLSRFAAFEGPCQLYCKEHKDSAWVKIQTLLTLGNGIINTLKIIKQAQAF GIDEAVTENLKALKEQFIAFQLAEADVKKSLKVPSFAEPLPDKESEFFYPIDEKALAKMNGYQLATICLE ELNSPKPSPLIERILSNKKFWKRINSAFESGVFKGRTDDPAGKIAKIREWHQLLQISGKKTAGQIDELQK IVISLQSKIKKQTIEFEELEATLIQIKEKYQLLEKMAEQSEHEKSSAQSIIRSLNLELGQLKLQLQEQEK LQFQLKELKEKIHEQTTLSKRLGEELQTQKKTNTHQEETIQRITKEKSLADSSLESLRKELHELAKKERS LHKTLEEKQLQVQELEEQLAEKEKENLALKKADKQSQHEKSLDKSAIESLTSELNQLKLELQKQETLELQ LKSLRKQIQEQTLLVEGLKEELQKQKKSNTHQEETIERITKEKSLADSALESLRKEMHELTRKNEENQLK LTKQVHSLSEQLEEKQLQIREFEKQLQEKEKRVEQSEKEKASEKRTVASLREQVSNLKLQLQQLGEVIQE KEKGSSLISQQSKQIIALQEIVEDQKRQLEELKIKIQELVSANQELGKQNQSLSKENLHNKNTVEDLEKK LTELNVQLEQLHQSSNEKEQTIRKLREELIKKDSSLKQNEEMQLAQKHLQEEIDRLQKEIKQQQLNTNQL ESIVAQSKEAEKRYQQALQQKKGIYLARMERVSPIYLQIQQIEQKAKELEERRETEASTAAKTLATKLRL EIKNYLDNNESDEKSALNSFKINAKRHIENSKETLNQHREEWKYLLANVTLGVFLLGIGYLAAILINKAT TGNYTFFSQTNSGKKLDALEKAISSTHSETLVYG |
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| Nucleotide Sequence: 3885 bp [Download] |
| >gi|54292964|ref|NC_006369.1|:2740414-2744298 Legionella pneumophila str. Lens, complete genome ATGTTAACTTATCAAGGTAAAGAAATAGTTCGATTTAAAGAAAAAACAGGTGGTAAAAATAAAAGTGATG TCGATGGTTTTTACAAAGACAGCGATGGCCGGAAATTTTTTATAAAAAAACCGGGGGACCCTCGTGAGCT ATTCACAGAATTATTTGCAGGCTTGCTATTAAAAGAGTTCATGAAGCGAGGATTGATTGATGAAAGCTAT TTTCCATCATTGATTTGCGCAGATGTCATTCAATTTGAAGACAAATCCTATGGCCTGATACAGCCGCTGG TTTCATTTGATGAATTACACAAAATCATTGGAACAAGCTACGGTGATGGCAGTGATCGTAATACGATAAA GGAAACCTTCTTTGGGCCAGGTTATTATGCCGGGATCACAAAACAAAATAAATATTTTGGCCTTTCTATG GCCCTTATGTTTTCTCTATTGCTGGGAGCCCATAGTGTACATAGTGGCAATATCGTTGTACTCAAAGGAG AAGGAGAAGAAAAAAGCAAACAATTTGGCCGAATCGATTGGGGAGATGCCTTCCGTTATTTCGCTCATCG AAACAATAATGACAATCTCCTTTATGCTTATGAAAACAGAGGTTGGTTTAATTATAAATCACTAACTAAA GATTATTTCCTGAACTATAAGAAGATCAATGGCCTCTTCCCTGCGATGGCTGAAAAAGCCCGACAATTGC AATCCAAACTAAATCCTGAATTGCTTATTGAAATAGTAACTAGCGCACTCAAAAATATTCCAGCTGATCT GATAGAAGAAAAAACCAAAATCCAACTTGCTGCCTACATGTGTATGGATTCATTTAAAGAGGTAACATTT GGCCCAAAGGGTAATTGCAAAGATTTTGCCATTGCCATGGCTACATTATTAGAAAATCGTTTAGGAAAAA TTGCTGTTCTTAAAGATATGTCCCCATTGAGCAATCCTGAAGAGCTGTATCAAAGTATTTTGGAATTAAA ACCCTTGACGCTTCTTATGACCTCTTCAACCTCTTTTTCAGAAACCATAAATCAATGGGCAGATATCTTA AAAACTACAGACATGGAAAAATTTTCGTTTGATAGTAATCCAATCAACCTACCGGAATTAGTCAAACAAT TTAACCTTTACGTTGATGAACTAGCCATCACGTGTGAAGCCAATAATGTCTGGGCAAAAGAAAGAATAGA CAGCACCCCTAATCTGTTTGCTCTCTATGATAATAGCGGTGGTGAAGCGATTCACGGACATGCCTTTGTT CCTTACTACAAAGAAAGCATTGTATTGCGCCGCCTATTTACAGTAGACCCTAATACTTTCAACTTATCTC GTTTTGCTGCTTTTGAAGGACCATGCCAACTCTATTGCAAGGAACATAAAGACTCTGCCTGGGTTAAAAT CCAAACCTTACTGACTTTAGGTAATGGAATTATTAATACGCTAAAAATAATCAAACAGGCTCAAGCATTC GGAATAGATGAGGCAGTTACAGAGAATTTAAAAGCATTGAAAGAACAATTCATTGCTTTTCAACTTGCGG AAGCTGATGTAAAAAAATCATTAAAAGTACCTTCTTTTGCAGAGCCCTTGCCTGATAAGGAAAGTGAGTT TTTTTATCCCATTGATGAAAAAGCATTAGCTAAAATGAATGGATATCAACTTGCAACGATTTGTCTGGAA GAACTAAATAGCCCTAAACCGTCGCCTTTAATTGAAAGAATTCTCAGTAATAAAAAATTTTGGAAACGTA TTAACTCTGCTTTTGAAAGTGGTGTATTTAAAGGCCGCACAGATGATCCCGCCGGTAAAATAGCTAAAAT CCGTGAATGGCATCAATTATTACAGATTTCTGGTAAAAAAACTGCTGGACAAATTGATGAGCTGCAAAAG ATAGTAATTTCTCTTCAATCAAAAATTAAAAAGCAAACGATTGAATTTGAGGAGCTGGAAGCGACTTTAA TCCAAATAAAAGAAAAATATCAGTTACTGGAGAAAATGGCTGAGCAAAGCGAACATGAGAAATCTTCCGC CCAATCCATTATTCGCTCTCTGAATTTAGAACTGGGTCAGCTTAAATTACAACTGCAAGAGCAAGAAAAA TTACAGTTCCAATTAAAAGAACTCAAAGAGAAAATACATGAACAAACGACTCTATCCAAGCGATTAGGAG AGGAGCTGCAAACGCAAAAGAAAACCAACACGCACCAGGAAGAAACCATTCAAAGAATCACCAAAGAAAA ATCATTGGCTGATTCTTCCCTTGAGTCGCTTCGAAAAGAACTGCATGAATTGGCAAAAAAAGAACGCTCT CTTCATAAAACGCTCGAAGAAAAACAATTACAAGTACAAGAGTTAGAAGAGCAATTAGCAGAGAAAGAAA AGGAAAATCTAGCCCTGAAAAAAGCTGACAAACAAAGTCAACATGAAAAATCCCTGGATAAATCTGCTAT TGAATCTCTAACTTCAGAGCTTAATCAGCTTAAATTAGAACTGCAAAAACAAGAAACATTAGAATTGCAG TTAAAATCTTTAAGAAAACAAATTCAAGAGCAAACATTGCTTGTAGAAGGCTTGAAAGAGGAGTTACAAA AACAAAAGAAAAGCAACACACACCAGGAAGAAACTATTGAAAGAATCACTAAAGAAAAATCATTGGCTGA TTCTGCTCTTGAATCGCTTCGAAAAGAGATGCATGAATTAACTCGAAAAAACGAAGAAAATCAACTTAAA TTAACAAAACAAGTCCACTCTCTTAGTGAACAACTTGAAGAGAAACAATTACAAATTAGGGAATTTGAGA AGCAATTACAAGAAAAAGAAAAAAGAGTCGAGCAAAGTGAGAAAGAGAAAGCTTCCGAAAAACGAACTGT GGCTTCACTTAGGGAGCAAGTAAGCAATTTAAAATTGCAATTACAGCAACTTGGAGAGGTAATTCAGGAA AAAGAAAAAGGCTCCTCTTTGATAAGCCAGCAATCCAAACAAATTATTGCTCTTCAAGAGATTGTAGAAG ATCAAAAAAGACAATTGGAAGAATTGAAAATAAAAATTCAGGAACTTGTATCTGCAAATCAAGAGCTTGG AAAACAAAATCAAAGTTTGAGCAAGGAAAATTTACATAATAAGAATACAGTTGAAGATCTTGAGAAAAAA TTGACCGAATTAAATGTTCAATTGGAACAATTGCACCAATCTTCAAATGAAAAAGAACAAACCATTAGAA AATTGAGAGAAGAACTCATTAAGAAAGATTCTTCGCTCAAACAAAATGAGGAAATGCAATTAGCCCAAAA ACATCTGCAAGAGGAAATTGATCGTCTACAAAAAGAAATTAAACAACAACAATTAAATACAAATCAATTA GAATCTATAGTTGCTCAAAGTAAAGAGGCTGAAAAACGCTATCAGCAAGCTTTACAACAGAAAAAGGGAA TTTACCTTGCGCGAATGGAAAGAGTGTCTCCTATTTATTTGCAAATACAGCAAATTGAACAAAAGGCCAA AGAATTGGAGGAAAGAAGGGAAACAGAAGCATCAACAGCGGCAAAAACACTCGCAACAAAACTTCGTTTA GAGATAAAAAATTATCTCGACAATAATGAGTCCGATGAAAAAAGTGCCTTAAACTCATTCAAAATAAATG CCAAACGGCATATTGAAAACTCGAAGGAAACGCTAAATCAACATCGGGAAGAATGGAAGTACCTGTTAGC CAATGTTACTTTAGGGGTATTCTTGCTTGGAATCGGTTATCTCGCCGCTATTTTGATTAACAAAGCAACT ACTGGCAATTATACCTTTTTCAGCCAAACTAACAGCGGGAAAAAATTGGACGCGTTGGAAAAAGCGATTT CTTCCACTCACTCCGAAACATTAGTTTATGGATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |