| Effector Protein ID: 54295300 |
 T4SS name [ID] | Dot/Icm [41] |
| Gene symbol | - |
| Locus tag | lpl2385 |
| Strain | Legionella pneumophila str. Lens |
| Replicon | chromosome [GenBank: NC_006369] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2715575..2717098 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | SidD |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SidD catalyzes AMP release from Rab1, generating de-AMPylated Rab1 accessible for inactivation by LepB. (Neunuebel, et al. 2011) |
| UniProt ID | Q5WTY8 |
| KEGG ID | lpf:lpl2385 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 507 a.a. [Download] |
| >gi|54295300|ref|YP_127715.1| hypothetical protein lpl2385 [Legionella pneumophila str. Lens] MVYYAIIKDIVFTYNLQFTHLIHNDRISEVNLGGVTMRSIITQICNGVLHGQTYQSGSNDLDKGNSEIFA SSLFVHLNEQGKEIIKHKDSDDKIVIGYTKDGMAFQIVVDGFYGCERQAVFSFIDNHVLPLIDNFSLDLA RYPNSKNVTESFIHTIYSLRSKHAPLAEFTMSLCVTYQKDDQLFCAGFGIGDTGIAIKRNEGTIEQLVCH TEVDGFKDAFDNYSSTNIDSVIERNSVFNTKVMPGDELVGYTYVPPALEITEKEFEVETVDGKKINKRIV RHLNLDPGNFDDKDPLFSQLLQVVKSKQKQLVEQAKETGQIQRFGDDFTVGRLVIPDQLLINQLRTHALS IGVSDGLLSYIKNENENKGFLGIYGFFTGADKNIEKATLYKNLIAKYQNNPFTSLIILSALVSDSKTPVM TQYLVDYLDFSSKASLANKITGLLLKELENPDMREILGSRLATDVIEELETKIIRYIHNPTGSDIHSTLN LWTADKIKAATNSSLTI |
| - |
| Nucleotide Sequence: 1524 bp [Download] |
| >gi|54292964|ref|NC_006369.1|:2715575-2717098 Legionella pneumophila str. Lens, complete genome TTGGTATATTATGCGATCATTAAGGATATTGTCTTTACATATAATTTACAATTTACACATCTAATACACA ATGACAGGATATCTGAAGTAAATTTAGGAGGAGTAACGATGCGTTCGATTATTACACAAATCTGTAATGG TGTTCTTCATGGACAAACCTATCAGTCTGGTTCCAATGATTTAGATAAGGGTAATAGTGAAATCTTTGCA TCCAGCCTGTTTGTACATTTGAATGAACAGGGCAAAGAAATTATAAAGCACAAGGATTCTGACGATAAAA TAGTCATTGGATATACCAAAGATGGAATGGCTTTTCAAATTGTAGTGGATGGCTTTTATGGATGCGAACG TCAGGCTGTTTTTTCATTTATTGATAACCATGTACTCCCTTTAATTGATAACTTCTCCTTAGATCTCGCC AGATACCCAAATTCAAAAAATGTTACTGAATCATTCATTCATACTATTTACTCTTTGCGCAGCAAACATG CTCCATTGGCAGAGTTTACTATGTCTTTATGCGTAACTTATCAAAAGGATGATCAACTGTTTTGTGCAGG ATTTGGCATTGGTGACACCGGAATAGCTATCAAACGAAACGAAGGAACAATTGAACAATTAGTGTGTCAT ACAGAAGTTGATGGATTCAAAGACGCATTTGACAACTATTCATCCACCAATATCGACTCGGTCATTGAAA GAAATTCTGTCTTTAATACTAAAGTAATGCCTGGTGATGAGCTGGTGGGATACACTTATGTTCCACCGGC ATTAGAAATTACTGAAAAAGAGTTTGAAGTAGAAACTGTTGATGGTAAGAAAATAAACAAAAGAATTGTA AGACATCTAAATCTCGATCCTGGAAATTTTGATGACAAAGATCCCTTATTTTCTCAATTGCTACAGGTTG TAAAATCCAAACAAAAACAGCTGGTTGAGCAAGCAAAAGAAACAGGACAAATCCAACGTTTTGGTGATGA TTTTACAGTAGGAAGATTAGTCATTCCTGATCAGTTACTAATAAATCAATTAAGAACTCATGCTTTATCA ATCGGAGTAAGTGACGGATTACTTTCATACATCAAGAATGAAAATGAAAACAAAGGTTTTCTTGGGATAT ATGGTTTCTTCACAGGAGCTGATAAAAATATAGAAAAAGCAACTCTTTATAAAAATCTCATCGCAAAATA CCAAAATAATCCTTTTACCTCGCTAATTATTCTTTCTGCTCTAGTCTCTGATAGTAAAACACCCGTAATG ACTCAATACTTAGTTGACTATCTGGATTTCTCGTCGAAAGCATCACTTGCTAATAAAATTACAGGATTGC TTTTAAAAGAATTAGAAAATCCAGATATGAGAGAAATACTGGGATCCAGGTTAGCAACTGATGTTATAGA AGAATTAGAAACTAAAATTATTCGTTATATTCATAACCCAACAGGCTCGGATATTCATTCAACGCTAAAC CTTTGGACTGCAGATAAAATTAAGGCTGCAACTAACTCGAGTCTTACTATTTAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |