| Effector Protein ID: 54295022 |
 T4SS name [ID] | Dot/Icm [41] |
| Gene symbol | - |
| Locus tag | lpl2102 |
| Strain | Legionella pneumophila str. Lens |
| Replicon | chromosome [GenBank: NC_006369] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2381661..2383478 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LegS2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegS2 is homologous to eukaryotic sphingosine-1-phosphate lyase and localizes to the mitochondria in host cells (Degtyar, et al. 2009) |
| UniProt ID | Q5WUR6 |
| KEGG ID | lpf:lpl2102 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pyridoxal_deC [PF00282], Evalue: 6.6e-16, Aligned region: 188..376 Aminotran_5 [PF00266], Evalue: 1.2e-09, Aligned region: 184..487 DegT_DnrJ_EryC1 [PF01041], Evalue: 5.6e-06, Aligned region: 210..328 |
| Protein Sequence: 605 a.a. [Download] |
| >gi|54295022|ref|YP_127437.1| hypothetical protein lpl2102 [Legionella pneumophila str. Lens] MFGFISDLLTAAVSSLDELLQDTPAHQIILGTAALYFLYNQYHNPSISRWYLSRNNASMKQRIIDSAYAL AKNLPGVNQIIEKELNKELSSTREKLRIQRSGMTLREEIPEEGLSPQDILSAFDVDVEKCHFDFLSVNND SPEREFLVGGGDGKDSGALYAIHPKELTELLKEVYGATALTNPLHDKWPRINAMQAEVIRWCQNLFHGSK EGYGLLTHGGTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAFKKAAELTGAILITVPVDKKTGAVNP RVMSSYITRNTAVIVGSAPSFMNGIHDPVSELGQLAKKKNVPFHVDACLGGFLTAFLDTSSEPMDFRVPG VTSISADLHKYGCCPKGTSVCLFSEDSPALSVYAALNWSGGLYATPGILDGSTSGARVAEVYATLSYYGK NKYQEIAKSIIKLRNAIQKELTALVEEGNGLTSEDIYVYGNPQWSILGFRSNTCNAHFIADELEKRGWKL NLLQNPDGFHLCLTHVHTLVRGFETQFIKDLREAVIDVKNYPPGKKASGNVKVYGAVGMMPIELQKEICK QYQKARLDFTAASHGSLGIFTTSPTEEDDGLRNRKVGEQKVQTSL |
| - |
| Nucleotide Sequence: 1818 bp [Download] |
| >gi|54292964|ref|NC_006369.1|:c2383478-2381661 Legionella pneumophila str. Lens, complete genome ATGTTCGGTTTTATTTCAGATTTATTAACAGCAGCAGTCAGTTCTTTAGATGAATTATTACAAGATACTC CGGCACATCAAATCATATTAGGCACAGCTGCTCTTTATTTTCTTTATAATCAATACCATAACCCATCGAT TTCCAGGTGGTACCTTAGCCGCAATAACGCCAGTATGAAGCAGCGTATTATTGATAGTGCTTACGCCTTG GCAAAAAATTTACCTGGCGTGAATCAGATCATTGAGAAAGAGCTCAATAAAGAACTCTCTTCAACGAGAG AAAAATTGAGAATTCAGCGTTCCGGTATGACTCTCAGGGAGGAAATACCTGAAGAAGGGCTTTCTCCCCA AGATATTTTGAGTGCATTTGATGTGGATGTGGAAAAATGTCATTTTGATTTTTTATCCGTAAATAATGAC AGCCCTGAGAGGGAGTTTCTTGTTGGAGGAGGGGATGGTAAAGATTCAGGTGCATTATACGCTATTCACC CTAAGGAATTGACAGAGCTGCTTAAAGAAGTTTATGGGGCAACTGCTCTAACTAATCCTTTGCATGATAA ATGGCCTCGAATTAACGCAATGCAAGCGGAGGTGATTCGCTGGTGTCAAAATCTGTTTCATGGTTCAAAA GAAGGTTATGGTTTATTAACTCATGGGGGTACAACCAGCATTATTGAGGCGATGGCTGCTTATGTCATTC GCGCAAGGGCAAAAGGCATTGATTATCCTGAAATTGTCGTTCCTGAAACAGCACATGCTGCATTTAAAAA AGCAGCCGAATTAACTGGAGCAATATTAATTACGGTTCCTGTTGATAAAAAAACAGGTGCGGTGAATCCC AGGGTCATGAGTTCCTATATTACCAGAAATACTGCCGTAATAGTTGGATCTGCCCCATCTTTCATGAATG GAATTCATGATCCTGTCTCTGAGTTAGGTCAATTAGCAAAGAAAAAAAATGTTCCTTTTCATGTAGATGC CTGTTTGGGTGGGTTTTTAACGGCTTTTTTAGACACTTCATCCGAGCCTATGGATTTTAGAGTACCTGGA GTGACTTCCATTTCAGCCGACTTGCATAAATATGGCTGTTGTCCAAAAGGCACCTCTGTTTGTCTTTTTA GTGAGGATTCGCCTGCTTTGTCAGTTTATGCCGCATTAAACTGGTCAGGTGGATTGTATGCTACGCCAGG AATTCTGGATGGTTCAACCAGTGGAGCTCGTGTCGCGGAAGTCTACGCTACATTGTCTTACTATGGGAAA AATAAATATCAGGAAATCGCCAAAAGCATTATCAAATTACGCAATGCCATTCAAAAAGAATTGACGGCAT TAGTGGAGGAAGGCAATGGATTAACCAGCGAAGATATTTATGTTTATGGTAATCCTCAATGGTCCATTCT GGGGTTTAGAAGTAACACTTGCAATGCCCATTTCATTGCAGATGAATTGGAGAAGCGGGGATGGAAGCTT AACTTGCTACAAAATCCGGATGGGTTTCATTTATGTTTGACCCATGTGCACACTTTAGTAAGGGGCTTCG AAACGCAATTTATTAAAGATTTAAGAGAGGCGGTGATTGATGTTAAAAATTATCCCCCTGGAAAGAAAGC AAGCGGTAATGTCAAAGTGTATGGTGCTGTCGGTATGATGCCGATTGAACTTCAGAAAGAGATTTGTAAA CAATATCAAAAAGCCCGCCTTGATTTTACAGCAGCCAGCCACGGGAGCTTGGGGATATTTACAACTTCAC CTACAGAAGAGGACGATGGACTTAGAAACAGGAAAGTTGGGGAACAAAAGGTGCAAACCTCGCTTTGA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |