| Effector Protein ID: 54294987 |
 T4SS name [ID] | Dot/Icm [41] |
| Gene symbol | - |
| Locus tag | lpl2066 |
| Strain | Legionella pneumophila str. Lens |
| Replicon | chromosome [GenBank: NC_006369] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2327815..2329452 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LegK2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegK2 is a protein kinase involved in endoplasmic reticulum recruitment and intracellular replication. (Hervet, et al. 2011) |
| UniProt ID | Q5WUV1 |
| KEGG ID | lpf:lpl2066 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pkinase_Tyr [PF07714], Evalue: 3.1e-05, Aligned region: 131..230 |
| Protein Sequence: 545 a.a. [Download] |
| >gi|54294987|ref|YP_127402.1| hypothetical protein lpl2066 [Legionella pneumophila str. Lens] MVYYINLKEQPLPQDKEILTQLIKQYLLSGSSQSALFANHPYALNDEDGNEIEFLLSHDVFKNQRQDGIT EFLILNGPKIGSGTKGMAIQSNLAMYLWDEKLVVFPKENILKVLYQNFSNVEKLIEQESFHYSILSGNSN AELINLQGSDRLPESLGFFMQKEEGCVLEKLLEDLDLLQKLTFSDKMELAISFLTELENLHNKGYAHGDL TFKNILYNEKNNQLKIIDAGEMTVADERLLAQDILIARDMVSLLFTTDEANQFKASSYWSDEPTVRRIVN PNPVEAKLNRILNSKYSCISEFKSAIEWNYNEYLSQLNPLLQRNELSKVEREASNLQAYKDQMDKQQLLG EIQGCKKPYWAMKGSLLYADQYRLKVFFDYLDIIGSAFKNDKINEKSARAAYDFLTAQINKLFEDHEKNS QLSFKSFSEDVQQFLNHVNTFLIKHPLASSNSIASIIRLLKQLDNQASFEPEQSLKTFSSYKEVMIQKLL EPFETLVDEMTSAPATVSDFIEKQSDTKRRLQEMKFSANQDKQPIFTPSLMRGPS |
| - |
| Nucleotide Sequence: 1638 bp [Download] |
| >gi|54292964|ref|NC_006369.1|:c2329452-2327815 Legionella pneumophila str. Lens, complete genome ATGGTTTATTACATAAATTTGAAGGAACAACCCTTACCTCAAGATAAAGAAATTTTAACGCAGTTAATTA AGCAATATTTATTGTCTGGTTCCAGTCAGTCCGCATTATTTGCTAACCATCCTTACGCACTAAACGATGA AGATGGAAATGAAATAGAATTCCTCTTGAGTCATGATGTATTCAAAAATCAACGCCAGGATGGTATTACG GAGTTTTTAATTTTAAATGGCCCAAAAATAGGGAGCGGAACTAAAGGTATGGCGATACAGAGTAATCTGG CTATGTACTTATGGGATGAAAAGTTGGTCGTTTTTCCCAAAGAGAATATACTGAAGGTTTTATATCAAAA TTTTAGTAATGTCGAGAAGCTAATAGAACAGGAGTCTTTCCATTATTCGATTTTATCAGGCAACTCCAAT GCAGAATTAATCAATTTGCAAGGGTCTGATCGACTTCCAGAATCTCTAGGTTTTTTTATGCAAAAAGAAG AGGGATGTGTCCTGGAAAAACTTCTAGAGGATCTGGACTTGCTACAAAAATTAACATTTTCAGACAAAAT GGAGTTAGCCATTTCATTTTTAACTGAGTTGGAAAATCTGCATAACAAAGGCTACGCCCATGGCGATTTA ACTTTCAAAAATATTTTATATAACGAAAAAAATAATCAATTAAAAATCATTGATGCAGGAGAGATGACAG TAGCAGATGAACGCCTTTTAGCACAGGATATTTTAATCGCCAGGGACATGGTATCTCTCTTATTTACAAC GGATGAAGCAAATCAATTTAAAGCATCAAGCTATTGGTCTGATGAACCTACAGTCAGGCGAATAGTTAAC CCCAACCCAGTAGAAGCAAAGTTAAATAGAATTTTGAACAGTAAGTACAGTTGTATTTCAGAGTTCAAGT CGGCCATTGAATGGAATTACAATGAATATCTAAGTCAATTGAATCCTCTATTGCAAAGAAATGAGCTTTC AAAAGTGGAAAGAGAAGCTTCGAATTTACAGGCTTACAAGGATCAAATGGATAAACAACAACTCCTGGGA GAAATTCAGGGGTGTAAAAAACCTTATTGGGCTATGAAAGGCAGTTTGCTTTATGCGGATCAATATCGTC TAAAAGTATTTTTTGATTACTTGGATATAATTGGTTCCGCATTTAAAAATGATAAAATCAATGAAAAGTC GGCCAGAGCGGCCTATGATTTTCTAACAGCACAAATCAATAAATTGTTTGAGGATCATGAGAAAAACTCA CAATTAAGCTTCAAAAGTTTTTCAGAAGATGTGCAGCAATTCTTAAATCATGTGAATACCTTTTTAATAA AACATCCGCTTGCCTCCTCTAATTCGATAGCTTCCATCATTCGGCTATTGAAACAGTTGGATAATCAAGC GAGTTTTGAGCCGGAACAATCGCTTAAGACTTTCTCTTCGTATAAAGAAGTTATGATTCAAAAATTATTA GAACCATTTGAAACACTAGTGGATGAAATGACTAGTGCACCTGCTACAGTATCTGATTTCATTGAAAAAC AATCTGACACCAAAAGAAGACTTCAGGAAATGAAATTTTCTGCAAATCAAGATAAGCAACCTATATTTAC ACCTTCATTGATGCGAGGCCCAAGCTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Hervet E; Charpentier X; Vianney A; Lazzaroni JC; Gilbert C; Atlan D; Doublet P (2011). Protein kinase LegK2 is a type IV secretion system effector involved in endoplasmic reticulum recruitment and intracellular replication of Legionella pneumophila. Infect Immun. 79(5):1936-50. [PudMed:21321072] 
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| experimental literature |
| in silico analysis literature |