| Effector Protein ID: 54294476 |
 T4SS name [ID] | Dot/Icm [41] |
| Gene symbol | - |
| Locus tag | lpl1545 |
| Strain | Legionella pneumophila str. Lens |
| Replicon | chromosome [GenBank: NC_006369] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1720236..1721825 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LegK1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | The canonical serine/threonine kinase activity of LegK1 is essential for potent activation of the NF-kB pathway. LegK1 mimics host IKK and directly phosphorylates the Ser32 and Ser36 residues of the inhibitory IkBa protein, leading to IkBa ubiquitination/degradation and subsequent nuclear translocation of p65. (Ge and Shao, 2011) |
| UniProt ID | Q5WWA8 |
| KEGG ID | lpf:lpl1545 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pkinase [PF00069], Evalue: 5.9e-27, Aligned region: 86..362 Pkinase_Tyr [PF07714], Evalue: 5.8e-14, Aligned region: 86..290 |
| Protein Sequence: 529 a.a. [Download] |
| >gi|54294476|ref|YP_126891.1| hypothetical protein lpl1545 [Legionella pneumophila str. Lens] MPRTMFFSVDAANLQNLQITNQKAFAALESYLNDNDSPGAWNNNQGYKYTHKDVTYCFSFNQSLVRRPRK SDQKKHTFEIFDPNKNPLGKGAYGIVYPILGTIQFEFGNAIKRPPKNKLVKIQNHSERDQSHSVLREYQG LLQSGHIAVKPPIFVENNESKFSYLIMEKAEGIVLERFLNPIKRLNLSEEVPELNLINRIEITFAILKAI KEQVTDKHLIHRDIKPGNIIIDFSKSPPIAKVIDFGFVLRASEQDYRRCGTRAYRAPESFNTQALYTAKA DVWSTGRILSYLWGDKYTNYYISRDKGLDYVIEKSRNELLFSDPELELYLTKEDKSKIRSCLSTMLILDP EERGSIDKAIKQFSQIDFEKYKRLKRSTNFEIDLTDDDIKLRKQLNSIHLHLITLQSKEKDLRNRACFDA ANAMSQLVAKLTTYTNYLEKNPDPFLIKRYKECCIVEMDLANLTLQNHRDALWLVAELSTAILLLGVGYL FAFGINYYYTGRLGLFSQTRSEKLVEEMKSSVLGIAVGN |
| - |
| Nucleotide Sequence: 1590 bp [Download] |
| >gi|54292964|ref|NC_006369.1|:c1721825-1720236 Legionella pneumophila str. Lens, complete genome ATGCCTCGTACAATGTTTTTTTCCGTTGATGCCGCTAATCTCCAAAATTTACAAATTACAAATCAAAAAG CTTTTGCAGCGTTGGAGAGTTATCTGAATGATAATGATTCACCAGGTGCTTGGAATAATAATCAAGGATA CAAATATACTCATAAGGATGTTACTTATTGCTTCTCATTTAATCAATCCTTAGTGAGACGCCCAAGAAAA TCGGATCAAAAAAAACATACATTTGAAATTTTTGACCCTAATAAGAACCCTTTAGGCAAGGGAGCGTACG GTATTGTGTATCCTATTTTAGGTACAATTCAGTTTGAATTTGGAAATGCAATTAAAAGACCACCAAAGAA TAAATTAGTTAAAATACAAAACCATAGTGAACGCGATCAAAGTCATTCTGTACTACGTGAATATCAAGGG CTTCTTCAATCAGGGCATATAGCGGTTAAACCGCCAATATTTGTAGAAAACAATGAGAGTAAATTCAGTT ACTTGATTATGGAAAAAGCAGAGGGTATCGTTTTAGAGAGGTTTCTAAATCCCATTAAGCGGCTTAATTT GTCTGAAGAGGTACCTGAGCTTAATCTTATTAATCGGATTGAGATTACTTTTGCCATTTTAAAAGCAATT AAAGAGCAGGTGACGGATAAGCATTTGATTCATCGAGATATAAAACCAGGAAATATTATAATCGATTTTA GCAAGTCGCCTCCGATAGCTAAAGTAATCGATTTTGGTTTTGTGCTTAGAGCGTCAGAACAGGATTATCG TCGTTGTGGAACCCGAGCATACAGAGCGCCTGAATCCTTCAATACCCAGGCATTGTACACAGCAAAAGCT GATGTTTGGTCAACAGGCAGGATATTAAGTTATTTGTGGGGAGATAAATATACTAATTATTATATCTCTC GTGATAAGGGTTTGGACTACGTGATTGAGAAATCAAGAAACGAATTACTCTTCTCTGACCCAGAATTGGA ACTCTACTTAACCAAGGAAGATAAAAGTAAAATCAGGTCGTGCCTAAGCACAATGCTTATACTTGACCCT GAGGAAAGAGGATCTATTGATAAGGCTATCAAGCAGTTTTCCCAAATTGATTTTGAAAAATATAAAAGAT TAAAGCGCTCTACAAATTTTGAAATTGATTTAACAGATGATGATATTAAATTAAGAAAACAGCTCAATTC AATTCACCTGCATTTGATTACCCTACAGAGCAAAGAAAAGGATTTGCGTAATAGAGCATGCTTTGATGCA GCAAATGCAATGAGTCAATTGGTTGCCAAGCTCACTACCTACACCAATTATCTTGAAAAAAATCCAGATC CATTTTTAATAAAACGTTATAAAGAATGCTGTATCGTAGAAATGGATTTGGCTAATTTGACTTTGCAAAA TCACCGAGATGCCTTATGGTTAGTGGCTGAGTTATCAACTGCTATCCTTTTGCTTGGTGTAGGGTATTTA TTTGCGTTTGGTATAAATTATTACTACACAGGTCGCCTGGGATTATTTTCTCAAACCAGGTCTGAAAAAT TGGTGGAGGAAATGAAAAGCTCGGTATTAGGTATTGCGGTTGGAAATTAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Hervet E; Charpentier X; Vianney A; Lazzaroni JC; Gilbert C; Atlan D; Doublet P (2011). Protein kinase LegK2 is a type IV secretion system effector involved in endoplasmic reticulum recruitment and intracellular replication of Legionella pneumophila. Infect Immun. 79(5):1936-50. [PudMed:21321072] 
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| experimental literature |
| in silico analysis literature |