| Effector Protein ID: 54293940 |
 T4SS name [ID] | Dot/Icm [41] |
| Gene symbol | - |
| Locus tag | lpl0997 |
| Strain | Legionella pneumophila str. Lens |
| Replicon | chromosome [GenBank: NC_006369] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1128576..1130270 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | SidK |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SidK interacts with VatA, a key component of the proton pump, leading to the inhibition of ATP hydrolysis and proton translocation. When delivered into macrophages, SidK inhibits vacuole acidification and bacterial killing. (Xu et al., 2010) |
| UniProt ID | Q5WXU4 |
| KEGG ID | lpf:lpl0997 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 564 a.a. [Download] |
| >gi|54293940|ref|YP_126355.1| hypothetical protein lpl0997 [Legionella pneumophila str. Lens] MGGLTSEQYHSQVVGKIGYIARCMQTIDPENNLKKIREDYQDVLIWAEKNYRFEEILEASKSGKCPNDLD ALSRRSLILQELLRLVSSISPFKMKLDLIESQYEKMKQHVNLWKSDYHVKLNQLNQLTDYLKNAAPTPKN HFLRAMTSALQMQIAQTGITEDNEGINQLFKLGLHLLAMANEKINEQYDLFKGYVKDQPEESPFEGILPA EDQKILVKAMIDYAMPKLSSKVLQDKLSALSSSDVLTKTLLDSIDRTVEENEKLNALSKVKLGKFGLDIR EVEEIYSQALKISPQDALQYTAQQCDAQLLSMAFPDSQNYIVESISDKKAKAIAELIHSKEFIYQIIKTE VFKQVDPNEKIRLQASTELYQLLGRIMDKQIHLFAKMNLEQINEYIQTKTKAILDKIPERVELLTFMGFE IPTFKGIETLMTDISHSQDNETLAIAQEFYANIKNAKKQLLGDKLIEDITPQDVEKFFNQCSQYGSEAAE KLADNRPVLTKIADILTAIARWAISLIGFNTPPQFLAPTRTCVDQVSDEITKIKLKLEDTLGSLQKVHEE NLSL |
| - |
| Nucleotide Sequence: 1695 bp [Download] |
| >gi|54292964|ref|NC_006369.1|:c1130270-1128576 Legionella pneumophila str. Lens, complete genome ATGGGTGGCTTAACTAGCGAGCAATATCACAGTCAAGTAGTCGGTAAAATCGGATATATCGCCAGATGCA TGCAAACTATAGATCCTGAAAATAATTTGAAAAAAATAAGAGAGGATTACCAAGATGTATTGATATGGGC AGAGAAAAATTATCGTTTTGAGGAGATATTGGAAGCCAGCAAATCTGGAAAATGCCCTAATGATCTGGAT GCATTAAGTCGACGATCGCTAATACTCCAAGAATTGCTGCGGCTTGTTTCATCAATTAGTCCATTTAAAA TGAAATTAGACCTGATTGAGTCTCAATATGAAAAAATGAAGCAGCATGTGAATTTATGGAAAAGTGATTA CCATGTAAAACTAAATCAACTGAATCAATTAACAGATTACCTCAAAAATGCAGCACCAACTCCTAAAAAT CATTTTCTAAGAGCAATGACTTCTGCATTGCAAATGCAGATAGCCCAAACTGGGATTACAGAAGATAATG AAGGCATCAACCAGTTGTTTAAACTGGGATTGCATTTGCTCGCAATGGCTAACGAAAAAATAAATGAGCA ATATGACCTGTTTAAAGGGTATGTAAAAGATCAGCCTGAAGAATCTCCTTTTGAAGGCATTTTGCCTGCG GAAGACCAGAAAATTTTAGTTAAAGCTATGATAGATTATGCCATGCCGAAACTTTCAAGCAAGGTTTTAC AAGATAAATTATCGGCACTATCCAGTTCCGATGTATTAACAAAAACATTACTTGATAGCATCGACAGAAC TGTTGAGGAAAACGAAAAATTAAATGCTTTAAGCAAAGTCAAATTAGGTAAATTTGGCCTGGATATCAGG GAAGTTGAAGAGATTTACTCTCAAGCTCTGAAAATATCACCACAAGATGCTTTGCAATATACCGCTCAAC AATGTGATGCCCAATTATTAAGCATGGCATTTCCTGATTCCCAAAATTACATTGTTGAATCTATATCGGA CAAAAAGGCCAAGGCCATTGCAGAGCTAATACATAGTAAAGAATTTATTTATCAAATTATTAAGACAGAA GTTTTTAAACAAGTTGATCCTAATGAGAAAATTCGACTACAAGCTTCGACAGAATTGTATCAGCTTCTTG GGAGAATAATGGATAAACAGATCCATCTTTTTGCCAAGATGAATCTCGAACAAATTAATGAATATATTCA AACCAAAACCAAAGCAATCCTGGATAAAATTCCTGAAAGAGTTGAGTTATTAACTTTTATGGGCTTTGAA ATTCCAACTTTCAAGGGAATTGAGACACTTATGACCGATATCTCCCATTCTCAGGATAATGAAACTCTGG CGATAGCCCAAGAATTTTATGCAAATATAAAAAATGCAAAGAAACAATTGCTGGGTGATAAACTGATTGA AGACATTACTCCACAGGATGTAGAGAAATTTTTTAATCAATGTAGTCAATACGGTTCAGAAGCAGCTGAA AAGTTAGCTGACAATCGTCCGGTATTGACAAAAATAGCCGATATTTTGACAGCAATTGCCCGCTGGGCGA TTAGTTTAATAGGTTTCAACACGCCACCGCAGTTTTTGGCTCCAACCAGAACCTGTGTGGATCAGGTATC TGATGAAATCACTAAAATTAAACTCAAACTTGAAGATACTTTGGGAAGCTTGCAAAAAGTACATGAAGAG AACTTAAGCCTTTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |