| Effector Protein ID: 54293370 |
 T4SS name [ID] | Dot/Icm [41] |
| Gene symbol | sdhA |
| Locus tag | lpl0419 |
| Strain | Legionella pneumophila str. Lens |
| Replicon | chromosome [GenBank: NC_006369] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 463771..468060 [-] |
| Product | SdhA, substrate of the Dot/Icm system |
| Effector type | Protein |
| Descripton | SdhA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SdhA is critical for intracellular growth and functions to prevent host cell death. SdhA also functions to inhibit Legionella infection-induced type I interferon response. Besides, SdhA prevente bacterial DNA release and AIM2 inflammasome activation. |
| UniProt ID | Q5WZG3 |
| KEGG ID | lpf:lpl0419 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | FlaC_arch [PF05377], Evalue: 8.8e-05, Aligned region: 1037..1072 |
| Protein Sequence: 1429 a.a. [Download] |
| >gi|54293370|ref|YP_125785.1| SdhA, substrate of the Dot/Icm system [Legionella pneumophila str. Lens] MISEKIKLLESFKQNQFSKLIEKINSKILVTLKSGHFNPRLAPYLEKMNKDGVPFTDFDLDPENISQIKK LINALYHARLAFLDLENIDIRNYKRTLPDLKLLYSNTIHQAYQAGYLITNLDVDLQEMFKEEIDLILPVI GQLQAFAGEHQECTKRLAESWKDFPISYKAGEVTGIALEQMQPRTGDWDYQFLTQFSAVLPGYIEKLTQY IQQYSSQIKEKEPTLNNEKLEELQNASLKLLNDLEHLKGNDFFISLKVLKYIHIIRNIITLATSSVEQMG HFSDSSQDVIRDNLAQLKYVVLPTLFGLVDKIEDNAMLKPGTLSIPLMEKIKPLYQLLIYYASKPVNFKE KGEELLSIEDSRFLALRLERTYQRIDEANKALFKIQKAQEALDNFYKILDTPPYNKQPIHQLPKEIKNQL ITYYKIISPYMMDVDPDLNILLIDSFQGPESWSSYVKKPWRWLRGTLPADHASFVLAQKEALQTLISKKK ATQQFHIELNRDLIESVHKQTNLVLFPYNEKTNVFLLDETKALNPANGATDKLKFRPEKGHNILVNPEDL TSEQALDLYQWYRNKREKFRVASKAYNEFITLLKKQTKTIAETEGRILHLNNLDKETKTRCRNLYNIFQP YFIDGIPPELRASAISFDKFLVHSFSNESSTYDAPAVDLFEKLDEHFQIYFTEIDLQWSKKSNQYLKWAQ EKFASENNSTELEHDEKLESRAHHLIKHTNFSKCIYEFRTELNQVISLFNNAMKAQLKQQPNGIPYPELQ DKNKELAQSAQVIAIKRIFNSLYHVEKIVVELEKLDTRSYESIYVYHLIQAYDHINEIKKLALKLAVDPH FKLIASELLEKAQTLIATIQEHSDAYQVSPLEVPYNHDIKYNALWYTLNAFYISPKHIRSLRNTNYLTTE ELNDLHLKAKKATVTVENIIKSSNSYFKLFLQTPAMYSLYREMTNKLNEFISTSHDAVMNNLDQFRSKIF TPMLMEADAWEDKLGLVPGTISGPLKTITDEYYKGLLHPLALHSKAHIRMICDKSPIDQRIKTTHKKLEN ATQHLDKIEKNYKHIIKLYEIIKTKGGKTTDDELIETYKKALYKLVKLQKRLPENTDPDPEDYELDTLLN SELKEYEPKLTLIKPLIIASYHHYEGLKATYLMKANTAREKLSYLKELRSTQEQEDLLYIEEYTTESFNK QLDAFCNRHIGLQYTDKEYRTKLREYLLTFKESIIQRSKSAEDINLTIKNLLKEKIKNFERDNFEKYYHL DAVRVALAQFKNYFSLSTAAIEQNNSTFESEETLAKKTELINKLVDISEDGTLTPKERVDQISFHVKNPN FERIIMDYKQESYFSFTYLKQCILSLLEALCLYTPERRKLFNNLESSVKTQPKINELTKRFGLFAGNESA ISTESRAITPVSSVENNGTIELNQLAPSA |
| - |
| Nucleotide Sequence: 4290 bp [Download] |
| >gi|54292964|ref|NC_006369.1|:c468060-463771 Legionella pneumophila str. Lens, complete genome ATGATTTCAGAAAAGATCAAGCTTTTAGAATCCTTTAAGCAAAACCAATTCTCTAAATTAATTGAAAAAA TTAATTCAAAAATCCTTGTGACTTTAAAAAGTGGACATTTCAACCCCAGACTAGCCCCCTACTTGGAAAA AATGAATAAAGACGGGGTTCCATTCACCGATTTTGATCTTGACCCGGAAAATATTTCTCAAATCAAAAAA CTTATTAACGCCCTTTACCATGCCCGTTTAGCTTTTCTGGATTTAGAGAATATTGATATACGCAACTACA AACGAACACTCCCTGACCTCAAATTACTTTATAGCAATACGATTCACCAGGCCTATCAAGCCGGTTATCT AATCACTAACCTCGATGTTGATTTGCAGGAAATGTTCAAGGAAGAGATTGATCTTATTCTCCCTGTCATT GGACAACTACAAGCCTTTGCTGGTGAACACCAGGAATGCACCAAGCGTTTGGCAGAGTCTTGGAAGGATT TTCCTATAAGCTATAAAGCAGGAGAAGTTACAGGCATTGCCTTAGAGCAAATGCAACCGAGAACAGGAGA TTGGGATTACCAATTCCTCACTCAATTCAGTGCCGTATTACCTGGTTATATAGAAAAATTAACTCAATAC ATTCAACAATACTCTTCGCAAATCAAAGAAAAAGAGCCTACCCTAAATAATGAAAAGCTGGAAGAGTTAC AAAACGCATCATTAAAATTACTAAATGACCTTGAACATCTGAAAGGGAATGACTTTTTTATATCCCTTAA AGTTTTAAAATACATTCACATTATCCGTAATATCATCACATTGGCGACAAGCTCTGTTGAGCAAATGGGA CATTTCAGTGATTCATCCCAAGACGTCATTCGTGATAATTTGGCTCAATTAAAATACGTTGTATTACCTA CGTTATTTGGGTTAGTGGATAAAATTGAAGACAATGCCATGCTGAAGCCTGGTACACTGTCTATTCCGTT AATGGAAAAAATCAAACCTCTATACCAACTTTTAATTTATTACGCATCAAAACCCGTCAATTTCAAAGAA AAAGGAGAAGAGTTACTCAGTATAGAGGACTCCCGTTTTCTCGCTTTAAGACTGGAAAGAACATATCAAC GAATTGATGAAGCTAATAAAGCCCTTTTTAAAATTCAAAAAGCGCAAGAAGCTCTGGACAATTTTTACAA AATACTGGACACCCCCCCCTATAATAAGCAACCCATACATCAATTACCGAAAGAAATTAAAAATCAACTG ATTACATATTACAAAATAATCAGTCCTTATATGATGGATGTGGATCCTGATCTCAATATTTTGTTGATCG ATAGTTTTCAAGGCCCGGAATCCTGGTCTTCTTATGTAAAGAAGCCGTGGCGTTGGTTAAGAGGCACTCT TCCTGCCGATCACGCCAGTTTTGTTTTAGCGCAAAAGGAAGCATTACAAACTTTAATTAGCAAAAAGAAA GCCACTCAACAATTTCATATCGAATTGAATAGAGACCTTATCGAATCTGTTCACAAACAAACAAATCTGG TTTTATTCCCTTATAATGAAAAAACGAATGTCTTTCTTCTGGATGAGACAAAAGCACTAAACCCTGCTAA TGGCGCTACGGACAAACTAAAATTCAGACCAGAGAAAGGACATAATATACTGGTTAATCCTGAGGATTTA ACATCTGAACAGGCTCTTGACCTCTATCAATGGTATAGAAACAAACGTGAAAAATTCAGAGTTGCCAGCA AAGCATATAACGAATTTATTACCTTATTAAAAAAGCAAACCAAGACAATCGCTGAAACGGAAGGCAGGAT TCTCCATTTAAATAATCTTGATAAAGAGACCAAAACTCGCTGCCGTAATTTATATAATATATTTCAACCT TATTTTATCGATGGGATACCTCCTGAACTCAGAGCTTCCGCAATAAGTTTTGACAAATTTTTGGTCCATT CCTTTTCTAATGAGTCATCCACCTATGATGCTCCGGCAGTTGACCTGTTTGAAAAACTGGATGAACATTT TCAAATTTATTTTACAGAAATTGATTTACAATGGAGTAAAAAGAGTAATCAATATTTAAAATGGGCCCAG GAAAAATTTGCCAGTGAAAATAACTCAACCGAACTTGAACATGATGAAAAACTGGAAAGCAGAGCCCATC ATTTAATTAAACATACCAATTTCTCTAAATGCATATATGAGTTCAGAACGGAGCTTAATCAAGTCATTTC ATTATTTAATAATGCAATGAAAGCCCAACTTAAGCAGCAACCCAACGGAATTCCTTACCCTGAATTGCAA GATAAAAATAAAGAGCTTGCCCAGAGCGCACAGGTTATCGCAATAAAACGCATATTCAACAGCCTTTATC ATGTTGAAAAAATTGTTGTTGAACTGGAAAAGCTGGATACCAGAAGTTACGAAAGCATCTATGTTTATCA TTTAATACAAGCCTATGATCACATTAATGAAATTAAGAAGCTAGCGCTAAAACTTGCTGTGGATCCTCAT TTTAAGCTCATAGCAAGCGAGTTACTGGAAAAAGCGCAAACGCTTATTGCAACAATACAAGAACACAGTG ATGCCTATCAGGTATCCCCCTTAGAAGTACCTTATAACCATGATATTAAGTACAATGCCCTTTGGTACAC ACTCAATGCTTTTTATATTTCACCAAAACACATTAGAAGCTTAAGAAATACCAACTATCTCACGACAGAA GAACTCAACGACTTACACTTAAAGGCAAAGAAAGCAACTGTTACTGTAGAAAATATTATTAAGAGTTCAA ACTCCTATTTCAAATTATTCTTACAAACGCCTGCCATGTATTCTCTCTATAGAGAAATGACTAATAAACT GAATGAATTTATTAGCACATCACATGACGCAGTAATGAATAATCTGGATCAATTCCGCTCCAAGATTTTC ACCCCCATGCTGATGGAAGCGGACGCATGGGAAGATAAATTAGGATTGGTACCAGGCACTATCTCAGGAC CATTAAAAACAATAACGGATGAATATTATAAAGGCCTGTTACATCCTTTAGCGCTGCATTCCAAAGCCCA TATTCGAATGATATGTGATAAATCACCAATAGATCAAAGAATAAAAACAACACATAAAAAACTCGAAAAT GCAACACAACATTTGGATAAAATAGAAAAAAACTATAAACATATCATTAAGTTATATGAAATTATTAAAA CAAAAGGCGGCAAAACCACTGATGATGAATTAATCGAAACTTATAAAAAAGCTCTGTACAAATTGGTAAA ACTACAGAAGCGATTACCAGAGAATACAGATCCTGATCCTGAAGATTATGAATTAGACACTCTTTTAAAT TCAGAACTGAAAGAGTATGAACCTAAATTAACGCTCATAAAGCCTCTCATTATCGCAAGCTACCATCATT ATGAAGGCTTAAAAGCCACTTATCTTATGAAAGCAAATACTGCCAGAGAAAAGTTGAGCTATCTTAAAGA GTTACGATCGACTCAGGAACAAGAAGATCTCCTTTATATAGAAGAATACACTACAGAATCATTTAATAAA CAATTAGATGCTTTCTGCAACCGCCATATAGGTTTACAATACACTGACAAGGAATATCGCACAAAACTTA GAGAATATTTACTGACTTTTAAAGAAAGTATTATTCAACGCTCAAAATCCGCAGAAGATATTAATTTAAC TATAAAAAATTTGCTAAAGGAAAAAATTAAAAATTTTGAAAGAGATAATTTTGAGAAATATTATCATCTT GATGCAGTAAGAGTCGCTTTAGCTCAATTTAAAAACTACTTTAGTCTTTCTACCGCTGCCATCGAGCAAA ATAATTCGACATTTGAAAGCGAAGAGACACTGGCGAAAAAGACAGAGCTCATTAATAAACTGGTTGATAT CAGTGAAGATGGAACCCTTACGCCAAAAGAGCGTGTAGACCAAATATCTTTCCATGTTAAAAATCCTAAT TTTGAAAGAATCATCATGGATTACAAACAGGAAAGCTATTTTAGCTTTACCTATTTAAAACAATGCATCT TATCCTTATTGGAAGCGCTTTGCCTGTACACTCCGGAGAGAAGAAAACTATTTAATAATTTGGAAAGCTC TGTAAAAACCCAGCCTAAAATCAATGAATTGACCAAACGATTTGGATTATTTGCTGGCAATGAGTCAGCT ATCTCTACTGAATCCAGGGCAATTACCCCAGTTTCTTCTGTTGAAAATAATGGAACAATTGAGTTAAACC AATTAGCGCCATCAGCATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
|
| in silico analysis literature |