| Effector Protein ID: 54293279 |
 T4SS name [ID] | Dot/Icm [41] |
| Gene symbol | sdbA |
| Locus tag | lpl0327 |
| Strain | Legionella pneumophila str. Lens |
| Replicon | chromosome [GenBank: NC_006369] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 372667..376020 [+] |
| Product | SdbA protein, substrate of the Dot/Icm system |
| Effector type | Protein |
| Descripton | SdbA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SdbA has been proved to contribute to sustained NF-kappaB activation in A549 epithelial cells, and are essential for L. pneumophila replication (Bartfeld, et al, 2009) |
| UniProt ID | Q5WZQ4 |
| KEGG ID | lpf:lpl0327 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1117 a.a. [Download] |
| >gi|54293279|ref|YP_125694.1| SdbA protein, substrate of the Dot/Icm system [Legionella pneumophila str. Lens] MHKKYNYYSLEKEKKTFWQHILDILKAPFRLPGWVVSFFLARNITHVALNPNNIPQQRLIHLTKTSNSPE DDIVVINFKKRPPHKWFNDTLIKIANTIAALPFVTPRLRIRLHYDNENDINHVNKLLAEIDALVQGKSKQ KYCKGRAFDWSKIHLKGLEFLDPKMRGYVYEQLHEKYGYVSYTTKRKPNIEFFTLKTPDGSELDSVQVTG EDEEKKPMGERKFIITCIARDQNFINWIKDLNYTAKNLGATAISFNYRGVDYSRGLVWTENNLVDDILAQ VQRLISLGADPKNICLDGMCIGGAVATIAAAKLHEKGMKVKLNNERSFTSLSSLVFGFIVPELQTANWWS PLTYGRFLLAGVVYALLTPLIWLAGWPVDVTKAWNRIPAQDKMYSVVRDKDNGLYDGVIHDHFCSIASLV DSQINSILYKLSTDQPLTEEEKQILCDDQFSHHFKPSQSVLKNPKYKGPHFISRQDLVAELGHREEYTNH DYFLDRLREKFQLDRATRPVALAEDGEKDIDGIPSQLSNHKERPLIIASSGGTGHISATHGIINDLQSKT DNVVITQHHAELYKNKPFSITSVLIRIGVWFTSLPILEDILKGVMRFIGYPVLPSSSIFWDQMSKIQQSE TKKENGIETGRTRPYVDMLLDIYPEGYEYTAFNNATHLTSSIEDIQTMISFKGHVEEDNRNIVYQNILQR LMHAAKQNTPYTRLISTQALSLGAICDAVKYYNTVFLPVYNAERGTSYQPIAIDQYMTDLPSLGCIHFMN NLEELTSEQRQLMEIHAVNMSEPFKEAHFGKEQGFKAVHNIDPRNNPMIRNAFKDPSLTKYLDKTQAFDL HFNVYKKEKQSALPVLNGKEKITIKPHAKIASIMIGSLAANASADYAKYLLNQGYEHIFLFGGLNDSIAA RIDQIINSYPASRRDEISKKIILLGNQSDVEMAPIMTRSNCVVIRGGGLSVMEQMAMPIMDDKIVLLHHE DNEEGPLTSGLSWEDGNADKLIEYLSEKGAYAKKTSPGLCSGHLHEAEKDFEKKYITQLKSTGTKGKVDL TIPQQKKRPLKKEWDRKTGYTESGHILSHQHRFFNTIPEGREPLGSKEEIHHHEQLSSQSLVSVTAG |
| - |
| Nucleotide Sequence: 3354 bp [Download] |
| >gi|54292964|ref|NC_006369.1|:372667-376020 Legionella pneumophila str. Lens, complete genome ATGCATAAAAAATACAACTACTACAGTCTTGAAAAAGAAAAAAAAACATTCTGGCAACATATACTGGATA TTCTGAAGGCCCCATTTAGGCTACCTGGTTGGGTCGTTTCTTTTTTCTTGGCACGAAATATTACTCATGT GGCATTAAATCCTAATAATATTCCGCAACAACGTTTAATACATCTTACTAAAACAAGCAATAGTCCAGAG GATGATATTGTTGTCATTAATTTCAAAAAACGGCCTCCTCACAAATGGTTTAATGACACGCTGATTAAAA TAGCCAATACCATTGCGGCTCTCCCTTTTGTAACACCAAGATTACGTATAAGATTACATTACGATAATGA GAATGATATTAATCATGTGAACAAGTTGCTTGCCGAGATCGATGCGCTTGTTCAGGGCAAATCAAAACAA AAGTATTGCAAAGGCAGGGCATTCGACTGGTCAAAAATTCATCTGAAGGGATTGGAATTCCTGGATCCTA AAATGAGAGGCTATGTTTATGAACAACTGCATGAAAAATATGGTTATGTCTCATATACAACAAAACGCAA ACCTAATATTGAATTTTTCACCTTAAAAACTCCTGATGGATCTGAATTGGATTCAGTGCAAGTTACAGGT GAAGACGAAGAAAAAAAACCAATGGGGGAGCGCAAGTTTATTATTACCTGTATTGCGCGGGATCAAAATT TCATCAATTGGATAAAGGATTTAAACTATACGGCAAAAAATCTGGGCGCCACAGCCATCAGCTTCAACTA CAGAGGCGTGGATTACAGTCGCGGTCTTGTCTGGACAGAAAATAATCTTGTTGACGATATTCTGGCTCAG GTGCAAAGGCTAATTAGCCTTGGTGCCGACCCTAAGAACATCTGCCTTGATGGTATGTGTATAGGTGGGG CGGTAGCAACAATTGCTGCAGCAAAACTTCATGAGAAGGGCATGAAAGTCAAGTTGAATAATGAACGCTC TTTTACTTCTCTTTCTTCTCTGGTATTTGGTTTTATTGTACCTGAATTACAAACAGCAAATTGGTGGAGC CCTTTGACTTATGGCCGCTTCCTACTGGCTGGTGTAGTTTATGCTTTACTCACGCCTTTAATTTGGCTGG CAGGATGGCCAGTTGATGTGACCAAAGCCTGGAATAGAATACCTGCTCAGGATAAAATGTATTCTGTTGT GCGGGATAAAGACAATGGTTTGTACGATGGAGTAATTCACGATCACTTCTGTTCCATTGCGTCGTTGGTT GATTCTCAAATTAATTCTATTTTATATAAATTATCCACTGATCAGCCGCTTACTGAGGAAGAAAAACAAA TTTTGTGTGATGATCAGTTTTCTCACCATTTTAAACCAAGTCAAAGTGTTTTAAAAAATCCAAAATACAA AGGCCCGCATTTTATTTCCCGACAAGATTTGGTAGCTGAGCTTGGTCATCGAGAAGAATATACCAATCAT GATTATTTCCTTGACCGCTTGCGGGAAAAATTTCAATTGGATCGCGCAACACGGCCAGTGGCTTTGGCTG AAGATGGGGAAAAGGATATAGATGGGATTCCATCGCAACTATCTAATCATAAAGAGCGTCCCTTAATTAT TGCCAGCAGTGGAGGAACAGGGCATATCTCTGCCACGCATGGCATCATTAATGATTTACAGAGTAAAACA GATAATGTTGTCATTACGCAGCATCATGCGGAACTCTACAAAAACAAGCCCTTCTCAATTACATCTGTTC TGATTCGTATTGGTGTTTGGTTTACCTCTCTTCCTATCCTGGAAGACATACTGAAAGGAGTTATGAGGTT TATCGGATATCCCGTTTTACCGAGCTCCTCCATCTTTTGGGATCAAATGTCTAAAATACAGCAGAGTGAA ACTAAAAAAGAGAATGGAATTGAAACAGGCAGAACCCGTCCTTATGTGGACATGCTGTTGGATATATACC CGGAGGGATATGAATACACGGCATTCAATAACGCGACTCACTTGACTTCCAGTATTGAAGACATTCAAAC GATGATAAGCTTCAAGGGGCATGTTGAAGAGGATAACAGGAATATAGTCTATCAAAATATATTACAACGC CTTATGCATGCGGCGAAACAGAATACTCCTTACACAAGATTAATTTCCACACAGGCACTTTCTTTGGGAG CTATTTGCGATGCCGTTAAATACTACAATACGGTATTTCTGCCTGTATACAATGCTGAAAGAGGAACTTC CTATCAGCCTATTGCTATTGATCAGTATATGACCGATTTGCCTTCACTGGGCTGTATTCATTTTATGAAT AATTTGGAGGAACTCACATCAGAGCAAAGACAATTGATGGAGATACATGCAGTAAATATGAGTGAACCAT TTAAAGAGGCGCATTTTGGCAAAGAACAAGGCTTTAAAGCGGTTCATAATATTGACCCACGCAATAACCC AATGATTCGCAATGCCTTTAAAGACCCCTCATTGACAAAATACCTGGATAAGACCCAGGCATTTGATTTG CACTTTAATGTTTATAAAAAGGAAAAGCAAAGTGCACTGCCAGTGTTAAATGGTAAAGAAAAAATTACAA TCAAACCGCATGCTAAAATTGCTTCCATCATGATAGGCTCTCTGGCGGCAAATGCTTCAGCTGATTATGC GAAGTATTTATTGAATCAGGGGTATGAGCATATTTTTCTTTTCGGCGGGCTTAATGATTCCATTGCAGCA CGTATCGATCAAATCATCAATTCTTATCCTGCCTCCAGGCGTGATGAGATAAGTAAAAAAATTATTCTCC TGGGGAATCAATCTGACGTTGAAATGGCACCGATAATGACGCGTAGTAACTGTGTGGTTATCCGTGGGGG TGGTTTAAGTGTCATGGAACAAATGGCCATGCCCATTATGGATGATAAAATTGTATTATTACATCATGAA GATAATGAAGAGGGTCCTTTAACATCTGGTCTCAGTTGGGAAGATGGGAATGCTGATAAATTAATTGAGT ACCTGTCCGAAAAAGGGGCATATGCTAAAAAAACTTCACCTGGCTTGTGTTCCGGTCATCTCCATGAGGC AGAAAAGGATTTTGAAAAGAAATATATTACCCAGCTGAAGTCGACAGGAACCAAGGGAAAAGTAGATTTA ACCATTCCTCAGCAAAAGAAGCGTCCCCTGAAAAAAGAATGGGATAGGAAAACGGGATATACTGAATCCG GACATATATTATCCCATCAGCATAGATTTTTTAACACGATACCTGAAGGAAGAGAGCCACTTGGCTCCAA GGAAGAGATACATCACCATGAGCAGCTTTCCAGTCAAAGTTTGGTTAGTGTAACCGCTGGTTGA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
|
| in silico analysis literature |