| Effector Protein ID: 52843057 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legC8 |
| Locus tag | lpg2862 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 3237892..3239802 [-] |
| Product | coiled-coil containing protein |
| Effector type | Protein |
| Descripton | Lgt2/legC8 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Lgt2 is necessary for egress of Legionella from the host cell. (Belyi, et al. 2011) |
| UniProt ID | Q5ZRL9 |
| KEGG ID | lpn:lpg2862 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 636 a.a. [Download] |
| >gi|52843057|ref|YP_096856.1| coiled-coil containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MSEQYWRFKLMTEGGCNQNEATRLITVLKRKLKPFPEESINKLFENDNFCNRLSSYMAYGFGAAEEWIKK QQILSNIQPLTSEQRVDITPEKDTVSDNKPNIFGAAITFGKSPVVKLLKQNAREICESILMDEPNLKQVE YIFRLLALQVQETYSGEQAEKLYECIRDKKPIPSKFEEILLPIVNRIKENHTEILNESKRNHLGVTIQLN DPYSFSTKNSFCIWFSNNPNSAMPKKIKDILEERAKQNAPGVTKLVYSRACLTKKENTNFVQWAKENGIT LLDFDELKCQGEDLELWNLAQAELKAMREGKGGNPAAASDLVRWISGVIGDVPIAYVDADMPMLTGNKSI KSEEVYAGHPVLLNMGSALVKDGVNLPMENVAFNTDIINFTGECKDRSIAIKRIAQSLIGNYLHVTERIS KSGNPELKRLGLMPGYHQLLKDCEENNNKLSLPMLRKALTQAHSNLSSYVRFIGVQRFAEMVGAPEDAPL FQEALQQGNTIVLTNALVAYLVHGMDNVSRLNSSEKENLIKKYLGTQLSLLYKPLVMEFSGPCAVTREIL PLLPTGEPTRYIENLKQPDAQILRVLQTHACVAGKTNFTSDNIPNWITSSEEVERTQSLRTDGLSWMPSE QARLSK |
| - |
| Nucleotide Sequence: 1911 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c3239802-3237892 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAGCGAACAATATTGGCGTTTCAAATTGATGACTGAGGGTGGATGTAATCAAAATGAAGCAACCAGAC TTATAACCGTTTTAAAACGTAAGTTGAAGCCATTCCCTGAGGAGTCAATCAATAAATTATTCGAAAACGA TAATTTTTGTAATCGACTTTCCTCTTACATGGCATATGGATTTGGGGCAGCAGAAGAATGGATAAAAAAG CAACAAATATTAAGTAATATCCAACCGTTAACTTCTGAACAAAGAGTTGATATCACACCAGAGAAGGATA CGGTTAGTGATAATAAGCCGAATATCTTTGGCGCTGCAATTACATTTGGAAAATCACCTGTAGTGAAGCT TCTTAAGCAAAATGCCAGAGAAATATGCGAATCAATTTTAATGGATGAACCAAATCTAAAACAGGTCGAA TACATCTTCAGGTTATTGGCACTTCAAGTCCAAGAGACTTATTCAGGTGAGCAAGCTGAAAAGTTATACG AATGTATTCGGGATAAAAAGCCAATACCCTCAAAATTTGAGGAAATATTGCTCCCAATAGTGAATCGTAT TAAAGAGAACCATACAGAAATCCTTAATGAATCTAAAAGGAATCACTTGGGAGTAACTATTCAGTTAAAC GATCCCTATAGTTTTTCAACAAAAAATTCTTTTTGTATTTGGTTTAGTAATAATCCTAACAGTGCCATGC CAAAAAAAATTAAGGATATTTTGGAAGAAAGAGCCAAACAAAATGCACCAGGAGTAACAAAATTAGTTTA TAGCCGAGCTTGTTTGACCAAGAAAGAAAATACTAATTTTGTTCAGTGGGCAAAAGAGAATGGTATTACA TTATTAGATTTTGATGAGTTAAAATGTCAGGGCGAGGATTTAGAATTATGGAATTTGGCACAGGCCGAGT TAAAGGCGATGCGTGAAGGTAAAGGAGGGAATCCTGCTGCTGCCTCTGATCTGGTGCGATGGATATCAGG TGTCATAGGAGATGTTCCCATAGCCTACGTTGATGCCGATATGCCAATGCTTACTGGTAATAAAAGCATT AAGTCTGAAGAGGTTTATGCGGGACATCCTGTGCTATTAAATATGGGATCTGCATTGGTTAAAGATGGGG TTAATTTGCCCATGGAAAATGTTGCATTTAATACGGATATTATCAATTTCACTGGTGAATGTAAGGATAG AAGCATTGCCATTAAACGGATTGCTCAATCGCTGATTGGCAACTACCTCCATGTTACAGAGCGGATTTCT AAGAGTGGTAATCCAGAACTCAAGAGACTTGGCCTGATGCCAGGCTACCATCAGCTTTTGAAAGATTGTG AAGAAAACAACAACAAGTTGTCTCTACCGATGTTACGAAAAGCATTGACACAGGCTCACAGTAATTTGAG TTCTTATGTAAGATTTATTGGCGTACAGCGATTTGCTGAAATGGTTGGTGCGCCAGAGGATGCCCCATTA TTCCAGGAAGCATTACAACAAGGTAATACCATTGTCTTAACAAATGCATTAGTGGCTTATTTAGTTCATG GTATGGATAACGTATCAAGATTAAACTCATCTGAAAAAGAGAATTTAATTAAGAAATATTTGGGCACTCA GCTTTCTTTATTATACAAACCCTTGGTGATGGAGTTCTCTGGGCCCTGTGCAGTAACTCGTGAAATACTA CCGCTATTACCTACTGGTGAACCAACACGTTATATTGAAAACCTCAAACAGCCTGATGCACAAATTTTAC GTGTATTGCAAACGCATGCCTGTGTGGCTGGGAAGACTAATTTTACTTCCGATAATATTCCAAATTGGAT AACTTCCTCAGAAGAAGTTGAGCGTACACAATCCCTGCGAACGGATGGCTTGAGTTGGATGCCTAGTGAG CAAGCACGATTATCAAAATAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Tzivelekidis T; Jank T; Pohl C; Schlosser A; Rospert S; Knudsen CR; Rodnina MV; Belyi Y; Aktories K (2011). Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases. PLoS One. 6(12):e29525. [PudMed:22216304] 
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(3) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| (4) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
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(5) Fontana MF; Banga S; Barry KC; Shen X; Tan Y; Luo ZQ; Vance RE (2011). Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog. 7(2):e1001289. [PudMed:21390206]
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(6) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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| experimental literature |
| in silico analysis literature |