SecReT4
T4SS ID5
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_002942
Location479014..515432; 566512..567138; 3021320..3039999
NameDot/Icm
Functioneffector translocation
ClassificationType IVB; Type I
experimental Experimental investigation has been performed on this T4SS.
structure Information of structure: structureRalF, SidD, SidJ-CaM, SidF, LegAS4, RavZ, DotL(656-783)-IcmS-IcmW, Outer membrane complex, WipB, DotD, IcmS-IcmW-DotL complex, DotM, SidJ-CaM-AMP ternary complex, SdeA, DotF fused to a superfolder GFP, LpiR1, VipD, AnkX, Lem14, LidA (60-594), LidA in complex with active Rab8a, DotL(656-783)-IcmS-IcmW-LvgA, Lgt1, DotN, PI(4)P-Specific Membrane Recruitment of DrrA/SidM, DrrA/SidM, Se-labelled SidJ complex with CaM, IcmR and IcmQ, RidL, LppA, Inner membrane part, LegC3, SidJ-Human calmodulin complex, Rab1b in complex with the GEF domain of DrrA/SidM, Lpg0393, Inner membrane complex, DotL(590-659)-DotN, DotI, SidC

T4SS components
ComponentDotADotBDotCDotDIcmBIcmCIcmDIcmEIcmF
Number111112111
ComponentIcmGIcmHIcmJIcmKIcmLIcmMIcmNIcmOIcmP
Number111111111
ComponentIcmQIcmRIcmSIcmTIcmVIcmWIcmXLvgA
Number11111111

The information of T4SS components from NC_002942
Region 1: 479014..515432
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1lpg0437474811..476811 [+], 200152840682hypothetical protein  interaction
2lpg0438477096..477314 [-], 21952840683hypothetical protein 
3lpg0439477490..478539 [-], 105052840684hypothetical protein 
4lpg0440478631..478843 [+], 21352840685hypothetical protein 
5lpg0441 (icmT)479014..479274 [+], 26152840686IcmT protein  IcmT
6lpg0442 (icmS)479275..479619 [+], 34552840687IcmS protein  IcmSaccesspry protein
7lpg0443 (icmR)479719..480081 [+], 36352840688IcmR  IcmR
8lpg0444 (icmQ)480148..480747 [+], 60052840689IcmQ protein  IcmQ
9lpg0445 (icmP)480922..482064 [+], 114352840690IcmP protein  IcmP
10lpg0446 (icmO)482061..484412 [+], 235252840691IcmO protein  IcmO
11lpg0447 (lphA)484816..485385 [+], 57052840692protein LphA  IcmN
12lpg0448 (icmM)485397..485681 [+], 28552840693IcmM (DotJ)  IcmM
13lpg0449 (icmL)485697..486335 [+], 63952840694IcmL protein  IcmL
14lpg0450 (icmK)486335..487420 [+], 108652840695IcmK protein  IcmK
15lpg0451 (icmE)487425..490571 [+], 314752840696IcmE protein  IcmE
16lpg0452 (icmG)490586..491395 [+], 81052840697IcmG protein  IcmG
17lpg0453 (icmC)491403..491987 [+], 58552840698hypothetical protein  IcmC
18lpg0454 (icmD)492130..492411 [+], 28252840699IcmD protein  IcmD
19lpg0455 (icmJ)492591..493235 [+], 64552840700IcmJ protein  IcmJ
20lpg0456 (icmB)493271..496300 [+], 303052840701IcmB protein  IcmB
21lpg0457 (tphA)496446..497702 [-], 125752840702TphA (ProP) 
22lpg0458 (icmF)497705..500626 [-], 292252840703IcmF  IcmF
23lpg0459 (icmH)500626..501411 [-], 78652840704IcmH (DotU)  IcmH
24lpg0460 (purH)501696..503285 [-], 159052840705bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 
25lpg0461 (prmA)503312..504181 [-], 8705284070650S ribosomal protein L11 methyltransferase 
26lpg0462 (accC)504183..505532 [-], 135052840707acetyl CoA carboxylase, biotin carboxylase subunit 
27lpg0463505539..506021 [-], 48352840708acetyl-CoA carboxylase biotin carboxyl carrier protein 
28lpg0464 (aroQ)506035..506472 [-], 438528407093-dehydroquinate dehydratase 
29lpg0465506479..506718 [-], 24052840710hypothetical protein 
30lpg0466506656..508464 [+], 180952840711pyruvate carboxylase subunit B 
31lpg0467509030..510661 [+], 163252840712zinc metalloprotease 
32lpg0468510663..511514 [-], 85252840713lipase A 
33lpg0469511961..512734 [+], 77452840714hypothetical protein 
34lpg0470512912..513922 [-], 101152840715fructose bisphosphate aldolase 
35lpg0471 (poxF)514072..514818 [-], 74752840716phenol hydroxylase 
36lpg0472514890..515432 [+], 54352840717IcmC protein  IcmC
37lpg0473515576..515872 [-], 29752840718hypothetical protein 
38lpg0474516084..516827 [+], 74452840719CDP-diacylglycerol--serine O-phosphatidyltransferase 
39lpg0475 (ptsH)517068..517337 [-], 27052840720sugar transport PTS system phosphocarrier HPr protein 
40lpg0476517528..517827 [-], 30052840721sigma-54 modulation protein 
41lpg0477517854..519248 [-], 139552840722RNA polymerase factor sigma-54 
42lpg0478 (rpmG)519458..519622 [-], 1655284072350S ribosomal protein L33 
43lpg0479 (rpmB)519637..519873 [-], 2375284072450S ribosomal protein L28 
44lpg0480519971..520132 [+], 16252840725hypothetical protein 
 
Region 2: 566512..567138
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1lpg0520563556..564326 [-], 77152840765UbiE/COQ5 family methlytransferase 
2lpg0521564280..564888 [-], 60952840766hypothetical protein 
3lpg0522564885..565352 [-], 46852840767acetyltransferase 
4lpg0523 (aacA4)565504..566067 [-], 56452840768aminoglycoside N (6')-acetyltransferase 
5lpg0525566512..567138 [+], 62752840769virulence protein  LvgAaccesspry protein
6lpg0526567168..567602 [-], 43552840770hypothetical protein 
7lpg0527567697..568848 [-], 115252840771hypothetical protein 
8lpg0528 (sdhC)569140..569532 [+], 39352840772succinate dehydrogenase cytochrome b556 subunit C 
9lpg0529 (sdhD)569526..569873 [+], 34852840773succinate dehydrogenase hydrophobic membrane anchor protein subunit D 
10lpg0530 (sdhA)569875..571644 [+], 177052840774succinate dehydrogenase flavoprotein subunit A 
 
Region 3: 3021320..3039999
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1lpg2670 (ftsY)3016947..3018053 [-], 110752842876cell division membrane protein FtsY 
2lpg26713018077..3019402 [+], 132652842877zinc protease 
3lpg26723019399..3020703 [+], 130552842878zinc protease 
4lpg26733020700..3021245 [+], 54652842879N-6 adenine-specific DNA methylase 
5lpg2674 (dotD)3021320..3021811 [+], 49252842880lipoprotein DotD  DotD
6lpg2675 (dotC)3021792..3022703 [+], 91252842881DotC  DotC
7lpg2676 (dotB)3022673..3023836 [+], 116452842882ATPase  DotB
8lpg26773023919..3025646 [+], 1728528428835'-nucleotidase 
9lpg26783025688..3026485 [-], 79852842884hypothetical protein 
10lpg26793026515..3027459 [-], 94552842885D-isomer specific 2-hydroxyacid dehydrogenase 
11lpg2680 (murE3)3027690..3028718 [+], 102952842886UDP-N-acetylmuramyl tripeptide synthase 
12lpg26813028993..3029880 [+], 888528428874-hydroxy-2-oxovalerate aldolase 
13lpg26823030019..3030726 [+], 70852842888hypothetical protein 
14lpg26833030713..3032560 [+], 184852842889DlpA protein 
15lpg26843032560..3033420 [+], 86152842890hypothetical protein 
16lpg26853033585..3034331 [-], 74752842891dienelactone hydrolase 
17lpg2686 (dotA)3034433..3037579 [-], 314752842892defect in organelle trafficking protein DotA  DotA
18lpg2687 (icmV)3037576..3038031 [-], 45652842893intracellular multiplication protein IcmV  IcmV
19lpg2688 (icmW)3038144..3038599 [+], 45652842894intracellular multiplication protein IcmW  IcmWaccesspry protein
20lpg2689 (icmX)3038599..3039999 [+], 140152842895intracellular multiplication protein IcmX  IcmX
21lpg2690 (lphB)3040006..3041637 [-], 163252842896protein LphB 
22lpg26913041997..3044540 [+], 254452842897cation transporting ATPase PacS 
 
accesspry protein This T4SS contains information of accessory protein.
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes
Allows survival and growth in macrophages, prevent phagosome acifidication and lysosome fusion, essential for induction of apoptosis in human macrophages

Effectors
RavA, CegC1/PlcC, lpg0021, RavB, AnkQ/legA10, lpg0041, lpg0045, lpg0046, Ceg2, Ceg3, lpg0081, Lem1, Ceg4, VipF, CegC2, sidP, SdhB, cetLP1, RavD, RavC, LegU1, lpg0172, lpg0181, Ceg5, RavE, RavF, RavG, Ceg7, SidE/laiD, Ceg8, Ceg9, lpg0257, lpg0260, SdbA, LegG2, Ceg10, Lem2, lpg0294, lpg0364, lpg0365, lpg0375, SdhA, VipA, lpg0393, LegA7/ceg11, AnkY/legA9, AnkG/ankZ/legA7, lpg0405, LegY, AnkJ/legA11, Ceg14, Ceg15, AnkC/legA12, LegD2, lpg0518, Ceg17, SidA, lpg0634, WipB, AnkN/ankX legA8, Lem3, lpg0716, RavH, lpg0796, Ceg18, RavI, LidA, RavJ, LegL1, lpg0963, lpg0967, SidK, RavK, lpg1083, Lem4, lpg1106, RavL, RavM, Lem5, RavN, Lem6, Ceg19, lpg1124, RavO, lpg1137, CegC3, Lem7, lpg1147, lpg1148, RavP, RavQ, lpg1158, RavR, lpg1171, RavS, VpdB, lpg1273, Lem8, LegC1, RavT, RavW, LegT, SidG, EnhC homologue, Lgt1, LicA, VpdC, lpg1449, lpg1453, LegK1, lpg1484, Lgt3/legc5, RavX, Lem9, Lem10, RavY, lpg1578, LegC6, Lem11, LegL2, Ceg23, Lem23, lpg1639, SidB, lpg1654, LegL3, lpg1661, cetLP3, lpg1666, lpg1667, lpg1670, RavZ, lpg1684, lpg1685, MavA, lpg1689, lpg1692, PpeA/legC3, PpeB, lpg1716, lpg1717, AnkI/legAS4, lpg1751, lpg1752, lpg1776, RvfA, MarB, lpg1803, Ceg25, Lem14, YlfB/legC2, lpdA, LegLC8, lpg1907, lpg1924, Lem15, Lem16, LegLC4, Lem17, RalF, LegC4, LegL5, lpg1959, LirA, lpg1961, LirB, PieA/lirC, PieB/lirD, PieC/lirE, PieD/lirF, PieE, PieF, lpg1975, PieG/legG1, SetA, lpg1986, lpg2050, LegA6, LegK2, AnkB/legAU13/ceg27, MavC, MvcA, lpg2149, SdeC, SdeC, SidJ, SdeB, LaiA/SdeA, lpg2160, Lem19, LegS2, CegC4, CegC4, WipC, LegA2, Lem20, LpnE, lpg2223, PpgA, lpg2239, Lem21, lpg2271, YlfA/legC7, AnkH/legA3, ankW, Ceg28(RidL), AnkK/legA5, lpg2327, Lem22, MavE, MavF, lpg2359, lpg2370, lpg2372, lpg2382, SdbC, LegL6, LegL6, Lem23, lpg2407, Ceg29, VpdA, Lem24, LegA1, lpg2420, Lem25, MavG, MavH, Ceg30, lpg2434, lpg2443, MavI, AnkF/legA14/ceg31, GobX, AnkD/legA15, lpg2461, SidM/drrA, SidD, SdbB, LepB, MavJ, SidI/ceg32, lpg2505, SdjA, SdeD, SdcA, SidC, Lem26, MavK, MavL, LnaB, Lem27, lpg2538, lpg2539, lpg2541, lpg2546, LecE, lpg2555, LegK3, MavM, SidF, LegS1, Ceg33, Lem28, lpg2628, lpg2637, MavV, lpg2692, LegD1, WipA, LegN, lpg2744, lpg2745, LepA, Lem29, VipE, MavN, lppA, Ceg34, lpg2828, SidH, LubX/legU2, VipD, lpg2832, lpg2844, Lgt2/legC8, lpg2874, lpg2879, lpg2884, lpg2885, lpg2888, LncP, lpg2912, lpg2936, lpg2975, LegP, lpg3000

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1lpg0008 11612..12871 [-], 126052840264hypothetical protein  RavA
2lpg0012 15332..16909 [-], 157852840268hypothetical proteinexperimental  CegC1/PlcCinteraction
3lpg0021 27119..27598 [+], 48052840277hypothetical proteinexperimental  lpg0021
4lpg0030 38093..39007 [-], 91552840286hypothetical protein  RavB
5lpg0038 (legA10)44731..46254 [-], 152452840294ankyrin repeat-containing proteinexperimental  AnkQ/legA10
6lpg0041 48185..50431 [+], 224752840297hypothetical protein  lpg0041
7lpg0045 54060..54272 [-], 21352840301hypothetical proteinexperimental  lpg0045
8lpg0046 54482..54880 [+], 39952840302hypothetical protein  lpg0046
9lpg0059 66075..67181 [+], 110752840315hypothetical protein  Ceg2
10lpg0080 89551..90318 [+], 76852840335hypothetical proteinexperimental  Ceg3
11lpg0081 90308..91633 [-], 132652840336hypothetical proteinexperimental  lpg0081
12lpg0090 99689..103663 [+], 397552840345hypothetical proteinexperimental  Lem1
13lpg0096 109946..111139 [+], 119452840351hypothetical proteinexperimental  Ceg4
14lpg0103 (vipF)118383..119243 [-], 86152840358GNAT family acetyltransferaseexperimental  VipF
15lpg0126 143588..146896 [+], 330952840381hypothetical proteinexperimental  CegC2
16lpg0130 151762..154230 [+], 246952840385hypothetical proteinexperimental  sidPinteraction
17lpg0135 (sdhB)157650..163277 [-], 562852840390hypothetical proteinexperimental  SdhB
18lpg0140 169315..170649 [+], 133552840395hypothetical proteinexperimental  cetLP1
19lpg0160 192160..193137 [+], 97852840415hypothetical proteinexperimental  RavDinteraction
20lpg0170 199432..200187 [-], 75652840425ABC transporter permeaseexperimental  RavC
21lpg0171 (legU1)200453..201019 [-], 56752840426hypothetical proteinexperimental  LegU1interaction
22lpg0172 201209..201934 [+], 72652840427hypothetical protein  lpg0172
23lpg0181 211023..211934 [+], 91252840436hypothetical protein  lpg0181
24lpg0191 221236..222189 [+], 95452840446hypothetical proteinexperimental  Ceg5
25lpg0195 225828..226832 [-], 100552840450hypothetical protein  RavE
26lpg0196 227034..228308 [-], 127552840451hypothetical protein  RavF
27lpg0210 243721..244344 [+], 62452840465hypothetical protein  RavG
28lpg0227 260923..262029 [+], 110752840482hypothetical proteinexperimental  Ceg7
29lpg0234 (sidE)272577..277121 [-], 454552840489protein SidEexperimental  SidE/laiDinteraction
30lpg0240 (recN)284008..284787 [+], 78052840495DNA repair proteinexperimental  Ceg8
31lpg0246 293014..293739 [+], 72652840501hypothetical proteinexperimental  Ceg9interaction
32lpg0257 303412..304404 [+], 99352840512multidrug resistance secretion protein  lpg0257
33lpg0260 308513..308911 [+], 39952840515hypothetical protein  lpg0260
34lpg0275 323554..326904 [+], 335152840530protein SdbAexperimental  SdbA
35lpg0276 (legG2)327062..328561 [+], 150052840531hypothetical protein  LegG2
36lpg0284 338278..339402 [-], 112552840539hypothetical proteinexperimental  Ceg10
37lpg0285 339639..340322 [+], 68452840540hypothetical proteinexperimental  Lem2
38lpg0294 350967..351659 [+], 69352840549hypothetical proteinexperimental  lpg0294
39lpg0364 404182..404487 [-], 30652840609hypothetical protein  lpg0364
40lpg0365 404662..407352 [-], 269152840610hypothetical proteinexperimental  lpg0365
41lpg0375 414141..414740 [+], 60052840620hypothetical protein  lpg0375
42lpg0376 (sdhA)414780..419069 [-], 429052840621protein SdhAexperimental  SdhAinteraction
43lpg0390 (vipA)431953..433011 [-], 105952840635VipAexperimental  VipAinteraction
44lpg0393 435144..436007 [+], 86452840638hypothetical proteinexperimental  lpg0393interaction
45lpg0401 440213..440887 [-], 67552840646hypothetical protein  LegA7/ceg11
46lpg0402 (legA9)441321..443024 [+], 170452840647ankyrin repeat-containing protein  AnkY/legA9interaction
47lpg0403 (legA7)443204..444748 [+], 154552840648ankyrin repeat-containing protein  AnkG/ankZ/legA7
48lpg0405 446478..447068 [+], 59152840650hypothetical proteinexperimental  lpg0405
49lpg0422 (legY)462427..463776 [-], 135052840667glucoamylase  LegY
50lpg0436 (legA11)473739..474548 [-], 81052840681ankyrin repeat-containing proteinexperimental  AnkJ/legA11
51lpg0437 474811..476811 [+], 200152840682hypothetical proteinexperimental  Ceg14interaction
52lpg0439 477490..478539 [-], 105052840684hypothetical protein  Ceg15
53lpg0483 (legA12)522033..523520 [+], 148852840728ankyrin repeat-containing proteinexperimental  AnkC/legA12
54lpg0515 (legD2)556665..557597 [+], 93352840760phytanoyl-CoA dioxygenase  LegD2
55lpg0518 559574..560422 [-], 84952840763hypothetical proteinexperimental  lpg0518
56lpg0519 560931..563144 [-], 221452840764hypothetical proteinexperimental  Ceg17
57lpg0621 (sidA)654121..655545 [-], 142552840858protein SidAexperimental  SidA
58lpg0634 670559..671908 [-], 135052840871hypothetical proteinexperimental  lpg0634
59lpg0642 680594..682168 [+], 157552840879hypothetical proteinexperimental  WipB
60lpg0695 (legA8)755316..758165 [+], 285052840932ankyrin repeat-containing proteinexperimental  AnkN/ankX legA8interaction
61lpg0696 758172..759884 [-], 171352840933hypothetical proteinexperimental  Lem3interaction
62lpg0716 781434..782447 [+], 101452840953hypothetical protein  lpg0716
63lpg0733 799869..801317 [+], 144952840970hypothetical protein  RavH
64lpg0796 870831..871481 [+], 65152841033hypothetical protein  lpg0796
65lpg0898 972975..973706 [-], 73252841133hypothetical proteinexperimental  Ceg18
66lpg0926 1001252..1002262 [-], 101152841161hypothetical protein  RavI
67lpg0940 1017170..1019359 [-], 219052841175LidAexperimental  LidAinteraction
68lpg0944 1024610..1025785 [-], 117652841179hypothetical protein  RavJ
69lpg0945 (legL1)1025948..1026838 [-], 89152841180Gala protein type 1, 3 or 4  LegL1
70lpg0963 1054066..1055307 [-], 124252841198hypothetical proteinexperimental  lpg0963
71lpg0967 1060107..1060700 [-], 59452841202hypothetical protein  lpg0967
72lpg0968 1061065..1062786 [-], 172252841203hypothetical proteinexperimental  SidKinteraction
73lpg0969 1063227..1063967 [+], 74152841204hypothetical proteinexperimental  RavKinteraction
74lpg1083 1178481..1179164 [+], 68452841317hypothetical protein  lpg1083
75lpg1101 1204272..1205240 [+], 96952841335hypothetical proteinexperimental  Lem4
76lpg1106 1209726..1211000 [-], 127552841340hypothetical protein  lpg1106
77lpg1108 1211847..1212728 [-], 88252841342lipase  RavL
78lpg1109 1212967..1215027 [-], 206152841343hypothetical protein  RavM
79lpg1110 1215532..1216227 [+], 69652841344hypothetical protein  Lem5
80lpg1111 1216316..1216954 [-], 63952841345hypothetical protein  RavN
81lpg1120 1229115..1230881 [-], 176752841354hypothetical proteinexperimental  Lem6
82lpg1121 1231463..1232233 [+], 77152841355hypothetical proteinexperimental  Ceg19
83lpg1124 1235312..1235902 [-], 59152841358hypothetical protein  lpg1124
84lpg1129 1243201..1244760 [+], 156052841363hypothetical protein  RavO
85lpg1137 1252018..1252986 [-], 96952841371hypothetical protein  lpg1137
86lpg1144 1258828..1259334 [-], 50752841378hypothetical proteinexperimental  CegC3
87lpg1145 1259593..1261902 [+], 231052841379hypothetical proteinexperimental  Lem7
88lpg1147 1263574..1264077 [+], 50452841381hypothetical protein  lpg1147
89lpg1148 1264367..1265878 [+], 151252841382hypothetical proteinexperimental  lpg1148
90lpg1152 1269764..1270720 [-], 95752841386hypothetical protein  RavP
91lpg1154 1272593..1273675 [+], 108352841388hypothetical protein  RavQ
92lpg1158 1278130..1278900 [+], 77152841392hypothetical proteinexperimental  lpg1158
93lpg1166 1286250..1288262 [-], 201352841400hypothetical protein  RavR
94lpg1171 1294101..1294520 [+], 42052841405hypothetical protein  lpg1171
95lpg1183 1309096..1310988 [+], 189352841417hypothetical protein  RavS
96lpg1227 1353613..1355409 [+], 179752841459hypothetical proteinexperimental  VpdB
97lpg1273 1401419..1402483 [+], 106552841504hypothetical proteinexperimental  lpg1273
98lpg1290 1416806..1418392 [-], 158752841521hypothetical proteinexperimental  Lem8
99lpg1312 (legC1)1440709..1444116 [+], 340852841543coiled-coil-containing protein  LegC1
100lpg1316 1446245..1447267 [-], 102352841547hypothetical protein  RavT
101lpg1317 1447359..1448246 [-], 88852841548hypothetical protein  RavW
102lpg1328 (legT)1464351..1466816 [-], 246652841559thaumatin domain-containing protein  LegT
103lpg1355 (sidG)1497609..1500533 [-], 292552841585protein SidGexperimental  SidG
104lpg1356 1501020..1502150 [+], 113152841586hypothetical proteinexperimental  EnhC homologue
105lpg1368 1513119..1514696 [+], 157852841598hypothetical proteinexperimental  Lgt1interaction
106lpg1408 (licA)1553994..1555145 [+], 115252841638choline kinaseexperimental  LicA
107lpg1426 1575093..1577747 [+], 265552841656hypothetical proteinexperimental  VpdC
108lpg1449 1596957..1599569 [+], 261352841679hypothetical protein  lpg1449
109lpg1453 1602449..1602967 [+], 51952841683hypothetical protein  lpg1453
110lpg1483 (legK1)1638274..1639863 [+], 159052841713serine/threonine-protein kinaseexperimental  LegK1interaction
111lpg1484 1639917..1640726 [-], 81052841714hypothetical protein  lpg1484
112lpg1488 (legC5)1642834..1645431 [+], 259852841718coiled-coil-containing proteinexperimental  Lgt3/legc5interaction
113lpg1489 1645642..1646673 [+], 103252841719hypothetical protein  RavX
114lpg1491 1648274..1649515 [+], 124252841721hypothetical proteinexperimental  Lem9
115lpg1496 1652066..1653862 [+], 179752841726hypothetical proteinexperimental  Lem10
116lpg1551 1714678..1715424 [-], 74752841781hypothetical protein  RavY
117lpg1578 1743361..1743810 [-], 45052841808hypothetical proteinexperimental  lpg1578
118lpg1588 (legC6)1755600..1757618 [-], 201952841818hypothetical proteinexperimental  LegC6
119lpg1598 1765512..1766573 [-], 106252841828hypothetical proteinexperimental  Lem11
120lpg1602 (legL2)1766981..1768267 [-], 128752841830hypothetical protein  LegL2
121lpg1621 1789603..1790922 [-], 132052841849hypothetical proteinexperimental  Ceg23
122lpg1625 1794227..1794619 [-], 39352841853hypothetical proteinexperimental  Lem23
123lpg1639 1811280..1812596 [-], 131752841867hypothetical protein  lpg1639
124lpg1642 (sidB)1815442..1816695 [-], 125452841870protein SidBexperimental  SidB
125lpg1654 1829032..1830150 [-], 111952841882hypothetical protein  lpg1654
126lpg1660 (legL3)1836560..1838041 [+], 148252841888hypothetical proteinexperimental  LegL3
127lpg1661 1838135..1839253 [-], 111952841889hypothetical proteinexperimental  lpg1661
128lpg1663 1840168..1840674 [+], 50752841891hypothetical proteinexperimental  cetLP3
129lpg1666 1849247..1850650 [-], 140452841894hypothetical protein  lpg1666
130lpg1667 1850812..1852203 [-], 139252841895hypothetical protein  lpg1667
131lpg1670 1856669..1857559 [+], 89152841898hypothetical protein  lpg1670
132lpg1683 1873124..1874632 [+], 150952841911hypothetical protein  RavZinteraction
133lpg1684 1874936..1876333 [+], 139852841912hypothetical protein  lpg1684
134lpg1685 1876344..1877213 [-], 87052841913hypothetical protein  lpg1685
135lpg1687 1877800..1879002 [-], 120352841915hypothetical protein  MavA
136lpg1689 1880467..1881093 [+], 62752841917hypothetical proteinexperimental  lpg1689
137lpg1692 1885806..1887116 [+], 131152841920hypothetical protein  lpg1692
138lpg1701 (legC3)1895076..1896758 [+], 168352841929kinectin 1experimental  PpeA/legC3interaction
139lpg1702 1896894..1898534 [+], 164152841930hypothetical proteinexperimental  PpeB
140lpg1716 1911490..1911948 [+], 45952841944hypothetical protein  lpg1716
141lpg1717 1912012..1913700 [-], 168952841945hypothetical proteinexperimental  lpg1717
142lpg1718 (legAS4)1914091..1915728 [-], 163852841946hypothetical proteinexperimental  AnkI/legAS4interaction
143lpg1751 1953138..1954448 [-], 131152841978hypothetical proteinexperimental  lpg1751
144lpg1752 1954461..1955108 [-], 64852841979hypothetical proteinexperimental  lpg1752
145lpg1776 1984497..1984982 [+], 48652842003hypothetical protein  lpg1776
146lpg1797 2004190..2005470 [+], 128152842024hypothetical protein  RvfA
147lpg1798 2005655..2006851 [-], 119752842025hypothetical protein  MarB
148lpg1803 2011770..2012705 [-], 93652842030hypothetical protein  lpg1803
149lpg1836 2056349..2057767 [+], 141952842063coiled coil domain-containing protein  Ceg25
150lpg1851 2072773..2073435 [-], 66352842078hypothetical proteinexperimental  Lem14
151lpg1884 (legC2)2102459..2103676 [+], 121852842102microtubule binding proteinexperimental  YlfB/legC2interaction
152lpg1888 2105414..2106745 [-], 133252842106hypothetical proteinexperimental  lpdAinteraction
153lpg1890 (legLC8)2108003..2109724 [-], 172252842108hypothetical proteinexperimental  LegLC8
154lpg1907 2126619..2128424 [-], 180652842125hypothetical proteinexperimental  lpg1907
155lpg1924 2146745..2149537 [+], 279352842142hypothetical protein  lpg1924
156lpg1933 2158158..2158772 [-], 61552842150hypothetical proteinexperimental  Lem15
157lpg1947 2174909..2175658 [+], 75052842164hypothetical proteinexperimental  Lem16
158lpg1948 (legLC4)2175670..2176677 [-], 100852842165hypothetical proteinexperimental  LegLC4
159lpg1949 2176986..2178326 [-], 134152842166hypothetical proteinexperimental  Lem17
160lpg1950 (sec7)2178619..2179743 [+], 112552842167guanine nucleotide exchange proteinexperimental  RalFinteraction
161lpg1953 (legC4)2181810..2184092 [-], 228352842170hypothetical protein  LegC4
162lpg1958 (legL5)2189637..2191265 [+], 162952842175hypothetical proteinexperimental  LegL5
163lpg1959 2191518..2193512 [+], 199552842176hypothetical protein  lpg1959
164lpg1960 2193697..2194470 [+], 77452842177hypothetical proteinexperimental  LirA
165lpg1961 2194507..2196039 [-], 153352842178hypothetical proteinexperimental  lpg1961
166lpg1962 2196167..2196733 [+], 56752842179peptidyl-prolyl cis-trans isomeraseexperimental  LirB
167lpg1963 2196799..2198898 [-], 210052842180hypothetical proteinexperimental  PieA/lirCinteraction
168lpg1964 2199220..2200530 [+], 131152842181hypothetical proteinexperimental  PieB/lirD
169lpg1965 2200794..2203760 [-], 296752842182hypothetical proteinexperimental  PieC/lirE
170lpg1966 2204165..2205730 [-], 156652842183hypothetical proteinexperimental  PieD/lirF
171lpg1969 2208464..2210371 [-], 190852842186hypothetical proteinexperimental  PieEinteraction
172lpg1972 2212015..2212392 [-], 37852842189hypothetical protein  PieF
173lpg1975 2214817..2215467 [+], 65152842192hypothetical protein  lpg1975
174lpg1976 (legG1)2215443..2216303 [+], 86152842193UVB-resistance protein UVR8experimental  PieG/legG1interaction
175lpg1978 2217148..2219082 [-], 193552842195teichoic acid biosynthesis proteinexperimental  SetAinteraction
176lpg1986 2226164..2229016 [-], 285352842203hypothetical protein  lpg1986
177lpg2050 2292022..2293080 [-], 105952842267hypothetical protein  lpg2050
178lpg2131 (legA6)2374714..2375256 [-], 54352842345ankyrin 3  LegA6
179lpg2137 (legK2)2384233..2385849 [-], 161752842351calmodulin-dependent protein kinaseexperimental  LegK2
180lpg2144 (legAU13)2390645..2391163 [+], 51952842358F-box proteinexperimental  AnkB/legAU13/ceg27interaction
181lpg2147 2394467..2395915 [+], 144952842361hypothetical proteinexperimental  MavCinteraction
182lpg2148 2395991..2397271 [+], 128152842362hypothetical proteinexperimental  MvcA
183lpg2149 2397359..2397718 [+], 36052842363hypothetical protein  lpg2149
184lpg2153 2401678..2406279 [+], 460252842367Sid related protein-likeexperimental  SdeC
185lpg2154 2406709..2407614 [+], 90652842368Sid related protein-likeexperimental  SdeC
186lpg2155 2407667..2410288 [+], 262252842369hypothetical proteinexperimental  SidJinteraction
187lpg2156 2410554..2416334 [+], 578152842370Sid related protein-likeexperimental  SdeB
188lpg2157 2416693..2421213 [+], 452152842371Sid related protein-likeexperimental  LaiA/SdeAinteraction
189lpg2160 2423699..2425147 [-], 144952842374hypothetical proteinexperimental  lpg2160
190lpg2166 2431605..2432864 [+], 126052842380hypothetical proteinexperimental  Lem19
191lpg2176 (legS2)2440714..2442540 [-], 182752842389sphingosine-1-phosphate lyase Iexperimental  LegS2interaction
192lpg2199 2481832..2482464 [-], 63352842412hypothetical protein  CegC4
193lpg2200 2482630..2483166 [-], 53752842413hypothetical proteinexperimental  CegC4
194lpg2206 2489349..2490449 [+], 110152842419hypothetical protein  WipC
195lpg2215 (legA2)2498937..2500532 [-], 159652842428ankyrin repeat-containing protein  LegA2
196lpg2216 2500553..2502325 [-], 177352842429purine NTPaseexperimental  Lem20
197lpg2222 2508818..2509945 [-], 112852842435hypothetical proteinexperimental  LpnEinteraction
198lpg2223 2510199..2511422 [-], 122452842436hypothetical protein  lpg2223
199lpg2224 2512062..2513843 [+], 178252842437UVB-resistance protein UVR8  PpgA
200lpg2239 2533540..2537397 [+], 385852842452hypothetical protein  lpg2239
201lpg2248 2549049..2551283 [-], 223552842461hypothetical proteinexperimental  Lem21
202lpg2271 2574377..2575027 [+], 65152842484hypothetical protein  lpg2271
203lpg2298 (legC7)2596514..2597791 [-], 127852842508inclusion membrane protein Aexperimental  YlfA/legC7interaction
204lpg2300 (legA3)2601375..2602778 [-], 140452842510ankyrin repeat-containing proteinexperimental  AnkH/legA3, ankW
205lpg2311 2610805..2614308 [-], 350452842521interaptinexperimental  Ceg28(RidL)interaction
206lpg2322 (legA5)2623900..2625825 [-], 192652842532ankyrin repeat-containing proteinexperimental  AnkK/legA5
207lpg2327 2631759..2632652 [+], 89452842537hypothetical proteinexperimental  lpg2327
208lpg2328 2632916..2633299 [+], 38452842538hypothetical proteinexperimental  Lem22
209lpg2344 2647010..2647636 [+], 62752842554hypothetical protein  MavE
210lpg2351 2655484..2656404 [+], 92152842561hypothetical proteinexperimental  MavF
211lpg2359 2663704..2664147 [+], 44452842569hypothetical proteinexperimental  lpg2359
212lpg2370 2674400..2675338 [+], 93952842579hypothetical protein  lpg2370
213lpg2372 2677194..2678462 [+], 126952842581hypothetical protein  lpg2372
214lpg2382 2687420..2688874 [+], 145552842591hypothetical protein  lpg2382
215lpg2391 (sdbC)2702256..2703560 [-], 130552842600protein SdbCexperimental  SdbC
216lpg2392 (legL6)2703828..2704712 [+], 88552842601hypothetical protein  LegL6
217lpg2400 (legL7)2711277..2712341 [+], 106552842609hypothetical proteinexperimental  LegL6
218lpg2406 2717701..2718798 [+], 109852842615hypothetical proteinexperimental  Lem23
219lpg2407 2718993..2719298 [-], 30652842616hypothetical proteinexperimental  lpg2407
220lpg2409 2720506..2721324 [+], 81952842618hypothetical proteinexperimental  Ceg29
221lpg2410 2721767..2723764 [+], 199852842619patatin-like phospholipaseexperimental  VpdA
222lpg2411 2723867..2724694 [-], 82852842620hypothetical proteinexperimental  Lem24
223lpg2416 (legA1)2728074..2729180 [+], 110752842625ankyrin repeat-containing protein  LegA1
224lpg2420 2732983..2733534 [+], 55252842629hypothetical protein  lpg2420
225lpg2422 2734836..2737097 [-], 226252842631hypothetical proteinexperimental  Lem25
226lpg2424 2739205..2740551 [-], 134752842633hypothetical protein  MavG
227lpg2425 2741056..2741862 [-], 80752842634hypothetical protein  MavH
228lpg2433 2749238..2750998 [+], 176152842642hypothetical proteinexperimental  Ceg30
229lpg2434 2751265..2751759 [+], 49552842643hypothetical protein  lpg2434
230lpg2443 2757867..2758424 [-], 55852842652hypothetical protein  lpg2443
231lpg2444 2758651..2759265 [-], 61552842653hypothetical protein  MavI
232lpg2452 (legA14)2764049..2766814 [-], 276652842660ankyrin repeat-containing protein  AnkF/legA14/ceg31
233lpg2455 2769090..2769719 [+], 63052842663hypothetical proteinexperimental  GobXinteraction
234lpg2456 (legA15)2769925..2771340 [+], 141652842664ankyrin repeat-containing protein  AnkD/legA15
235lpg2461 2774397..2775035 [+], 63952842669hypothetical protein  lpg2461
236lpg2464 2777324..2779267 [-], 194452842672hypothetical proteinexperimental  SidM/drrAinteraction
237lpg2465 (sidD)2779337..2780860 [+], 152452842673protein SidDexperimental  SidDinteraction
238lpg2482 2795479..2796825 [+], 134752842690protein SdbCexperimental  SdbB
239lpg2490 (lepB)2804259..2808143 [+], 388552842698hypothetical proteinexperimental  LepBinteraction
240lpg2498 2815381..2816313 [+], 93352842706hypothetical protein  MavJ
241lpg2504 2820928..2823756 [+], 282952842712hypothetical proteinexperimental  SidI/ceg32interaction
242lpg2505 2823758..2824645 [+], 88852842713hypothetical protein  lpg2505
243lpg2508 2827446..2829869 [-], 242452842716hypothetical proteinexperimental  SdjA
244lpg2509 2829940..2831133 [-], 119452842717protein SdeDexperimental  SdeD
245lpg2510 2831384..2834110 [+], 272752842718protein SdcAexperimental  SdcAinteraction
246lpg2511 (sidC)2834261..2837014 [+], 275452842719protein SidC, interaptinexperimental  SidCinteraction
247lpg2523 2849475..2851814 [+], 234052842731hypothetical proteinexperimental  Lem26
248lpg2525 2852975..2854309 [+], 133552842733hypothetical proteinexperimental  MavK
249lpg2526 2854590..2855957 [-], 136852842734hypothetical protein  MavL
250lpg2527 2856264..2857940 [-], 167752842735hypothetical proteinexperimental  LnaBinteraction
251lpg2529 2859811..2861529 [-], 171952842737hypothetical proteinexperimental  Lem27
252lpg2538 2869817..2871232 [-], 141652842746hypothetical protein  lpg2538
253lpg2539 2871814..2872221 [-], 40852842747hypothetical protein  lpg2539
254lpg2541 2872931..2873764 [-], 83452842749hypothetical protein  lpg2541
255lpg2546 2878610..2880019 [-], 141052842754hypothetical protein  lpg2546
256lpg2552 2884137..2885804 [-], 166852842760hypothetical proteinexperimental  LecEinteraction
257lpg2555 2888571..2889425 [-], 85552842763hypothetical protein  lpg2555
258lpg2556 (legK3)2890013..2891401 [+], 138952842764protein kinase  LegK3
259lpg2577 2905863..2906621 [-], 75952842783hypothetical protein  MavM
260lpg2584 (sidF)2913345..2916083 [+], 273952842790inhibitor of growth protein SidFexperimental  SidFinteraction
261lpg2588 (legS1)2919924..2921081 [-], 115852842794acid sphingomyelinase-like phosphodiesteraseexperimental  LegS1
262lpg2591 2924663..2925160 [-], 49852842797hypothetical proteinexperimental  Ceg33
263lpg2603 2937032..2938336 [+], 130552842809hypothetical proteinexperimental  Lem28
264lpg2628 2969395..2970147 [-], 75352842834hypothetical protein  lpg2628
265lpg2637 2978466..2979677 [-], 121252842843hypothetical protein  lpg2637
266lpg2638 2980029..2981411 [-], 138352842844hypothetical protein  MavV
267lpg2692 3044791..3045321 [+], 53152842898hypothetical protein  lpg2692
268lpg2694 (legD1)3046318..3047175 [-], 85852842900phytanoyl-CoA dioxygenase  LegD1
269lpg2718 3069837..3071399 [-], 156352842923hypothetical proteinexperimental  WipAinteraction
270lpg2720 (legN)3072810..3073841 [+], 103252842925cNMP binding domain-containing protein  LegN
271lpg2744 3094245..3095414 [-], 117052842948hypothetical proteinexperimental  lpg2744
272lpg2745 3095575..3097542 [-], 196852842949hypothetical protein  lpg2745
273lpg2793 (lepA)3143077..3146532 [+], 345652842990interaptinexperimental  LepAinteraction
274lpg2804 3158378..3159784 [-], 140752843000hypothetical proteinexperimental  Lem29
275lpg2813 (vipE)3173075..3173935 [+], 86152843009VipE  VipE
276lpg2815 3175334..3177385 [+], 205252843011hypothetical proteinexperimental  MavNinteraction
277lpg2819 3181506..3182465 [-], 96052843015tyrosine phosphatase II superfamily proteinexperimental  lppAinteraction
278lpg2826 3189788..3191521 [-], 173452843022hypothetical proteinexperimental  Ceg34
279lpg2828 3192992..3194248 [+], 125752843024hypothetical protein  lpg2828
280lpg2829 (sidH)3194315..3200992 [-], 667852843025protein SidHexperimental  SidH
281lpg2830 (legU2)3201113..3201853 [-], 74152843026UBOX-containing proteinexperimental  LubX/legU2interaction
282lpg2831 (vipD)3202105..3203970 [+], 186652843027VipDexperimental  VipDinteraction
283lpg2832 3204025..3205665 [-], 164152843028hypothetical proteinexperimental  lpg2832
284lpg2844 3218707..3219792 [-], 108652843040hypothetical protein  lpg2844
285lpg2862 (legC8)3237892..3239802 [-], 191152843057coiled-coil containing proteinexperimental  Lgt2/legC8interaction
286lpg2874 3252163..3253047 [-], 88552843069hypothetical proteinexperimental  lpg2874
287lpg2879 3258575..3260326 [-], 175252843074hypothetical protein  lpg2879
288lpg2884 3264725..3265462 [-], 73852843079hypothetical protein  lpg2884
289lpg2885 3265772..3266326 [-], 55552843080hypothetical protein  lpg2885
290lpg2888 3268809..3270722 [+], 191452843083hypothetical proteinexperimental  lpg2888
291lpg2905 3286884..3288533 [+], 165052843099ubiquinone biosynthesis AarFexperimental  LncPinteraction
292lpg2912 3296964..3298451 [+], 148852843106hypothetical protein  lpg2912
293lpg2936 3321700..3322434 [-], 7355284313016S ribosomal RNA methyltransferase RsmEexperimental  lpg2936
294lpg2975 3364068..3366683 [-], 261652843168hypothetical proteinexperimental  lpg2975
295lpg2999 (legP)3391003..3391803 [+], 80152843192hypothetical protein  LegP
296lpg3000 3391800..3393638 [-], 183952843193hypothetical protein  lpg3000

interaction This effector contains information of interaction.

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Proteins        Genes
The information on structure of this T4ss

#NameImageResourceDetailReference
1AnkX4BEP PDB (4BEP)Crystal structure of the Legionella pneumophila FIC domain-containing effector AnkX protein (apo-form).(1) PubMed: 23572077
2DotD3ADY PDB (3ADY)Crystal structure of DotD from Legionella.(2) PubMed: 20949065
3DotF fused to a superfolder GFP0566 EMDB(0566)Subtomogram average of the Legionella pneumophila Dot/Icm type IV secretion system with DotF fused to a superfolder GFP (aligning the OM-complex).(3) PubMed: 31011165
4DotI3WZ4 PDB (3WZ4)Structure of the periplasmic domain of DotI (crystal form I).(4) PubMed: 26039110
5DotI3WZ5 PDB (3WZ5)Structure of the periplasmic domain of DotI (crystal form II).(5) PubMed: 26039110
6DotL(590-659)-DotN5X42 PDB (5X42)Structure of DotL(590-659)-DotN derived from Legionella pneumophila.(6) PubMed: 28714967
7DotL(656-783)-IcmS-IcmW5X1E PDB (5X1E)Structure of DotL(656-783)-IcmS-IcmW derived from Legionella pneumophila.(7) PubMed: 28714967
8DotL(656-783)-IcmS-IcmW-LvgA5X90 PDB (5X90)Structure of DotL(656-783)-IcmS-IcmW-LvgA derived from Legionella pneumophila.(8) PubMed: 28714967
9DotM5X1U PDB (5X1U)Structure of the cytosolic domain of DotM derived from Legionella pneumophila.(9) PubMed: 28714967
10DotN5X1H PDB (5X1H)Structure of Legionella pneumophila DotN.(10) PubMed: 28714967
11DrrA/SidM3NKU PDB (3NKU)Crystal structure of the N-terminal domain of DrrA/SidM from Legionella pneumophila.(11) PubMed: 20651120
12IcmR and IcmQ3FXD PDB (3FXD)Crystal structure of interacting domains of IcmR and IcmQ.(12) PubMed: 19368892
13IcmR and IcmQ3FXE PDB (3FXE)Crystal structure of interacting domains of IcmR and IcmQ (seleno-derivative).(13) PubMed: 19368892
14IcmS-IcmW-DotL complex5XNB PDB (5XNB)Crystal structure of the IcmS-IcmW-DotL complex of the Legionella type IVb secretion system.(14) PubMed: 29203674
15Inner membrane complex8567 EMDB(8567)In vivo structure of the Legionella pneumophila Dot/Icm type IV secretion system (aligning the inner membrane complex).(15) PubMed: 28336774
16Inner membrane part8569 EMDB(8569)In vivo structure of the Legionella pneumophila Dot/Icm type IV secretion system core complex (aligning the inner membrane part).(16) PubMed: 28336774
17LegAS45CZY PDB (5CZY)Crystal structure of LegAS4.(17) PubMed: 26315269
18LegC34MU6 PDB (4MU6)Crystal Structure of the N-terminal domain of Effector Protein LegC3 from Legionella pneumophila.(18) PubMed: 24531477
19Lem144HFV PDB (4HFV)Crystal structure of lpg1851 protein from Legionella pneumophila (putative T4SS effector).(19) PubMed: 27986836
20Lgt12WZF PDB (2WZF)Legionella pneumophila glucosyltransferase crystal structure.(20) PubMed: 20030628
21LidA (60-594)4H5Y PDB (4H5Y)High-resolution crystal structure of Legionella pneumophila LidA (60-594).(21) PubMed: 24293259
22LidA in complex with active Rab8a3TNF PDB (3TNF)LidA from Legionella in complex with active Rab8a.(22) PubMed: 22011575
23Lpg03934R0G PDB (4R0G)Crystal structure of Lpg0393 from Legionella pneumophila.(23) PubMed: 25821953
24LpiR15FIA PDB (5FIA)Structure of the effector protein LpiR1 (Lpg0634) from Legionella pneumophila.(24) PubMed: 27226543
25LppA4TVV PDB (4TVV)Crystal structure of LppA from Legionella pneumophila.(25) PubMed: 25339170
26Outer membrane complex8566 EMDB(8566)In vivo structure of the Legionella pneumophila Dot/Icm type IV secretion system (aligning the outer membrane complex).(26) PubMed: 28336774
27Outer membrane complex8568 EMDB(8568)In vivo structure of the Legionella pneumophila Dot/Icm type IV secretion system core complex (aligning the outer membrane complex).(27) PubMed: 28336774
28PI(4)P-Specific Membrane Recruitment of DrrA/SidM4MXP PDB (4MXP)Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM.(28) PubMed: 24530282
29Rab1b in complex with the GEF domain of DrrA/SidM3JZA PDB (3JZA)Crystal structure of human Rab1b in complex with the GEF domain of DrrA/SidM from Legionella pneumophila.(29) PubMed: 20064470
30RalF1XSZ PDB (1XSZ)The structure of RalF.(30) PubMed: 15520000
31RavZ5CQC PDB (5CQC)Crystal structure of the legionella pneumophila effector protein RavZ.(31) PubMed: 26343456
32RidL5OH5 PDB (5OH5)Legionella pneumophila RidL N-terminal retromer binding domain.(32) PubMed: 29146912
33RidL5OH6 PDB (5OH6)Legionella pneumophila RidL N-terminal domain lacking beta hairpin.(33) PubMed: 29146912
34SdeA5CRA PDB (5CRA)Structure of the SdeA DUB Domain.(34) PubMed: 26598703
35SdeA5CRB PDB (5CRB)Crystal Structure of SdeA DUB.(35) PubMed: 26598703
36SdeA5CRC PDB (5CRC)Structure of the SdeA DUB Domain.(36) PubMed: 26598703
37Se-labelled SidJ complex with CaM6K4L PDB (6K4L)Crystal structure of Se-labelled SidJ complex with CaM at 2.95 A.(37) PubMed: 31330531
38SidC4TRH PDB (4TRH)The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling.(38) PubMed: 25006264
39SidC4TRG PDB (4TRG)the SNL domain of SidC.(39) PubMed: 25006264
40SidD4IIP PDB (4IIP)Legionella pneumophila effector.(40) PubMed: 23696742
41SidF4FYE PDB (4FYE)Crystal structure of a Legionella phosphoinositide phosphatase, SidF.(41) PubMed: 22872863
42SidF4FYF PDB (4FYF)Structural basis for substrate recognition by a novel Legionella phosphoinositide phosphatase.(42) PubMed: 22872863
43SidF4FYG PDB (4FYG)Structural basis for substrate recognition by a novel Legionella phosphoinositide phosphatase.(43) PubMed: 22872863
44SidJ-CaM6K4K PDB (6K4K)Crystal structure of SidJ-CaM binary complex at 2.71 A.(44) PubMed: 31330531
45SidJ-CaM-AMP ternary complex6K4R PDB (6K4R)Crystal structure of SidJ-CaM-AMP ternary complex at 3.11 A.(45) PubMed: 31330531
46SidJ-Human calmodulin complex6S5T PDB (6S5T)Legionella pneumophila SidJ-Human calmodulin complex.(46) PubMed: 31330532
47VipD4AKF PDB (4AKF)Crystal structure of VipD from Legionella pneumophila.(47) PubMed: 23271971
48WipB5NNY PDB (5NNY)Crystal structure of the phosphatase domain from the Legionella effector WipB.(48) PubMed: 28842705
(1) Campanacci V et al. (2013). Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain. EMBO J. 32(10):1469-77. [PudMed:23572077] experimental
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(5) Kuroda T et al. (2015). Molecular and structural analysis of Legionella DotI gives insights into an inner membrane complex essential for type IV secretion. Sci Rep. 5:10912. [PudMed:26039110] experimental
(6) Kwak MJ et al. (2017). Architecture of the type IV coupling protein complex of Legionella pneumophila. Nat Microbiol. 2:17114. [PudMed:28714967] experimental
(7) Kwak MJ et al. (2017). Architecture of the type IV coupling protein complex of Legionella pneumophila. Nat Microbiol. 2:17114. [PudMed:28714967] experimental
(8) Kwak MJ et al. (2017). Architecture of the type IV coupling protein complex of Legionella pneumophila. Nat Microbiol. 2:17114. [PudMed:28714967] experimental
(9) Kwak MJ et al. (2017). Architecture of the type IV coupling protein complex of Legionella pneumophila. Nat Microbiol. 2:17114. [PudMed:28714967] experimental
(10) Kwak MJ et al. (2017). Architecture of the type IV coupling protein complex of Legionella pneumophila. Nat Microbiol. 2:17114. [PudMed:28714967] experimental
(11) Müller MP et al. (2010). The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science. 329(5994):946-9. [PudMed:20651120] experimental
(12) Raychaudhury S et al. (2009). Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila. Structure. 17(4):590-601. [PudMed:19368892] experimental
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(14) Xu J et al. (2017). Structural insights into the roles of the IcmS-IcmW complex in the type IVb secretion system of Legionella pneumophila. Proc Natl Acad Sci U S A. 114(51):13543-13548. [PudMed:29203674] experimental
(15) Ghosal D et al. (2017). In situ structure of the Legionella Dot/Icm type IV secretion system by electron cryotomography. EMBO Rep. 18(5):726-732. [PudMed:28336774] experimental
(16) Ghosal D et al. (2017). In situ structure of the Legionella Dot/Icm type IV secretion system by electron cryotomography. EMBO Rep. 18(5):726-732. [PudMed:28336774] experimental
(17) Son J et al. (2015). Crystal structure of Legionella pneumophila type IV secretion system effector LegAS4. Biochem Biophys Res Commun. 465(4):817-24. [PudMed:26315269] experimental
(18) Yao D et al. (2014). Structure of the N-terminal domain of the effector protein LegC3 from Legionella pneumophila. Acta Crystallogr D Biol Crystallogr. 70(Pt 2):436-41. [PudMed:24531477] experimental
(19) Urbanus ML et al. (2016). Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila. Mol Syst Biol. 12(12):893. [PudMed:27986836] experimental
(20) Hurtado-Guerrero R et al. (2010). Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase. Biochem J. 426(3):281-92. [PudMed:20030628] experimental
(21) Meng G et al. (2013). The crystal structure of LidA, a translocated substrate of the Legionella pneumophila type IV secretion system.. Protein Cell. 4(12):897-900. [PudMed:24293259] experimental
(22) Schoebel S et al. (2011). Protein LidA from Legionella is a Rab GTPase supereffector. Proc Natl Acad Sci U S A. 108(44):17945-50. [PudMed:22011575] experimental
(23) Sohn YS et al. (2015). Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22. PLoS One. 10(3):e0118683. [PudMed:25821953] experimental
(24) Beyrakhova KA et al. (2016). Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila. J Biol Chem. 291(30):15767-77. [PudMed:27226543]
(25) Weber S et al. (2014). A type IV translocated Legionella cysteine phytase counteracts intracellular growth restriction by phytate. J Biol Chem. 289(49):34175-88. [PudMed:25339170] experimental
(26) Ghosal D et al. (2017). In situ structure of the Legionella Dot/Icm type IV secretion system by electron cryotomography. EMBO Rep. 18(5):726-732. [PudMed:28336774] experimental
(27) Ghosal D et al. (2017). In situ structure of the Legionella Dot/Icm type IV secretion system by electron cryotomography. EMBO Rep. 18(5):726-732. [PudMed:28336774] experimental
(28) Del Campo CM et al. (2014). Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM. Structure. 22(3):397-408. [PudMed:24530282] experimental
(29) Schoebel S et al. (2009). RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity. Mol Cell. 36(6):1060-72. [PudMed:20064470] experimental
(30) Amor JC et al. (2005). The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site. J Biol Chem. 280(2):1392-400. [PudMed:15520000] experimental
(31) Horenkamp FA et al. (2015). The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs. Dev Cell. 34(5):569-76. [PudMed:26343456] experimental
(32) Bärlocher K et al. (2017). Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5. Nat Commun. 8(1):1543. [PudMed:29146912] experimental in_silico
(33) Bärlocher K et al. (2017). Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5. Nat Commun. 8(1):1543. [PudMed:29146912] experimental in_silico
(34) Sheedlo MJ et al. (2015). Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination. Proc Natl Acad Sci U S A. 112(49):15090-5. [PudMed:26598703] experimental
(35) Sheedlo MJ et al. (2015). Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination. Proc Natl Acad Sci U S A. 112(49):15090-5. [PudMed:26598703] experimental
(36) Sheedlo MJ et al. (2015). Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination. Proc Natl Acad Sci U S A. 112(49):15090-5. [PudMed:26598703] experimental
(37) Gan N et al. (2019). Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase. Nature. 572(7769):387-391. [PudMed:31330531] experimental
(38) Hsu F et al. (2014). The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling. Proc Natl Acad Sci U S A. 111(29):10538-43. [PudMed:25006264] experimental
(39) Hsu F et al. (2014). The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling. Proc Natl Acad Sci U S A. 111(29):10538-43. [PudMed:25006264] experimental
(40) Chen Y et al. (2013). Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD. PLoS Pathog. 9(5):e1003382. [PudMed:23696742] experimental
(41) Hsu F et al. (2012). Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase. Proc Natl Acad Sci U S A. 109(34):13567-72. [PudMed:22872863] experimental
(42) Hsu F et al. (2012). Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase. Proc Natl Acad Sci U S A. 109(34):13567-72. [PudMed:22872863] experimental
(43) Hsu F et al. (2012). Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase. Proc Natl Acad Sci U S A. 109(34):13567-72. [PudMed:22872863] experimental
(44) Gan N et al. (2019). Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase. Nature. 572(7769):387-391. [PudMed:31330531] experimental
(45) Gan N et al. (2019). Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase. Nature. 572(7769):387-391. [PudMed:31330531] experimental
(46) Bhogaraju S et al. (2019). Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation. Nature. 572(7769):382-386. [PudMed:31330532] experimental
(47) Ku B et al. (2012). VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages. PLoS Pathog. 8(12):e1003082. [PudMed:23271971] experimental
(48) Prevost MS et al. (2017). The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery. Sci Rep. 7(1):9450. [PudMed:28842705] experimental
The information on requirements for T4SS substrate-channel docking

Certain T4SS substrates require secretion chaperones for translocation. These chaperones often possess physical properties (small size of 15 kDa, acidic pI, and amphipathic helices) resembling those of chaperones associated with the type III secretion systems, a family of macromolecular translocation systems ancestrally related to bacterial flagella.

#Accessory protein(GI)motif(s)Substrate(s)FunctionReference
1IcmS (52840687)C-terminal fragment-The IcmS adaptors essential for translocation of different subsets of effectors through the Legionella Dot/Icm translocation apparatus.(1) PubMed: 28714967
2IcmS (52840687)NDSdeASdeA is secreted into host cells in an IcmS-dependent manner.(2) PubMed: 15773981
3IcmS/IcmW (chaperones)CT Val-2 and Leu-3 required for translocationAnkBThe IcmSW chaperone complex is essential for translocation of AnkB.(3) PubMed: 18811729
4IcmS/IcmW (chaperones)C-terminal hydrophbic tail, CT20aasidGThe IcmSW complex interacts with a central region of the SidG protein. It resulted in a conformational change in the SidG protein as determined by differences in protease sensitivity in vitro. (4) PubMed: 18069892
5IcmS/IcmW (chaperones)C-terminal hydrophobic tail, CT100aa sufficientsidCIcmSW could enhance effector protein translocation by mediating a conformational change. (5) PubMed: 16714592
6IcmS/IcmW (chaperones)C-terminal hydrophobic tail. CT30aa sufficientlegS2LegS2 translocation depends on a functional IcmS IcmW complex.(6) PubMed: 19438520
7IcmS/IcmW (chaperones)NDAnkJThe IcmSW chaperones are essential for translocation of AnkJ.(7) PubMed: 20028808
8IcmW (52842894)C-terminal fragment-The IcmW adaptors essential for translocation of different subsets of effectors through the Legionella Dot/Icm translocation apparatus.(8) PubMed: 19946141
9LvgA (52840769)C-terminal fragment-The LvgA adaptors essential for translocation of different subsets of effectors through the Legionella Dot/Icm translocation apparatus.(9) PubMed: 28714967
Tips:
1.Substrate(s): For the conjugation systems, the listed proteins are relaxases that bind a cognate T4CP and are delivered to recipient cells. For the effector translocator systems, the listed proteins are effectors that play a role in the infection processes of the bacterial pathogen.
2.motif(s):The motifs listed are required for substrate translocation. In some cases, the protein or its C-terminal fragment (CT) is sufficient to mediate translocation to target cells, as shown by fusion to a reporter protein such as Cre recombinase or adenylate cyclase. Amino acids (aa) at positions listed relative to the C-terminal fragment (subscript) are required for translocation, as shown by mutational analysis. ND, not determined. Parentheses indicate that the interaction between a protein substrate and a cognate T4CP has been experimentally shown.
3.Accessory protein: Accessory factors required for T4SS channel docking or translocation. The proposed function in mediating substrate-T4SS channel docking is shown in parentheses.PubMed:19946141

(1) Kwak MJ et al. (2017). Architecture of the type IV coupling protein complex of Legionella pneumophila. Nat Microbiol. 2:17114. [PudMed:28714967] experimental
(2) Bardill JP; Miller JL; Vogel JP (2005). IcmS-dependent translocation of SdeA into macrophages by the Legionella pneumophila type IV secretion system. Mol Microbiol. 56(1):90-103. [PudMed:15773981] experimental
(3) Al-Khodor S; Price CT; Habyarimana F; Kalia A; Abu Kwaik Y (2008). A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa. Mol Microbiol. 70(4):908-23. [PudMed:18811729] experimental
(4) Cambronne ED; Roy CR (2007). The Legionella pneumophila IcmSW complex interacts with multiple Dot/Icm effectors to facilitate type IV translocation. PLoS Pathog. 3(12):e188. [PudMed:18069892] experimental
(5) VanRheenen SM; Luo ZQ; O'Connor T; Isberg RR (2006). Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells. Infect Immun. 74(6):3597-606. [PudMed:16714592] experimental
(6) Degtyar E; Zusman T; Ehrlich M; Segal G (2009). A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria. Cell Microbiol. 11(8):1219-35. [PudMed:19438520] experimental in_silico
(7) Habyarimana F et al. (2010). Molecular characterization of the Dot/Icm-translocated AnkH and AnkJ eukaryotic-like effectors of Legionella pneumophila. Infect Immun. 78(3):1123-34. [PudMed:20028808] experimental
(8) Alvarez-Martinez CE; Christie PJ (2009). Biological diversity of prokaryotic type IV secretion systems. Microbiol Mol Biol Rev. 73(4):775-808. [PudMed:19946141]
(9) Kwak MJ et al. (2017). Architecture of the type IV coupling protein complex of Legionella pneumophila. Nat Microbiol. 2:17114. [PudMed:28714967] experimental
The information on host-pathogen interaction.

#Name(Protein GI)Host site/SubstrateSourceFunctionReference
1AnkB (52842358)Legionella-containing vacuole (LCV) membranemurineLegionella uses the AnkB to develop processes of K48-linked polyubiquitination and the proteasome to generate satisified amino acids for itself.(1) PubMed: 22096100insolico
2AnkB (52842358)ParvBmurineAnkB can reduce ubiquitination of ParvB via colocalization of AnkB and ParvB at the periphery of lamellipodia.(2) PubMed: 20345489insolico
3AnkN/ankX legA8 (52840932)Rab1 and Rab35humanAnkX modified both Rab1 and Rab35 by cAMP(Fic) domain-dependent manner.(3) PubMed: 21822290insolico
4AnkY/legA9 (52840647)unknownunknownLegA9 promotes recruitment of the autophagic machinery to L. pneumophila vacuoles to clear infection.(4) PubMed: 23420491experimental
5Ceg14 (52840682)the cytoskeleton of host cellyeastCeg14 modulates the cytoskeleton of host cell and this toxicity can be reduced by overexpression of profilin.(5) PubMed: 24286927experimental
6Ceg9 (52840501)Reticulon 4 (Rtn4)humanCeg9 interacts with Rtn4 to subvert vesicle trafficking.(6) PubMed: 26099580experimental
7CegC1/PlcC (52840268)Phosphatidylcholinehuman, amoebaePlcC can hydrolyzed a broad phospholipid spectrum and add Zn(2+) ions activated PlcC-derived PLC activity.(7) PubMed: 23457299experimental
8GobX (52842663)Golgi membranesmurineGobX has the activity of E3 ubiquitin ligase and utilizes S-palmitoylation of host cell to localize to Golgi membranes.(8) PubMed: 26316537experimental
9IroT/mavN (52843011)unknownunknownIroT/mavN is a membrane protein and is involved in ferrous iron transport.(9) PubMed: 25141909insolico
10LaiA/SdeA (52842371)unknownunknownLaiA/SdeA can facilitate bacterial adherence and uptake.(10) PubMed: 15972519experimental
11LecE (52842760)Pah1yeastLecE has the ability to active the yeast lipin homolog Pah1, which is an enzyme to catalyze the conversion of diacylglycerol to phosphatidic acid.(11) PubMed: 23133385experimental
12LegAS4 (52841946)histone H3humanLegAS4 has activity of SET-domain histone lysine methyltransferase (HKMTase) to facilitate transcription of rDNA.(12) PubMed: 23797873experimental
13LegG1 (52842193)RAs-related Nuclear protein (Ran)humanRan activation and RanBP1 can facilitate formation of LCV and LegG1 functions as a activator of bacterial Ran on LCVs to facilitate LCV motility, stabilization of microtubule and intracellular replication of L. pneumophila.(13) PubMed: 24068924experimental
14LegK1 (52841713)NF-κBmurineLegK1 can imitate host IKK and phosphorylates the Ser32 and Ser36 residues of the inhibitory IkBa protein directly. This process leads to IkBa ubiquitination and degradation, which results in subsequent nuclear translocation of p65.(14) PubMed: 19666608experimental
15LegU1 (52840426)BAT3 (HLA-B associated transcript 3)humanLegU1 interacts with the host chaperone protein BAT3 specifically and can direct the ubiquitination of it.(15) PubMed: 20547746experimental
16Lem3 (52840933)Rab1humanLem3 has activity of dephosphocholinase that can remove the phosphocholine group from Rab1 to reverse modification which mediated by AnkX on Rab1.(16) PubMed: 22307087experimental
17LepA (52842990)unknownunknownLepA enabled the Legionella to grab a protozoan exocytic pathway for dissemination of it.(17) PubMed: 14988561experimental
18LepB (52842698)GTPhumanLepB has the activity of GTPase-activating protein and it can inactivate Rab1 by stimulating GTP hydrolysis to remove Rab proteins from membranes.(18) PubMed: 17952054experimental
19LepB (52842698)Phosphatidylinositol 3-phosphatehumanLepB_NTD, which is a functional domain identified in LepB, has a activity of lipid hinase that converts PtdIns3P into PtdIns(3,4)P2 specifically.(19) PubMed: 27941800experimental
20Lgt1 (52841598)elongation factor(EF)1AhumanLgt1 can modify the mammalian elongation factor (EF)1A selectively through using UDP-glucose as a cosubstrate to inhibit synthesis of eukaryotic protein and death of target cells.(20) PubMed: 17068130experimental
21Lgt1 (52841598)mechanistic target of rapamycin complex 1 (mTORC1)human, murineLgt family proteins have the ability of activation of mTORC1.(21) PubMed: 29166595experimental
22Lgt2 (52843057)mechanistic target of rapamycin complex 1 (mTORC1)human, murineLgt family proteins have the ability of activation of mTORC1.(22) PubMed: 29166595experimental
23Lgt3 (52841718)mechanistic target of rapamycin complex 1 (mTORC1)human, murineLgt family proteins have the ability of activation of mTORC1.(23) PubMed: 29166595experimental
24LidA (52841175)Rab6A'humanLidA blocks the hydrolysis of GTP by Rab6A', which is a regulator of retrograde vesicle trafficking in eukaryotic cells, to maintain Rab6A' in the active conformation.(24) PubMed: 23569112experimental
25LidA (52841175)Rab1humanLidA interects with Rab1 to make the Rab1-guanosine nucleotide complex stable and interfer with the covalent modification of Rab1 by phosphocholination or AMPylation. (25) PubMed: 22228731experimental
26LnaB (52842735)NF-κBmurineLnaB can active NF-κB during L. pneumophila infection in host cells.(26) PubMed: 20148897experimental
27LncP (52843099)Mitochondrionhuman, murineLncP is integrated into the mitochondrial inner membrane and catalyzes unidirectional transport and exchange of ATP transport across membranes.(27) PubMed: 22241989experimental
28LpdA (52842106)unknownyeastLpdA contains a functional PLD domain and has the ability to convert PC to PA and to free choline.(28) PubMed: 23133385experimental
29Lpg0393 (52840638)RAB5, RAB21 and RAB22humanLpg0393 has the activity of a guanine-nucleotide exchange factor and can activate RAB5, RAB21 and RAB22.(29) PubMed: 25821953experimental
30LpnE (52842435)OCRL1amoebaeLpnE binds to OCRL1 on LCVs. It makes intracellular replication down-regulated to sustaining a protective niche.(30) PubMed: 19021631experimental
31LppA (52843015)unknownunknownLppA has the activity of phytate phosphatase and counteracts growth restriction of bacteria by phytate through hydrolyzing to inactivate the chelator.(31) PubMed: 25339170experimental
32LpSpl/LegS2 (52842389)Sphingosine-1-phosphate (S1P)murineLpSpl depletes host S1P to repress autophagy in the host cell. It also facilitate intracellular replication of Legionella pneumophila.(32) PubMed: 26831115experimental
33LubX (52843026)Clk1 (Cdc2-like kinase 1)murineLubX has two domains which is similar to the U-box. It mediates polyubiquitination of host Clk1 and has activity of ubiquitin ligase.(33) PubMed: 18284575experimental
34MavC (52842361)UBE2NmurineMavC induces monoubiquitination of UBE2N and ubiquitination of UBE2N and then the NF-κB signalling in the initial phase of bacterial infection is inhibited.(34) PubMed: 30420781experimental
35MitF (LegG1) (52842193)Ran GTPasehumanMitF(LegG1) is a Ran GTPase activator and induces mitochondrial fragmentation.(35) PubMed: 28867389experimental
36PieA/lirC (52842180)Legionella-containing vacuole (LCV)humanPieA can alter lysosome morphology.(36) PubMed: 19165328experimental
37PieE (52842186)Endoplasmic reticulum (ER)humanPieE localized to ER and interacted with Rab GTPases 1a, 1b, 2a, 5c, 6a, 7, and 10.(37) PubMed: 25118235insolico
38PpeA/legC3 (52841929)unknownunknownLegC3 subverts vesicle trafficking to contribute to the intracellular trafficking of L. pneumophila.(38) PubMed: 18670632experimental
39RalF (52842167)ADP ribosylation factor (ARF) family murineRalF is an exchange factor for the ADP ribosylation factor (ARF) family of GTPases. The RalF protein is enssential for the localization of ARF on phagosomes which contains L. pneumophila.(39) PubMed: 11809974experimental
40RavD (52840415)Linear ubiquitinhumanRavD has activity of deubiquitinase specific for linear ubiquitin to repress the NF-κB pathway during infection.(40) PubMed: 31110362experimental
41RavK (52841204)actinhuman, apeRavK has an H95EXXH99 motif which is associated with diverse metalloproteases and targets to the actin to cleave it at a site between residues Thr351 and Phe352.(41) PubMed: 28129393experimental
42RavZ (52841911)Atg8 proteinshumanRavZ uncouple Atg8 proteins which attached to phosphatidylethanolamine on autophagosome membranes directly to interfere with autophagy.(42) PubMed: 23112293experimental
43RidL (52842521)Vps29amoebaeRidL interacts with the retromer subunit of Vps29. Then it blocks retrograde vesicle trafficking and facilitates intracellular replication of bacteria.(43) PubMed: 29146912experimental
44SdcA (52842718)Phosphatidylinositol-4-phosphate (PtdIns4P)amoebaeSdcA interacts with PI(4)P directly and specifically to modulate host cell PI metabolism.(44) PubMed: 16710455experimental
45SdhA (52840621)unknownunknownSdhA prevents DNA of bacteria release into macrophage cytosol and this process is important for the growth of L.pneumophila. The absence of SdhA resulted in the secretion of IL-1β, the activation of elevated caspase-1 and pyroptosis of macrophage during Legionella infection. (45) PubMed: 22474394experimental
46SetA (52842195)Phosphatidylinositol 3-phosphatehumanSetA has the activity of mono-O-glucosyltransferase and glycohydrolase, and it interacts to PtdIns(3)P. SetA recruits the Legionella effector to the surface of Legionella-containing vacuole (LCV) and subvert vesicle trafficking to promote cell death.(46) PubMed: 22288428experimental
47SidC (52842719)Phosphatidylinositol-4-phosphate (PtdIns4P)murineDuring the maturation of LCVs, SidC and SdcA play a part in three steps. The three steps are the interaction with early secretory vesicles, the recruiting of ER vesicles and the membrane dynamics of the LCVs,respectively.(47) PubMed: 18673369experimental
48SidC (52842719)UbiquitinhumanSidC is an E3 ubiquitin ligase and is important for the enrichment of ER proteins and conjugation of ubiquitin and bacterial vacuoles.(48) PubMed: 25006264experimental
49SidD (52842673)Rab1murineSidD generates de-AMPylated Rab1 through catalyzing AMP release from Rab1.(49) PubMed: 21680813experimental
50SidE (52840489)small GTPasehumanSidE can ubiquitinate some small GTPases of the Rab family, which are associated with the endoplasmic reticulum.(50) PubMed: 27049943experimental
51SidF (52842790)D3 phosphate of PI(3,4)P2 and PI(3,4,5)P3 on LCVmurineSidF hydrolyzes PI(3,4)P2 and PI(3,4,5)P3. This process may lead to the accumulation of PI(4)P on LCV and recruitment of other effectors which anchor on the LCV membrane by binding to PI(4)P. SidF may help bateria to escape from the degradative phagolysosomal pathway by promoting the programming of LCV for bacterial growth.(51) PubMed: 22872863experimental
52SidF (52842790)BNIP3 and Bcl-rambohuman, murineSidF interacts with two proapoptotic members of Bcl2 protein family named BNIP3 and Bcl-rambo to contribute to apoptosis resistance of L. pneumophila.(52) PubMed: 17360363experimental
53SidI (52842712)eEF1A and eEF1BgammamurineSidI interacts with eEF1A and eEF1Bgamma specifically to inhibit host protein synthesis.(53) PubMed: 19386084experimental
54SidJ (52842369)Rab33bhumanSidJ is a ubiquitindeconjugating enzyme which has the ability to impose temporal regulation on the activity of SidE and deubiquitinate Rab33b.(54) PubMed: 28497808experimental
55SidJ (52842369)glutamatehumanSidJ is a glutamylase and can obstruct the ubiquitin ligase activity of SdeA through modifing the catalytic glutamate in the mono-ADP ribosyl transferase domain of the SdeA.(55) PubMed: 31330532experimental
56SidK (52841203)VatAyeastSidK interacts with VatA which is a important component of the proton pump. This process leads to the inhibition of ATP hydrolysis and translocation of proton.(56) PubMed: 20333253experimental
57SidM/drrA (52842672)Rab1murineSidM is a exchange factor of guanosine nucleotide which targets host cell Rab1. It disturb the secretory pathway and causes fragmentation of Golgi.(57) PubMed: 16824952experimental
58SidM/drrA (52842672)Phosphatidylinositol-4-phosphate (PtdIns4P)yeastSidM/drrA interacts with PI(4)P mediated by a P4M domain and it activates and AMPylates Rab1.(58) PubMed: 25643265experimental
59SidP (52840385)PI(3)P and PI(3,5)P2yeastSidP is a PI-3-phosphatase which has the ability of hydrolyzing PI(3)P and PI(3,5)P2 in vitro. Then bacteria can overturn phosphoinositide (PI) metabolism in host cell.(59) PubMed: 23843460experimental
60VipA (52840635)actinhumanVipA is a actin nucleator that can change dynamics of cytoskeleton to target host cell pathways to contribute to the intracellular lifestyle of Legionella.(60) PubMed: 22383880experimental
61VipD (52843027)Phosphatidylinositol 3-phosphateapeVipD localizes to endosomes to catalyze the removal of Phosphatidylinositol 3-phosphate from endosomal membranes only by binding to endosomal Rab5 or Rab22.(61) PubMed: 24616501experimental
62VipD (52843027)Rab5 and Rab22human, murineVipD interferes with endosomal trafficking in macrophages by targeting Rab5 and Rab22.(62) PubMed: 23271971experimental
63WipA (52842923)lysosomehumanWipA has a domain of Ser/Thr phosphatase and targets to lysosome to modulate sensing of cellular nutrient and the control of energy metabolism.(63) PubMed: 28842705experimental
64YlfA/legC7 (52842508)unknownunknownYlfA/legC7 subverts vesicle trafficking to contribute to the intracellular trafficking of L. pneumophila.(64) PubMed: 18670632experimental
65YlfB/legC2 (52842102)unknownunknownYlfB/legC2 subverts vesicle trafficking to contribute to the intracellular trafficking of L. pneumophila.(65) PubMed: 18670632experimental
experimental This T4SE is mentioned in the literature.
insolico This T4SE is highly identical with the protein mentioned in the literature.
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experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation

Genomics & Bioinformatics Group in MML, SJTU