| Effector Protein ID: 52843026 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legU2 |
| Locus tag | lpg2830 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 3201113..3201853 [-] |
| Product | UBOX-containing protein |
| Effector type | Protein |
| Descripton | LubX/legU2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LubX has been proved to contribute to sustained NF-kappaB activation in A549 epithelial cells, and are essential for L. pneumophila replication (Bartfeld, et al, 2009) |
| UniProt ID | Q5ZRQ0 |
| KEGG ID | lpn:lpg2830 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | U-box [PF04564], Evalue: 5e-26, Aligned region: 38..107 U-box [PF04564], Evalue: 5e-26, Aligned region: 132..195 zf-RING_LisH [PF13445], Evalue: 2.3e-10, Aligned region: 132..167 |
| Protein Sequence: 246 a.a. [Download] |
| >gi|52843026|ref|YP_096825.1| UBOX-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MGYRIEMATRNPFDIDHKSKYLREAALEANLSHPETTPTMLTCPIDSGFLKDPVITPEGFVYNKSSILKW LETKKEDPQSRKPLTAKDLQPFPELLIIVNRFVETQTNYEKLKNRLVQNARVAARQKEYTEIPDIFLCPI SKTLIKTPVITAQGKVYDQEALSNFLIATGNKDETGKKLSIDDVVVFDELYQQIKVYNFYRKREMQKNQI QPSVSSGFGFFSLNFLTSWLWGTEEKKEKTSSDMTY |
| - |
| Nucleotide Sequence: 741 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c3201853-3201113 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGGGGTATAGAATAGAAATGGCGACACGAAATCCTTTTGATATTGATCATAAAAGTAAATACTTAAGAG AAGCAGCATTAGAGGCCAATTTATCTCATCCAGAAACAACACCAACAATGCTGACTTGCCCTATTGACAG CGGATTTCTAAAAGATCCCGTGATCACACCAGAAGGTTTTGTTTATAATAAATCCTCTATTTTAAAATGG TTAGAAACGAAAAAAGAAGACCCACAAAGCCGTAAACCCTTAACGGCTAAAGATTTGCAACCATTCCCCG AGTTATTGATTATAGTCAATAGATTTGTTGAGACACAAACGAACTATGAAAAATTAAAAAACAGATTAGT GCAAAATGCTCGGGTTGCTGCACGCCAAAAAGAATACACTGAAATTCCGGATATATTTCTTTGCCCAATA AGTAAAACGCTTATCAAAACACCTGTCATTACTGCCCAAGGGAAAGTATATGATCAAGAAGCATTAAGTA ACTTTCTTATCGCAACGGGTAATAAAGATGAAACAGGCAAAAAATTATCCATTGATGATGTAGTGGTGTT TGATGAACTCTATCAACAGATAAAAGTTTATAATTTTTACCGCAAACGCGAAATGCAAAAAAATCAAATT CAACCTTCAGTAAGTAGTGGTTTTGGCTTTTTTAGCTTGAATTTTCTCACCTCATGGTTATGGGGAACTG AGGAGAAAAAAGAAAAGACATCATCTGATATGACGTACTAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(4) Kubori T; Hyakutake A; Nagai H (2008). Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions. Mol Microbiol. 67(6):1307-19. [PudMed:18284575]
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| experimental literature |
| in silico analysis literature |