| Effector Protein ID: 52843025 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | sidH |
| Locus tag | lpg2829 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 3194315..3200992 [-] |
| Product | protein SidH |
| Effector type | Protein |
| Descripton | SidH |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SidH may play minor roles in Legionella replication |
| UniProt ID | Q5ZRQ1 |
| KEGG ID | lpn:lpg2829 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 2225 a.a. [Download] |
| >gi|52843025|ref|YP_096824.1| protein SidH [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MKRTIETYIIYLKEDLKIADTCKTIKDGLLKSITDKTHFSEELATYFERDNPNAPFKVNTTDPTQVAVLK KLLNALENAEKSFRAIENIDISRDRYTAMIAKDAVMVSYKAVHEIYAALQLINHSNSDIQDIVGPHIQKL LPQMALASKALGNFAPEHPEESAGAVLAGVVNMLPTEKPTESESLGKLSNLIFELPHYFEELQKLIATGA SGIATKSITSAEDYQSAMIKKANETKYYFEQLSSKSGLLAIPSYLSIVKRLIAHSTDLVNAGAPLTKQAY LDAVAKLEDIKHNILPQLISELEMVEESMGLKPGLLTDPALEQMNKYYTQLAEQVDNIAKAAGVLDTVSD YSDSIGGKIVRFLAGDSKKLDVGPKLTPAPDLGVLMDDVFIQKRRSNQESRLNEARLSSEDKSVLAAANR FFDKIGSYNSIHKAWSKWSLANISQSEKDALIKEYKQFQPHFAALYPDIDKLVVDALTQPTGSNIVSRLY SSDYKQLWSSDHFKQVLSCKDSVLSSIQQSLAQSEFKAKLIEKTMSHSEETAYSMNNKTTNLTTRVQPFE PLKFTLEDDKPVEYYHKRVIAASNQILELERAQKGVAEFFNYIQKKYPHENPSFDSLDESDKEFLRKAYK TFQPQLLALKHDDINTRLVSSLTSSKPTDPPLRLTDLVSLKSGINDYLNEKISDLNQDKTTLLDKEEEAR EEQYAKNPLVAKGAELEKQTLFGQMSKLKLSKSVDDFFNKKFQTYLKDNLSPEVWKQLSSNGETLDFDKI PYLEFHKDSPEVAMYKQLINSMHYMKNGLEKLESLNDYGDPNNIYHRTRFVMTTFNALVMNICFSKYYVM EAGNNPGLKAIVQEGLDLLKPLEGMPLIGDYLKTTEKQEPPKQNIITAWKKQQAVVESGLSKGPKPKTDQ QLISEQLGKIQEAIDNFDGDLEVSDSAREKIKTQIGEFAKGISGLSFGPGSVKKILAALTKLETQLSNLD KESPEVTLGKLKDIHSELNAQFRAAAEYTEYHSGQKFGSYSNNISTIVSNFCNGLVSNLPLKQEPAPKVK APEKPVTPVITGTTNPHEVVFGTKHEEFNSVYQPYLLLKRITDEFRDQNNPYKPSFDELKEEAVSYYDKI QPLLESVDPKFDKNFIAKHKESSTLLKAIDEVMSMRQRINNPESSFAKLKDLHLEGDFEKEENKEKFRQL YKEIQPYLHKIDSTYDQTQFLEGLKTAKDFSGALQRIMNEENALQQSTSLKDTSYLQLIAESLYQIPVKL NKLKAEPDTPEPSKEEIDANVKAFVEGLNGLSFGPGSVKKILSTAAKLQMQLSDIGKEGRELTMGRLKEI QAEFGTILMAAADNAEFHLGLKPGTYSRTVSERFEKFYSSLIVNLPLEKDQTGLELLIDTTSTQKRLARE MERLESVKEDTSAIDTKKSIFGTEHEQFSTLYQPYASLRHIAKDIEDGVHMNLYERTLEELKEEASNEYK KIQPYLAKINPEFTEDYISKTDGEYSLLHAIDRVFEERHKINKPSSPFDKLRDLYLDGDFEKEENKEQFL QLYAELQPHLIKINYQYDLAYFLRELQTPEDFKAATERIINDESKLQELITGLDDTKRLKVKLCEERIGY FIDLLKKQELEVGPEKIQAFKEKIFFNYIHANVNSALDAKIGSHAEQFLQFIEKDFLDKKNEILEKITID QDMEEEIAKAIDRIAPDIINNKIESFKKLLFDSYIQSDIKNSLHNELGIYTSLFIDKISPEIHLHQSEIL GNVAFDSKMGAEIGSKINAITPGILLNNNPLKEAYVDLNNTLKEINTLLDEENKKTRDNPCRNEKIAKLT SLKDRLSDLDSIPKENTVEFLKKMQEETRSSLKSLESNDALINIYDVLNSLKETIENGSDLPEIKKDKLQ MISDVQNILSNFDKNPAERLNLAVQILNDSNPEVLSKTKGNFLIGEAFKGQVFTNYINTKISEQLNNELG PYGKVFLKQIMPDFIAKKSEIIKEIAIDNMETGLETQFKIHAPAIFEKNKELKAAYEQLNVHLKEVQSLI EAEEKKPKGNPCREEKIAALRSHQSQLMNTQRIPDHETLRFLQEQNKSAKSFMGKLEKYDTMISVYDSLT EIREHVSNHKSLSKEIKDEKIQEISKMEDMLKTTSKEPSIRLAEVKAHGLSDQCKNVLLKNSDNFLVSFF KTLFSKLFNIKNENETLVSSFKQRLQNIKGPEPVATPMETPENEAPLVNANITRF |
| - |
| Nucleotide Sequence: 6678 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c3200992-3194315 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAAAAGAACCATTGAAACCTACATCATCTATTTAAAAGAAGATTTAAAAATAGCTGATACTTGTAAAA CAATAAAAGATGGTTTGTTAAAATCGATTACCGATAAAACCCATTTTTCTGAGGAATTGGCTACTTATTT TGAACGAGATAACCCCAATGCCCCTTTTAAAGTTAACACGACTGATCCTACCCAAGTCGCTGTTCTGAAA AAATTGCTTAATGCTCTGGAAAATGCTGAAAAGTCGTTTCGAGCTATTGAAAATATTGATATCAGTCGTG ATAGGTACACTGCCATGATCGCTAAAGATGCAGTCATGGTCAGTTATAAAGCGGTGCATGAAATTTATGC GGCTCTTCAACTAATCAATCACAGTAATTCGGACATACAAGATATAGTAGGCCCACATATCCAAAAATTA TTACCACAAATGGCTTTAGCCAGTAAGGCATTAGGAAATTTTGCTCCGGAGCATCCTGAGGAGAGTGCCG GGGCAGTGCTTGCTGGTGTAGTCAATATGCTTCCAACTGAAAAGCCAACCGAGTCAGAAAGTTTGGGTAA ACTCAGTAACCTTATTTTTGAATTGCCTCATTACTTCGAGGAGTTACAAAAATTAATCGCTACCGGGGCA TCAGGGATTGCCACCAAATCAATTACCAGTGCTGAAGACTATCAATCCGCAATGATAAAAAAGGCAAATG AAACAAAATATTATTTTGAACAACTCAGTTCCAAGAGTGGGCTATTAGCAATCCCAAGCTATCTTTCAAT AGTCAAAAGATTAATTGCCCATAGTACTGATTTGGTTAATGCCGGTGCTCCTCTGACAAAACAAGCTTAT TTGGATGCTGTCGCTAAGCTTGAAGACATTAAACATAATATTTTACCCCAATTGATTTCAGAGCTGGAAA TGGTTGAAGAAAGCATGGGTTTAAAACCAGGTTTACTGACCGATCCCGCTCTTGAACAAATGAATAAATA CTATACGCAGCTGGCAGAGCAAGTTGATAATATTGCCAAGGCAGCTGGAGTTCTTGATACTGTTTCAGAT TATTCTGATTCAATAGGGGGAAAAATCGTTCGTTTTCTTGCTGGAGATAGCAAAAAACTGGATGTGGGGC CAAAATTAACGCCTGCACCTGATTTAGGTGTTTTGATGGACGATGTATTTATTCAGAAGAGAAGATCTAA TCAGGAAAGCCGACTTAATGAAGCCAGACTTAGCTCTGAAGACAAAAGTGTACTTGCCGCGGCCAATCGT TTCTTTGATAAAATCGGCTCCTACAATAGCATTCACAAAGCATGGTCCAAGTGGAGTTTGGCAAACATTA GTCAGAGTGAAAAGGACGCTTTAATCAAGGAGTACAAACAGTTTCAGCCACATTTTGCGGCATTATACCC AGATATTGACAAACTGGTTGTAGATGCTCTTACTCAGCCTACCGGAAGCAATATCGTTTCCAGACTATAC AGTTCCGATTATAAGCAATTATGGAGTTCTGATCATTTTAAGCAGGTATTATCCTGTAAGGACTCTGTGC TATCCAGTATTCAGCAAAGCCTTGCTCAATCTGAGTTTAAAGCAAAGCTCATTGAAAAAACCATGAGTCA CTCAGAAGAGACAGCTTATTCAATGAATAATAAAACAACTAATCTAACTACTCGGGTTCAACCGTTTGAA CCACTAAAATTTACTTTGGAGGACGATAAACCGGTTGAGTATTACCATAAGAGGGTTATTGCAGCATCTA ACCAAATTTTAGAACTTGAAAGAGCACAGAAAGGAGTAGCGGAGTTTTTTAATTATATTCAGAAAAAGTA TCCCCATGAAAACCCATCGTTTGATTCTCTGGATGAATCGGATAAAGAATTTCTTCGCAAGGCTTATAAA ACATTTCAACCACAATTATTGGCGTTGAAGCATGATGATATTAACACTCGCCTTGTAAGCAGCCTAACCA GTTCAAAACCAACGGACCCTCCTCTTCGCCTCACCGATCTGGTATCTCTTAAATCAGGTATTAATGACTA TTTAAATGAGAAAATTAGTGATTTAAATCAGGATAAAACGACTTTGCTGGATAAGGAGGAAGAAGCTCGC GAAGAACAATATGCAAAAAATCCCTTGGTAGCGAAGGGGGCAGAACTTGAGAAACAAACGCTCTTTGGGC AGATGAGTAAATTGAAGTTATCCAAGTCTGTTGATGATTTTTTCAATAAAAAATTTCAGACTTATCTTAA GGACAATCTTTCTCCTGAGGTATGGAAACAGCTCTCATCGAATGGAGAAACGCTTGATTTTGACAAAATA CCGTATCTCGAGTTTCATAAAGACAGCCCTGAAGTTGCCATGTACAAGCAATTAATAAACTCCATGCATT ATATGAAGAATGGCTTGGAAAAGCTGGAGTCGTTAAATGACTATGGTGACCCCAATAACATTTATCACCG TACGCGATTTGTCATGACCACATTTAATGCTCTGGTTATGAATATCTGTTTCAGTAAGTACTATGTTATG GAGGCAGGAAATAATCCAGGATTAAAGGCAATTGTCCAAGAGGGTTTGGATTTGCTAAAACCATTAGAGG GTATGCCACTCATAGGTGATTATTTAAAAACCACAGAAAAACAAGAGCCCCCCAAGCAAAATATTATTAC TGCATGGAAGAAACAACAAGCGGTTGTAGAATCTGGTTTGTCAAAAGGACCTAAGCCTAAAACAGATCAG CAATTAATTAGTGAGCAATTGGGTAAAATTCAGGAAGCCATCGATAATTTTGATGGTGACCTGGAAGTTT CAGATTCAGCCAGGGAAAAAATAAAAACTCAAATTGGCGAATTTGCCAAGGGGATCAGTGGCTTGTCTTT TGGCCCTGGTTCTGTGAAAAAAATACTGGCTGCCTTGACCAAACTCGAAACCCAGCTTTCTAATCTGGAT AAGGAAAGTCCTGAAGTAACACTTGGTAAACTTAAGGACATTCATTCCGAATTGAATGCGCAATTCAGGG CGGCTGCAGAATATACCGAGTATCATTCAGGTCAAAAGTTTGGCTCCTACTCCAATAACATAAGCACTAT TGTCAGTAATTTTTGTAATGGTCTTGTTAGTAATCTGCCTTTAAAACAAGAACCGGCACCAAAGGTTAAG GCACCAGAAAAACCTGTTACTCCTGTTATTACTGGTACAACTAACCCTCATGAGGTAGTTTTTGGCACAA AACATGAAGAATTTAATAGCGTTTATCAGCCCTATCTCTTGTTAAAGCGTATTACTGATGAGTTTCGAGA TCAAAATAATCCATATAAACCTTCTTTTGACGAATTAAAAGAGGAAGCGGTTAGTTATTATGACAAAATC CAACCTCTTCTCGAGTCTGTTGATCCAAAATTTGATAAAAATTTCATAGCAAAACATAAAGAGTCATCAA CACTACTGAAAGCTATTGATGAAGTGATGTCAATGCGCCAACGCATTAATAATCCTGAAAGTAGTTTTGC TAAACTTAAGGATTTGCATTTGGAAGGAGACTTTGAAAAAGAGGAAAACAAGGAAAAATTTCGACAGCTA TACAAGGAAATTCAGCCGTACCTCCATAAAATCGATAGTACTTATGATCAAACGCAATTTTTAGAAGGTT TAAAGACAGCAAAGGATTTCAGTGGTGCTTTGCAAAGAATTATGAATGAGGAAAATGCTCTTCAACAAAG TACGTCACTGAAAGATACTTCTTATTTACAATTAATTGCAGAAAGCCTCTATCAAATTCCAGTCAAGCTC AATAAGTTAAAAGCGGAACCTGACACTCCAGAACCTTCCAAAGAGGAAATAGATGCGAATGTGAAAGCAT TTGTTGAAGGATTAAATGGATTATCCTTTGGTCCAGGTTCAGTTAAAAAGATTCTGAGTACTGCCGCTAA ACTGCAGATGCAGCTTTCTGATATTGGTAAAGAAGGACGAGAATTAACAATGGGGCGTTTAAAAGAAATT CAAGCAGAGTTCGGCACCATTTTAATGGCGGCTGCTGATAATGCAGAATTTCATTTGGGCCTAAAGCCCG GTACGTATTCTCGTACTGTGAGTGAGCGATTTGAAAAGTTCTATAGTTCTCTGATTGTCAATTTACCTTT GGAAAAAGATCAAACGGGTTTGGAGTTATTAATTGATACAACAAGCACACAAAAACGTTTGGCAAGAGAA ATGGAACGCCTTGAAAGTGTCAAGGAAGATACCAGTGCAATCGATACGAAAAAAAGTATATTTGGTACAG AGCATGAGCAATTCAGTACTTTATATCAACCATATGCCAGCTTAAGGCATATTGCGAAGGATATAGAAGA TGGGGTGCACATGAATCTGTACGAGAGGACATTAGAGGAATTAAAAGAAGAAGCTTCGAATGAATATAAA AAAATTCAACCTTATCTTGCTAAAATTAATCCTGAATTTACTGAGGATTACATTTCCAAAACAGATGGTG AGTACTCATTACTCCATGCCATTGACAGGGTATTCGAAGAGCGTCATAAAATTAATAAACCATCCAGCCC TTTTGATAAATTAAGGGATTTATATTTGGATGGCGATTTCGAAAAAGAAGAGAATAAAGAACAATTTTTG CAGCTTTATGCGGAGCTTCAACCCCATCTTATCAAAATAAACTACCAATATGATCTCGCTTATTTTCTTA GGGAGTTGCAAACACCGGAAGATTTTAAAGCCGCGACAGAAAGAATTATTAATGATGAAAGTAAACTTCA AGAATTGATTACCGGTTTGGATGATACAAAACGATTAAAGGTAAAATTATGTGAAGAGCGTATAGGTTAT TTTATTGATCTGCTAAAGAAACAGGAGCTGGAAGTTGGGCCAGAAAAAATACAAGCCTTTAAAGAAAAAA TATTTTTTAATTACATCCATGCTAATGTCAATAGTGCCCTTGATGCTAAAATTGGTTCTCATGCCGAACA GTTTCTACAATTCATTGAAAAGGATTTTCTCGATAAAAAAAATGAGATTTTAGAGAAAATTACTATTGAC CAAGATATGGAAGAGGAAATTGCAAAAGCAATAGACAGAATAGCCCCTGACATTATCAATAATAAAATAG AGTCTTTTAAAAAATTACTATTTGACAGTTATATTCAGAGCGATATTAAAAACTCTCTGCACAATGAATT GGGAATTTATACCAGTTTATTTATCGATAAAATAAGCCCGGAAATTCATTTGCATCAATCTGAAATATTG GGAAATGTTGCATTTGACAGCAAAATGGGGGCTGAAATTGGCTCAAAAATTAATGCGATTACTCCCGGAA TTTTGCTGAATAACAATCCATTGAAAGAGGCGTACGTTGATTTAAATAATACATTGAAGGAAATTAATAC ATTACTTGATGAGGAAAATAAAAAGACCAGGGATAATCCTTGTCGCAATGAAAAAATAGCCAAATTGACT TCTCTAAAGGATCGCTTGAGTGATTTGGACAGTATTCCTAAAGAAAATACAGTGGAATTCCTTAAGAAGA TGCAAGAAGAAACAAGGTCTTCGCTGAAATCTCTGGAAAGCAATGACGCCTTAATCAATATTTATGATGT ACTTAATTCTTTAAAAGAAACCATAGAGAACGGGAGTGACTTACCCGAAATCAAAAAAGATAAGTTACAA ATGATTTCCGATGTTCAGAATATCCTCTCGAATTTTGATAAAAACCCAGCCGAGCGTTTAAATTTGGCAG TGCAAATATTAAATGACTCTAACCCCGAAGTCTTGTCAAAAACTAAAGGAAACTTTCTTATTGGAGAAGC ATTTAAAGGACAAGTTTTTACTAATTATATTAATACTAAAATCAGCGAGCAATTGAACAACGAACTCGGT CCTTATGGAAAGGTATTCTTGAAGCAAATCATGCCTGATTTTATTGCCAAAAAATCTGAAATAATCAAAG AAATAGCCATTGATAATATGGAAACAGGGCTTGAAACCCAGTTTAAAATTCATGCTCCTGCTATTTTTGA AAAGAATAAGGAGTTAAAAGCAGCTTACGAGCAATTAAACGTCCATCTAAAAGAAGTACAGAGCCTGATT GAGGCAGAAGAAAAGAAACCTAAAGGTAATCCCTGCCGTGAAGAAAAAATAGCCGCATTAAGATCCCATC AGTCTCAGTTAATGAATACCCAACGTATTCCGGATCATGAGACACTCAGGTTTTTGCAGGAGCAGAATAA AAGTGCGAAAAGTTTTATGGGTAAATTAGAAAAATATGACACGATGATCAGTGTGTATGACTCACTGACA GAAATAAGAGAGCATGTTAGTAATCATAAGAGTTTGTCAAAAGAAATCAAAGATGAAAAAATTCAGGAAA TATCAAAGATGGAAGACATGCTAAAAACAACCAGCAAAGAGCCTTCTATTCGTTTGGCAGAGGTCAAGGC TCACGGCCTAAGTGATCAATGTAAAAATGTATTACTTAAAAATTCTGACAATTTTCTGGTGAGTTTCTTT AAAACGCTATTTTCCAAATTATTTAATATTAAAAACGAAAATGAAACTTTGGTTTCATCATTCAAACAAA GGCTGCAAAATATCAAGGGTCCAGAGCCCGTCGCTACGCCTATGGAGACTCCAGAAAATGAAGCACCTTT AGTGAATGCCAATATTACCAGATTCTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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| experimental literature |
| in silico analysis literature |