| Effector Protein ID: 52843015 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2819 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 3181506..3182465 [-] |
| Product | tyrosine phosphatase II superfamily protein |
| Effector type | Protein |
| Descripton | lppA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LppA counter acts bacterial growth restriction by phytate by hydrolyzing and thus inactivating the chelator. |
| UniProt ID | Q5ZRR1 |
| KEGG ID | lpn:lpg2819 |
| PDB ID | 4TVV |
| Domain hit(s) vs Pfam | PTPlike_phytase [PF14566], Evalue: 1.6e-31, Aligned region: 106-249 |
| Protein Sequence: 319 a.a. [Download] |
| >gi|52843015|ref|YP_096814.1| tyrosine phosphatase II superfamily protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MSFKGFKVVMLILLSTQSYASKLASSIVCDSTIENPCIVQDSKTQFSPVIRYREVASIADVYGGNITGIN KFHLSGSEQPSEKGWEAIAESISRKMGAETKKVIVLDLRQESHGYLNGRAITLVSAYNWINLGKSNSQST LDQENWLAGLRSRKIVNGVLTVPQYVAKQYSQGKSMVVSTVKNEEYYVYKKGFDYYRIFISDHRAPLDSE VDALVALIKNNPEDTWYHVHCRGGKGRTTTVFAMFDMLKNADKVSFEEIIARQASIPPFYNLMVTNREIP ELTPYYEQRLQFLIHFYEFARQSLMGYSGTWSEWKKLNI |
| - |
| Nucleotide Sequence: 960 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c3182465-3181506 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAGCTTTAAAGGATTTAAAGTGGTAATGCTGATATTATTATCAACTCAAAGTTATGCCTCTAAATTGG CATCCTCCATTGTTTGTGATTCAACTATTGAAAATCCATGTATTGTTCAGGATAGTAAAACCCAATTTTC ACCCGTCATTAGATATAGAGAGGTTGCATCAATTGCGGATGTTTACGGTGGCAATATCACAGGGATTAAT AAATTTCATTTGTCAGGAAGCGAGCAACCAAGCGAAAAGGGTTGGGAGGCTATTGCCGAGTCTATTTCCA GAAAAATGGGGGCTGAAACAAAAAAAGTCATAGTGCTCGATCTTCGCCAGGAGAGTCATGGTTATCTAAA TGGGAGAGCGATTACTTTAGTTAGCGCCTATAACTGGATAAATTTGGGAAAGTCGAATAGTCAGAGTACT TTGGACCAGGAAAACTGGTTAGCCGGCTTAAGATCCAGAAAAATTGTTAACGGTGTTTTAACTGTGCCCC AATATGTAGCCAAACAATATTCTCAAGGCAAATCGATGGTAGTGAGCACTGTAAAAAATGAAGAATATTA TGTATATAAAAAAGGATTTGATTATTATCGCATATTCATATCCGATCACCGGGCTCCTTTAGATTCTGAA GTGGATGCGCTTGTCGCACTGATAAAAAATAATCCGGAAGACACATGGTATCATGTCCACTGCCGTGGCG GGAAAGGCCGTACGACGACTGTTTTTGCCATGTTTGATATGTTAAAGAATGCAGACAAGGTTAGCTTTGA AGAAATCATCGCACGCCAAGCCTCCATTCCACCTTTTTATAATTTGATGGTGACGAATCGTGAAATCCCT GAGTTAACTCCTTATTATGAGCAAAGACTGCAATTTTTGATTCATTTTTATGAATTTGCTCGCCAATCCC TTATGGGATATTCAGGTACCTGGTCAGAATGGAAAAAGCTCAATATCTAG |
| Reference |
(1) Weber S et al. (2014). A type IV translocated Legionella cysteine phytase counteracts intracellular growth restriction by phytate. J Biol Chem. 289(49):34175-88. [PudMed:25339170] 
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| experimental literature |