| Effector Protein ID: 52842990 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | lepA |
| Locus tag | lpg2793 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 3143077..3146532 [+] |
| Product | interaptin |
| Effector type | Protein |
| Descripton | LepA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Bacterial egress |
| UniProt ID | Q5ZRT5 |
| KEGG ID | lpn:lpg2793 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1151 a.a. [Download] |
| >gi|52842990|ref|YP_096789.1| interaptin [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MNEIILHLMNEISTLTPPINPLNLKQIFSSTLLPEGKAPVEVESQLNLLLLIKKYVDEYSSLAEEQEEYK RKKHKLDEVMKKGEELQRKISDLAKKIEHAKNELNPLYKEIEPKANEVLSKQNPLAPPYKFPEYGEVQKS IVVGHYSYLFKTSKEIETTRAKLKLVLLKNKWNALMADLSQFGIQPPVEEDAVDSLQKFIAAVELEIKKL TRACEKWDELQKRFAKQLSATDINKKETELEKQIELLLKDLGRIETVVTNHSLAPDLKAELTRKFQESED TQGLIQEYQNQIDGLLSNFNPSSWLSWYSDSNYSDNQQKLKNSVSFLQLLAQQKELKIKHHELVKQQELL IKAIPETPSNEEDISIYKKLVPDAIDLINEIPIESIPNFVLPSGLSYDSSPADFYLVLLILMPKVSEKKE QFSQALEKLQEMPALGKQIQQLRSGYDLPITMDVQLPSLQEAEESKDSLNEEDPLKEELKSQIKLCQSYL ETAKQIDLLMKDHGQTTNEAKALIEQLRLISNQPLKNEDINSIKEDLSTLANQIQSLVSELNQLPLPNLS GEKIDPPLEKQEIAVDKTIPLTVELMHPAQVIQIGNDSPIEKQQLDNEEETPVVLESLRPRPVIHKESES ITQKLQVDNGQEMPVVLDSTCTPQAIHKELESTTEKLQVDNGHEIPVVLESTRSPQIIHTESESVGKKQH VEVEQEIPVTLELIRPSSMVEKDSVATVEKQQVTERQETPIVLESTRLSPMVQKDTGLSGEKQHKEIEQE ISVVTELTPHTQVVRQGSESSLEQQVPNGQETLAVVKSSPSEPLRPSTPEVPAISRKPNGLSLFNGHDEL SEDNILAFFDEAGNQISISSEEDSETFTVDRGKVISSGIDKAFKEKPVSTGHELDKLSNPQHQESAPSIS PLPPSSILLKQKLDSFHVQNMEYIKQHSEEIQLWYKGLYDAAQSSCVNEALGLKALHLLKDILFELKNQN DLSVLLAYKRMCPNPLQDIQNILRLKPALPIVDESIDEEQQLKNWPEELQKFHQQYVKLKKEHPLEAELF IQAIHSLISIKHLMELPDAKTSNREAMPLITQDPRYEPLKRHRGFIRAWEYIEDFFRMLIGKLTGQDEYE YSKRPCFFKTRSHRLLEEVDTILHSMAPTSS |
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| Nucleotide Sequence: 3456 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:3143077-3146532 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAACGAAATCATACTGCACTTAATGAATGAAATCTCTACCTTGACTCCACCAATTAACCCCTTAAATT TAAAGCAAATATTTAGTTCAACCCTACTGCCGGAAGGAAAAGCTCCTGTTGAAGTTGAATCCCAGTTAAA TCTTTTATTGTTAATTAAAAAATATGTTGATGAATATTCCAGTTTAGCTGAAGAACAAGAAGAGTATAAA AGAAAAAAACACAAACTAGATGAGGTCATGAAAAAAGGAGAAGAACTGCAAAGAAAAATTTCTGATTTGG CTAAAAAAATTGAGCACGCAAAAAATGAATTAAATCCTTTATACAAAGAAATCGAGCCTAAAGCGAACGA AGTCCTGTCCAAACAAAATCCATTAGCGCCTCCTTATAAATTCCCTGAATACGGAGAGGTTCAAAAATCA ATCGTGGTTGGGCACTACAGTTATCTCTTCAAAACCAGTAAGGAAATAGAAACTACACGTGCCAAATTAA AGCTGGTTTTGCTGAAAAATAAATGGAATGCCTTAATGGCAGATTTGTCTCAGTTCGGCATTCAACCCCC TGTGGAAGAAGATGCTGTTGATAGTTTACAAAAATTTATAGCTGCAGTTGAATTGGAAATTAAAAAATTA ACTCGCGCTTGTGAAAAATGGGATGAATTGCAAAAGCGATTCGCCAAACAATTATCTGCAACTGATATTA ATAAAAAAGAGACTGAGCTAGAAAAACAAATTGAACTATTGCTTAAAGACCTGGGTCGTATTGAAACCGT AGTAACTAACCACTCCCTGGCACCCGATTTAAAAGCAGAGTTAACCAGGAAATTTCAAGAAAGTGAAGAC ACTCAAGGATTGATACAGGAATACCAAAACCAGATTGATGGATTATTATCTAATTTTAACCCATCTTCCT GGCTTTCATGGTATTCGGATTCTAATTATTCTGATAATCAGCAAAAACTTAAGAATTCAGTTAGCTTCCT GCAATTATTAGCTCAACAAAAAGAGCTAAAAATCAAACATCATGAACTTGTGAAACAGCAAGAACTGTTG ATTAAAGCGATACCAGAAACTCCTTCAAATGAAGAGGATATATCTATTTATAAAAAATTAGTTCCTGATG CCATTGACCTGATAAATGAAATACCAATAGAAAGTATACCAAATTTTGTTTTACCAAGTGGCCTTTCTTA TGACTCTTCGCCGGCCGATTTTTATTTGGTACTTCTCATTCTCATGCCAAAAGTTTCGGAAAAGAAGGAA CAATTTTCACAAGCGTTGGAAAAACTTCAAGAAATGCCTGCTCTGGGCAAACAAATACAACAACTAAGAA GTGGATACGATTTACCTATAACTATGGATGTACAACTTCCAAGTTTGCAAGAAGCTGAAGAAAGTAAAGA TTCATTGAATGAAGAGGATCCACTTAAAGAAGAGTTAAAAAGCCAGATTAAACTATGCCAATCTTATCTT GAAACAGCCAAGCAAATTGATTTGCTTATGAAAGATCATGGACAAACAACCAATGAAGCAAAAGCACTTA TTGAGCAATTACGTTTAATTTCAAATCAACCACTAAAGAACGAAGACATAAACTCTATTAAAGAAGATTT ATCTACTCTTGCCAATCAAATCCAATCCCTTGTGTCTGAATTAAATCAATTACCTTTGCCTAATCTGTCC GGTGAAAAAATTGATCCTCCATTGGAAAAACAGGAAATAGCAGTAGATAAAACAATCCCTCTTACTGTGG AATTGATGCACCCTGCCCAAGTAATTCAGATAGGCAATGATTCTCCCATAGAAAAACAGCAGCTAGACAA TGAGGAAGAAACGCCGGTTGTTCTGGAATCATTACGCCCCCGTCCAGTCATTCATAAGGAATCTGAATCT ATCACCCAAAAACTGCAAGTAGACAATGGACAAGAAATGCCGGTTGTTCTGGATTCAACATGCACTCCTC AAGCCATTCATAAGGAACTTGAATCTACCACTGAAAAACTGCAAGTAGACAATGGACACGAAATACCGGT TGTTCTCGAGTCAACACGCTCTCCTCAAATCATTCATACTGAGTCTGAATCTGTTGGTAAAAAACAGCAT GTAGAAGTAGAGCAAGAGATACCAGTCACACTGGAATTAATACGACCCTCTTCTATGGTTGAAAAGGATT CCGTGGCTACTGTAGAAAAACAGCAAGTAACTGAGAGACAGGAAACACCAATCGTCCTTGAATCAACACG ACTCTCTCCTATGGTTCAGAAAGACACTGGGCTTTCTGGCGAAAAGCAACATAAAGAGATAGAACAAGAA ATATCTGTCGTTACGGAATTAACACCCCACACCCAAGTGGTTCGGCAAGGCTCTGAGTCCAGTTTAGAAC AACAAGTACCCAACGGACAAGAAACACTGGCTGTTGTCAAATCAAGCCCATCGGAACCATTGAGACCATC AACCCCTGAAGTTCCAGCTATATCCAGGAAACCAAATGGCTTGTCATTATTTAATGGTCACGATGAATTA TCAGAAGATAATATTTTAGCCTTTTTTGATGAGGCTGGTAATCAAATTAGCATCTCATCTGAAGAAGATT CTGAGACGTTTACCGTAGACAGGGGAAAAGTAATTTCCTCAGGGATTGATAAAGCATTTAAAGAAAAGCC TGTTTCTACAGGCCATGAGTTAGATAAATTATCAAATCCTCAACACCAGGAATCTGCCCCTAGCATCTCC CCTTTACCACCATCTTCTATCCTGCTTAAGCAAAAATTAGATTCATTTCATGTACAAAACATGGAATATA TAAAGCAACATTCAGAAGAAATACAGCTATGGTATAAAGGTTTATATGATGCAGCGCAAAGTTCTTGTGT AAATGAGGCATTGGGTCTTAAAGCACTTCATCTTTTAAAAGACATCTTGTTTGAATTAAAAAATCAAAAT GATTTATCTGTATTACTAGCTTACAAGCGCATGTGCCCAAACCCATTGCAAGATATACAAAATATTCTCC GCTTAAAACCTGCTCTGCCTATAGTTGATGAATCGATTGATGAAGAACAGCAATTAAAGAATTGGCCTGA AGAATTGCAAAAATTTCATCAGCAATATGTAAAATTGAAAAAGGAACATCCATTGGAAGCTGAATTATTT ATTCAGGCAATCCATTCACTTATTTCAATTAAACATTTGATGGAACTCCCTGATGCAAAAACTTCAAACC GAGAAGCCATGCCTCTCATTACTCAAGATCCCCGATATGAACCTTTAAAACGGCATAGAGGATTTATAAG AGCATGGGAATATATTGAAGATTTTTTCCGAATGTTAATAGGTAAGTTAACAGGGCAAGATGAATATGAG TATTCAAAAAGGCCTTGTTTTTTCAAAACAAGATCTCACCGATTACTTGAAGAGGTTGACACAATACTCC ACTCCATGGCTCCAACAAGTAGTTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Chen J; de Felipe KS; Clarke M; Lu H; Anderson OR; Segal G; Shuman HA (2004). Legionella effectors that promote nonlytic release from protozoa. Science. 303(5662):1358-61. [PudMed:14988561]
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| experimental literature |
| in silico analysis literature |