| Effector Protein ID: 52842809 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2603 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2937032..2938336 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | Lem28 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Binding to PtdIns(4)P |
| UniProt ID | Q5ZSB6 |
| KEGG ID | lpn:lpg2603 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 434 a.a. [Download] |
| >gi|52842809|ref|YP_096608.1| hypothetical protein lpg2603 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MYSDFFFTIMLKYSTNMLELAMPKINKIVNGTDLTPHYLSEPNKEFKIYRYNNEVYAVRFENDEPMDYVL MWKSHKSEHTQNSEMIKNTEEDYKELGKGEQGTVYEKTEDKAMKVSRGRHPREFYEEINLHIIEQQFFLK YHGIQEHFVLGLWNIKNEENVYFYMPKINAIPINKKIDQPKIEEFVLALKELNDAGYWHPDLANNPYHIS PQNLIATEEMVKTIDLDGGFRYDKGRVDELSRKSLVYGKDQWLYVYNFIYPPTDEEDHRIDWRVPIEKWY ENNRDESLSDNPHTLLRFYHEGLISLPKKLAHDLHETILEELSQDKKFKKHSHEVGVNRFFSPKKQEIYE GLKGDGLKKVILKELRDSLAEIRTMEQLEEKKLEFLASPEMQILAEGQDKTTKALNLKTSSRKKVMVIFK EAEERILNSPNVSI |
| - |
| Nucleotide Sequence: 1305 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2937032-2938336 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGTATTCTGATTTTTTTTTCACTATAATGCTCAAATATTCAACTAATATGTTAGAGCTTGCTATGCCTA AAATAAATAAAATTGTTAATGGAACAGACCTAACCCCCCATTATCTGAGTGAGCCAAACAAAGAATTTAA AATCTATCGTTATAATAACGAAGTTTATGCTGTTCGTTTTGAGAATGATGAACCCATGGATTATGTTTTA ATGTGGAAAAGTCACAAGAGTGAGCATACGCAGAACAGTGAAATGATTAAAAATACTGAAGAGGATTATA AGGAGCTTGGAAAAGGAGAACAAGGAACGGTATATGAGAAAACAGAAGATAAGGCTATGAAAGTATCTCG AGGCAGACATCCAAGAGAATTTTATGAAGAAATTAACCTCCATATTATAGAACAGCAATTTTTCCTTAAA TATCATGGCATTCAAGAACACTTTGTTCTAGGACTCTGGAATATCAAAAATGAAGAAAACGTGTATTTCT ACATGCCTAAAATCAATGCGATCCCTATTAATAAAAAAATCGACCAGCCCAAAATTGAGGAATTTGTTCT TGCGCTTAAAGAACTTAATGATGCAGGGTACTGGCATCCTGATTTGGCAAATAATCCTTATCATATTAGT CCACAAAATCTGATTGCAACAGAAGAAATGGTAAAGACTATTGATCTTGATGGTGGCTTTCGGTACGACA AGGGAAGAGTTGATGAACTCAGCAGGAAGTCTCTTGTTTATGGTAAAGATCAATGGCTATATGTCTATAA TTTCATCTATCCACCCACCGATGAGGAGGATCACAGAATTGATTGGAGAGTCCCTATAGAGAAATGGTAT GAAAATAACAGAGACGAATCTTTATCGGATAATCCCCATACGTTGCTTCGATTTTACCATGAGGGACTTA TATCATTGCCAAAAAAACTTGCTCATGATCTGCATGAGACAATATTAGAAGAGTTATCTCAGGATAAAAA ATTTAAAAAACATTCGCATGAGGTAGGGGTGAATCGCTTTTTTAGCCCGAAAAAACAAGAAATCTATGAG GGTTTAAAGGGTGATGGGCTAAAAAAAGTGATCCTGAAAGAACTTAGAGATTCGTTGGCTGAGATAAGAA CAATGGAGCAATTGGAGGAAAAAAAACTGGAGTTTTTAGCTTCCCCAGAAATGCAAATTCTTGCTGAAGG TCAGGATAAGACAACAAAAGCACTGAACTTAAAAACCAGTTCTCGTAAAAAGGTGATGGTAATATTTAAA GAAGCAGAAGAGCGAATACTGAATAGCCCTAATGTAAGCATTTAG |
| Reference |
(1) Hubber A et al. (2014). The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins. PLoS Pathog. 10(7):e1004222. [PudMed:24992562] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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| experimental literature |
| in silico analysis literature |