| Effector Protein ID: 52842794 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legS1 |
| Locus tag | lpg2588 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2919924..2921081 [-] |
| Product | acid sphingomyelinase-like phosphodiesterase |
| Effector type | Protein |
| Descripton | LegS1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZSD1 |
| KEGG ID | lpn:lpg2588 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Metallophos_2 [PF12850], Evalue: 8.1e-08, Aligned region: 23..266 |
| Protein Sequence: 385 a.a. [Download] |
| >gi|52842794|ref|YP_096593.1| acid sphingomyelinase-like phosphodiesterase [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MNFSIRVILLLTGFVSLAFSAPKFLTISDIHYGAENIAKDGQDTGKEFLDVTFKRFEELSQNVDFILHLG DLPTHSLFSIPKKEEYEQVVFHGLHEANPGQKPMFYITGNNDSLLGNYQPFSSDNKSPLNLALDWDGACA YCDGLIIDDTHMRKDGYYSSYVIPNNKEIILIALNSVQWTKTPVFLPKYPNQQRDAFVQLFWLEQQLKNH RAKQLLLAMHVPPGTAYNGNRFWHDIYLDRFLTLLDKYHQSYDQITILFSHSHMEEFRKIRLSDGSTIYA FSTPGISRAHHNNPGMKIFDLDKQMRVRNSTTYYTSDLYEWGNEYYQAMNTPDAIFPNCQNKTIPQCLDT LSPEQVCNNLEVGLFYGVKSTRVPYQGCIKTYQIN |
| - |
| Nucleotide Sequence: 1158 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2921081-2919924 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGAATTTTAGTATTCGAGTAATTCTTTTGTTAACAGGTTTTGTTTCTTTAGCCTTTTCTGCACCAAAAT TTCTAACAATCTCTGATATTCATTATGGTGCAGAAAATATAGCAAAGGATGGGCAGGATACTGGAAAGGA GTTTTTGGATGTCACGTTCAAACGATTTGAGGAATTGTCTCAAAATGTAGATTTTATTTTACATTTGGGT GATCTGCCTACTCACTCGTTATTTTCGATACCTAAAAAAGAAGAATACGAACAAGTTGTATTTCATGGTT TGCATGAAGCGAATCCGGGTCAAAAGCCCATGTTTTATATTACAGGAAATAATGATTCCTTGCTTGGCAA TTACCAGCCATTTTCTTCAGACAATAAGTCGCCACTCAATTTGGCTCTGGATTGGGATGGTGCTTGTGCT TATTGTGATGGGTTAATTATTGATGATACTCATATGCGCAAGGATGGCTATTACTCCAGTTATGTCATCC CCAATAATAAAGAGATTATTTTAATAGCACTTAATTCGGTTCAATGGACCAAGACCCCTGTTTTTTTACC AAAGTACCCTAATCAACAAAGGGATGCCTTTGTACAATTATTTTGGCTTGAACAACAATTAAAAAATCAT CGTGCAAAGCAATTGTTGTTGGCGATGCATGTTCCTCCTGGTACAGCCTATAACGGCAACCGGTTTTGGC ATGACATTTATCTGGATAGATTTTTGACGTTATTAGACAAATATCATCAATCCTATGATCAAATCACCAT ACTGTTCTCACACTCCCATATGGAGGAATTCAGGAAAATCAGATTATCCGATGGCTCAACTATTTATGCG TTTTCTACTCCCGGAATTAGCAGGGCGCATCACAACAATCCCGGGATGAAAATTTTTGATTTAGACAAGC AAATGAGGGTCAGAAATTCTACTACTTATTATACGTCCGATTTGTATGAGTGGGGTAATGAGTATTATCA AGCCATGAATACTCCTGACGCCATTTTTCCAAATTGTCAAAATAAAACGATACCCCAGTGCCTGGACACC TTAAGTCCAGAGCAAGTATGCAATAATCTGGAAGTGGGACTATTTTATGGGGTGAAAAGTACGCGTGTTC CCTATCAGGGATGCATTAAAACTTACCAGATTAATTAA |
| Reference |
(1) Gomez-Valero L et al. (2014). Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease. Genome Biol. 15(11):505. [PudMed:25370836] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |