| Effector Protein ID: 52842790 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | sidF |
| Locus tag | lpg2584 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2913345..2916083 [+] |
| Product | inhibitor of growth protein SidF |
| Effector type | Protein |
| Descripton | SidF |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Antiapoptosis |
| UniProt ID | Q5ZSD5 |
| KEGG ID | lpn:lpg2584 |
| PDB ID | 4FYG, 4FYF, 4FYE |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 912 a.a. [Download] |
| >gi|52842790|ref|YP_096589.1| inhibitor of growth protein SidF [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MPRITENIETYVTHLLSDLEPVPSQNQHLAYGYPGERQVFKDPMLDGKQVVVVNSQYDKHGRPVTGQPDV IQEANNYIDNLVAAAKSLIDKDKKGEKDLRKNAIDEMAKTFKKSISETIPSDKAKADLFSSKKSSANKDF LEQLAKVEGSLQQFTQAVAKASGHKLKALDKEGHNIRSHNRDTLIHRFKAPNSKEGEEQFIMYIPCGRYT KRQQRLMGKDESEVNRDHDTTSHKRSDLVLGNSSMARMIAGTRHSDGTVTIHHDSFSGPGARMPYSDFKG ADDYKKLAIKAVTLINQEEVIQTLAQRQIDRMTNEDLWNKIPEEYRPDELPPDAEKARAQLIKLYVEHNP LSVTECYTQVVTAGQRVAAENQKEQFEYVRQMMDAFDGSKAKITIQTGSNTEVETAVGYQARMSSWGVNW FRQVGALNPLSDNSVTKNQNARFVNQMTDDVIRNLDKVAQNLGDYDKAGALHTLLKGPDVSDLNQQITEK ENALKEVKGAYREALFSYFEEYQKGEGKWDQAKLDQLKNQVDGYEKSIKKQESAIYELHNQIDALRKAYY TEHKGQINKALQELKEQISPVIQNKETDPETKSRLQHFYNSCAYLTQAQELYYENTWHHGKNNFKLQTLM ASLSCELDYANTKGCKSNNDRGQRLAQKIVGNALWTAMSEDGLYTGEFLDHRRTHGKEVSNVEQLDRELT TIQALHHTANTGVSGGKFEIQDKANFADNGLFGKVANFAKIKEMGPENAFTKNMGTKIKAGLGLGLLAAG GFVALTLLFPPAGLAVAALGIGVAAGAAIVAGVTFAATYLFGTAIDAINNKIEEGKIKSIVREGMKAASE NSPQHKTEQKDHLTVNAKLHQQLGVTRESVLERQSTPKQEFEKPKDMTSKVDLTAAMEDDNRSESTPTPV NF |
| - |
| Nucleotide Sequence: 2739 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2913345-2916083 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGCCACGAATCACTGAAAATATAGAAACCTATGTCACGCATTTATTAAGTGATCTGGAACCCGTTCCTT CTCAAAATCAGCATCTTGCCTACGGTTATCCCGGCGAAAGACAGGTATTCAAAGACCCGATGCTGGATGG GAAACAAGTCGTGGTGGTGAACAGTCAATATGATAAACATGGCAGACCTGTTACAGGGCAGCCTGATGTG ATCCAAGAGGCGAATAATTATATAGACAATCTTGTAGCCGCTGCCAAATCTCTGATAGACAAAGATAAGA AAGGTGAGAAGGATTTGAGAAAAAATGCCATTGATGAAATGGCAAAAACTTTCAAAAAGTCCATTTCAGA AACCATTCCTTCCGACAAAGCAAAAGCGGATTTGTTTTCAAGTAAAAAAAGCTCTGCCAATAAAGACTTT CTGGAACAGTTGGCCAAAGTCGAAGGCAGTTTACAGCAATTCACACAGGCTGTCGCAAAAGCCTCAGGTC ATAAATTAAAAGCACTGGATAAAGAAGGGCATAATATTCGCAGTCATAATCGCGATACCTTGATACATCG CTTTAAAGCGCCCAACTCTAAAGAAGGCGAAGAACAATTTATTATGTACATTCCGTGTGGAAGGTACACC AAACGCCAACAAAGACTAATGGGCAAGGATGAATCTGAAGTCAACAGAGATCACGACACTACAAGTCATA AACGTTCTGACCTGGTTCTGGGCAACAGCAGTATGGCGCGCATGATTGCCGGGACAAGACATTCTGATGG CACCGTGACTATTCACCATGACAGTTTTTCTGGTCCTGGTGCACGCATGCCCTATTCTGATTTTAAGGGT GCTGATGACTATAAAAAGCTGGCTATCAAAGCGGTCACCTTAATCAACCAGGAAGAAGTCATCCAAACCC TGGCACAGCGTCAAATTGACCGAATGACCAATGAAGACCTTTGGAATAAAATTCCTGAAGAGTACCGCCC TGATGAGCTTCCTCCTGATGCGGAGAAAGCACGAGCGCAATTAATAAAGCTGTATGTAGAACATAATCCA TTATCTGTCACGGAATGTTATACACAAGTTGTAACAGCCGGACAAAGGGTAGCGGCCGAAAATCAAAAAG AACAATTTGAATACGTACGGCAAATGATGGATGCTTTTGATGGCTCCAAAGCAAAAATCACCATTCAAAC CGGCTCCAATACAGAAGTGGAAACAGCGGTTGGTTATCAGGCGCGTATGAGTTCCTGGGGAGTGAATTGG TTTAGACAGGTTGGAGCGCTCAATCCGCTCTCTGACAATAGTGTCACAAAAAATCAAAATGCGCGTTTTG TAAATCAAATGACTGATGACGTCATCAGAAATTTAGACAAAGTGGCACAAAACCTGGGTGATTATGACAA AGCAGGCGCATTACACACATTATTAAAAGGCCCAGACGTCAGCGACCTTAATCAACAAATCACTGAGAAA GAAAATGCCTTAAAAGAGGTGAAAGGAGCCTATCGAGAAGCATTATTCAGCTATTTCGAAGAATATCAGA AAGGCGAAGGGAAATGGGATCAAGCCAAACTGGATCAATTGAAAAATCAGGTTGATGGCTATGAAAAAAG CATTAAAAAACAAGAATCAGCCATTTATGAACTACATAATCAAATCGATGCCTTAAGAAAGGCTTATTAC ACAGAACACAAAGGGCAAATCAATAAGGCTTTACAAGAACTTAAAGAACAAATAAGCCCTGTAATCCAGA ATAAAGAAACAGATCCTGAAACCAAATCCAGACTGCAGCACTTTTACAATTCATGTGCTTACCTCACGCA AGCTCAAGAGCTCTATTATGAGAACACCTGGCATCATGGCAAAAATAATTTCAAGCTGCAAACCTTAATG GCTTCTCTCTCCTGCGAGCTGGATTACGCCAATACGAAAGGATGTAAGAGTAATAATGATCGTGGCCAAA GATTGGCGCAAAAAATTGTTGGGAATGCTTTATGGACAGCAATGAGTGAGGACGGGTTATACACTGGTGA ATTTCTGGATCATCGAAGGACACATGGTAAAGAAGTCAGTAATGTAGAACAACTTGATCGGGAACTTACT ACTATACAGGCCCTTCATCATACTGCCAATACGGGTGTTTCCGGCGGAAAGTTTGAAATTCAGGATAAAG CCAATTTCGCTGATAATGGCCTTTTTGGCAAGGTCGCTAATTTTGCCAAAATAAAAGAAATGGGGCCTGA AAACGCTTTTACCAAAAATATGGGTACAAAAATTAAAGCAGGTCTCGGGCTTGGGTTACTAGCAGCTGGT GGATTTGTCGCCCTTACTTTGCTATTCCCTCCGGCAGGCTTGGCTGTGGCCGCCTTGGGAATTGGTGTGG CAGCCGGTGCTGCCATTGTTGCTGGCGTTACTTTTGCGGCCACTTATCTTTTTGGTACCGCTATTGATGC TATTAATAACAAGATAGAAGAAGGAAAGATTAAATCCATTGTTCGCGAGGGTATGAAAGCGGCATCAGAA AATTCACCACAACACAAAACCGAACAAAAGGATCATTTAACGGTGAATGCCAAACTTCATCAACAATTAG GTGTGACGCGAGAGTCTGTCTTGGAAAGACAATCCACTCCAAAACAAGAGTTTGAAAAACCCAAAGATAT GACCTCGAAAGTTGACTTAACAGCAGCGATGGAGGATGATAATCGAAGCGAAAGCACCCCCACGCCAGTA AACTTCTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
|
(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
|
| experimental literature |
| in silico analysis literature |