| Effector Protein ID: 52842760 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2552 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2884137..2885804 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LecE |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LecE is found to activate the yeast lipin homolog (Pah1) which converts PA to DAG.It is found to be localized to the LCV during infection thus the combined lipid biosynthetic reactions that might occur on the LCV will include conversion of PC into PA (by LpdA) and then conversion of PA to DAG (by LecE activated PA phosphatase) a process which is expected to result in changes of the lipid composition of the LCV that can affect its fate in the host cell as well as the host proteins and bacterial effectors that will be recruited to the LCV. |
| UniProt ID | Q5ZSG5 |
| KEGG ID | lpn:lpg2552 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 555 a.a. [Download] |
| >gi|52842760|ref|YP_096559.1| hypothetical protein lpg2552 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MKEIVSLLEQDQIDFANHKRPEVIMVLRRKFRTQKDWIITSFNQYQFTKEESQKVQQAILNGDLRITDLL NRPFSHYFWSFLTFKWGEILSGGKRLSKQEVLQIASCSSNGQEFARTPTQNRNRLIKGVPLVIGKVVTSM ALCMVFCLGLLSTLGAPFGLSLGLAIILSLCNGIVCLLSRGKAMLDSAGFQPQKQKTFKTLEENIKEKTI FDRGQKLFFGVVTLLACISAGISGYAGLVGLLTFLGAGMLISNPLVLILTIGLSVVAAVSFYSFQAIGIR ENYTKFKNLFIEDYQKPYGLLRCVLLGMVSTVFLAVYATLTWFTTVSGVNKLFNALGATPDTLLAHFIAM ICTSTTMVVNTFSQVYKVFNPKTYVDLKEKFESIYQPPEENLTRAQKIKHGAINMLKLFALIGDSLAYSV AGGIRSGIHIGETLGETIGAKFALTITMAILSPVILVFVSIAFTWPTVFDRKKSTPCPSEMDKPLIEKMS HSHTSDVLQNNTLLPTSEKLSKPDDSNIRQAGLRFFDVGLSEERTHKPNSNPTLESRAVLTSPSP |
| - |
| Nucleotide Sequence: 1668 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2885804-2884137 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAAAGAAATAGTTAGTTTATTAGAACAAGATCAAATCGACTTTGCTAATCATAAACGTCCCGAAGTGA TAATGGTTTTAAGAAGAAAATTTCGTACTCAAAAAGATTGGATTATTACCTCTTTCAACCAATATCAATT TACTAAAGAAGAATCGCAAAAAGTTCAACAAGCCATTCTAAACGGGGATCTTCGCATAACAGATCTTCTT AATCGTCCTTTTTCTCACTATTTTTGGAGTTTCCTTACCTTTAAGTGGGGAGAGATACTTTCAGGTGGAA AAAGATTATCTAAGCAGGAAGTCTTACAGATTGCTAGCTGCTCTAGCAATGGCCAGGAATTTGCGAGAAC ACCGACTCAAAATAGAAACAGGCTGATAAAAGGAGTGCCATTGGTCATTGGCAAAGTCGTTACCTCCATG GCGCTGTGTATGGTATTTTGCCTGGGATTATTAAGTACTTTAGGAGCGCCTTTTGGCCTTAGCCTCGGTT TGGCGATAATACTTTCCTTATGTAATGGAATAGTTTGCTTATTAAGCCGCGGAAAAGCCATGCTTGATAG TGCCGGCTTTCAGCCTCAAAAACAAAAAACGTTTAAGACCCTTGAAGAAAATATAAAAGAAAAAACGATA TTCGATAGAGGCCAGAAATTATTTTTTGGTGTAGTGACCTTGTTAGCGTGCATTTCTGCGGGCATCTCTG GATATGCTGGTCTCGTAGGACTTCTCACGTTTTTGGGGGCGGGCATGCTAATCTCTAACCCTCTGGTTTT GATACTTACAATTGGGCTGTCTGTGGTTGCAGCGGTCTCTTTTTATTCGTTTCAAGCTATCGGCATACGT GAAAATTATACAAAATTTAAAAATCTTTTTATTGAAGATTACCAAAAACCCTATGGTCTTTTGCGATGTG TTTTATTAGGAATGGTAAGTACGGTCTTTTTGGCTGTTTATGCGACGCTAACTTGGTTTACAACGGTTTC AGGGGTTAATAAGCTTTTCAATGCCTTAGGTGCGACTCCTGATACCCTTTTAGCACACTTTATTGCCATG ATATGTACTTCAACAACGATGGTTGTCAATACTTTTTCACAAGTATATAAAGTCTTTAACCCGAAAACGT ATGTCGATCTAAAAGAAAAATTTGAATCAATATACCAACCACCGGAAGAAAACCTAACAAGAGCGCAAAA GATAAAGCACGGAGCTATCAACATGCTCAAATTGTTTGCATTGATAGGTGATTCTCTTGCTTATTCTGTT GCTGGTGGAATCCGAAGCGGGATTCATATTGGTGAAACGCTGGGAGAAACAATAGGGGCAAAATTTGCAT TAACCATTACCATGGCAATATTGTCTCCGGTCATTTTAGTATTTGTATCGATAGCTTTTACCTGGCCCAC CGTTTTTGATAGGAAAAAATCGACTCCATGTCCTTCAGAGATGGACAAGCCATTGATAGAGAAAATGAGT CACAGCCATACTTCAGATGTGCTGCAAAATAATACTCTATTACCAACATCAGAAAAATTATCCAAACCTG ATGATTCAAATATCAGGCAAGCTGGGCTAAGATTTTTTGATGTGGGCTTGAGCGAAGAGCGTACTCATAA GCCCAATTCTAACCCTACTTTAGAGAGCAGGGCTGTTTTGACATCCCCCTCGCCATAA |
| Reference |
(1) Viner R et al. (2012). Identification of two Legionella pneumophila effectors that manipulate host phospholipids biosynthesis. PLoS Pathog. 8(11):e1002988. [PudMed:23133385] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |