SecReT4
Effector Protein ID: 52842735
T4SS name [ID]Dot/Icm [5]
Gene symbol-
Locus taglpg2527
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]2856264..2857940 [-]
Producthypothetical protein
Effector typeProtein
DescriptonLnaB
T4CP requirementT4CP Depedent
Target/EffectionLnaB is a activator of NF-kappaB (Losick, et al. 2010)
UniProt IDQ5ZSJ0
KEGG IDlpn:lpg2527
PDB IDNA
Domain hit(s) vs Pfam NA
Protein Sequence: 558 a.a.     [Download]
>gi|52842735|ref|YP_096534.1| hypothetical protein lpg2527 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MLYFVLCDLKFNQFSRYPMSYQKIELSISLSLDSPKLDESDFILLSVKYLEKSLGKKKEFSGFFEDIEKL
YFKQNYKEAIEKILDFCKKNESLLSEQVVQRLAEVAPRLKSNPKDNESRRLYETLYADHLESVIKQESDL
SVFNELRDSYNAVKPEYAVTHETEIKTLDEAKQFILSFVMLNDNVELPLKAQSERYPKKDRSREELGNTP
SANPGIMKPNSPNFTDNLVPVRDVPKIAINEKVAGGYSKTKPTTPFVASLSGTTYSLMVVLTDYIEKHKT
DKDIEKKVNQIINLWISSYIKEGYHSYSEVVDVLTEPFLQSIFDKANIKLNYGVLDDTHAEFRKAQDYVF
GLTIQSAMHHELQERFKNKEKLQEEVKNFESGLNKLNQNVENTGRHREALNKLNEVFQDWSAGKKSYDAF
KSESNQLIHDIESEEQKSNRGLGSMLKNLGNYLLYLITLRFLKEDYPKPSSPVTMLVTELRGTLEQIDHF
HKTSLSLKKATQPDPKNTSSSDETADVRKSAVDTDKPSKNQDSEVKKTLDSEQLEEVQRQDDKSARLQ
-
Nucleotide Sequence: 1677 bp     [Download]
>gi|52840256|ref|NC_002942.5|:c2857940-2856264 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
TTGTTATATTTTGTACTATGTGATTTAAAATTTAATCAATTTAGCAGATATCCTATGTCATACCAAAAAA
TAGAACTCAGTATTTCATTATCATTAGATTCTCCAAAATTAGATGAGTCTGATTTTATATTGCTCTCAGT
TAAGTATCTTGAAAAGTCACTTGGCAAAAAGAAAGAGTTTTCTGGTTTTTTTGAAGACATAGAAAAGCTC
TATTTTAAGCAGAATTACAAGGAAGCAATTGAAAAAATATTGGATTTTTGTAAAAAAAATGAATCCTTGT
TAAGTGAGCAAGTTGTCCAGAGGCTGGCAGAGGTCGCTCCCAGATTAAAAAGCAATCCTAAAGACAATGA
AAGCAGAAGGCTTTATGAAACCTTGTATGCAGATCACCTTGAATCAGTCATTAAACAAGAGAGTGATCTT
TCCGTATTTAACGAATTGAGAGACAGTTATAATGCGGTGAAACCTGAGTATGCAGTAACTCATGAGACCG
AAATCAAAACTTTGGATGAAGCAAAGCAATTTATTTTATCTTTTGTCATGCTGAATGATAATGTTGAATT
ACCTTTAAAAGCACAATCAGAGAGATACCCAAAAAAGGACAGATCCAGAGAAGAGTTGGGGAATACTCCA
TCTGCGAATCCAGGGATTATGAAACCTAACTCACCTAATTTTACCGATAACCTGGTGCCTGTCAGAGATG
TGCCCAAAATAGCCATTAATGAGAAAGTGGCGGGTGGGTATTCAAAAACTAAGCCTACTACTCCTTTTGT
GGCGTCGCTGTCTGGCACAACCTACTCACTTATGGTGGTGTTAACGGACTATATTGAAAAGCATAAAACA
GATAAAGACATTGAAAAAAAAGTAAACCAGATTATTAATTTATGGATTTCCAGTTATATCAAGGAAGGTT
ATCACAGCTACAGTGAGGTTGTGGATGTTTTGACAGAGCCGTTTCTTCAATCCATTTTTGATAAAGCAAA
TATTAAATTAAATTATGGTGTACTTGACGACACGCATGCAGAATTTCGTAAAGCTCAGGATTATGTTTTT
GGTTTGACAATTCAATCAGCGATGCATCATGAGTTACAAGAGCGATTTAAGAATAAAGAAAAACTTCAGG
AAGAGGTAAAGAATTTTGAATCTGGGTTAAATAAACTCAACCAGAATGTCGAAAATACAGGTCGCCATCG
CGAGGCACTGAATAAATTAAACGAGGTATTTCAGGATTGGTCTGCGGGCAAAAAAAGCTATGATGCTTTT
AAAAGTGAGTCTAATCAGCTGATTCATGATATTGAGTCTGAAGAACAAAAAAGTAATCGTGGTCTTGGCT
CCATGCTGAAGAACCTCGGGAACTATCTTTTATACTTGATTACCCTTCGTTTTTTGAAAGAAGACTATCC
AAAACCGTCTAGTCCGGTCACAATGTTAGTCACTGAATTAAGAGGCACACTTGAGCAAATAGATCATTTT
CATAAAACCAGCCTTTCTTTAAAAAAAGCAACGCAGCCTGACCCTAAAAATACTTCATCATCTGATGAGA
CAGCAGATGTTCGCAAATCAGCTGTTGATACTGACAAGCCTAGTAAAAATCAAGACAGTGAAGTGAAAAA
GACACTAGATTCTGAGCAATTGGAAGAAGTTCAAAGGCAAGATGACAAAAGCGCTCGTTTACAATAG

Reference
(1) Elzbieta Brzuszkiewicz et al. (2013). Legionella oakridgensis ATCC 33761 genome sequence and phenotypic characterization reveals its replication capacity in amoebae. Int J Med Microbiol. 303(8):514-28. [PudMed:23932911] experimental
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(3) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602]
(4) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
(5) Kubori T; Hyakutake A; Nagai H (2008). Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions. Mol Microbiol. 67(6):1307-19. [PudMed:18284575] experimental
 
experimental experimental literature
in_silico in silico analysis literature