| Effector Protein ID: 52842735 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2527 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2856264..2857940 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LnaB |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LnaB is a activator of NF-kappaB (Losick, et al. 2010) |
| UniProt ID | Q5ZSJ0 |
| KEGG ID | lpn:lpg2527 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 558 a.a. [Download] |
| >gi|52842735|ref|YP_096534.1| hypothetical protein lpg2527 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MLYFVLCDLKFNQFSRYPMSYQKIELSISLSLDSPKLDESDFILLSVKYLEKSLGKKKEFSGFFEDIEKL YFKQNYKEAIEKILDFCKKNESLLSEQVVQRLAEVAPRLKSNPKDNESRRLYETLYADHLESVIKQESDL SVFNELRDSYNAVKPEYAVTHETEIKTLDEAKQFILSFVMLNDNVELPLKAQSERYPKKDRSREELGNTP SANPGIMKPNSPNFTDNLVPVRDVPKIAINEKVAGGYSKTKPTTPFVASLSGTTYSLMVVLTDYIEKHKT DKDIEKKVNQIINLWISSYIKEGYHSYSEVVDVLTEPFLQSIFDKANIKLNYGVLDDTHAEFRKAQDYVF GLTIQSAMHHELQERFKNKEKLQEEVKNFESGLNKLNQNVENTGRHREALNKLNEVFQDWSAGKKSYDAF KSESNQLIHDIESEEQKSNRGLGSMLKNLGNYLLYLITLRFLKEDYPKPSSPVTMLVTELRGTLEQIDHF HKTSLSLKKATQPDPKNTSSSDETADVRKSAVDTDKPSKNQDSEVKKTLDSEQLEEVQRQDDKSARLQ |
| - |
| Nucleotide Sequence: 1677 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2857940-2856264 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGTTATATTTTGTACTATGTGATTTAAAATTTAATCAATTTAGCAGATATCCTATGTCATACCAAAAAA TAGAACTCAGTATTTCATTATCATTAGATTCTCCAAAATTAGATGAGTCTGATTTTATATTGCTCTCAGT TAAGTATCTTGAAAAGTCACTTGGCAAAAAGAAAGAGTTTTCTGGTTTTTTTGAAGACATAGAAAAGCTC TATTTTAAGCAGAATTACAAGGAAGCAATTGAAAAAATATTGGATTTTTGTAAAAAAAATGAATCCTTGT TAAGTGAGCAAGTTGTCCAGAGGCTGGCAGAGGTCGCTCCCAGATTAAAAAGCAATCCTAAAGACAATGA AAGCAGAAGGCTTTATGAAACCTTGTATGCAGATCACCTTGAATCAGTCATTAAACAAGAGAGTGATCTT TCCGTATTTAACGAATTGAGAGACAGTTATAATGCGGTGAAACCTGAGTATGCAGTAACTCATGAGACCG AAATCAAAACTTTGGATGAAGCAAAGCAATTTATTTTATCTTTTGTCATGCTGAATGATAATGTTGAATT ACCTTTAAAAGCACAATCAGAGAGATACCCAAAAAAGGACAGATCCAGAGAAGAGTTGGGGAATACTCCA TCTGCGAATCCAGGGATTATGAAACCTAACTCACCTAATTTTACCGATAACCTGGTGCCTGTCAGAGATG TGCCCAAAATAGCCATTAATGAGAAAGTGGCGGGTGGGTATTCAAAAACTAAGCCTACTACTCCTTTTGT GGCGTCGCTGTCTGGCACAACCTACTCACTTATGGTGGTGTTAACGGACTATATTGAAAAGCATAAAACA GATAAAGACATTGAAAAAAAAGTAAACCAGATTATTAATTTATGGATTTCCAGTTATATCAAGGAAGGTT ATCACAGCTACAGTGAGGTTGTGGATGTTTTGACAGAGCCGTTTCTTCAATCCATTTTTGATAAAGCAAA TATTAAATTAAATTATGGTGTACTTGACGACACGCATGCAGAATTTCGTAAAGCTCAGGATTATGTTTTT GGTTTGACAATTCAATCAGCGATGCATCATGAGTTACAAGAGCGATTTAAGAATAAAGAAAAACTTCAGG AAGAGGTAAAGAATTTTGAATCTGGGTTAAATAAACTCAACCAGAATGTCGAAAATACAGGTCGCCATCG CGAGGCACTGAATAAATTAAACGAGGTATTTCAGGATTGGTCTGCGGGCAAAAAAAGCTATGATGCTTTT AAAAGTGAGTCTAATCAGCTGATTCATGATATTGAGTCTGAAGAACAAAAAAGTAATCGTGGTCTTGGCT CCATGCTGAAGAACCTCGGGAACTATCTTTTATACTTGATTACCCTTCGTTTTTTGAAAGAAGACTATCC AAAACCGTCTAGTCCGGTCACAATGTTAGTCACTGAATTAAGAGGCACACTTGAGCAAATAGATCATTTT CATAAAACCAGCCTTTCTTTAAAAAAAGCAACGCAGCCTGACCCTAAAAATACTTCATCATCTGATGAGA CAGCAGATGTTCGCAAATCAGCTGTTGATACTGACAAGCCTAGTAAAAATCAAGACAGTGAAGTGAAAAA GACACTAGATTCTGAGCAATTGGAAGAAGTTCAAAGGCAAGATGACAAAAGCGCTCGTTTACAATAG |
| Reference |
(1) Elzbieta Brzuszkiewicz et al. (2013). Legionella oakridgensis ATCC 33761 genome sequence and phenotypic characterization reveals its replication capacity in amoebae. Int J Med Microbiol. 303(8):514-28. [PudMed:23932911] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| (3) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
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(4) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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(5) Kubori T; Hyakutake A; Nagai H (2008). Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions. Mol Microbiol. 67(6):1307-19. [PudMed:18284575]
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| experimental literature |
| in silico analysis literature |