| Effector Protein ID: 52842719 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | sidC |
| Locus tag | lpg2511 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2834261..2837014 [+] |
| Product | protein SidC, interaptin |
| Effector type | Protein |
| Descripton | SidC |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole. (Ragaz et al, 2008) |
| UniProt ID | Q5ZSK6 |
| KEGG ID | lpn:lpg2511 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 917 a.a. [Download] |
| >gi|52842719|ref|YP_096518.1| protein SidC, interaptin [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MVINMVDVIKFKEPERCDYLYVDENNKVHILLPIVGGDEIGLDNTCQTAVELITFFYGSAHSGVTKYSAE HQLSEYKRQLEEDIKAINSQKKISPHAYDDLLKEKIERLQQIEKYIELIQVLKKQYDEQNDIRQLRTGGI PQLPSGVKEIIKSSENAFAVRLSPYDNDKFTRFDDPLFNVKRNISKYDTPSRQAPIPIYEGLGYRLRSTL FPEDKTPTPINKKSLRDKVKSTVLSHYKDEDRIDGEKKDEKLNELITNLQNELVKELVKSDPQYSKLSLS KDPRGKEINYDYLVNSLMLVDNDSEIGDWIDTILDATVDSTVWVAQASSPFYDGAKEISSDRDADKISIR VQYLLAEANIYCKTNKLSDANFGEFFDKEPHATEIAKRVKEGFTQGADIEPIIYDYINSNHAELGLKSPL TGKQQQEITDKFTKHYNTIKESPHFDEFFVADPDKKGNIFSHQGRISCHFLDFFTRQTKGKHPLGDLASH QEALQEGTSNRLHHKNEVVAQGYEKLDQFKKEVVKLLAENKPKELLDYLVATSPTGVPNYSMLSKETQNY IAYNRNWPAIQKELEKATSIPESQKQDLSRLLSRDNLQHDNLSAITWSKYSSKPLLDVELNKIAEGLELT AKIYNEKRGREWWFKGSRNEARKTQCEELQRVSKEINTLLQSESLTKSQVLEKVLNSIETLDKIDRDISA ESNWFQSTLQKEVRLFRDQLKDICQLDKYAFKSTKLDEIISLEMEEQFQKIQDPAVQQIVRDLPSHCHND EAIEFFKTLNPEEAAKVASYLSLEYREINKSTDKKTLLEQDIPRLFKEVNTQLLSKLKEEKAIDEQVHEK LSQLADKIAPEHFTRNNIIKWSTNPEKLEESNLNEPIKSVQSPTTKQTSKQFREAMGEITGRNEPPTDTL YTGIIKK |
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| Nucleotide Sequence: 2754 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2834261-2837014 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGGTGATAAACATGGTTGACGTAATCAAATTCAAAGAGCCGGAACGTTGTGATTATCTATATGTTGATG AAAACAACAAAGTTCATATCCTTTTACCGATTGTAGGAGGAGATGAAATAGGCCTGGATAATACCTGTCA AACAGCAGTTGAGTTGATCACATTTTTCTATGGTAGTGCGCACAGTGGTGTGACTAAATATTCTGCTGAA CACCAACTCAGTGAATACAAAAGGCAATTGGAAGAAGACATCAAAGCCATCAATAGTCAAAAGAAAATTT CACCTCATGCTTATGACGATTTATTAAAAGAGAAAATAGAACGCTTACAGCAAATTGAAAAATACATTGA ATTAATTCAAGTACTAAAAAAACAATATGATGAACAAAATGATATCAGGCAACTTCGTACTGGAGGGATT CCGCAATTACCCTCTGGGGTAAAGGAAATCATTAAATCCTCTGAAAATGCTTTCGCTGTGAGACTTTCTC CATATGACAACGATAAATTCACTCGCTTTGATGACCCTTTATTCAATGTCAAAAGAAACATCTCAAAATA TGACACGCCCTCAAGACAAGCTCCTATTCCAATATACGAGGGATTAGGTTATCGCCTGCGTTCAACACTG TTCCCGGAAGATAAAACACCAACTCCAATTAATAAAAAATCACTTAGGGATAAAGTTAAAAGCACTGTTC TTAGTCATTATAAAGATGAAGATAGAATTGATGGAGAAAAAAAAGATGAAAAATTAAACGAACTAATTAC TAATCTTCAAAACGAACTTGTAAAAGAGTTAGTAAAAAGTGATCCTCAATATTCGAAACTATCTTTATCT AAAGATCCAAGAGGAAAAGAAATAAATTACGATTATTTAGTAAATAGTTTGATGCTTGTAGATAACGACT CTGAAATTGGTGATTGGATTGATACTATTCTCGACGCTACAGTAGATTCCACTGTCTGGGTAGCTCAGGC ATCCAGCCCTTTCTATGATGGTGCTAAAGAAATATCATCAGACCGCGATGCGGACAAGATATCCATCAGA GTTCAGTACCTGTTGGCCGAAGCCAATATTTACTGTAAAACAAACAAATTATCGGATGCTAACTTTGGAG AATTTTTCGACAAAGAGCCTCATGCTACTGAAATTGCGAAAAGAGTAAAGGAAGGATTTACGCAAGGTGC AGATATAGAACCAATTATATACGACTATATTAACAGCAACCATGCCGAGCTGGGATTAAAATCTCCGTTA ACCGGCAAACAACAACAAGAAATCACTGATAAATTTACAAAACATTATAATACGATTAAAGAATCTCCAC ATTTTGATGAGTTTTTTGTCGCTGATCCGGATAAAAAAGGCAATATCTTTTCTCATCAAGGCAGAATCAG TTGTCATTTTCTGGATTTCTTTACTCGACAAACCAAAGGCAAACATCCTCTTGGTGATCTTGCAAGTCAT CAGGAAGCTCTCCAGGAAGGAACCTCCAATCGCTTACATCACAAGAATGAGGTAGTAGCCCAGGGGTACG AAAAACTGGATCAATTCAAGAAAGAGGTTGTCAAACTGCTGGCTGAGAATAAACCAAAAGAATTATTGGA TTATTTGGTTGCTACCTCACCTACAGGTGTTCCAAATTACTCCATGCTTTCGAAGGAAACTCAAAATTAC ATTGCTTATAATCGTAACTGGCCAGCCATTCAAAAAGAGCTGGAAAAGGCTACCAGCATCCCGGAGAGTC AAAAACAAGATCTTTCAAGATTGCTTTCTCGTGATAATTTACAACACGATAATCTAAGCGCAATTACCTG GTCAAAATATTCCTCCAAGCCATTATTGGATGTGGAATTAAATAAAATCGCTGAAGGATTAGAACTCACT GCAAAAATTTACAATGAAAAGAGAGGACGCGAATGGTGGTTTAAAGGTTCAAGAAATGAAGCTCGTAAGA CCCAATGTGAAGAATTGCAAAGAGTATCCAAAGAAATCAATACTCTTCTGCAAAGTGAATCTTTAACGAA AAGCCAGGTACTTGAAAAGGTTTTAAATTCTATAGAAACATTAGATAAAATTGACAGAGACATTTCTGCC GAATCCAATTGGTTTCAAAGTACTCTGCAAAAGGAAGTCAGGTTATTTCGAGATCAATTGAAAGATATTT GCCAATTGGACAAGTATGCCTTTAAATCAACAAAACTTGATGAAATCATCTCTCTGGAAATGGAAGAACA ATTTCAAAAGATACAAGATCCTGCTGTTCAACAAATTGTCAGGGACTTGCCTTCTCATTGCCACAATGAT GAAGCAATTGAATTCTTTAAGACATTGAACCCTGAAGAGGCAGCAAAAGTAGCTAGCTATTTAAGCCTGG AATACAGGGAAATTAATAAATCAACCGATAAGAAAACTCTCCTAGAACAAGATATTCCCAGACTGTTTAA AGAAGTCAATACGCAGTTACTCTCCAAACTCAAAGAAGAAAAAGCTATTGATGAGCAAGTTCATGAAAAA CTCAGTCAACTGGCTGACAAAATTGCCCCTGAGCATTTTACAAGAAATAACATTATAAAATGGTCTACCA ACCCTGAAAAGCTTGAGGAATCAAATCTTAATGAGCCAATCAAATCAGTCCAAAGCCCTACTACTAAACA AACATCAAAACAATTCAGGGAAGCGATGGGTGAAATCACTGGAAGAAATGAGCCTCCTACAGACACTTTG TACACGGGAATTATAAAGAAATAG |
| Reference |
(1) Harding CR; Schroeder GN; Reynolds S; Kosta A; Collins JW; Mousnier A; Frankel G (2012). Legionella pneumophila pathogenesis in the Galleria mellonella infection model. Infect Immun. . [PudMed:22645286] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Xu L; Shen X; Bryan A; Banga S; Swanson MS; Luo ZQ (2010). Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector. PLoS Pathog. 6(3):e1000822. [PudMed:20333253]
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(4) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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(5) Brombacher E; Urwyler S; Ragaz C; Weber SS; Kami K; Overduin M; Hilbi H (2009). Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila. J Biol Chem. 284(8):4846-56. [PudMed:19095644]
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(6) Urwyler S; Nyfeler Y; Ragaz C; Lee H; Mueller LN; Aebersold R; Hilbi H (2009). Proteome analysis of Legionella vacuoles purified by magnetic immunoseparation reveals secretory and endosomal GTPases. Traffic. 10(1):76-87. [PudMed:18980612]
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(7) Tiaden A; Spirig T; Carranza P; Bruggemann H; Riedel K; Eberl L; Buchrieser C; Hilbi H (2008). Synergistic contribution of the Legionella pneumophila lqs genes to pathogen-host interactions. J Bacteriol. 190(22):7532-47. [PudMed:18805977]
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(8) Ragaz C; Pietsch H; Urwyler S; Tiaden A; Weber SS; Hilbi H (2008). The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole. Cell Microbiol. 10(12):2416-33. [PudMed:18673369]
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| experimental literature |
| in silico analysis literature |