| Effector Protein ID: 52842718 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2510 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2831384..2834110 [+] |
| Product | protein SdcA |
| Effector type | Protein |
| Descripton | SdcA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | A paralog of sidC which is important for Legionella-containing vacuole recruitment of endoplasmic reticulum -derived vesicles |
| UniProt ID | Q5ZSK7 |
| KEGG ID | lpn:lpg2510 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 908 a.a. [Download] |
| >gi|52842718|ref|YP_096517.1| protein SdcA [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MMNMVDKIKFKEPERCEYLHIAKDNKVHILLPIVGGDEIGLDNTCETTGELLTFFYGKTHGGTKYSAEHH LNEYKKNLEDDIKAIGVQRKISPNAYEDLLKEKKERLEQIEKYIDLIKVLKEKFDEQREIDKLRTEGIPQ LPSGVKEVIKSSENAFALRLSPDRPDSFTRFDDPLFSLKRNRSQYEAGGYQRATDGLGARLRSELLPPDK DTPIVFNKKSLKDKIVDSVLVQLDKDFNTKDGDRGQKFEDIKKLVLEEYKKIDSELQVDEDTYHQPLNLD YLENIACTLDDNSTAKDWVYGIIGATTEADYWPKKESESGTEKVSVFYEKQKEIKFESDTNTMSIKVQYL LAEINFYCKTNKLSDANFGEFFDKEPHATEVAKRVKEGLVQGAEIEPIIYNYINSHHAELGLTSELSSKQ QEEITEKFTQRYHIIENSPHFDEFFVADPDKKGNIFSHQGRMSCHFLDFFARQTKGKYPLGDLAGHQEAL QAGTSNRLHHKNEVVAQGYEKFDQFKKEVVKLLAESKPKELLDYLVATSPTGVPNYSMLSKETQNYIAYN RNWPAIQKELEKTTDIPENQKQDLLRLLSRNNLQHENLSAITWSKYSSKPLLDVELNKIAEGLDLTAKIY NEKRKSEWFKGSRNEARKTQCEELQRVSQEINALLQSESLTKSQVLEKVLNSIEALDKIDRDISAEYNLF KSTLQKEVQSFRDQLKDICQLDNYAFKSTKLDEIISLEMEEQFQMIKDPAVQQIVRDLPSHCHNNEVIEF FMTLNPEEAAKVASYLSLEYRELNKSTDKKTLLEQDIPKLFKEVNMELLSQLKQDSAVKEDVYEKFCQLA DKIPPEHFTRNNIRKWSANPEKLEESNLGELLKSSEGSITEMARKYRETINEMTGRNESLRETVRNTI |
| - |
| Nucleotide Sequence: 2727 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2831384-2834110 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome GTGATGAACATGGTTGACAAAATAAAATTCAAAGAGCCGGAGCGATGCGAATATTTACATATCGCTAAGG ATAATAAAGTCCATATTCTTTTACCTATTGTAGGTGGGGATGAAATAGGACTGGATAATACCTGTGAAAC AACAGGTGAGTTATTAACCTTTTTCTATGGAAAAACGCATGGTGGGACAAAGTATTCTGCTGAACATCAC CTAAATGAATATAAAAAGAATCTGGAAGATGATATAAAGGCAATCGGTGTTCAAAGAAAAATTTCACCAA ATGCCTATGAAGATCTATTAAAAGAGAAAAAAGAGCGCCTGGAACAAATCGAAAAATATATTGATTTAAT CAAAGTACTCAAAGAGAAATTTGATGAGCAAAGAGAAATAGACAAACTACGCACAGAAGGAATCCCGCAA TTACCTTCTGGAGTAAAGGAAGTCATTAAATCTTCTGAAAATGCCTTTGCTTTAAGGCTTTCCCCGGATA GACCAGACTCATTTACCCGCTTTGATGATCCTCTGTTTAGTCTCAAAAGAAACAGATCTCAATATGAAGC TGGGGGATACCAACGGGCAACTGATGGATTAGGGGCTCGTTTGCGTTCTGAGCTTCTACCACCAGATAAA GACACTCCTATTGTTTTTAATAAAAAATCACTGAAGGACAAAATCGTAGATTCTGTTTTAGTGCAACTTG ACAAAGATTTTAATACAAAAGATGGCGATCGTGGTCAAAAATTTGAGGATATAAAAAAACTCGTTCTAGA AGAGTACAAGAAAATTGATTCCGAACTTCAAGTGGATGAGGATACCTATCACCAACCACTTAACTTGGAT TATTTGGAAAACATAGCATGTACGTTAGATGACAACTCCACCGCGAAAGATTGGGTTTATGGAATTATTG GTGCTACAACAGAAGCTGATTATTGGCCAAAAAAGGAAAGTGAAAGTGGTACTGAAAAAGTTAGTGTATT CTATGAGAAGCAAAAGGAAATAAAATTTGAATCTGATACAAATACAATGTCAATTAAAGTCCAATATCTA TTAGCTGAGATTAATTTTTATTGTAAAACCAACAAGTTATCAGATGCTAACTTCGGTGAATTTTTTGATA AAGAGCCCCATGCTACTGAAGTTGCTAAAAGAGTGAAAGAAGGACTTGTTCAAGGAGCAGAGATTGAGCC TATTATTTACAATTACATTAACAGCCACCATGCCGAACTGGGATTAACATCTGAGTTAAGCAGCAAGCAA CAAGAGGAAATTACTGAAAAATTTACTCAACGTTATCACATTATTGAGAACTCTCCTCACTTTGATGAAT TTTTTGTCGCTGATCCTGATAAAAAAGGGAATATATTCTCCCATCAAGGCAGAATGAGTTGCCATTTCCT GGATTTCTTCGCTCGACAAACCAAAGGCAAATATCCCCTTGGTGATCTTGCAGGTCATCAAGAAGCACTC CAGGCAGGAACTTCCAATCGGTTACATCACAAGAATGAGGTAGTCGCTCAAGGATATGAAAAATTTGATC AATTCAAGAAAGAAGTCGTCAAACTGCTGGCAGAGAGTAAACCAAAAGAATTATTGGATTATTTGGTTGC TACCTCCCCCACAGGTGTTCCTAATTATTCCATGCTCTCAAAGGAAACTCAAAATTATATTGCTTACAAC CGTAACTGGCCAGCCATTCAAAAAGAGCTCGAAAAAACTACTGACATACCAGAGAACCAAAAACAAGATC TTTTAAGATTGCTTTCTCGTAATAATCTGCAACACGAGAACCTCAGTGCAATTACCTGGTCAAAATACTC TTCCAAGCCATTATTGGATGTGGAGTTAAATAAAATCGCCGAAGGTTTAGATCTAACTGCTAAAATTTAC AATGAAAAAAGAAAAAGTGAATGGTTTAAAGGTTCAAGAAATGAGGCTCGTAAGACCCAATGTGAAGAAT TGCAAAGAGTATCCCAAGAAATCAATGCTCTTCTGCAAAGTGAATCTTTAACAAAAAGCCAAGTTCTTGA AAAAGTTTTAAACTCCATAGAAGCATTGGATAAAATTGATAGAGACATTTCTGCTGAATATAATTTATTT AAGAGTACTCTGCAAAAAGAAGTACAATCATTTCGAGATCAATTGAAGGATATCTGTCAATTAGATAACT ATGCCTTTAAATCAACAAAACTTGATGAAATTATCTCTCTGGAAATGGAAGAACAATTTCAAATGATTAA AGATCCTGCTGTCCAACAAATTGTCCGAGACTTGCCTTCTCATTGTCATAATAATGAAGTGATTGAATTC TTTATGACATTAAATCCTGAAGAAGCAGCTAAAGTAGCTAGCTATTTAAGCCTCGAGTACCGGGAACTCA ATAAATCAACAGATAAGAAAACTCTCCTTGAACAAGATATTCCTAAATTATTTAAAGAAGTGAATATGGA ACTATTATCCCAATTAAAACAAGATAGTGCAGTTAAGGAAGACGTCTATGAAAAATTCTGTCAATTAGCT GATAAAATTCCTCCTGAGCATTTTACAAGGAATAATATCAGGAAATGGTCTGCCAATCCTGAAAAACTTG AGGAGTCCAATCTCGGTGAATTACTAAAATCCTCTGAAGGCTCAATTACTGAAATGGCAAGAAAATACAG AGAAACCATAAATGAAATGACAGGAAGAAATGAGTCACTCAGAGAAACTGTTAGGAATACAATATAG |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Tiaden A; Spirig T; Carranza P; Bruggemann H; Riedel K; Eberl L; Buchrieser C; Hilbi H (2008). Synergistic contribution of the Legionella pneumophila lqs genes to pathogen-host interactions. J Bacteriol. 190(22):7532-47. [PudMed:18805977]
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| experimental literature |
| in silico analysis literature |