| Effector Protein ID: 52842712 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2504 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2820928..2823756 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | SidI/ceg32 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SidI interacts with eEF1A and eEF1Bgamma and inhibits protein synthesis. SidI is also involved in a stress response of eukaryotic cell (Belyi, et al. 2011) |
| UniProt ID | Q5ZSL3 |
| KEGG ID | lpn:lpg2504 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 942 a.a. [Download] |
| >gi|52842712|ref|YP_096511.1| hypothetical protein lpg2504 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MTKIYLLTAPFDEEAKTGDGQYAASLELGFAENYEHIPCKWLKKDKGDYSIPFPTGTTSIPEETIPSAIV LQPVANENTVISGYKLKDTVSSPEKAQEVNNKTVSPRTPKIIVKHDNSLQSLTIMDIYSQKPIQFDESKV DEIIHSLETKKVNLEKAIEDNNAELSKIKKQKSKLAYLTRLYKENKENIQDYCTLNEYIEAHLFNPKFLS RHEKALNNFKALKSQFTGPVNLKELEKLTDKLTGIKEYSYDFHSNSLPYDLEHDKSFRNFYDFDGLKESI ESIIKELEVLNSIRQAVSDKYPNSFKALNETEEHDDKLKFINIIFNDGFSTTYDQQTFIKALSALDIEKA IDAYTNVKNKLENTQDIIANKEGCRNKLISELQTLIANKQEPYLSANEKLGGFYSKRKLSASEGFHLAYQ ANRRDPIKPEVIENIITKMKPIDEDTHLDIHIRPPDCGVFITPEDIKKFQEAGIKVNITIHEYKQNYTRR YLQQYTHDLMRQANSVQFFNAEDRENAIIAATYGDCDKRNTTEPTGVAKKIREVGEDFDLDKYPVQKYDL KGKSGLTVASQKLSTEPDHPLDVVAKAPNILSFGTIRPGKGFEEALKLAQLIKDNSLSIHEKIKRVPIVK LAGDPQDKALMKQIVVERFGKTAVKTYQKTHPYDNRFNNSQRRDYWKNLVRELNAKVKEEVAVLNNPYIE IYPWCEPHELLDLKQNCKYVCRMDDMGMRNNGSAIISVLDVGVVYTKFGSVTDDIFIKGGKYGNAVDIGE YRYGKYSLLKKEKEFKEQHEEEPLPKWLIKNPDSAYKRQSESRDPKDILDSIVAREENQLICDNIEDSDN YRTVVEAQKLLKERFTLKNAVDHLLENIGLGHLIAQEEVDELFETVDPVQAQIDNLDILSDIKTPRLCLS RSCPELGFFGSRRGDLEAKQENNKLKESILVF |
| - |
| Nucleotide Sequence: 2829 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2820928-2823756 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGACTAAAATATACTTATTAACTGCACCTTTTGATGAAGAAGCAAAAACAGGTGATGGGCAATACGCGG CCTCTTTAGAATTGGGTTTTGCTGAAAATTACGAACATATCCCCTGTAAATGGTTAAAAAAAGACAAAGG TGATTACAGCATCCCATTCCCAACAGGAACCACTTCTATACCGGAAGAAACGATACCAAGCGCAATAGTA TTACAGCCAGTTGCTAACGAAAATACAGTAATAAGCGGTTATAAATTAAAAGATACTGTTTCATCTCCAG AAAAAGCACAAGAAGTAAATAACAAAACGGTCAGTCCCAGAACACCAAAAATTATTGTAAAGCATGATAA TAGCCTGCAATCACTTACAATAATGGATATTTACTCTCAAAAACCTATCCAATTTGATGAGTCAAAAGTT GATGAAATAATTCACTCTTTAGAAACCAAAAAAGTAAACCTGGAAAAAGCTATAGAAGATAATAACGCTG AGCTGAGTAAAATTAAGAAACAAAAATCCAAATTAGCGTATTTGACTAGATTATATAAGGAAAACAAAGA GAATATTCAAGATTATTGCACCTTAAATGAATATATTGAGGCTCATTTATTTAATCCTAAATTTTTAAGC AGACATGAGAAAGCACTCAATAATTTTAAGGCACTTAAAAGCCAATTTACTGGCCCTGTCAATTTAAAAG AACTGGAAAAATTAACAGATAAACTGACTGGAATTAAAGAGTACAGCTACGATTTCCATAGTAACAGTTT ACCCTATGATTTAGAGCACGATAAAAGTTTCAGAAATTTTTATGATTTTGATGGATTAAAAGAATCTATT GAAAGCATTATCAAGGAATTAGAGGTGCTTAACAGCATTCGTCAGGCTGTATCAGACAAGTACCCCAATA GCTTTAAAGCGCTAAATGAAACAGAAGAGCACGACGATAAATTAAAATTTATCAATATTATTTTCAACGA TGGATTTAGCACCACTTATGACCAACAAACCTTTATCAAGGCCTTATCAGCTCTTGATATTGAAAAGGCA ATTGACGCTTATACAAATGTTAAAAACAAACTGGAAAACACTCAGGATATTATCGCCAATAAAGAGGGGT GTAGAAATAAGTTAATTTCAGAATTACAAACTTTAATTGCAAATAAACAAGAACCTTACCTCTCTGCAAA TGAAAAGCTTGGCGGTTTTTACAGTAAAAGAAAACTCTCCGCAAGTGAAGGATTTCATTTAGCCTATCAG GCAAACCGACGTGACCCGATAAAACCTGAAGTGATTGAAAACATTATTACCAAAATGAAACCCATTGATG AGGATACTCATCTTGATATTCATATTCGTCCACCAGATTGCGGGGTCTTTATTACTCCAGAAGACATCAA AAAATTTCAAGAGGCAGGTATTAAAGTCAATATCACAATCCATGAATATAAACAGAACTACACTCGACGT TATTTACAACAATATACTCATGATTTAATGCGCCAGGCAAACAGTGTGCAATTCTTTAATGCAGAAGATA GAGAAAATGCTATTATTGCCGCTACTTATGGTGATTGTGATAAGCGCAATACAACTGAACCGACTGGTGT TGCAAAAAAAATAAGAGAAGTCGGGGAAGATTTTGACTTAGATAAATACCCGGTTCAAAAATATGATTTA AAAGGAAAATCAGGATTAACCGTTGCATCACAAAAATTAAGTACTGAACCGGATCATCCATTGGATGTAG TAGCCAAGGCCCCTAATATCTTATCTTTTGGTACGATTCGTCCTGGCAAAGGGTTTGAAGAAGCGTTAAA GCTGGCTCAATTGATCAAAGATAACTCCCTTTCTATTCATGAAAAAATAAAACGGGTACCTATTGTAAAA CTGGCAGGTGACCCACAAGACAAAGCTTTAATGAAACAAATAGTTGTTGAAAGATTTGGTAAAACAGCGG TCAAAACTTATCAAAAAACTCATCCCTATGATAATCGATTCAATAATAGTCAGCGCAGAGATTATTGGAA AAATTTGGTTAGGGAGTTAAATGCAAAAGTTAAAGAAGAAGTCGCTGTTCTTAATAATCCTTACATCGAA ATATATCCTTGGTGTGAGCCGCATGAATTGCTGGATTTAAAGCAAAACTGTAAATACGTTTGTCGAATGG ATGACATGGGCATGAGAAACAATGGCTCAGCAATTATCAGTGTATTAGACGTTGGAGTCGTTTATACTAA ATTTGGTTCTGTTACAGACGATATTTTTATTAAAGGCGGTAAATACGGCAATGCCGTTGATATTGGAGAA TATCGTTATGGGAAATACAGTCTGTTAAAAAAGGAAAAGGAATTTAAAGAACAGCATGAGGAAGAACCAC TACCTAAGTGGCTAATCAAAAATCCAGACTCTGCTTATAAGCGACAATCAGAATCGAGAGATCCAAAGGA TATTTTAGACTCCATTGTTGCAAGAGAAGAAAATCAATTAATATGTGATAATATAGAAGATTCCGATAAT TATCGGACAGTAGTCGAAGCACAAAAGTTATTAAAAGAGCGCTTTACACTCAAAAATGCTGTAGATCATT TATTAGAGAATATAGGACTCGGCCATTTAATTGCTCAAGAAGAGGTCGATGAATTATTTGAGACAGTTGA TCCAGTGCAAGCACAAATAGATAATTTAGACATTCTTTCTGATATTAAAACACCACGTCTGTGTTTATCA CGCTCTTGCCCTGAGCTAGGTTTTTTCGGCTCACGTCGTGGTGACTTGGAGGCTAAACAAGAAAATAATA AACTTAAAGAATCGATACTGGTATTTTGA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| (2) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
(3) Fontana MF; Banga S; Barry KC; Shen X; Tan Y; Luo ZQ; Vance RE (2011). Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog. 7(2):e1001289. [PudMed:21390206] 
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(4) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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(5) Shen X; Banga S; Liu Y; Xu L; Gao P; Shamovsky I; Nudler E; Luo ZQ (2009). Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response. Cell Microbiol. 11(6):911-26. [PudMed:19386084]
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| experimental literature |
| in silico analysis literature |