| Effector Protein ID: 52842698 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | lepB |
| Locus tag | lpg2490 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2804259..2808143 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LepB |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LepB is a Rab1-specific GTPase-activating protein, which facilitates the removal of Rab1 by stimulating GTP hydrolysis. |
| UniProt ID | Q5ZSM7 |
| KEGG ID | lpn:lpg2490 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1294 a.a. [Download] |
| >gi|52842698|ref|YP_096497.1| hypothetical protein lpg2490 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MLIYQGKEIVRFKEKTGGKNKSDVDGFYKDNDGGKFFIKKPGDPRELFTELFAGLLLKEFMKRGLIDESY FPSLICADVIQFEDKSYGLIQPLVSFDELHKVIGTSSGDGKDRNTLKETLFGPGYYAGITKQNKYFGLSM ALMFSLLLGAHSVHSGNIVVLNGEEKEKSKQFGRIDWGDAFRYFAHPNNNDNLLYAYENRGWFNYKSLTK DYFLNYKKINGLFPAMAEKARQLQSKLNPELLVKIVTSALKNIPADLIDEKTKIQLAAYMCMDSFKEATF GTEGNCKDFAIAMATLLENRLGKIAVLKDMSPLSNPEELYQSILELKPLTLLMTSSTSFSETINQWADIL KTTDMEKFSFDSNPINLLELVKQFNLYVDELAITCEANNVWAKERIDSTPNLFALYDNSGGEAIHGHAFV PYYKESIVLRRLFTVDPNTFNLSRFAAFEGPCQLYCKEHKDSAWVKIQTLLTLGNGIINTLKIIKQAQAF GIDEAVTENLKALKEQFIAFQLAEADIKESLKAPSFAEPLPNKESEFFYPIDEKALAKMNGYQLATICLE ELNSPKPSPLIERILSNKKFWKRINSAFESGVFKGRTDDPAGKIAKIREWHQLLQISGKKTAGQIDELQK IVISLQSKIKRQTIEFEELEATLIQIKEKYQLLEKMAEQSEHEKSSAQSIIRSLNLELSQLKLQLQEQEK LQFQLKELKEKIHEQTTLSKRLGEELQTQKKTNTHQEETIQRITKEKSLADSSLESLRKELHELAKKERS LHKTLEEKQLQVQQLEEQLAEKEKENLALKKADKQSQHEKSLDKSAIESLTSELNQLKLELQKQETLQLQ LKSLRKQIQEQTLVVEGLKEELQKQKKSNTHQEETIERITKEKSLADSALESLRKEMYELTRKNEENQLK LTKQVHSLSEQLEEKQLQIREFEKQLQEKEKRVEQSEKGKASAKRTVASLREQVSNLKLQLQQLGEVIQE KEKGSSLISQQSKQIIALQEIIEDQKRQLEELKIKIQELVSANQELGKQNQSLSKENLHNKNTVEDLKKK LNELNVQLEQLHQSSNEKEQTIRKLREELIKKDSSLKQNEEMQLAQKHLQEEIDRLQKEIKQQQLNTNQL ESIIAQSKEAEKRYQQALQQKKGIYFARMERVSPIYLQIQQIEQKAKELEERRETEASTAAKTLATKLRL EIKNYLDNNESDEKSALNSFKINAKRHIENSKETLNQHREEWKYLLANVTLGVFLLGIGYLAAILINKAT TGNYTFFSQTNSGKKLDALEKAISSTHSETLVYG |
| - |
| Nucleotide Sequence: 3885 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2804259-2808143 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGTTAATTTATCAAGGTAAAGAAATAGTTCGATTTAAAGAAAAAACGGGGGGTAAAAATAAAAGCGACG TCGATGGTTTTTATAAAGACAATGATGGCGGGAAATTTTTTATAAAAAAACCAGGTGACCCTCGTGAACT ATTCACGGAATTATTTGCCGGTTTGTTATTAAAAGAATTCATGAAGCGAGGGTTGATTGATGAAAGTTAT TTTCCATCATTGATTTGCGCGGATGTCATTCAATTTGAAGACAAGTCCTATGGGCTCATCCAACCACTGG TTTCATTTGATGAATTACATAAAGTGATTGGAACGAGCTCTGGTGATGGCAAAGATCGTAATACACTAAA GGAAACCCTTTTTGGGCCAGGTTATTATGCTGGTATTACGAAACAAAATAAATACTTTGGCCTTTCTATG GCCCTTATGTTTTCTTTATTGTTGGGAGCCCATAGTGTACATAGTGGCAACATCGTTGTACTCAACGGAG AGGAAAAAGAAAAAAGCAAACAATTTGGCCGAATAGATTGGGGAGACGCATTCCGTTATTTCGCTCATCC TAACAATAATGACAATCTCCTTTATGCTTATGAAAACAGAGGTTGGTTTAATTATAAATCACTAACTAAA GATTATTTCCTCAACTATAAGAAGATCAACGGGCTCTTCCCTGCGATGGCTGAAAAAGCTCGACAATTGC AATCCAAACTCAATCCTGAATTACTTGTTAAAATAGTAACCAGCGCACTCAAAAATATTCCAGCTGATCT GATAGATGAAAAAACCAAAATCCAACTTGCCGCATACATGTGTATGGATTCATTTAAAGAGGCGACATTT GGCACTGAGGGTAATTGCAAAGATTTTGCCATTGCCATGGCCACATTATTAGAAAATCGTTTAGGAAAAA TTGCTGTTCTTAAAGATATGTCCCCATTGAGCAATCCTGAAGAGCTATATCAAAGTATTTTGGAATTAAA ACCCTTGACGCTTCTTATGACCTCTTCAACCTCTTTTTCAGAAACCATAAATCAATGGGCAGACATCTTA AAAACTACAGACATGGAAAAATTTTCGTTTGATAGTAATCCAATCAACCTACTGGAATTAGTCAAACAAT TTAATCTTTACGTTGATGAACTAGCCATCACGTGTGAAGCCAATAATGTCTGGGCAAAAGAAAGAATAGA CAGCACCCCTAATCTGTTTGCTCTCTACGATAATAGCGGTGGTGAAGCGATTCACGGACATGCCTTTGTT CCTTACTACAAAGAAAGCATTGTATTGCGCCGCCTATTTACAGTAGACCCTAATACTTTCAACTTATCTC GTTTTGCTGCTTTTGAAGGACCATGCCAACTCTATTGCAAGGAACATAAAGACTCTGCCTGGGTTAAAAT CCAAACCTTACTGACTTTAGGTAATGGAATTATTAATACGCTAAAAATAATCAAACAGGCTCAAGCATTC GGAATAGATGAGGCAGTTACAGAGAATTTAAAAGCATTGAAAGAACAATTCATTGCTTTTCAACTTGCGG AAGCTGATATAAAGGAATCATTAAAAGCACCTTCTTTTGCAGAGCCCTTGCCTAATAAGGAAAGTGAGTT TTTTTATCCCATTGATGAAAAAGCATTAGCTAAAATGAATGGATATCAACTTGCAACGATTTGTCTGGAA GAACTAAATAGCCCTAAACCGTCGCCTTTAATTGAAAGAATTCTCAGTAATAAAAAATTTTGGAAACGTA TTAACTCTGCTTTTGAAAGTGGTGTATTTAAAGGCCGCACAGATGATCCCGCCGGTAAAATAGCTAAAAT CCGTGAATGGCATCAATTATTACAGATTTCTGGTAAAAAAACTGCTGGACAAATTGATGAGCTGCAAAAG ATAGTAATTTCTCTTCAATCAAAAATTAAAAGGCAAACGATTGAATTTGAGGAGTTAGAAGCGACTTTAA TCCAAATAAAAGAAAAATATCAGTTACTGGAGAAAATGGCTGAGCAAAGCGAACATGAGAAATCTTCCGC CCAATCCATTATTCGCTCTCTGAATTTAGAACTGAGTCAGCTTAAATTACAACTGCAAGAGCAAGAAAAA TTACAGTTCCAGTTAAAAGAACTCAAAGAGAAAATACATGAACAAACTACTCTATCCAAGCGATTAGGAG AAGAGCTGCAAACGCAAAAGAAAACCAACACGCACCAGGAAGAAACCATTCAAAGAATCACCAAAGAAAA ATCATTGGCCGATTCTTCCCTTGAGTCGCTTCGAAAAGAACTGCATGAATTGGCAAAAAAAGAACGCTCT CTTCATAAAACGCTCGAAGAAAAACAATTACAAGTACAACAGTTAGAAGAGCAATTAGCAGAGAAAGAAA AGGAAAATCTAGCCCTGAAAAAAGCTGACAAACAAAGTCAACATGAAAAATCCCTGGATAAATCCGCTAT TGAATCTCTAACCTCAGAGCTTAATCAGCTTAAACTAGAACTGCAAAAACAAGAAACATTACAATTGCAG TTAAAATCTTTAAGAAAACAAATTCAAGAGCAAACATTAGTTGTAGAGGGCTTAAAAGAGGAGTTACAAA AACAAAAGAAAAGCAACACACACCAGGAAGAAACTATTGAAAGAATTACTAAAGAAAAATCATTAGCTGA TTCTGCTCTTGAATCACTTCGAAAAGAGATGTATGAATTAACTCGAAAAAACGAAGAAAATCAACTTAAA TTAACAAAACAAGTCCACTCTCTTAGCGAACAACTTGAAGAGAAACAATTACAAATTAGAGAATTTGAGA AGCAATTACAAGAAAAAGAAAAACGAGTTGAGCAAAGTGAGAAAGGTAAAGCTTCAGCAAAACGAACTGT GGCTTCACTTAGAGAGCAAGTAAGCAATTTAAAATTGCAATTACAGCAACTTGGAGAGGTAATTCAGGAA AAAGAAAAAGGCTCCTCTTTGATAAGCCAGCAATCCAAACAAATTATTGCTCTTCAAGAGATTATAGAAG ATCAAAAAAGACAATTGGAAGAATTGAAAATAAAAATTCAGGAACTTGTATCTGCAAATCAAGAGCTTGG AAAACAAAATCAAAGTTTGAGCAAGGAAAATTTACATAATAAGAATACAGTTGAAGATCTTAAGAAAAAA TTGAATGAATTAAATGTTCAATTGGAACAATTGCATCAATCTTCAAATGAAAAAGAACAAACCATTAGAA AATTGAGAGAAGAACTCATTAAGAAAGATTCTTCGCTCAAACAAAATGAGGAAATGCAATTAGCCCAAAA ACATCTGCAAGAGGAAATTGATCGTCTACAAAAAGAAATTAAACAACAACAATTAAATACAAATCAATTA GAATCTATAATTGCTCAAAGTAAAGAGGCTGAAAAACGCTATCAGCAAGCTTTACAACAGAAAAAGGGAA TTTACTTTGCGCGAATGGAAAGAGTGTCTCCTATTTATTTGCAAATACAGCAAATTGAACAAAAGGCCAA AGAATTGGAGGAAAGAAGGGAAACAGAAGCATCAACAGCGGCAAAGACACTCGCAACAAAACTTCGTTTA GAGATAAAAAATTATCTCGACAATAATGAGTCCGATGAAAAAAGTGCCTTAAACTCATTCAAAATAAATG CCAAACGGCATATTGAAAACTCGAAGGAAACGCTAAATCAACATCGTGAAGAATGGAAGTACCTGTTAGC CAATGTTACTTTAGGGGTATTCTTGCTTGGAATCGGTTATCTCGCCGCTATTTTGATTAACAAAGCAACT ACTGGCAATTATACCTTTTTCAGCCAAACTAACAGCGGGAAAAAATTGGACGCGTTGGAAAAAGCGATTT CCTCCACTCACTCCGAAACATTAGTTTATGGATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| (2) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(4) Chen J; Reyes M; Clarke M; Shuman HA (2007). Host cell-dependent secretion and translocation of the LepA and LepB effectors of Legionella pneumophila. Cell Microbiol. 9(7):1660-71. [PudMed:17371403]
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(5) Chen J; de Felipe KS; Clarke M; Lu H; Anderson OR; Segal G; Shuman HA (2004). Legionella effectors that promote nonlytic release from protozoa. Science. 303(5662):1358-61. [PudMed:14988561]
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| experimental literature |
| in silico analysis literature |