| Effector Protein ID: 52842673 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | sidD |
| Locus tag | lpg2465 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2779337..2780860 [+] |
| Product | protein SidD |
| Effector type | Protein |
| Descripton | SidD |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SidD catalyzes AMP release from Rab1, generating de-AMPylated Rab1 accessible for inactivation by LepB. (Neunuebel, et al. 2011) |
| UniProt ID | Q5ZSQ2 |
| KEGG ID | lpn:lpg2465 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 507 a.a. [Download] |
| >gi|52842673|ref|YP_096472.1| protein SidD [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MVYYEIIKDIVFTYNLQFTHLIHNDRISEVNLGGVTMRSIITQICNGVLHGQSYQSGSNDLDKGNSEIFA SSLFVHLNEQGKEIIKHKDSDDKIVIGYTKDGMAFQIVVDGFYGCERQAVFSFIDNYVLPLIDNFSLDLT RYPDSKKVTESLIHTIYSLRSKHAPLAEFTMSLCVTYQKDEQLFCAGFGIGDTGIAIKRNEGTIEQLVCH TEVDGFKDAFDNYSSANIDLVIERNSVFNTKVMPGDELVGYTYVPPMLEMTEKEFEVETVDGKKINKRIV RHLNLDPGNFDDKDPLFSQLLQVVKSKQKQLVEQAKETGQIQRFGDDFTVGRLVIPDQLLINQLRIHALS IGVSDGLLSYIKNENENKGFLGIYGFFTGADKNIEKATLYKNLIAKYQNNHFISLIILSALVSDSKTPLM TQYLVGYLDFPSKALLANKITELLLKELENPDMREILGSRLATDVIEELETKIIRYIHNPAGSDIHSTLN LWTADKIKAATNSSLTI |
| - |
| Nucleotide Sequence: 1524 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2779337-2780860 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGGTATATTATGAGATCATTAAGGATATTGTCTTTACATATAATTTACAATTTACACATCTAATACACA ATGACAGGATATCTGAAGTAAATTTAGGAGGAGTAACGATGCGTTCGATTATTACACAAATCTGTAATGG TGTTCTTCATGGACAAAGCTATCAATCTGGTTCCAATGATTTAGATAAGGGTAATAGTGAAATCTTTGCA TCCAGCCTCTTTGTACATTTGAATGAACAGGGCAAAGAAATTATAAAGCACAAGGATTCTGACGATAAAA TAGTCATTGGATATACCAAAGATGGAATGGCTTTTCAAATAGTGGTGGATGGCTTTTATGGATGCGAACG TCAGGCTGTTTTTTCATTTATTGATAACTATGTACTCCCTTTAATTGATAACTTCTCCTTAGATCTCACC AGATACCCGGATTCAAAAAAAGTTACCGAATCACTCATTCATACTATTTACTCTTTGCGCAGCAAACATG CTCCATTGGCAGAGTTCACTATGTCTTTATGCGTAACTTATCAAAAGGATGAACAACTGTTTTGTGCTGG ATTCGGCATTGGTGACACCGGAATAGCTATCAAACGAAACGAAGGAACAATTGAACAATTAGTTTGTCAT ACGGAAGTTGATGGATTCAAAGACGCATTTGACAACTATTCATCCGCCAATATCGACTTGGTCATTGAAA GAAATTCTGTCTTTAATACTAAAGTCATGCCCGGTGATGAACTAGTAGGATACACTTATGTTCCACCGAT GTTAGAAATGACTGAAAAAGAGTTTGAAGTAGAAACTGTTGATGGCAAGAAAATAAATAAAAGAATTGTA AGACATCTAAATCTCGATCCTGGAAATTTTGATGACAAAGACCCCTTATTTTCTCAATTGCTACAAGTTG TAAAATCCAAACAAAAACAGCTGGTTGAACAAGCAAAAGAAACAGGACAAATCCAACGTTTTGGTGATGA TTTTACAGTAGGAAGATTAGTCATTCCTGATCAGTTACTAATAAATCAATTAAGAATTCATGCTTTATCA ATCGGAGTAAGTGATGGATTACTTTCATACATCAAGAATGAAAATGAAAACAAAGGTTTTCTTGGTATAT ATGGTTTCTTCACAGGAGCTGATAAAAATATAGAAAAAGCGACTCTTTATAAAAATCTCATCGCAAAATA CCAAAATAATCATTTTATCTCTCTAATTATTCTTTCTGCTCTAGTCTCTGATAGTAAAACACCCCTAATG ACTCAGTACTTAGTTGGCTATCTGGATTTCCCGTCGAAAGCATTACTTGCTAATAAAATTACAGAATTGC TTTTAAAAGAATTAGAAAATCCGGATATGAGAGAAATACTGGGTTCCAGATTAGCAACTGATGTTATAGA GGAATTAGAAACTAAAATTATTCGTTATATTCACAACCCAGCAGGCTCGGATATTCATTCAACGCTAAAC CTTTGGACTGCAGATAAAATTAAGGCTGCAACTAACTCGAGTCTTACTATTTAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| (3) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
(4) Tan Y; Luo ZQ (2011). Legionella pneumophila SidD is a deAMPylase that modifies Rab1. Nature. 475(7357):506-9. [PudMed:21734656] 
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(5) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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| experimental literature |
| in silico analysis literature |