| Effector Protein ID: 52842672 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2464 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2777324..2779267 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | SidM/drrA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | DrrA is necessary for Rab1 recruitment and binds specifically to GDP-bound Rab1 (Machner & Isberg 2006, Murata et al. 2006) |
| UniProt ID | Q5ZSQ3 |
| KEGG ID | lpn:lpg2464 |
| PDB ID | 3JZA, 3L0I, 3L0M, 2WWX, 3N6O, 3JZ9 |
| Domain hit(s) vs Pfam | NTP_transf_2 [PF01909], Evalue: 6.9e-05, Aligned region: 91..123 |
| Protein Sequence: 647 a.a. [Download] |
| >gi|52842672|ref|YP_096471.1| hypothetical protein lpg2464 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MSIMGRIKMSVNEEQFGSLYSDERDKPLLSPTAQKKFEEYQNKLANLSKIIRENEGNEVSPWQEWENGLR QIYKEMIYDAFDALGVEMPKDMEVHFAGSLAKAQATEYSDLDAFVIVKNDEDIKKVKPVFDALNNLCQRI FTASNQIYPDPIGINPSRLIGTPDDLFGMLKDGMVADVEATAMSILTSKPVLPRYELGEELRDKIKQEPS FSNMVSAKKFYNKAIKDFTAPKEGAEVVSVKTHIMRPIDFMLMGLREEFNLYSEDGAHLSAPGTIRLLRE KNLLPEEQIARIESVYNQAMSKRFELHAEHKKEHDEMPYSDAKAMLDEVAKIRELGVQRVTRIENLENAK KLWDNANSMLEKGNISGYLKAANELHKFMKEKNLKEDDLRPELSDKTISPKGYAILQSLWGAASDYSRAA ATLTESTVEPGLVSAVNKMSAFFMDCKLSPNERATPDPDFKVGKSKILVGIMQFIKDVADPTSKIWMHNT KALMNHKIAAIQKLERSNNVNDETLESVLSSKGENLSEYLSYKYATKDEGREHRYTASTENFKNVKEKYQ QMRGDALKTEILADFKDKLAEATDEQSLKQIVAELKSKDEYRILAKGQGLTTQLLGLKTSSVSSFEKMVE ETRESIKSQERQTIKIK |
| - |
| Nucleotide Sequence: 1944 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2779267-2777324 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAGCATAATGGGGAGAATTAAAATGAGTGTTAATGAAGAGCAATTTGGTAGTTTATACAGTGATGAGC GAGACAAACCATTACTATCCCCAACCGCTCAGAAAAAATTTGAAGAATATCAGAACAAATTGGCTAATCT AAGTAAAATAATTCGAGAAAATGAGGGCAATGAAGTATCTCCATGGCAGGAGTGGGAGAATGGATTACGT CAAATTTACAAAGAAATGATTTATGATGCCTTTGACGCGCTTGGTGTCGAGATGCCGAAAGATATGGAAG TCCATTTTGCAGGTTCTCTTGCCAAGGCACAAGCCACTGAGTATAGTGATTTGGATGCCTTTGTTATTGT TAAAAATGACGAAGATATAAAAAAAGTAAAACCGGTCTTTGACGCATTAAATAATTTATGTCAGCGTATT TTTACTGCAAGCAATCAGATATATCCTGATCCTATTGGAATCAATCCAAGCCGTCTTATTGGTACGCCTG ATGATTTGTTTGGTATGTTAAAAGACGGGATGGTAGCTGATGTTGAAGCAACTGCAATGTCAATTTTAAC ATCAAAACCTGTTCTACCTCGCTATGAATTAGGAGAAGAGTTACGAGATAAAATCAAACAAGAACCTTCT TTCAGCAATATGGTTTCAGCCAAGAAGTTTTATAATAAAGCAATTAAAGACTTTACTGCACCTAAAGAGG GTGCAGAAGTAGTGAGTGTCAAAACTCATATTATGCGTCCCATCGATTTTATGCTGATGGGATTGCGTGA GGAATTTAATTTATACAGTGAGGATGGAGCTCATCTTTCGGCACCAGGAACTATACGTTTATTACGTGAA AAAAATTTATTGCCCGAAGAGCAAATTGCTCGAATCGAGTCAGTATACAATCAAGCGATGAGCAAGAGAT TTGAGTTGCATGCTGAGCACAAAAAAGAACATGATGAGATGCCTTATTCTGATGCTAAAGCAATGCTTGA TGAGGTAGCGAAAATAAGAGAGCTGGGTGTTCAACGTGTCACAAGGATTGAAAATCTGGAAAATGCCAAG AAGTTGTGGGACAACGCGAATAGCATGCTTGAAAAGGGTAACATCAGCGGATATCTTAAAGCAGCGAATG AGCTTCATAAATTTATGAAGGAAAAAAATCTTAAGGAAGATGATTTAAGGCCAGAGTTGAGTGATAAAAC AATATCTCCAAAAGGATATGCTATTTTACAATCTTTATGGGGAGCAGCTTCGGATTATAGTAGAGCGGCT GCAACTCTCACAGAATCAACGGTAGAGCCTGGTTTAGTATCAGCTGTTAACAAAATGTCAGCATTCTTTA TGGATTGTAAATTAAGTCCAAATGAGCGAGCAACCCCTGATCCAGATTTTAAGGTTGGGAAATCTAAAAT TTTAGTAGGTATAATGCAATTCATAAAAGATGTAGCAGACCCAACTTCGAAAATATGGATGCATAATACA AAAGCTTTGATGAATCATAAAATTGCTGCTATTCAAAAACTTGAGAGAAGCAATAATGTTAATGATGAAA CATTAGAGAGTGTGCTGAGCTCTAAAGGTGAAAATTTATCCGAATATCTTTCTTATAAATACGCAACAAA AGATGAAGGAAGAGAGCACCGCTATACGGCAAGCACGGAAAACTTTAAAAATGTTAAAGAAAAATATCAG CAAATGCGAGGTGATGCTTTAAAAACAGAAATCCTGGCTGATTTCAAGGATAAACTGGCTGAAGCTACCG ATGAACAGAGCCTTAAGCAAATTGTTGCTGAATTGAAAAGTAAAGATGAATATAGAATTTTGGCTAAGGG GCAAGGGTTAACAACCCAGCTTTTAGGGTTAAAGACAAGTTCAGTGTCTTCATTTGAGAAAATGGTTGAG GAAACAAGAGAAAGTATTAAGTCTCAAGAAAGACAAACCATTAAGATAAAATAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| (3) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
(4) Tan Y; Luo ZQ (2011). Legionella pneumophila SidD is a deAMPylase that modifies Rab1. Nature. 475(7357):506-9. [PudMed:21734656] 
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(5) Zhu Y; Hu L; Zhou Y; Yao Q; Liu L; Shao F (2010). Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. Proc Natl Acad Sci U S A. 107(10):4699-704. [PudMed:20176951]
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(6) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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(7) Brombacher E; Urwyler S; Ragaz C; Weber SS; Kami K; Overduin M; Hilbi H (2009). Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila. J Biol Chem. 284(8):4846-56. [PudMed:19095644]
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(8) Tiaden A; Spirig T; Carranza P; Bruggemann H; Riedel K; Eberl L; Buchrieser C; Hilbi H (2008). Synergistic contribution of the Legionella pneumophila lqs genes to pathogen-host interactions. J Bacteriol. 190(22):7532-47. [PudMed:18805977]
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(9) Machner MP; Isberg RR (2006). Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila. Dev Cell. 11(1):47-56. [PudMed:16824952]
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| experimental literature |
| in silico analysis literature |