| Effector Protein ID: 52842660 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legA14 |
| Locus tag | lpg2452 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2764049..2766814 [-] |
| Product | ankyrin repeat-containing protein |
| Effector type | Protein |
| Descripton | AnkF/legA14/ceg31 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZSR5 |
| KEGG ID | lpn:lpg2452 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 9.4e-15, Aligned region: 533..651 Ank_3 [PF13606], Evalue: 5.4e-11, Aligned region: 622..649 Ank [PF00023], Evalue: 1.6e-10, Aligned region: 623..653 Ank_4 [PF13637], Evalue: 7.4e-10, Aligned region: 592..641 Ank_5 [PF13857], Evalue: 2.2e-08, Aligned region: 608..653 |
| Protein Sequence: 921 a.a. [Download] |
| >gi|52842660|ref|YP_096459.1| ankyrin repeat-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MKDQLAKIFEKYPFVHLDKSGELSIIVPLTGAASISDNFTADETKPIFLYLFGDNTCKSDLERRTFFYGK QKSGGRHSVKPFTELFSNLIHELNGLKSSTEIRVDEQLFLETIIANLNELKEQALAFRKGNPGFEDMRND FSHSDEIMVSKSEFVVTVYPDRVRQFDLPNVMSLINPGESRYKQLLAQSDINQCLEALSLVQKPAAEGNL DLIADALGKLDADPIDYLCKKDNKDPQALFKAVYEILQKQDTSLENQQSAVFEVMEGNLVAAFGDNEDFS TWQKEEIVDAIKSIFKQANLLSEQSGTKQKTFADVYNQAFDKYNESTNDDSESGCKRRNTYQLFILQTFL YLCSLQLRLKNKEKAKKFLGLFEDRGTLNNLVLQLCNDEKAFMRMMADEFGLTSAEYASIAESTYGIVLA HIDAEHFDELRIACSAQLLQDSNYIVMGGRLCWSTSSINEEGNIRSLEQQKKISSENFEIFYNQRQSYID KSREFQQIKVLLDKEVNDEGIAEAVASKVRYLTKYQKSQILSEVIQKKKYEHAKLLIENYANLVFPSVFI SVIKSRPVHIDLIRAFLNADSRHALNIDGNDLIQAAKKGDFELVKIIIEHRPDLLESKDSFQQTPLLWAC VNGYVDIVEYLMDSGADIHVRTKVSGSHRYKIGETPTGGRTALDWARCYDKTDPVKASKIIALFDTYYQR MEDHFKANSAYKDQFNKAHLTQAINNGDLKLIALFLKYCPHLEKFFTQEDQLRAKQRHNQQMLRSQIMPY QNSFNKLLDELQRKAELLNKKYGTLHEATNVMQALINDLSTVGNDFFMDDITPQSFQKFERKCKQVLEEA SPVLSTHRGWHGYPDFVRRFIGVIATLAVIPALVVHFSSAKGYVGVFFSGKENIKTDSSEKMGEFANNLE TLKTEISNKLA |
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| Nucleotide Sequence: 2766 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2766814-2764049 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGAAAGACCAATTAGCCAAAATATTCGAAAAATACCCCTTTGTTCATTTAGATAAATCAGGTGAGCTAT CAATAATTGTGCCTTTAACAGGCGCGGCCAGTATTTCCGACAATTTTACTGCCGATGAAACCAAGCCAAT TTTTCTTTATTTATTTGGCGATAATACGTGCAAATCGGATTTAGAAAGAAGAACTTTTTTTTATGGTAAG CAGAAATCCGGAGGTCGTCACTCTGTAAAACCCTTTACCGAATTGTTCTCAAATTTGATTCATGAATTAA ATGGTCTCAAATCGTCTACTGAAATCCGTGTGGATGAGCAACTATTTCTTGAAACAATCATAGCAAATCT CAATGAGTTGAAAGAGCAAGCTCTCGCTTTCAGAAAAGGAAATCCAGGCTTTGAAGACATGAGGAATGAT TTTAGTCACAGCGATGAAATCATGGTATCAAAGAGCGAGTTTGTTGTAACGGTGTATCCAGACAGAGTGC GACAATTTGATTTGCCAAACGTAATGAGTCTTATAAACCCCGGTGAATCCCGCTACAAGCAATTACTTGC CCAGTCCGACATTAATCAATGCCTGGAAGCATTGTCTCTTGTGCAAAAGCCTGCTGCAGAGGGTAACTTG GACCTGATTGCTGATGCGCTGGGAAAACTGGATGCAGACCCCATCGATTACTTATGCAAAAAAGATAATA AAGATCCTCAAGCTTTATTTAAAGCGGTTTATGAAATTCTGCAAAAACAGGATACTTCTTTAGAAAATCA ACAATCAGCTGTTTTCGAAGTCATGGAAGGCAATTTGGTCGCTGCCTTTGGAGACAACGAAGACTTTAGT ACCTGGCAAAAGGAAGAGATAGTCGATGCCATTAAATCAATATTTAAACAAGCAAATTTGCTGAGTGAAC AATCAGGAACCAAGCAAAAAACATTTGCAGATGTCTACAATCAGGCTTTTGATAAATATAACGAAAGCAC TAATGATGATTCTGAATCAGGATGTAAACGCAGGAACACTTATCAGCTGTTTATTTTACAAACGTTTCTC TATTTGTGTTCTTTGCAGTTGCGTTTAAAAAACAAAGAAAAGGCAAAAAAATTCCTGGGTTTGTTTGAAG ACAGGGGTACGTTGAATAATTTGGTATTACAATTATGTAACGATGAAAAAGCGTTTATGAGAATGATGGC CGATGAATTTGGGCTGACTTCTGCAGAATACGCGTCTATTGCTGAATCAACTTATGGCATCGTCTTGGCT CATATTGATGCTGAACATTTTGATGAACTAAGAATAGCATGCAGTGCTCAATTGCTCCAGGATTCCAATT ATATCGTAATGGGAGGGCGTCTTTGTTGGAGCACCAGTTCTATTAATGAAGAGGGAAATATACGAAGTTT GGAGCAGCAAAAGAAAATTTCATCTGAAAATTTTGAAATTTTTTATAATCAAAGACAATCTTATATTGAT AAATCAAGAGAGTTTCAACAGATAAAAGTTCTGCTAGATAAAGAAGTGAATGACGAAGGGATAGCTGAAG CTGTGGCGTCAAAAGTTCGCTACCTGACGAAATATCAAAAGTCACAAATCTTAAGTGAAGTGATTCAAAA AAAGAAATACGAACATGCAAAACTTTTAATTGAAAACTATGCCAATCTTGTTTTCCCATCCGTGTTTATT TCAGTGATAAAGAGTAGACCGGTTCATATTGATTTGATTCGAGCGTTTCTCAACGCAGACTCTCGTCATG CGTTGAATATTGACGGGAATGATTTAATTCAGGCAGCAAAAAAAGGAGATTTTGAGCTGGTTAAAATCAT TATAGAACATAGACCAGATTTATTGGAATCCAAAGACTCTTTCCAACAAACTCCGTTGCTTTGGGCTTGT GTCAATGGCTATGTGGATATCGTGGAATATTTAATGGATTCAGGTGCTGATATTCATGTCAGAACAAAAG TGTCTGGGAGTCATCGATATAAAATTGGAGAAACCCCAACTGGGGGACGAACCGCACTTGATTGGGCGCG ATGCTATGATAAAACCGATCCTGTAAAGGCATCAAAGATAATTGCCTTATTTGATACTTATTATCAGCGC ATGGAAGACCATTTTAAAGCCAACAGTGCTTATAAAGACCAATTCAACAAGGCTCATTTAACCCAGGCGA TAAATAATGGGGATTTAAAATTAATCGCATTGTTTTTAAAGTATTGTCCACACCTCGAAAAATTTTTTAC TCAAGAAGATCAACTACGTGCAAAACAACGACATAATCAACAGATGTTGCGTTCTCAAATTATGCCGTAT CAAAATTCATTCAATAAATTATTAGATGAATTACAAAGAAAAGCAGAATTACTGAATAAAAAATATGGTA CTCTTCACGAAGCAACCAATGTCATGCAAGCACTAATTAATGACTTATCCACAGTAGGAAATGATTTTTT TATGGATGATATTACGCCTCAATCTTTTCAAAAATTTGAAAGGAAGTGTAAACAGGTTCTTGAGGAGGCC AGCCCAGTTTTATCAACGCATCGTGGTTGGCATGGCTATCCTGATTTTGTCAGAAGATTTATAGGAGTTA TTGCAACCTTGGCAGTTATTCCTGCATTGGTTGTACACTTTTCATCAGCAAAGGGATATGTAGGAGTTTT CTTTTCTGGCAAAGAAAATATAAAAACAGACTCTTCTGAAAAAATGGGTGAATTTGCGAATAACCTGGAA ACCCTAAAAACAGAAATATCCAATAAACTGGCTTAG |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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| experimental literature |
| in silico analysis literature |