| Effector Protein ID: 52842521 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2311 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2610805..2614308 [-] |
| Product | interaptin |
| Effector type | Protein |
| Descripton | Ceg28(RidL) |
| T4CP requirement | T4CP Depedent |
| Target/Effection | RidL (Lpg2311/Ceg28) binds the retromer cargo recognition subcomplex, inhibits retrograde trafficking, and promotes intracellular bacterial replication. |
| UniProt ID | Q5ZT54 |
| KEGG ID | lpn:lpg2311 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1167 a.a. [Download] |
| >gi|52842521|ref|YP_096320.1| interaptin [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MILEEYIRMAKNKEFFDALEEIAESAKNDETLRNELAKVLDDILKTDPSDPEAFRKIVAEHQEFWDEHDP SLMEFNEGRFFGKSRKQYLKSDDFLNSTDPTYNFQKLHQFAAEQRVKLGLEKSDTDTLVAILKNNPEECR AYIESKKPGLGNFSEGNVHGWLKEEYTPTIPPKAINKSTGVLSDEAIKRIKEQARDLLLLKLINSSGNTQ LLKDLRDAMSKPEAERAANALGFPTEGNGVLFLSREVVDALEERVEKLEQEAAKRGFDSYVQSLSHNALL AKKNGLESTTAAGFKNSLDEPYKTYLPESEWERAQGVLGARYLQAVLSSGTQNLKDALNAKDANALITEL KKPALLGPHDYIDKAVTEENLGSLKKNMMKSFINNIKDETNLKALDALKALDGAKNLDKFKEVLGKLGIT PADWVKDTDLKDMKQWARARQFELEINRVSSLGSGAHSKLMSTLTKLPVEKQREILAKPQQLRHLMNAYE SHVAEHYLGKNASGIAELLTENKRLEGFRAIHNAEVARVLANFKPEITLNDKQVAAINQALTTANSNPNT YTQATDYKILIDAIKTQSGSVNQKDFYNAFNLNDDGRAFTSSTPRKDEMSKQQQHNQHIYAEYNSTSNSG NKKLLAVLLSIEKPVTFSKDIVNRFLRPLKDSETPQDYADTLFGENPTNPANKKFKDDLLRELTPTVFNE IKNDLRKQELLDTNPAHVMTAIKALSTELESIKGITGPIRTNADKLKFINDIDPVHLYNPTFQGTARSKA AQMKERYEGLSRDCGLVVDQLRRQVVALEGHLKSLPKEGEFKAAGLTLEQKAEIKKLRTDLEAELSAVRE DLDFYKKIQGKLETIVKEVDVAAKGKMHYYYNSEGIKRHPPVSRDQIPPLPNVPNPSLRSSTTATTGSNG RIQEFLVGEKIPEGQIVVVDVSHKTAPKSGAPVETIGRYTQDNNVPDQVTSKKGEISKVPGSKFEILQFP TQVPPPNPPSGDPLVEAKVNFSMAMAADILASLDSPPTKDKPIRLRGSNPEELEYLYTALVILGEKNPKF KFNRDAIEVNSAVFHPDNVKGRLWGFSSNSLYSQVFTNTGLTETQNIIQSKIKHMQQMTDEKFSPQKERE KVDSKVQEITDKQSKMKKELNPVHKTTERTIEQEGPAPESPSTGMRK |
| - |
| Nucleotide Sequence: 3504 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2614308-2610805 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGATTCTCGAGGAGTACATCCGTATGGCCAAAAATAAAGAATTTTTTGATGCGCTGGAAGAAATTGCGG AATCAGCAAAAAATGATGAAACTCTTCGTAATGAGCTTGCAAAAGTTTTAGATGATATATTGAAAACTGA TCCCTCTGATCCTGAAGCTTTTAGAAAGATAGTAGCTGAGCATCAGGAGTTCTGGGATGAGCATGATCCT AGCTTGATGGAGTTTAATGAAGGGCGTTTTTTTGGTAAGAGTAGAAAACAATATTTGAAATCAGATGATT TTTTAAATTCTACAGATCCAACCTATAATTTTCAAAAATTACATCAATTTGCTGCAGAACAACGAGTCAA ACTCGGGTTAGAAAAATCAGATACAGACACTTTAGTTGCTATTTTAAAAAACAATCCTGAAGAGTGTAGG GCTTATATCGAATCCAAAAAGCCTGGTTTGGGTAATTTTAGTGAAGGAAATGTGCATGGTTGGTTAAAAG AAGAATATACCCCGACAATTCCTCCGAAAGCTATTAACAAATCTACTGGTGTTTTATCTGATGAAGCGAT CAAAAGAATTAAAGAACAAGCTCGTGACTTGTTATTGCTTAAATTGATTAACAGTTCTGGAAATACTCAA TTATTAAAGGATTTGCGTGATGCCATGAGTAAACCCGAGGCTGAACGTGCTGCGAATGCCTTGGGTTTTC CTACTGAAGGAAACGGGGTATTGTTTTTGAGTAGAGAAGTAGTTGATGCTCTGGAAGAAAGGGTTGAAAA ACTAGAACAGGAAGCTGCCAAGAGAGGATTTGATAGTTATGTCCAATCATTATCTCACAATGCGCTATTA GCCAAAAAAAACGGGTTAGAAAGTACGACAGCTGCAGGGTTTAAAAACAGTTTGGATGAACCTTATAAAA CGTACTTACCGGAGTCGGAATGGGAGAGAGCCCAAGGAGTATTGGGAGCTCGTTATCTTCAAGCGGTTTT ATCATCAGGCACCCAAAATCTCAAGGATGCTCTCAATGCTAAAGATGCCAATGCATTGATTACTGAATTA AAAAAACCTGCCCTCTTGGGACCCCATGACTACATTGATAAAGCGGTGACAGAAGAAAATTTAGGCTCGC TCAAAAAAAATATGATGAAGAGCTTTATTAATAATATCAAGGATGAAACAAATTTAAAGGCCTTGGATGC TTTAAAAGCATTAGACGGGGCTAAAAATTTGGATAAATTTAAAGAGGTACTCGGGAAGTTAGGTATTACT CCAGCGGATTGGGTGAAAGACACCGATTTGAAAGATATGAAGCAATGGGCAAGAGCTCGCCAGTTTGAAC TTGAAATAAATAGAGTGTCTTCTTTAGGCAGCGGGGCCCATTCGAAATTAATGAGCACATTAACTAAGCT TCCAGTCGAAAAACAAAGAGAGATTTTGGCCAAGCCACAACAATTACGCCATTTAATGAACGCTTATGAA TCTCATGTAGCAGAACATTACCTTGGGAAAAACGCATCCGGCATTGCAGAGCTCTTGACAGAGAATAAAA GACTCGAGGGATTTAGGGCTATTCACAATGCCGAGGTAGCCAGGGTTTTGGCTAATTTTAAACCCGAAAT CACTTTAAATGATAAGCAAGTTGCTGCTATTAATCAGGCATTAACCACCGCCAATTCTAACCCCAATACC TATACCCAGGCCACCGACTATAAAATCTTGATTGATGCGATTAAAACTCAATCTGGCTCGGTAAATCAAA AAGATTTTTATAATGCATTTAATTTAAACGATGATGGCAGAGCTTTTACCAGCTCAACTCCTCGAAAAGA TGAGATGAGTAAGCAGCAACAACATAACCAACATATATATGCTGAATACAACAGTACTTCTAATTCAGGT AATAAAAAATTATTAGCTGTCCTGTTGAGTATAGAGAAACCTGTCACCTTTTCCAAAGATATAGTCAATC GGTTTTTACGTCCTCTGAAGGATAGCGAAACTCCTCAAGATTATGCTGATACATTATTTGGAGAAAATCC AACTAATCCGGCAAATAAAAAATTTAAAGACGATTTGTTGCGGGAACTTACACCAACTGTATTTAACGAG ATAAAAAATGATCTCAGAAAACAGGAACTATTAGATACCAATCCAGCTCATGTGATGACAGCAATCAAAG CTCTGAGTACTGAATTAGAGTCTATTAAAGGAATCACAGGACCAATAAGAACAAACGCAGATAAGTTAAA GTTTATCAATGATATCGATCCGGTTCATTTATACAATCCAACCTTTCAGGGTACCGCCAGATCGAAAGCA GCTCAAATGAAAGAAAGATACGAAGGTTTGTCCAGGGATTGTGGACTGGTTGTTGATCAATTAAGGCGTC AGGTAGTCGCTCTCGAAGGTCATTTGAAGAGTCTGCCCAAAGAAGGTGAATTTAAGGCCGCTGGCTTGAC CCTGGAGCAAAAAGCGGAAATCAAAAAGTTGCGTACTGATTTGGAAGCCGAATTGAGTGCGGTGCGCGAG GATTTGGATTTTTATAAAAAAATACAAGGAAAGTTAGAGACTATTGTAAAAGAAGTGGATGTGGCAGCCA AAGGGAAGATGCATTACTACTACAATTCTGAGGGTATCAAACGCCATCCTCCTGTTTCACGTGATCAGAT ACCGCCATTACCCAATGTTCCTAATCCTTCTCTGAGATCGAGTACAACCGCTACTACTGGGTCTAACGGA AGGATACAAGAATTTCTTGTTGGTGAAAAAATACCGGAAGGGCAGATTGTTGTCGTTGATGTATCTCATA AAACAGCACCGAAATCCGGTGCTCCTGTGGAAACGATAGGACGGTATACTCAGGATAACAATGTTCCTGA TCAAGTAACGAGCAAAAAAGGAGAAATAAGCAAGGTTCCCGGAAGTAAATTTGAGATTTTACAATTCCCG ACCCAAGTTCCACCTCCAAACCCTCCAAGTGGAGATCCTCTGGTAGAAGCTAAAGTCAATTTTTCCATGG CGATGGCGGCTGATATTTTAGCGAGTCTGGATAGTCCGCCAACCAAGGATAAACCGATACGATTACGCGG ATCTAATCCCGAAGAACTGGAATATTTGTACACAGCCCTGGTGATCCTTGGTGAAAAGAATCCAAAATTC AAGTTTAACCGTGATGCGATTGAGGTGAATTCTGCAGTATTCCATCCGGATAATGTGAAAGGACGGTTGT GGGGATTTAGCAGCAATTCATTATATAGTCAGGTATTTACTAACACAGGATTAACAGAGACCCAGAATAT CATACAGTCTAAAATAAAACATATGCAACAAATGACTGATGAGAAATTTAGTCCTCAGAAAGAAAGAGAA AAAGTGGATTCCAAAGTACAAGAGATTACTGATAAACAAAGCAAGATGAAGAAGGAACTGAATCCGGTGC ATAAAACAACTGAAAGAACCATTGAACAAGAAGGACCTGCTCCTGAAAGTCCGAGTACAGGGATGCGTAA GTAA |
| Reference |
(1) Ivo Finsel et al. (2013). The Legionella effector RidL inhibits retrograde trafficking to promote intracellular replication. Cell Host & Microbe. 14,38–50. [PudMed:23870312] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |