SecReT4
Effector Protein ID: 52842521
T4SS name [ID]Dot/Icm [5]
Gene symbol-
Locus taglpg2311
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]2610805..2614308 [-]
Productinteraptin
Effector typeProtein
DescriptonCeg28(RidL)
T4CP requirementT4CP Depedent
Target/EffectionRidL (Lpg2311/Ceg28) binds the retromer cargo recognition subcomplex, inhibits retrograde trafficking, and promotes intracellular bacterial replication.
UniProt IDQ5ZT54
KEGG IDlpn:lpg2311
PDB IDNA
Domain hit(s) vs Pfam NA
Protein Sequence: 1167 a.a.     [Download]
>gi|52842521|ref|YP_096320.1| interaptin [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MILEEYIRMAKNKEFFDALEEIAESAKNDETLRNELAKVLDDILKTDPSDPEAFRKIVAEHQEFWDEHDP
SLMEFNEGRFFGKSRKQYLKSDDFLNSTDPTYNFQKLHQFAAEQRVKLGLEKSDTDTLVAILKNNPEECR
AYIESKKPGLGNFSEGNVHGWLKEEYTPTIPPKAINKSTGVLSDEAIKRIKEQARDLLLLKLINSSGNTQ
LLKDLRDAMSKPEAERAANALGFPTEGNGVLFLSREVVDALEERVEKLEQEAAKRGFDSYVQSLSHNALL
AKKNGLESTTAAGFKNSLDEPYKTYLPESEWERAQGVLGARYLQAVLSSGTQNLKDALNAKDANALITEL
KKPALLGPHDYIDKAVTEENLGSLKKNMMKSFINNIKDETNLKALDALKALDGAKNLDKFKEVLGKLGIT
PADWVKDTDLKDMKQWARARQFELEINRVSSLGSGAHSKLMSTLTKLPVEKQREILAKPQQLRHLMNAYE
SHVAEHYLGKNASGIAELLTENKRLEGFRAIHNAEVARVLANFKPEITLNDKQVAAINQALTTANSNPNT
YTQATDYKILIDAIKTQSGSVNQKDFYNAFNLNDDGRAFTSSTPRKDEMSKQQQHNQHIYAEYNSTSNSG
NKKLLAVLLSIEKPVTFSKDIVNRFLRPLKDSETPQDYADTLFGENPTNPANKKFKDDLLRELTPTVFNE
IKNDLRKQELLDTNPAHVMTAIKALSTELESIKGITGPIRTNADKLKFINDIDPVHLYNPTFQGTARSKA
AQMKERYEGLSRDCGLVVDQLRRQVVALEGHLKSLPKEGEFKAAGLTLEQKAEIKKLRTDLEAELSAVRE
DLDFYKKIQGKLETIVKEVDVAAKGKMHYYYNSEGIKRHPPVSRDQIPPLPNVPNPSLRSSTTATTGSNG
RIQEFLVGEKIPEGQIVVVDVSHKTAPKSGAPVETIGRYTQDNNVPDQVTSKKGEISKVPGSKFEILQFP
TQVPPPNPPSGDPLVEAKVNFSMAMAADILASLDSPPTKDKPIRLRGSNPEELEYLYTALVILGEKNPKF
KFNRDAIEVNSAVFHPDNVKGRLWGFSSNSLYSQVFTNTGLTETQNIIQSKIKHMQQMTDEKFSPQKERE
KVDSKVQEITDKQSKMKKELNPVHKTTERTIEQEGPAPESPSTGMRK
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Nucleotide Sequence: 3504 bp     [Download]
>gi|52840256|ref|NC_002942.5|:c2614308-2610805 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
ATGATTCTCGAGGAGTACATCCGTATGGCCAAAAATAAAGAATTTTTTGATGCGCTGGAAGAAATTGCGG
AATCAGCAAAAAATGATGAAACTCTTCGTAATGAGCTTGCAAAAGTTTTAGATGATATATTGAAAACTGA
TCCCTCTGATCCTGAAGCTTTTAGAAAGATAGTAGCTGAGCATCAGGAGTTCTGGGATGAGCATGATCCT
AGCTTGATGGAGTTTAATGAAGGGCGTTTTTTTGGTAAGAGTAGAAAACAATATTTGAAATCAGATGATT
TTTTAAATTCTACAGATCCAACCTATAATTTTCAAAAATTACATCAATTTGCTGCAGAACAACGAGTCAA
ACTCGGGTTAGAAAAATCAGATACAGACACTTTAGTTGCTATTTTAAAAAACAATCCTGAAGAGTGTAGG
GCTTATATCGAATCCAAAAAGCCTGGTTTGGGTAATTTTAGTGAAGGAAATGTGCATGGTTGGTTAAAAG
AAGAATATACCCCGACAATTCCTCCGAAAGCTATTAACAAATCTACTGGTGTTTTATCTGATGAAGCGAT
CAAAAGAATTAAAGAACAAGCTCGTGACTTGTTATTGCTTAAATTGATTAACAGTTCTGGAAATACTCAA
TTATTAAAGGATTTGCGTGATGCCATGAGTAAACCCGAGGCTGAACGTGCTGCGAATGCCTTGGGTTTTC
CTACTGAAGGAAACGGGGTATTGTTTTTGAGTAGAGAAGTAGTTGATGCTCTGGAAGAAAGGGTTGAAAA
ACTAGAACAGGAAGCTGCCAAGAGAGGATTTGATAGTTATGTCCAATCATTATCTCACAATGCGCTATTA
GCCAAAAAAAACGGGTTAGAAAGTACGACAGCTGCAGGGTTTAAAAACAGTTTGGATGAACCTTATAAAA
CGTACTTACCGGAGTCGGAATGGGAGAGAGCCCAAGGAGTATTGGGAGCTCGTTATCTTCAAGCGGTTTT
ATCATCAGGCACCCAAAATCTCAAGGATGCTCTCAATGCTAAAGATGCCAATGCATTGATTACTGAATTA
AAAAAACCTGCCCTCTTGGGACCCCATGACTACATTGATAAAGCGGTGACAGAAGAAAATTTAGGCTCGC
TCAAAAAAAATATGATGAAGAGCTTTATTAATAATATCAAGGATGAAACAAATTTAAAGGCCTTGGATGC
TTTAAAAGCATTAGACGGGGCTAAAAATTTGGATAAATTTAAAGAGGTACTCGGGAAGTTAGGTATTACT
CCAGCGGATTGGGTGAAAGACACCGATTTGAAAGATATGAAGCAATGGGCAAGAGCTCGCCAGTTTGAAC
TTGAAATAAATAGAGTGTCTTCTTTAGGCAGCGGGGCCCATTCGAAATTAATGAGCACATTAACTAAGCT
TCCAGTCGAAAAACAAAGAGAGATTTTGGCCAAGCCACAACAATTACGCCATTTAATGAACGCTTATGAA
TCTCATGTAGCAGAACATTACCTTGGGAAAAACGCATCCGGCATTGCAGAGCTCTTGACAGAGAATAAAA
GACTCGAGGGATTTAGGGCTATTCACAATGCCGAGGTAGCCAGGGTTTTGGCTAATTTTAAACCCGAAAT
CACTTTAAATGATAAGCAAGTTGCTGCTATTAATCAGGCATTAACCACCGCCAATTCTAACCCCAATACC
TATACCCAGGCCACCGACTATAAAATCTTGATTGATGCGATTAAAACTCAATCTGGCTCGGTAAATCAAA
AAGATTTTTATAATGCATTTAATTTAAACGATGATGGCAGAGCTTTTACCAGCTCAACTCCTCGAAAAGA
TGAGATGAGTAAGCAGCAACAACATAACCAACATATATATGCTGAATACAACAGTACTTCTAATTCAGGT
AATAAAAAATTATTAGCTGTCCTGTTGAGTATAGAGAAACCTGTCACCTTTTCCAAAGATATAGTCAATC
GGTTTTTACGTCCTCTGAAGGATAGCGAAACTCCTCAAGATTATGCTGATACATTATTTGGAGAAAATCC
AACTAATCCGGCAAATAAAAAATTTAAAGACGATTTGTTGCGGGAACTTACACCAACTGTATTTAACGAG
ATAAAAAATGATCTCAGAAAACAGGAACTATTAGATACCAATCCAGCTCATGTGATGACAGCAATCAAAG
CTCTGAGTACTGAATTAGAGTCTATTAAAGGAATCACAGGACCAATAAGAACAAACGCAGATAAGTTAAA
GTTTATCAATGATATCGATCCGGTTCATTTATACAATCCAACCTTTCAGGGTACCGCCAGATCGAAAGCA
GCTCAAATGAAAGAAAGATACGAAGGTTTGTCCAGGGATTGTGGACTGGTTGTTGATCAATTAAGGCGTC
AGGTAGTCGCTCTCGAAGGTCATTTGAAGAGTCTGCCCAAAGAAGGTGAATTTAAGGCCGCTGGCTTGAC
CCTGGAGCAAAAAGCGGAAATCAAAAAGTTGCGTACTGATTTGGAAGCCGAATTGAGTGCGGTGCGCGAG
GATTTGGATTTTTATAAAAAAATACAAGGAAAGTTAGAGACTATTGTAAAAGAAGTGGATGTGGCAGCCA
AAGGGAAGATGCATTACTACTACAATTCTGAGGGTATCAAACGCCATCCTCCTGTTTCACGTGATCAGAT
ACCGCCATTACCCAATGTTCCTAATCCTTCTCTGAGATCGAGTACAACCGCTACTACTGGGTCTAACGGA
AGGATACAAGAATTTCTTGTTGGTGAAAAAATACCGGAAGGGCAGATTGTTGTCGTTGATGTATCTCATA
AAACAGCACCGAAATCCGGTGCTCCTGTGGAAACGATAGGACGGTATACTCAGGATAACAATGTTCCTGA
TCAAGTAACGAGCAAAAAAGGAGAAATAAGCAAGGTTCCCGGAAGTAAATTTGAGATTTTACAATTCCCG
ACCCAAGTTCCACCTCCAAACCCTCCAAGTGGAGATCCTCTGGTAGAAGCTAAAGTCAATTTTTCCATGG
CGATGGCGGCTGATATTTTAGCGAGTCTGGATAGTCCGCCAACCAAGGATAAACCGATACGATTACGCGG
ATCTAATCCCGAAGAACTGGAATATTTGTACACAGCCCTGGTGATCCTTGGTGAAAAGAATCCAAAATTC
AAGTTTAACCGTGATGCGATTGAGGTGAATTCTGCAGTATTCCATCCGGATAATGTGAAAGGACGGTTGT
GGGGATTTAGCAGCAATTCATTATATAGTCAGGTATTTACTAACACAGGATTAACAGAGACCCAGAATAT
CATACAGTCTAAAATAAAACATATGCAACAAATGACTGATGAGAAATTTAGTCCTCAGAAAGAAAGAGAA
AAAGTGGATTCCAAAGTACAAGAGATTACTGATAAACAAAGCAAGATGAAGAAGGAACTGAATCCGGTGC
ATAAAACAACTGAAAGAACCATTGAACAAGAAGGACCTGCTCCTGAAAGTCCGAGTACAGGGATGCGTAA
GTAA

Reference
(1) Ivo Finsel et al. (2013). The Legionella effector RidL inhibits retrograde trafficking to promote intracellular replication. Cell Host & Microbe. 14,38–50. [PudMed:23870312] experimental
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
 
experimental experimental literature
in_silico in silico analysis literature