| Effector Protein ID: 52842510 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legA3 |
| Locus tag | lpg2300 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2601375..2602778 [-] |
| Product | ankyrin repeat-containing protein |
| Effector type | Protein |
| Descripton | AnkH/legA3, ankW |
| T4CP requirement | T4CP Depedent |
| Target/Effection | AnkH is required for intracellular replication |
| UniProt ID | Q5ZT65 |
| KEGG ID | lpn:lpg2300 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 2.7e-28, Aligned region: 19..93 Ank_2 [PF12796], Evalue: 2.7e-28, Aligned region: 36..125 Ank [PF00023], Evalue: 2.6e-17, Aligned region: 65..95 Ank_4 [PF13637], Evalue: 3.4e-14, Aligned region: 34..85 Ank_4 [PF13637], Evalue: 3.4e-14, Aligned region: 65..104 Ank_5 [PF13857], Evalue: 2.7e-12, Aligned region: 54..98 Ank_3 [PF13606], Evalue: 2.4e-11, Aligned region: 65..93 |
| Protein Sequence: 467 a.a. [Download] |
| >gi|52842510|ref|YP_096309.1| ankyrin repeat-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MSIANDIISHRMPDFDAYLRAGESLDDIDEYGFTPLIECAITRQIKIAEQLIARKVDINKPDVTGRTPLH WAVDNNDLDMTKLLLTYGADPNAYTRNGLCVLVYPVLRGQDAIKQLLYHHGAKLDFALDFINAKLIGHRF ELQGDVDIVNAKGEFIELDYEGFILEFTVAVVKDSLRRFISSYSTRHLRDYFPYIHNIMDAFTDAAELLQ YQHHPRLGEQHFKRIAALLKAPMLILPAASRGHALCFVRYHQWWAKIDRGENSLQEGSVNIYRITRPEAL TINFIHDFLYKKQNRRYYHQMINQQLGLLPFAQMPISSQISGNCSWANVQAVVPVAYSMQELTSVENFKP DVALSLYDEWVEWDKDRALDECIQRFYLASPERKASIAAILGGILFQACDHANKRHLERAEKILNILILD EYYYVLSSYLEEYCIKRLTRKGNNLLKILDDCGINPNIGVNPVATGL |
| - |
| Nucleotide Sequence: 1404 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2602778-2601375 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAGTATTGCAAACGATATTATCAGTCATAGAATGCCTGATTTTGATGCTTATCTGCGTGCAGGGGAAT CTTTGGATGATATCGATGAATATGGTTTTACTCCCCTCATAGAGTGTGCTATTACACGACAAATTAAAAT AGCAGAGCAGTTAATTGCTCGCAAAGTGGATATCAACAAGCCAGACGTCACAGGACGCACTCCATTACAT TGGGCAGTGGACAATAATGATTTGGATATGACCAAACTCTTATTAACCTACGGCGCTGATCCTAATGCCT ACACTCGTAATGGTCTTTGTGTGTTGGTTTATCCGGTTTTGCGTGGCCAAGATGCAATAAAGCAGTTGTT ATATCATCATGGCGCGAAGCTTGATTTTGCTCTTGATTTTATTAATGCCAAATTGATTGGTCATCGATTT GAATTGCAAGGCGATGTGGATATTGTCAATGCGAAAGGCGAATTCATCGAACTTGATTATGAAGGGTTTA TTTTGGAATTCACTGTTGCTGTTGTAAAAGACTCTCTGCGGAGATTTATCAGTAGTTATTCGACTCGGCA TTTAAGGGATTATTTTCCATATATTCATAATATTATGGATGCTTTTACTGATGCGGCAGAGCTGTTGCAG TATCAACATCATCCCAGGCTTGGCGAACAGCATTTCAAACGTATTGCTGCTTTGTTAAAAGCCCCTATGC TGATTCTTCCTGCGGCGAGTCGTGGCCATGCCTTATGCTTTGTCCGTTATCACCAGTGGTGGGCAAAAAT TGACAGAGGTGAAAATAGCTTACAAGAAGGAAGCGTTAATATTTACCGAATAACCAGGCCAGAGGCACTA ACAATCAATTTTATCCATGATTTTTTATATAAAAAACAAAACAGACGATATTATCATCAAATGATTAATC AACAATTGGGGCTGCTTCCTTTTGCTCAAATGCCAATTAGTTCTCAAATTAGTGGAAATTGTTCGTGGGC TAATGTGCAAGCTGTTGTACCAGTCGCGTATTCTATGCAGGAGCTGACCAGCGTAGAAAATTTTAAACCT GATGTGGCCTTATCACTATATGATGAGTGGGTCGAGTGGGATAAAGACAGGGCTCTTGATGAATGCATAC AACGATTTTATTTAGCCAGTCCTGAACGTAAGGCAAGTATTGCTGCAATCTTGGGAGGCATTTTGTTTCA GGCTTGTGATCACGCTAACAAGCGTCATCTGGAAAGAGCGGAGAAAATTCTTAATATTTTGATTTTAGAC GAATATTATTATGTTTTGAGCAGTTATCTGGAAGAATACTGTATTAAACGATTAACCCGTAAAGGAAATA ATTTATTAAAAATTCTGGATGATTGTGGGATTAATCCTAATATTGGCGTCAATCCTGTTGCGACAGGCCT ATAA |
| Reference |
(1) Gomez-Valero L et al. (2014). Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease. Genome Biol. 15(11):505. [PudMed:25370836] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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| experimental literature |
| in silico analysis literature |