SecReT4
Effector Protein ID: 52842510
T4SS name [ID]Dot/Icm [5]
Gene symbollegA3
Locus taglpg2300
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]2601375..2602778 [-]
Productankyrin repeat-containing protein
Effector typeProtein
DescriptonAnkH/legA3, ankW
T4CP requirementT4CP Depedent
Target/EffectionAnkH is required for intracellular replication
UniProt IDQ5ZT65
KEGG IDlpn:lpg2300
PDB IDNA
Domain hit(s) vs Pfam Ank_2 [PF12796], Evalue: 2.7e-28, Aligned region: 19..93
Ank_2 [PF12796], Evalue: 2.7e-28, Aligned region: 36..125
Ank [PF00023], Evalue: 2.6e-17, Aligned region: 65..95
Ank_4 [PF13637], Evalue: 3.4e-14, Aligned region: 34..85
Ank_4 [PF13637], Evalue: 3.4e-14, Aligned region: 65..104
Ank_5 [PF13857], Evalue: 2.7e-12, Aligned region: 54..98
Ank_3 [PF13606], Evalue: 2.4e-11, Aligned region: 65..93
Protein Sequence: 467 a.a.     [Download]
>gi|52842510|ref|YP_096309.1| ankyrin repeat-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MSIANDIISHRMPDFDAYLRAGESLDDIDEYGFTPLIECAITRQIKIAEQLIARKVDINKPDVTGRTPLH
WAVDNNDLDMTKLLLTYGADPNAYTRNGLCVLVYPVLRGQDAIKQLLYHHGAKLDFALDFINAKLIGHRF
ELQGDVDIVNAKGEFIELDYEGFILEFTVAVVKDSLRRFISSYSTRHLRDYFPYIHNIMDAFTDAAELLQ
YQHHPRLGEQHFKRIAALLKAPMLILPAASRGHALCFVRYHQWWAKIDRGENSLQEGSVNIYRITRPEAL
TINFIHDFLYKKQNRRYYHQMINQQLGLLPFAQMPISSQISGNCSWANVQAVVPVAYSMQELTSVENFKP
DVALSLYDEWVEWDKDRALDECIQRFYLASPERKASIAAILGGILFQACDHANKRHLERAEKILNILILD
EYYYVLSSYLEEYCIKRLTRKGNNLLKILDDCGINPNIGVNPVATGL
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Nucleotide Sequence: 1404 bp     [Download]
>gi|52840256|ref|NC_002942.5|:c2602778-2601375 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
ATGAGTATTGCAAACGATATTATCAGTCATAGAATGCCTGATTTTGATGCTTATCTGCGTGCAGGGGAAT
CTTTGGATGATATCGATGAATATGGTTTTACTCCCCTCATAGAGTGTGCTATTACACGACAAATTAAAAT
AGCAGAGCAGTTAATTGCTCGCAAAGTGGATATCAACAAGCCAGACGTCACAGGACGCACTCCATTACAT
TGGGCAGTGGACAATAATGATTTGGATATGACCAAACTCTTATTAACCTACGGCGCTGATCCTAATGCCT
ACACTCGTAATGGTCTTTGTGTGTTGGTTTATCCGGTTTTGCGTGGCCAAGATGCAATAAAGCAGTTGTT
ATATCATCATGGCGCGAAGCTTGATTTTGCTCTTGATTTTATTAATGCCAAATTGATTGGTCATCGATTT
GAATTGCAAGGCGATGTGGATATTGTCAATGCGAAAGGCGAATTCATCGAACTTGATTATGAAGGGTTTA
TTTTGGAATTCACTGTTGCTGTTGTAAAAGACTCTCTGCGGAGATTTATCAGTAGTTATTCGACTCGGCA
TTTAAGGGATTATTTTCCATATATTCATAATATTATGGATGCTTTTACTGATGCGGCAGAGCTGTTGCAG
TATCAACATCATCCCAGGCTTGGCGAACAGCATTTCAAACGTATTGCTGCTTTGTTAAAAGCCCCTATGC
TGATTCTTCCTGCGGCGAGTCGTGGCCATGCCTTATGCTTTGTCCGTTATCACCAGTGGTGGGCAAAAAT
TGACAGAGGTGAAAATAGCTTACAAGAAGGAAGCGTTAATATTTACCGAATAACCAGGCCAGAGGCACTA
ACAATCAATTTTATCCATGATTTTTTATATAAAAAACAAAACAGACGATATTATCATCAAATGATTAATC
AACAATTGGGGCTGCTTCCTTTTGCTCAAATGCCAATTAGTTCTCAAATTAGTGGAAATTGTTCGTGGGC
TAATGTGCAAGCTGTTGTACCAGTCGCGTATTCTATGCAGGAGCTGACCAGCGTAGAAAATTTTAAACCT
GATGTGGCCTTATCACTATATGATGAGTGGGTCGAGTGGGATAAAGACAGGGCTCTTGATGAATGCATAC
AACGATTTTATTTAGCCAGTCCTGAACGTAAGGCAAGTATTGCTGCAATCTTGGGAGGCATTTTGTTTCA
GGCTTGTGATCACGCTAACAAGCGTCATCTGGAAAGAGCGGAGAAAATTCTTAATATTTTGATTTTAGAC
GAATATTATTATGTTTTGAGCAGTTATCTGGAAGAATACTGTATTAAACGATTAACCCGTAAAGGAAATA
ATTTATTAAAAATTCTGGATGATTGTGGGATTAATCCTAATATTGGCGTCAATCCTGTTGCGACAGGCCT
ATAA

Reference
(1) Gomez-Valero L et al. (2014). Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease. Genome Biol. 15(11):505. [PudMed:25370836] experimental
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature