| Effector Protein ID: 52842508 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legC7 |
| Locus tag | lpg2298 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2596514..2597791 [-] |
| Product | inclusion membrane protein A |
| Effector type | Protein |
| Descripton | YlfA/legC7 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Vesicle trafficking |
| UniProt ID | Q5ZT67 |
| KEGG ID | lpn:lpg2298 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 425 a.a. [Download] |
| >gi|52842508|ref|YP_096307.1| inclusion membrane protein A [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MATNETELQVLIQHDSKSTITTSSLDSTDKDPKASTGTPEIESASLAQIVDTQKQLSQVKESLESIVDSI AENPSLITRAASAWGELPMWQKVTGGLVLTAPTLAVGLFAHIGVLLVIGGVTGLTYTAGAIVLDDHHTCN VNIAKRLKEGLFGLADLLQITIEALDAIRKKFAEEIEKFKNENLRLTDNIDRLGNEVESLSAQVELYMEI EKMLRKDTNEMEQTVKKLQESTTKQTDLLEKNQKELSKIRKEYEKSQLQLAEKIAELHEVRLSLGLEVQK AKTVAKTLEGTVQTLTGTVIADEEQRVSFQKKLDGFLNDKQLSFDQVAERICKAEEELKKVKEELRQSND RYSELLKRQEQQVERLEKLGLHKLERIVDKENVKPSNDPVHSGLLSHGIYSTPKGKVTQPKVEVVEDRQT IALVN |
| - |
| Nucleotide Sequence: 1278 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2597791-2596514 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGGCTACTAATGAAACAGAGCTTCAAGTATTGATCCAACATGATAGCAAATCAACAATCACTACTTCTA GCTTGGACAGTACTGATAAGGATCCTAAAGCAAGTACTGGCACTCCTGAAATTGAAAGCGCTAGTCTTGC CCAAATCGTCGATACCCAAAAACAACTGAGCCAAGTTAAAGAAAGCCTGGAATCAATAGTAGACAGTATA GCGGAAAATCCTAGCCTGATTACTCGCGCTGCGTCAGCCTGGGGCGAACTGCCTATGTGGCAGAAAGTCA CGGGTGGCCTTGTCCTGACAGCGCCTACTTTGGCAGTAGGATTATTTGCGCACATTGGCGTCTTATTAGT AATAGGGGGAGTTACAGGACTAACCTATACCGCAGGTGCAATTGTTTTGGACGACCACCATACATGCAAT GTGAATATTGCCAAACGATTAAAAGAAGGGCTTTTTGGTTTGGCAGATCTGTTACAAATTACGATTGAGG CATTGGATGCAATTCGCAAAAAATTTGCTGAAGAAATTGAGAAATTTAAGAATGAAAACCTCAGATTAAC TGATAACATTGACAGGCTGGGCAATGAAGTGGAATCACTGAGTGCTCAGGTTGAATTATATATGGAAATT GAGAAAATGCTCCGTAAAGATACAAATGAAATGGAGCAAACCGTCAAAAAACTTCAAGAATCTACAACAA AACAAACTGATTTATTGGAAAAAAATCAAAAGGAATTGTCAAAAATTAGAAAGGAATACGAAAAAAGCCA ATTGCAGTTAGCCGAAAAAATAGCTGAATTACATGAAGTCAGACTGTCGTTGGGTCTCGAAGTTCAAAAA GCTAAAACAGTTGCGAAAACGTTGGAAGGTACAGTCCAGACTTTAACTGGAACGGTCATTGCTGATGAAG AGCAACGTGTTTCTTTTCAAAAGAAACTGGATGGATTCCTGAATGACAAACAGCTCAGCTTTGATCAAGT AGCTGAACGAATTTGCAAGGCAGAAGAAGAACTTAAAAAAGTCAAAGAAGAATTAAGACAAAGCAATGAT CGTTATAGTGAACTGTTAAAGCGTCAGGAACAACAGGTTGAACGTTTGGAAAAATTGGGCTTGCATAAAT TGGAAAGAATAGTAGACAAAGAGAATGTGAAACCCAGTAATGACCCTGTCCACTCAGGTTTGCTTTCCCA TGGAATCTATAGTACGCCCAAGGGTAAAGTCACCCAGCCTAAAGTAGAGGTAGTAGAAGATAGACAAACT ATTGCTTTAGTCAATTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Rasis M; Segal G (2009). The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectors. Mol Microbiol. 72(4):995-1010. [PudMed:19400807]
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| experimental literature |
| in silico analysis literature |