| Effector Protein ID: 52842437 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2224 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2512062..2513843 [+] |
| Product | UVB-resistance protein UVR8 |
| Effector type | Protein |
| Descripton | PpgA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | PpgA contain a RCC1 domain that is linked to eukaryotic GEFs for Ran-GTPase activity. (Ge and Shao, 2011) |
| UniProt ID | Q5ZTD8 |
| KEGG ID | lpn:lpg2224 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | RCC1 [PF00415], Evalue: 4.5e-32, Aligned region: 265..305 RCC1 [PF00415], Evalue: 4.5e-32, Aligned region: 379..424 |
| Protein Sequence: 593 a.a. [Download] |
| >gi|52842437|ref|YP_096236.1| UVB-resistance protein UVR8 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MKEPRELNRQPNPEHMAQLIKDTPKDVWFHLAKYLPDHELLNLMQVDKRLNRFFKEGTPPKEIIKKIEHA PLKVVSSGVNTFILTQYHGKPLLLACGQNKDGQLGCGDTKIRTALTPVNIPESFASIESVQISLFHAVLW GRDKDNKPILATCGLNDKGQLGCGDYKSRALFTQVKLAEDITSIESVEINIFHSVILGHDKHNRPVLASC GSNHLGKLGCGDIKDKTTFTRMKLPTEIVSIDTLQMNWHTIVSGRDKNNKPVLAACGWNDRGQLGCGDKK ERALLTPVKLPENIVSIQSAQIGTSRTTVLGRDKDNKPILTYCGWNERNQMGWSNTEDKTALTPAKLPEN IVSIELMQISTSRTVILGRDKNNKPILAACGLNNHGQLGCGDIKTRTTLYPIKFPKDIVSIESVQISDNH TVILGRDKHKNPIIAACGLNNYGQLGCGDTKNRMLLTPIKLPKEIVCIDSVTVKYSSLFVSGRDKNHRPI LAACGDNRYGQLGVPSKKLLTELTIVPTPILTLPATPKREASSRKEATEKALVFATHGSREQKPRKSNRI LTAIIASFGRFFTGAHPHTPDSDKESPSPKRSA |
| - |
| Nucleotide Sequence: 1782 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2512062-2513843 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAAAGAACCTCGTGAACTTAATCGCCAACCCAATCCAGAACACATGGCTCAACTCATTAAAGACACGC CCAAAGACGTTTGGTTTCATCTCGCAAAATATCTTCCTGACCATGAATTACTCAACCTCATGCAAGTCGA CAAACGCTTAAATCGCTTCTTCAAAGAAGGTACCCCCCCAAAAGAAATAATAAAAAAAATAGAACACGCC CCCCTTAAGGTCGTTTCTTCAGGCGTCAATACCTTCATTCTAACCCAATACCACGGCAAACCACTCTTAC TCGCCTGCGGACAAAACAAAGACGGTCAATTAGGCTGTGGGGATACGAAAATTAGAACAGCACTCACCCC TGTCAATATCCCTGAATCATTTGCCTCCATCGAGTCGGTGCAGATCAGTCTTTTCCATGCAGTGCTTTGG GGACGTGATAAAGACAATAAGCCGATACTAGCGACTTGCGGATTAAATGATAAAGGTCAGCTGGGTTGTG GAGACTATAAGTCTAGAGCATTATTCACCCAAGTCAAATTAGCAGAAGACATCACTTCCATCGAATCAGT AGAAATCAACATTTTCCATTCTGTGATTTTAGGCCATGATAAACATAACAGACCAGTACTTGCATCCTGT GGAAGCAATCACTTGGGTAAATTAGGTTGTGGAGACATAAAAGATAAAACAACATTCACCCGAATGAAAT TACCTACAGAAATTGTTTCCATAGATACTTTACAGATGAATTGGCATACAATTGTTTCAGGACGCGATAA GAATAACAAACCAGTACTGGCAGCTTGTGGATGGAATGATAGAGGCCAACTAGGGTGTGGGGATAAAAAG GAAAGAGCATTACTCACCCCAGTCAAGTTACCTGAAAACATCGTTTCCATCCAATCAGCACAAATTGGCA CCAGTCGTACTACAGTTCTAGGTCGCGATAAAGACAATAAACCGATACTTACCTATTGTGGATGGAATGA AAGAAACCAAATGGGTTGGAGTAACACTGAAGATAAAACAGCACTCACCCCAGCAAAATTACCTGAAAAC ATCGTTTCCATTGAGTTAATGCAAATCAGTACTAGCCGCACTGTAATTTTAGGTCGCGATAAAAACAACA AACCAATATTGGCTGCTTGTGGGCTAAATAATCACGGTCAACTTGGGTGCGGTGATATTAAAACCAGAAC AACTCTTTATCCAATCAAATTCCCCAAAGACATTGTTTCTATTGAGTCGGTGCAAATCAGTGATAACCAT ACGGTGATTTTGGGAAGAGATAAGCACAAGAATCCGATAATAGCAGCCTGTGGACTTAATAATTACGGTC AACTAGGCTGTGGGGATACAAAAAACAGAATGCTACTCACACCCATCAAACTGCCCAAAGAGATAGTTTG CATAGACTCCGTGACAGTAAAATACAGCAGCCTTTTTGTTTCAGGTCGTGATAAAAACCATCGTCCCATA CTGGCGGCTTGCGGGGATAATCGCTACGGTCAACTTGGGGTTCCAAGCAAGAAACTTCTAACCGAACTGA CCATCGTTCCCACACCCATTCTCACATTGCCTGCAACACCAAAAAGAGAGGCTTCTTCCAGGAAAGAGGC TACAGAGAAAGCTCTAGTCTTTGCTACCCATGGCAGCAGAGAGCAAAAACCCCGAAAAAGCAATAGGATA CTCACTGCAATCATTGCATCATTCGGTCGTTTTTTTACTGGAGCACATCCTCATACTCCGGACTCCGATA AAGAAAGCCCTTCACCCAAACGAAGCGCCTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |