| Effector Protein ID: 52842435 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2222 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2508818..2509945 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LpnE |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Vacuolar trafficking |
| UniProt ID | Q5ZTE0 |
| KEGG ID | lpn:lpg2222 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Sel1 [PF08238], Evalue: 3.9e-75, Aligned region: 52..87 Sel1 [PF08238], Evalue: 3.9e-75, Aligned region: 89..122 Sel1 [PF08238], Evalue: 3.9e-75, Aligned region: 123..158 Sel1 [PF08238], Evalue: 3.9e-75, Aligned region: 160..194 Sel1 [PF08238], Evalue: 3.9e-75, Aligned region: 195..230 Sel1 [PF08238], Evalue: 3.9e-75, Aligned region: 231..266 Sel1 [PF08238], Evalue: 3.9e-75, Aligned region: 267..302 Sel1 [PF08238], Evalue: 3.9e-75, Aligned region: 304..337 |
| Protein Sequence: 375 a.a. [Download] |
| >gi|52842435|ref|YP_096234.1| hypothetical protein lpg2222 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MDMKKYILSLSLLTVINSSAIATTQEGEEAYNKGYYEKAFILLSPEADKGDAKAQYLLGKMYYNAQGVTY NPEKTEQLLLASANQGNVDAQVLLAGFYWYLNTPEGYKKAFEWYQKAADQNNADGQYGLGYMYDTGTGVP QNSDTAMVWYKKAAEQGNSNAALAIGYNYDTGTGVKKDKTQALNWYAKAADLGNASAQYNLGLMYEQGDG VPKDYQKAAEYFEKAANQGHAKSQLELGYLYDSGKLGKSDLQKAAFWYQKSADLGNANAQFNLADMYFYG DGVGKSLEQSVYWMQKAAEQGYGKAQNQLGIYYRDGIGVAADPVKAYAWFTAAKNNGFEKAASNASDLEK SMNPEDLSKARILGQQYTDNYKAKK |
| - |
| Nucleotide Sequence: 1128 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2509945-2508818 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGGACATGAAAAAATATATTTTATCTCTTTCTCTACTGACGGTGATTAACTCTTCAGCTATCGCTACGA CTCAGGAAGGTGAGGAGGCCTATAACAAGGGGTATTACGAAAAAGCATTTATTTTGTTGTCTCCTGAAGC GGATAAAGGAGATGCCAAGGCTCAATATTTGCTGGGTAAGATGTATTATAATGCCCAAGGTGTAACTTAT AATCCGGAAAAAACAGAGCAATTATTACTTGCCTCAGCGAATCAAGGCAATGTCGATGCCCAGGTATTGT TAGCCGGTTTCTATTGGTACCTTAATACACCAGAGGGCTATAAAAAGGCGTTCGAATGGTATCAGAAAGC AGCGGATCAAAATAATGCGGATGGTCAATATGGCTTGGGCTATATGTATGATACAGGAACTGGTGTACCT CAGAATTCCGATACAGCCATGGTATGGTATAAAAAAGCAGCAGAGCAAGGCAACTCTAATGCGGCTTTGG CTATTGGTTATAATTATGATACCGGTACAGGGGTGAAAAAGGATAAGACTCAAGCTCTCAACTGGTATGC AAAAGCAGCTGACTTAGGTAATGCCAGCGCACAATATAATCTTGGTTTGATGTATGAGCAAGGGGATGGT GTTCCTAAAGATTATCAGAAAGCAGCAGAGTATTTCGAGAAAGCAGCGAATCAAGGTCATGCCAAATCGC AATTGGAGTTAGGTTATTTATATGATTCTGGAAAATTAGGTAAATCGGATCTGCAAAAGGCTGCTTTTTG GTATCAAAAAAGCGCAGATCTGGGGAATGCCAATGCGCAATTTAATTTAGCTGATATGTATTTTTACGGT GATGGGGTCGGTAAAAGCCTTGAGCAATCCGTATACTGGATGCAAAAAGCAGCTGAGCAAGGGTATGGTA AGGCTCAAAATCAATTAGGTATCTATTACAGAGACGGTATTGGTGTTGCTGCTGATCCTGTAAAAGCTTA TGCTTGGTTTACAGCAGCCAAGAATAATGGCTTTGAAAAAGCGGCGAGCAATGCCAGTGATCTTGAGAAA TCTATGAACCCAGAGGATCTGAGTAAGGCGAGAATTTTAGGACAACAATATACGGATAATTACAAGGCCA AAAAATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
|
(2) Weber SS; Ragaz C; Hilbi H (2009). The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE. Cell Microbiol. 11(3):442-60. [PudMed:19021631] 
|
| experimental literature |
| in silico analysis literature |