| Effector Protein ID: 52842428 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legA2 |
| Locus tag | lpg2215 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2498937..2500532 [-] |
| Product | ankyrin repeat-containing protein |
| Effector type | Protein |
| Descripton | LegA2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZTE7 |
| KEGG ID | lpn:lpg2215 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 1.3e-10, Aligned region: 247..386 |
| Protein Sequence: 531 a.a. [Download] |
| >gi|52842428|ref|YP_096227.1| ankyrin repeat-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MSQSVDQSQVIDRLNRYLKWHNMPVSMNEEGICNGLVTVYAKYVLDGKEKRFFELLDQIVRMEADSAIES EINQFVYDVVLTLFPHQFNKKLSQANSMCALTVNNKPLVSSFDFAIATQDKNWEEIFKNLALQEDEIARV SGTAHAVAVRRKNNKYIVYDPNYSSGTKEFSNEHELISELHYNVFGYHNGFYIKGGLLGMMVSVIRYPDN KKPRAFPQVTQLYDRYLTKNNINDVAVSFHGGTFNTLEHAAMVSHAEVIKNLLEKGAKDNDHQAAGNAVM YNNVEALKALLGKNRETELFQRLFHAALESGREEVYDALFSMKGALPFNSSVQAIRAAAKGGNSVLLAKV MNYFKRNHTGFSDLEDAIFSAITSGSVQCVKLLVNQLNESKKPLDDKKRMEYLLESIKQNQSYMVAYFLK DIPPEHLKTIYMSVSAVERTNLHILRQLQNYGVPFSDMSKAVFEQKEHHFVGLKRILGIFLCKFTDFLKE LLFNDRGIHCHRAEESGVKKSFFAFPKKLVGVEQLQIPKLY |
| - |
| Nucleotide Sequence: 1596 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2500532-2498937 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAGTCAATCGGTTGATCAAAGTCAAGTCATTGATCGATTAAATCGGTATCTCAAATGGCATAATATGC CAGTTAGCATGAATGAAGAAGGAATTTGCAATGGCTTGGTTACCGTGTACGCAAAATACGTACTCGATGG TAAAGAAAAGCGCTTTTTTGAATTGCTTGATCAGATAGTCAGAATGGAGGCAGACTCAGCAATAGAGTCT GAGATAAATCAGTTTGTCTATGATGTCGTTCTCACTTTATTCCCGCATCAATTTAATAAAAAACTAAGTC AGGCTAATTCCATGTGTGCCTTGACAGTAAACAATAAACCCTTGGTTTCTTCTTTTGATTTTGCAATTGC AACTCAAGATAAAAATTGGGAGGAAATCTTTAAAAATCTTGCTCTGCAAGAGGATGAGATTGCTCGTGTT AGCGGAACAGCGCATGCTGTAGCCGTCAGGAGAAAAAATAATAAATACATTGTATACGATCCTAATTACT CGTCTGGTACTAAGGAGTTCTCCAATGAACACGAATTGATTTCCGAGTTACATTACAATGTATTCGGGTA TCATAATGGATTTTATATTAAGGGTGGTCTTTTGGGGATGATGGTTAGTGTCATCCGCTATCCCGACAAT AAGAAGCCAAGAGCTTTTCCTCAAGTGACTCAGCTTTATGATCGTTATTTAACCAAAAACAATATTAATG ACGTAGCTGTTTCATTTCATGGTGGAACATTTAATACTTTAGAGCATGCTGCAATGGTTAGTCATGCAGA AGTAATAAAAAATTTGCTTGAGAAAGGAGCAAAAGATAATGATCATCAGGCTGCTGGAAATGCTGTTATG TACAACAATGTAGAAGCATTAAAAGCTTTACTGGGAAAAAATAGAGAGACAGAACTCTTTCAAAGGCTAT TTCACGCGGCTTTGGAGAGCGGGAGAGAAGAAGTTTATGATGCCTTGTTTTCCATGAAAGGTGCCTTGCC ATTTAATTCGTCTGTTCAAGCCATTCGAGCTGCAGCAAAAGGGGGTAATTCTGTTCTCTTGGCCAAGGTA ATGAATTATTTTAAAAGAAATCATACTGGATTTTCAGATCTTGAAGACGCCATTTTTTCTGCAATTACCA GTGGAAGTGTCCAATGTGTCAAATTACTTGTTAACCAATTAAATGAAAGTAAAAAACCTTTAGATGATAA AAAAAGGATGGAGTATTTGCTTGAGTCAATAAAGCAAAATCAATCTTATATGGTGGCTTATTTTCTTAAA GATATCCCACCGGAACATTTAAAAACAATCTATATGAGTGTCTCTGCTGTTGAGAGAACAAATCTGCATA TTTTACGTCAGTTACAGAATTATGGAGTTCCATTTTCAGATATGTCAAAGGCTGTTTTTGAACAAAAAGA GCACCATTTTGTAGGTTTAAAACGGATACTAGGTATTTTTCTGTGTAAATTCACTGATTTTCTTAAAGAA CTCTTATTCAATGATCGCGGAATACATTGCCATCGAGCAGAAGAGAGTGGAGTAAAAAAATCATTTTTTG CCTTCCCTAAAAAACTGGTTGGAGTTGAACAATTACAAATCCCCAAACTTTATTGA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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| experimental literature |
| in silico analysis literature |