| Effector Protein ID: 52842389 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legS2 |
| Locus tag | lpg2176 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2440714..2442540 [-] |
| Product | sphingosine-1-phosphate lyase I |
| Effector type | Protein |
| Descripton | LegS2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegS2 is homologous to eukaryotic sphingosine-1-phosphate lyase and localizes to the mitochondria in host cells (Degtyar, et al. 2009) |
| UniProt ID | Q5ZTI6 |
| KEGG ID | lpn:lpg2176 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pyridoxal_deC [PF00282], Evalue: 3e-15, Aligned region: 194..382 Aminotran_5 [PF00266], Evalue: 1.2e-09, Aligned region: 201..494 DegT_DnrJ_EryC1 [PF01041], Evalue: 4.7e-06, Aligned region: 220..335 |
| Protein Sequence: 608 a.a. [Download] |
| >gi|52842389|ref|YP_096188.1| sphingosine-1-phosphate lyase I [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MFVRICAMFGFVSDLLTAAVSSLDELLQDTPAHQIILGTAALYFLYNQYHNPSISRWYRSRNNASMKQRI IDSAYALAKNLPGVNQIIEKELNKELSSTREKLRIQRSGMTLREEIPEEGLSPQDILSAFDVDVEKCHFD FLSVTNDSPEREFLVERGDGKDSGALYAIHPKELTELLKEVYGATALTNPLHDKWPRINAMQAEVIRWCQ NLFHGSKECYGLLTHGGTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAFKKAAELTGAILITVPVDK KTGAVNPKVMSSYITRNTAVIVGSAPSFMNGIHDPVSELGQLAKKKNVPFHVDACLGGFLTAFLDTSSEP MDFRVPGVTSISADLHKYGCCPKGTSVCLFSEDSPALSVYAALNWSGGLYATPGILDGSTSGARVAEVYA TLSYYGKNKYQEIAKSIITLRNAIQKELTTLLEEGNGLTSEDIYVYGNPQWSILGFRSNTCNAHFIADEL EKRGWKLNLLQNPDGFHLCLTHVHTLVKGFETQFIKDLREAVIDVKNYPPGKKPSGNVKVYGAVGMMPIE LQREICKQYQKARLNYTSASPGSLRIFTNVPVEEDEGLRNRKTEKYKV |
| - |
| Nucleotide Sequence: 1827 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2442540-2440714 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGTTCGTAAGGATATGTGCAATGTTCGGGTTTGTTTCAGATTTATTAACAGCAGCGGTCAGTTCTTTAG ATGAATTATTACAAGATACTCCGGCACATCAAATCATATTAGGCACAGCTGCTCTTTATTTTCTTTATAA TCAATACCATAACCCATCGATTTCCAGGTGGTACCGTAGCCGTAATAACGCCAGTATGAAGCAGCGTATT ATTGATAGTGCTTACGCCTTGGCAAAAAATTTACCTGGGGTGAATCAGATCATTGAGAAAGAGCTCAATA AAGAACTCTCTTCAACGAGAGAAAAATTGAGAATTCAGCGTTCCGGTATGACTCTGAGGGAGGAAATACC GGAGGAAGGGCTTTCTCCCCAAGATATTTTGAGTGCATTTGATGTGGATGTGGAAAAATGTCATTTTGAT TTTTTATCCGTAACTAATGACAGCCCTGAGAGGGAGTTTCTTGTTGAAAGAGGGGATGGTAAAGATTCAG GTGCATTATACGCTATTCACCCTAAGGAACTGACAGAGCTGCTTAAAGAAGTTTATGGGGCAACTGCTCT CACTAATCCTTTGCATGATAAATGGCCTAGAATTAACGCAATGCAAGCGGAGGTGATTCGCTGGTGTCAA AATTTGTTTCATGGTTCAAAAGAATGTTATGGTTTATTAACTCATGGGGGTACGACCAGCATTATTGAGG CGATGGCTGCTTATGTCATTCGCGCAAGGGCAAAAGGCATTGATTATCCTGAAATTGTCGTTCCTGAAAC AGCACATGCTGCATTTAAAAAAGCAGCCGAATTAACTGGAGCAATATTAATTACGGTTCCTGTTGATAAA AAAACGGGTGCGGTGAATCCCAAGGTCATGAGTTCCTATATTACCAGAAATACTGCTGTAATCGTTGGAT CTGCCCCATCTTTCATGAATGGAATTCATGATCCTGTCTCTGAGTTAGGTCAATTAGCAAAGAAAAAAAA TGTTCCTTTTCATGTGGATGCCTGTTTGGGTGGATTTTTAACGGCTTTTTTAGATACTTCATCAGAACCT ATGGATTTTAGAGTACCTGGAGTGACTTCCATTTCAGCCGATTTGCATAAATATGGCTGTTGTCCTAAAG GCACCTCTGTTTGTCTTTTTAGTGAGGATTCGCCTGCTTTGTCGGTTTATGCCGCATTAAACTGGTCAGG TGGATTGTATGCTACACCAGGAATTCTCGATGGTTCAACCAGTGGGGCTCGGGTTGCAGAGGTCTATGCC ACTTTGTCTTACTATGGAAAAAATAAATATCAGGAAATCGCTAAAAGCATTATCACATTACGCAATGCGA TTCAAAAAGAATTAACGACATTACTGGAGGAAGGCAATGGATTAACCAGTGAGGATATTTATGTTTATGG TAATCCTCAATGGTCCATCCTGGGTTTTAGAAGTAACACTTGCAATGCTCATTTCATTGCAGATGAATTG GAGAAGCGAGGTTGGAAGCTTAATTTGCTACAAAATCCGGACGGATTTCACTTATGTTTGACTCATGTGC ACACATTAGTCAAAGGTTTCGAAACGCAATTTATAAAAGATTTAAGAGAGGCGGTGATTGATGTTAAAAA TTATCCTCCTGGAAAGAAACCAAGCGGTAATGTCAAAGTGTATGGTGCTGTTGGTATGATGCCGATTGAG CTTCAGCGAGAAATTTGTAAACAATATCAAAAAGCCCGTCTTAATTATACTTCTGCCAGTCCAGGGAGTT TGAGGATATTTACAAATGTGCCTGTAGAAGAAGATGAAGGACTTAGAAATAGAAAAACAGAGAAATATAA AGTGTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Degtyar E; Zusman T; Ehrlich M; Segal G (2009). A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria. Cell Microbiol. 11(8):1219-35. [PudMed:19438520]
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| experimental literature |
| in silico analysis literature |