SecReT4
Effector Protein ID: 52842389
T4SS name [ID]Dot/Icm [5]
Gene symbollegS2
Locus taglpg2176
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]2440714..2442540 [-]
Productsphingosine-1-phosphate lyase I
Effector typeProtein
DescriptonLegS2
T4CP requirementT4CP Depedent
Target/EffectionLegS2 is homologous to eukaryotic sphingosine-1-phosphate lyase and localizes to the mitochondria in host cells (Degtyar, et al. 2009)
UniProt IDQ5ZTI6
KEGG IDlpn:lpg2176
PDB IDNA
Domain hit(s) vs Pfam Pyridoxal_deC [PF00282], Evalue: 3e-15, Aligned region: 194..382
Aminotran_5 [PF00266], Evalue: 1.2e-09, Aligned region: 201..494
DegT_DnrJ_EryC1 [PF01041], Evalue: 4.7e-06, Aligned region: 220..335
Protein Sequence: 608 a.a.     [Download]
>gi|52842389|ref|YP_096188.1| sphingosine-1-phosphate lyase I [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MFVRICAMFGFVSDLLTAAVSSLDELLQDTPAHQIILGTAALYFLYNQYHNPSISRWYRSRNNASMKQRI
IDSAYALAKNLPGVNQIIEKELNKELSSTREKLRIQRSGMTLREEIPEEGLSPQDILSAFDVDVEKCHFD
FLSVTNDSPEREFLVERGDGKDSGALYAIHPKELTELLKEVYGATALTNPLHDKWPRINAMQAEVIRWCQ
NLFHGSKECYGLLTHGGTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAFKKAAELTGAILITVPVDK
KTGAVNPKVMSSYITRNTAVIVGSAPSFMNGIHDPVSELGQLAKKKNVPFHVDACLGGFLTAFLDTSSEP
MDFRVPGVTSISADLHKYGCCPKGTSVCLFSEDSPALSVYAALNWSGGLYATPGILDGSTSGARVAEVYA
TLSYYGKNKYQEIAKSIITLRNAIQKELTTLLEEGNGLTSEDIYVYGNPQWSILGFRSNTCNAHFIADEL
EKRGWKLNLLQNPDGFHLCLTHVHTLVKGFETQFIKDLREAVIDVKNYPPGKKPSGNVKVYGAVGMMPIE
LQREICKQYQKARLNYTSASPGSLRIFTNVPVEEDEGLRNRKTEKYKV
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Nucleotide Sequence: 1827 bp     [Download]
>gi|52840256|ref|NC_002942.5|:c2442540-2440714 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
TTGTTCGTAAGGATATGTGCAATGTTCGGGTTTGTTTCAGATTTATTAACAGCAGCGGTCAGTTCTTTAG
ATGAATTATTACAAGATACTCCGGCACATCAAATCATATTAGGCACAGCTGCTCTTTATTTTCTTTATAA
TCAATACCATAACCCATCGATTTCCAGGTGGTACCGTAGCCGTAATAACGCCAGTATGAAGCAGCGTATT
ATTGATAGTGCTTACGCCTTGGCAAAAAATTTACCTGGGGTGAATCAGATCATTGAGAAAGAGCTCAATA
AAGAACTCTCTTCAACGAGAGAAAAATTGAGAATTCAGCGTTCCGGTATGACTCTGAGGGAGGAAATACC
GGAGGAAGGGCTTTCTCCCCAAGATATTTTGAGTGCATTTGATGTGGATGTGGAAAAATGTCATTTTGAT
TTTTTATCCGTAACTAATGACAGCCCTGAGAGGGAGTTTCTTGTTGAAAGAGGGGATGGTAAAGATTCAG
GTGCATTATACGCTATTCACCCTAAGGAACTGACAGAGCTGCTTAAAGAAGTTTATGGGGCAACTGCTCT
CACTAATCCTTTGCATGATAAATGGCCTAGAATTAACGCAATGCAAGCGGAGGTGATTCGCTGGTGTCAA
AATTTGTTTCATGGTTCAAAAGAATGTTATGGTTTATTAACTCATGGGGGTACGACCAGCATTATTGAGG
CGATGGCTGCTTATGTCATTCGCGCAAGGGCAAAAGGCATTGATTATCCTGAAATTGTCGTTCCTGAAAC
AGCACATGCTGCATTTAAAAAAGCAGCCGAATTAACTGGAGCAATATTAATTACGGTTCCTGTTGATAAA
AAAACGGGTGCGGTGAATCCCAAGGTCATGAGTTCCTATATTACCAGAAATACTGCTGTAATCGTTGGAT
CTGCCCCATCTTTCATGAATGGAATTCATGATCCTGTCTCTGAGTTAGGTCAATTAGCAAAGAAAAAAAA
TGTTCCTTTTCATGTGGATGCCTGTTTGGGTGGATTTTTAACGGCTTTTTTAGATACTTCATCAGAACCT
ATGGATTTTAGAGTACCTGGAGTGACTTCCATTTCAGCCGATTTGCATAAATATGGCTGTTGTCCTAAAG
GCACCTCTGTTTGTCTTTTTAGTGAGGATTCGCCTGCTTTGTCGGTTTATGCCGCATTAAACTGGTCAGG
TGGATTGTATGCTACACCAGGAATTCTCGATGGTTCAACCAGTGGGGCTCGGGTTGCAGAGGTCTATGCC
ACTTTGTCTTACTATGGAAAAAATAAATATCAGGAAATCGCTAAAAGCATTATCACATTACGCAATGCGA
TTCAAAAAGAATTAACGACATTACTGGAGGAAGGCAATGGATTAACCAGTGAGGATATTTATGTTTATGG
TAATCCTCAATGGTCCATCCTGGGTTTTAGAAGTAACACTTGCAATGCTCATTTCATTGCAGATGAATTG
GAGAAGCGAGGTTGGAAGCTTAATTTGCTACAAAATCCGGACGGATTTCACTTATGTTTGACTCATGTGC
ACACATTAGTCAAAGGTTTCGAAACGCAATTTATAAAAGATTTAAGAGAGGCGGTGATTGATGTTAAAAA
TTATCCTCCTGGAAAGAAACCAAGCGGTAATGTCAAAGTGTATGGTGCTGTTGGTATGATGCCGATTGAG
CTTCAGCGAGAAATTTGTAAACAATATCAAAAAGCCCGTCTTAATTATACTTCTGCCAGTCCAGGGAGTT
TGAGGATATTTACAAATGTGCCTGTAGAAGAAGATGAAGGACTTAGAAATAGAAAAACAGAGAAATATAA
AGTGTAA

Reference
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
(3) Degtyar E; Zusman T; Ehrlich M; Segal G (2009). A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria. Cell Microbiol. 11(8):1219-35. [PudMed:19438520] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature